[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"severe-acquired-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:severe-acquired-brain-injury":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,55,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100648025","feasibility-and-acceptability-of-stimolirpinia-for-cognitive-rehabilitation-after-severe-acquired-brain-injury-100648025",false,"NCT07718321","Feasibility and Acceptability of StimolIrpinia for Cognitive Rehabilitation After Severe Acquired Brain Injury","StimolIrpinia","Patients With Severe Acquired Brain Injury - Inclusion Criteria\n\n* Age between 18 and 75 years.\n* Level of Cognitive Functioning (LCF) score \\>= 5 at study entry.\n* Stable clinical diagnosis, assessed by at least four repeated LCF evaluations within a 1-week time window.\n* History of severe acquired brain injury of traumatic, anoxic, vascular, or mixed etiology, defined as Glasgow Coma Scale score \\\u003C= 8 for at least 24 hours after brain injury.\n* Pathological performance on at least one Oxford Cognitive Screening (OCS) subscale.\n* Having lived for a prolonged period in the Irpinia area, including Partenio, Valle Ufita-Baronia, Serinese-Solofrana, Alta Irpinia, Vallo di Lauro-Baianese, and\u002For Terminio-Cervialto.\n* Written informed consent signed by the patient or by the patient's legal representative.\n\nPatients With Severe Acquired Brain Injury - Exclusion Criteria • Severe medical conditions that may prevent participation in rehabilitation sessions, including severe language deficits incompatible with understanding instructions, severe cardiovascular instability, photosensitive or reflex epilepsy, and disabling visual or hearing deficits.\n\nRehabilitation Professionals\u002FOperators - Inclusion Criteria\n\n* Age \\>= 18 years.\n* Proven experience in neuromotor and\u002For cognitive rehabilitation of patients with severe acquired brain injury.\n* Written informed consent to participate in the study.\n\nRehabilitation Professionals\u002FOperators - Exclusion Criteria\n\n• Participation in the development of the StimolIrpinia repository, resulting in prior familiarity with the repository.",true,"ALL","18 Years","75 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"NA","This single-center pilot study evaluates the feasibility, acceptability, usability, and preliminary stimulus validation of StimolIrpinia, a multimedia repository of culturally and territorially relevant autobiographical stimuli designed to support cognitive rehabilitation activities in patients with severe acquired brain injury (sABI). The repository includes images, videos, maps, local cultural information, and printable materials related to the Irpinia area in Campania, Italy. Healthy adult volunteers will review the stimuli for their ability to evoke autobiographical memories, familiarity, emotional activation, and pleasantness. Hospitalized patients with sABI will complete six 30-minute StimolIrpinia-supported rehabilitation sessions over two weeks in addition to their routine comprehensive rehabilitation program. Rehabilitation professionals will receive standardized training and will use the repository to personalize cognitive rehabilitation exercises. Usability and acceptability will be evaluated from both patient and operator perspectives.",[28,29,30,31],"Severe Acquired Brain Injury","Cognitive Impairment","Cognitive Rehabilitation","Neurorehabilitation",[33,34,35,36,37,38,39,40,41],"severe acquired brain injury","cognitive rehabilitation","ecological rehabiliation","autobiographical stimuli","multimedia repository","acceptability","usability","feasibility","irpinia","RECRUITING","2026-07-16",{"date":45,"type":46},"2026-07-21","ACTUAL",{"date":48,"type":46},"2026-06-22",{"date":50,"type":22},"2027-08-22",{"name":52,"class":53},"Alfonso Magliacano","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},"100647752","cross-cultural-adaptation-and-multicenter-validation-of-the-italian-versions-of-the-brief-evaluation-of-receptive-aphasia-bera-and-swallowing-assessment-in-disorders-of-consciousness-swadoc-100647752","NCT07711119","Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC)","Adattamento Trans-culturale e Validazione Multicentrica Della Versione Italiana Delle Scale Brief Evaluation of Receptive Aphasia (BERA) e SWallowing Assessment in Disorders of Consciousness (SWADOC)","Inclusion Criteria:\n\n* Age \\>= 18 years.\n* Native Italian speaker.\n* Diagnosis of severe acquired brain injury.\n* At least 28 days since the acute event.\n* For SWADOC validation: stable clinical diagnosis of disorder of consciousness, including UWS, MCS, or EMCS, assessed with the Coma Recovery Scale-Revised repeated at least five times over two weeks.\n* For BERA validation: stable clinical diagnosis of MCS or EMCS assessed with the Coma Recovery Scale-Revised repeated at least five times over two weeks.\n* For BERA validation: presence of visual fixation and\u002For visual pursuit assessed with the Coma Recovery Scale-Revised.\n* No remote history of neurological, neurodegenerative, or psychiatric disease; for SWADOC validation, no remote history of otorhinolaryngological disease.\n* Written informed consent provided by the primary caregiver\u002Flegal representative according to local regulations.\n\nExclusion Criteria:\n\n* Occurrence of a second cerebral event between enrollment and data collection.\n* Unstable general clinical condition preventing assessment, including but not limited to need for ventilatory support, severe infection, or status epilepticus.",{"count":63,"type":22},79,"OBSERVATIONAL","Patients with severe acquired brain injury may evolve from coma into prolonged disorders of consciousness. In these patients, residual language comprehension and swallowing abilities are difficult to evaluate because standard assessments often depend on verbal or motor responses. The Brief Evaluation of Receptive Aphasia (BERA) assesses receptive language abilities through visual\u002Feye-movement responses, whereas the SWallowing Assessment in Disorders of Consciousness (SWADOC) assesses oral and pharyngeal components of swallowing in patients with disorders of consciousness. This national multicenter observational study aims to perform the Italian cross-cultural adaptation and validation of BERA and SWADOC. Consecutive adult inpatients with severe acquired brain injury and disorders of consciousness will be recruited from four Italian centers. SWADOC will be administered to 57 patients, and BERA will be administered to a nested subgroup of 22 patients who meet additional criteria. Inter-rater reliability, test-retest reliability over 24 hours, and convergent validity with Coma Recovery Scale-Revised scores will be analyzed.",[67,28],"Consciousness Disorders",[69,33,70,71,72,73,74,75],"disorders of consciousness","BERA","Brief Evaluation of Receptive Aphasia","SWADOC","swallowing assessment","Receptive Aphasia","rehabilitation","NOT_YET_RECRUITING","2026-07-14",{"date":79,"type":46},"2026-07-17",{"date":81,"type":22},"2026-09-01",{"date":83,"type":22},"2028-08-31",{"name":52,"class":53},4,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":54},"100602155","personality-traits-as-a-variable-in-the-recovery-of-patients-with-acquired-brain-injury-100602155","NCT07119827","Personality Traits as a Variable in the Recovery of Patients With Acquired Brain Injury","Neuropsychology and Personality: Personality Traits as a Variable in the Recovery of Patients With Acquired Brain Injury","Inclusion Criteria:\n\n* diagnosis of one of the following two conditions:\n* Severe Acquired Brain Injury (sABI) of traumatic or non-traumatic etiology; the term sABI includes acute brain injuries of traumatic or non-traumatic origin (vascular, infectious, metabolic, or anoxic), in which the patient initially presents with a coma state (Glasgow Coma Scale - GCS less than 8) and simultaneously exhibits motor, sensory, cognitive, and\u002For behavioral impairments.\n* Ischemic or hemorrhagic stroke without features of Severe Acquired Brain Injury (sABI) (Glasgow Coma Scale \\[GCS\\] score ≥ 8 and no alteration of consciousness).\n* Time from injury between:\n* 7 and 90 days for Severe Acquired Brain Injury (sABI) patients\n* 3 and 30 days for stroke patients\n* Level of Cognitive Functioning (LCF) score ≥ 6 for sABI patients\n* Signed informed consent for study participation\n* Presence of a support family member (caregiver) able to assist with completing the personality questionnaire (HEXACO Adjective Scale, HAS)\n\nExclusion Criteria:\n\n* Pre-existing neurological pathology\n* Severe aphasia or severe inattention that precludes administration of the tests required by the protocol, as identified during cognitive screening.\n* Patients with a language barrier due to insufficient proficiency in Italian.\n* Particularly vulnerable populations:\n\nThe following patients will be excluded from the study: patients in emergency situations.","80 Years",{"count":95,"type":22},250,"This study aims to evaluate the potential effects of premorbid personality on the short- and long-term global cognitive recovery in patients with severe acquired brain injury (sABI) or stroke.\n\nThe secondary aims are to assess the effects of premorbid personality on the sort- and long-term recovery in autonomy (disability), cognitive functions, psycho-behavioral functioning, motor skills, and social participation. Evaluate the incidence of premorbid personality alterations. Investigate personality changes 12-18 months after the neurological event.",[98,28,99],"Ictus","sABI",[101,102,33,103,104,105,106,107,108,99],"premorbid personality","stroke","recovery","cognitive deficits","motor deficits","disability","psychological functioning","behaviour","2026-06-29",{"date":111,"type":46},"2026-07-02",{"date":113,"type":46},"2025-05-01",{"date":115,"type":22},"2028-05-01",{"name":117,"class":53},"Universita di Verona"]