[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sexual-assault-and-rape\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sexual-assault-and-rape":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100647248","adapting-a-sexual-assault-prevention-intervention-for-transgender-undergraduates-a-one-arm-pilot-trial-100647248",false,"NCT07706322","Adapting a Sexual Assault Prevention Intervention for Transgender Undergraduates: A One-Arm Pilot Trial","Adapting a Sexual Assault Prevention Intervention for Transgender Undergraduates","TEA3","Inclusion criteria:\n\n* Participants must be adults ages 18 to 25, AND\n* Have a gender identity that differs from their sex assigned at birth (e.g. trans or nonbinary) AND\n* Be an undergraduate student AND\n* Be available during the program times, AND\n* Provide the contact information for another trans or nonbinary undergraduate who they would be willing to participate in the intervention with OR express willingness to being partnered with another trans or nonbinary undergraduate at their university AND\n* Have access to and willingness to use the videoconferencing software Zoom for the program AND\n* Consent to being recorded while participating.\n\nExclusion Criteria:\n\n* Participant is less than 18 years of age or older than 25 years of age, OR\n* Does not identify as a trans or nonbinary individual, OR\n* Is not an undergraduate student, OR\n* Is not available during the program times, OR\n* Does not provide the contact information for another trans or nonbinary undergraduate student who they would be willing to participate in the intervention with AND does not express a willingness to being partnered with another undergraduate OR\n* Does not have access to and or is unwilling to use the videoconferencing software Zoom, OR\n* Does not consent to being recorded while participating.",true,"ALL","18 Years","25 Years",{"count":22,"type":23},80,"ESTIMATED","INTERVENTIONAL",[26],"NA","The purpose of this study is to adapt and pilot a sexual assault prevention intervention for transgender and nonbinary (trans) undergraduate students. Forty percent of trans individuals (i.e., individuals whose gender identity does not align with their sex assigned at birth, inclusive of nonbinary people) are sexually assaulted during their time in college. Despite the magnitude of this issue, there are no sexual assault prevention interventions that have lowered victimization of trans students. The Enhanced Assess, Acknowledge, Act (EAAA) intervention is recommended by the Centers for Disease Control and Prevention (CDC) and is the only intervention proven to lower rape victimization by over 50% among cisgender female undergraduates. However, trans-specific vulnerabilities to violence are not addressed in EAAA, nor in the online adaptation of EAAA recently piloted by the study team called internet-delivered EAAA (IDEA3). This project will adapt and pilot IDEA3 for trans and nonbinary students to develop one of the first evidence-based sexual assault prevention interventions for trans and nonbinary young adults. We will adapt IDEA3 for trans students ages 18-25 and test it in an initial group which we will use to make revisions to the program. Then, we will collect participant survey and focus group data on feasibility and acceptability from 4 more groups of participants, revising the intervention between groups. Finally, we will collect preliminary data on whether the program increased participants' confidence in their ability to defend themselves.",[29],"Sexual Assault and Rape","NOT_YET_RECRUITING","2026-07-10",{"date":33,"type":34},"2026-07-15","ACTUAL",{"date":36,"type":23},"2026-09-02",{"date":38,"type":23},"2027-06",{"name":40,"class":41},"Sarah Peitzmeier","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":24,"phases":51,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100407458","healthy-recovery-after-trauma-study-100407458","NCT04585685","Healthy Recovery After Trauma Study","HRT","Inclusion Criteria:\n\n* individuals with a history of sexual trauma meeting past-month diagnostic criteria for PTSD (meeting diagnostic status on the DIAMOND and score greater than or equal to 36 on the PCL-5) and\n* reporting current experiences of trauma-related mental contamination (greater than or equal to 10 on the PEMC).\n* 18 years of age or older\n* fluent in English\n* Patients on psychotropic medications will be included if they have been maintained on a stable dose for at least 4 weeks prior to beginning the study and are willing to maintain a stable dosage throughout the study period; this procedure allows for a broader range of participants and avoids having outcomes assessment confounded by the initiation of medication during treatment.\n* Finally, patients must be willing to refrain from additional trauma-related treatment for the duration of the study.\n\nExclusion Criteria:\n\n* We will exclude individuals diagnosed with psychological conditions that may be better addressed by alternative treatments; these conditions include\n* psychotic disorders\n* dissociative identity disorder\n* unmanaged (i.e., unmedicated or currently experiencing a manic\u002Fhypomanic episode) bipolar disorder\n* bulimia nervosa\n* anorexia nervosa\n* imminent risk of suicide (i.e., intent\u002Fplan)\n* severe substance use disorders.",{"count":50,"type":23},12,[26],"Mental contamination-an internal experience of dirtiness evoked in the absence of physical contact with an external source-has been linked to the development and maintenance of posttraumatic stress disorder (PTSD) following exposure to sexual abuse or assault (Adams et al., 2014; Badour et al., 2013; Brake et al., 2017). Mental contamination has been associated with greater PTSD severity (Rachman et al., 2015) and higher elevations in specific PTSD symptom clusters (particularly those of intrusive reexperiencing, negative cognitions\u002Fmood, and arousal\u002Freactivity; Brake et al., 2019; Fergus \\& Bardeen, 2016). Additionally, trauma-related mental contamination has been linked to a number of negative posttraumatic emotions such as shame, guilt, disgust, and anger (Fairbrother \\& Rachman, 2004; Radomsky \\& Elliott, 2009) Despite clear and consistent links between mental contamination and problematic posttraumatic outcomes following sexual trauma, there is a dearth of research investigating how existing or promising new interventions for PTSD impact mental contamination.\n\nCognitive Processing Therapy (CPT) is an efficacious and effective 12-session manualized cognitive-behavioral intervention for PTSD that is considered a gold-standard empirically-supported treatment for PTSD that is recommended by the American Psychological Association (APA, 2017). In addition to PTSD symptom improvement, CPT has also demonstrated benefit for improving feelings of shame and guilt, which are often seen among individuals with trauma-related mental contamination (Nishith et al., 2005; Resick et al., 2002, 2008). Cognitive reappraisal, a primary technique employed in CPT, involves challenging one's view of an emotionally-eliciting situation to alter its emotional impact (Gross \\& John, 2003). However, some investigators have suggested that cognitive reappraisal may be less effective in targeting moral emotions such as shame, guilt, and self-disgust that are based on an individual's standards and virtues (Finlay, 2015). Self-compassion (SC; i.e., self-directed care and kindness; forgiveness; and feelings of common humanity; Neff, 2003) has been proposed as an alternative method for addressing trauma-related shame and preliminary evidence suggests a 6-session self-compassion intervention may have benefit for reducing both PTSD symptoms and trauma-related shame (Au et al., 2017). Given the centrality of shame, guilt, and self-disgust to the experience of mental contamination, and the fact that mental contamination often arises in response to experiences involving moral violation or betrayal (Millar et al., 2016; Rachman, 2010), a SC intervention for PTSD may also offer promise as a standalone or adjunctive intervention for reducing trauma-related mental contamination. A test of these interventions for their impact on reducing trauma-related mental contamination is needed.\n\nThe current study will use Single Case Experimental Design to isolate and evaluate the effects of CPT and SC in reducing both PTSD symptoms and trauma-related mental contamination among individuals with PTSD resulting from sexual trauma.\n\nAims: 1) explore whether participants demonstrate reductions in mental contamination and PTSD symptoms in response to 12-sessions of CPT or 6-sessions of a SC intervention; 2) evaluate whether presentation of either treatment first yields differences in symptom reduction for PTSD and\u002For mental contamination symptoms; 3) evaluate whether the addition of the alternative module will enhance reductions in PTSD symptoms and mental contamination; 4) evaluate if such reductions are maintained during follow-up.\n\nVisual inspection analysis and statistical methods will be used to draw conclusions regarding the effects of the interventions on PTSD symptoms and mental contamination.",[54,55,56,29],"Stress Disorders, Post-Traumatic","Shame","Guilt",[58,59,60,61,62,63,64],"post-traumatic stress disorder","mental contamination","cognitive processing therapy","self-compassion","shame","guilt","sexual trauma","RECRUITING","2025-11-05",{"date":68,"type":34},"2025-11-10",{"date":70,"type":34},"2020-09-10",{"date":72,"type":23},"2026-11",{"name":74,"class":41},"Christal L Badour",1]