[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-barrier-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-barrier-dysfunction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100648808","effect-of-fpp-on-cutaneous-barrier-integrity-100648808",false,"NCT07725835","Effect of FPP on Cutaneous Barrier Integrity","Pilot Study of Fermented Papaya Preparation (FPP) Impact on Transepidermal Water Loss of Skin on Face, Arms, and Hands","FPP OSATO","Inclusion Criteria:\n\n1. 50-75 years\n2. Willing to allow collection of 3 blood samples (Baseline, Week 12 and Week 20)\n3. Willing to log daily compliance with FPP intake during the study period (12 weeks)\n4. Absence of active systemic disease per investigator judgement.\n5. No current use of immunosuppressant or immunomodulatory medications.\n6. No active dermatological conditions at measurement sites that could impair measure, per investigator judgement.\n7. Investigator determination of general good health.\n\nExclusion Criteria:\n\n1. Co-morbidity or concurrent medication that the Investigator deems impactful to patient safety or ability to adhere to FPP dosage.\n2. Co-morbidity or concurrent medication that the Investigator deems confounding to outcome measure (i.e., topical or systemic steroid).\n3. Current or history of allergy to FPP ingredients: Dextrose, Carica papaya, or Food yeast.\n4. Concurrent participation in another interventional trial that may impact measures, per investigator judgement.\n5. Uncontrolled diabetes (A1c \\>7%).\n6. Open wounds or actively receiving Wound Care services.\n7. Pregnant or breastfeeding women.\n8. Current use of warfarin.",true,"ALL","50 Years","75 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","This pilot study will test how Fermented Papaya Preparation (FPP) impacts overall TEWL of areas that commonly display diminished barrier function, such as the skin from face, arms, and hands. Areas of diminished barrier function are defined as those not visible to the eye but identified as areas of high transepidermal water loss (TEWL) as measured by a non-invasive pen-like device. A TEWL value of 20 or higher at a location would be considered high TEWL. Participants will attend 5 visits over 20 weeks, with 12-weeks of FPP treatment, and 8-weeks of follow-up.",[29,30],"Skin Barrier Dysfunction","Healthy Volunteers","NOT_YET_RECRUITING","2026-08-17",{"date":34,"type":35},"2026-08-19","ACTUAL",{"date":37,"type":23},"2026-09",{"date":39,"type":23},"2028-07",{"name":41,"class":42},"University of Pittsburgh","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":18,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":24,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":43},"100646447","cholesterol-cream-vs-urea-cream-for-skin-barrier-and-quality-of-life-in-ichthyosis-100646447","NCT07689435","Cholesterol Cream vs Urea Cream for Skin Barrier and Quality of Life in Ichthyosis","A Comparative Study on the Efficacy of 10% Cholesterol Cream Versus 10% Urea Cream in Improving Skin Barrier Function and Quality of Life in Patients With Autosomal Recessive Congenital Ichthyosis","CURE-ARCI","Inclusion Criteria:\n\n1. Male or female patients aged 7 to 65 years\n2. Confirmed diagnosis of Autosomal Recessive Congenital Ichthyosis (ARCI), established by history, family\u002Fgenetic history, clinical presentation, and\u002For genetic testing\n3. Disease activity stable (not in an acute flare)\n4. Thai nationality\n5. Receiving care at the Institute of Dermatology\n6. Willing and able to provide informed consent (or, for participants under 18, assent with parental\u002Flegal guardian consent)\n\nExclusion Criteria:\n\n1. Presence of any other concurrent skin disease\n2. Known history of allergy to any component of the study creams\n3. Active skin infection (e.g., herpes zoster, viral, fungal, bacterial, or parasitic infection)\n4. History of any malignancy\n5. Pregnant (confirmed by positive urine pregnancy test), breastfeeding, or planning pregnancy during the study period","7 Years","65 Years",{"count":55,"type":23},24,[26],"This study looks at whether a cream containing 10% cholesterol works better than a cream containing 10% urea for people with autosomal recessive congenital ichthyosis (ARCI), a rare inherited skin condition that causes dry, thickened, scaly skin from birth.\n\nPeople with ARCI have a weakened skin barrier because their skin cannot properly produce or arrange the natural fats (lipids) needed to keep moisture in and irritants out. This leads to excessive water loss through the skin, dryness, itching, cracking, and a higher risk of skin infections. The current standard treatment is urea cream, which helps soften and remove scale but does not repair the underlying fat structure of the skin barrier. Cholesterol is one of the key natural fats that makes up a healthy skin barrier, so applying it directly to the skin may help rebuild that barrier more effectively than urea.\n\nIn this study, each participant will have one cream applied to one side of the body and the other cream applied to the matching area on the opposite side, so that each person acts as their own comparison. Researchers will measure how much water the skin loses (transepidermal water loss), skin hydration, and skin pH before and after treatment. They will also assess dryness and itching, take standardized clinical photographs, and ask participants to complete quality-of-life questionnaires (the Dermatology Life Quality Index, or its children's version, the Children's Dermatology Life Quality Index) as well as a satisfaction questionnaire for each cream.\n\nThe goal is to find out whether cholesterol cream restores the skin barrier better than urea cream, reduces dryness and itching more effectively, and leads to a better quality of life for people living with ARCI. The results may help guide more targeted skin care recommendations for this rare genetic condition.\n\nThis study is being conducted at the Institute of Dermatology, Bangkok, Thailand, and has been approved by the Institute's Ethics Committee.",[59,29,60],"Autosomal Recessive Congenital Ichthyosis","Ichthyosis Inherited",[59,62,63,64,65],"Cholesterol Cream","Urea Cream","Skin Barrier Function","Dermatology Life Quality Index","2026-07-07",{"date":68,"type":35},"2026-07-08",{"date":70,"type":23},"2026-07-15",{"date":72,"type":23},"2027-06-30",{"name":74,"class":75},"Institute of Dermatology, Thailand","OTHER_GOV"]