[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-hydration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-hydration":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,82,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100651805","driving-time-and-facial-skin-hydration-asymmetry-in-florida-drivers-100651805",false,"NCT07764809","Driving Time and Facial Skin Hydration Asymmetry in Florida Drivers","Driving Time and Left-Cheek Skin Hydration Asymmetry in Florida Residents: An Observational Study on Cumulative UVA Exposure Through Vehicle Side Windows","DCHA-FL-25-65","Inclusion Criteria:\n\n* Female sex, aged 25 to 65 years (inclusive)\n* Valid driver's license and active driving for a minimum of 3 years\n* Driving frequency of at least 3 days per week on average\n* Florida residency for a minimum of 2 years prior to enrollment\n* Ability to provide written informed consent in English or Russian\n\nExclusion Criteria:\n\n* Window tinting on the driver-side window of the participant's primary vehicle\n* Regular sunscreen application specifically to the left side of the face before driving (more than half of driving occasions in the past month)\n* Active skin disease on the face at time of assessment\n* Injectable cosmetic procedures (Botox or fillers) in the past 6 months\n* Laser resurfacing or chemical peel in the past 3 months\n* Inability to refrain from facial cosmetics for at least 2 hours prior to the visit",true,"FEMALE","25 Years","65 Years",{"count":22,"type":23},80,"ESTIMATED","OBSERVATIONAL","his observational study examines whether time spent driving is associated with differences in skin hydration between the left and right cheeks in female drivers residing in Florida. In left-hand-drive vehicles, the driver's left cheek is chronically exposed to ultraviolet A (UVA) radiation through the unshaded side window during every daytime driving episode. A prior study by IAS Skin Care (NCT07564869, n=30) found that the left cheek was less hydrated than the right cheek in 60% of participants, suggesting a possible effect of driving-related UVA exposure on facial skin hydration asymmetry.\n\nEighty female drivers aged 25-65 years residing in Florida will be enrolled. At a single visit, skin hydration will be measured at three facial zones (left cheek, right cheek, and forehead as a symmetrical control zone) using the BT-Analyze bioimpedance device. Participants will complete a structured questionnaire on driving habits, sun protection practices, and skin history. The primary outcome is the Hydration Asymmetry Index (HAI = right cheek minus left cheek BT-Analyze score). Associations between driving time, cumulative driving exposure, window tinting, sunscreen use, and HAI will be examined using Spearman correlation, Mann-Whitney U tests, and multiple linear regression.",[27,28,29],"Skin Diseases","Photoaging","Skin Hydration",[31,32,33,34,35,36,37,38],"skin hydration","UVA exposure","driving","photoaging","bioimpedance","facial asymmetry","Florida","BT-Analyze","NOT_YET_RECRUITING","2026-08-10",{"date":42,"type":43},"2026-08-14","ACTUAL",{"date":45,"type":23},"2026-10-01",{"date":47,"type":23},"2027-03-01",{"name":49,"class":50},"IAS Skin Care","INDUSTRY",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100650168","a-clinical-trial-to-evaluate-the-effects-of-nailas-collagen-marine-plus-food-supplement-on-skin-hydration-elasticity-fine-lines-and-wrinkles-and-hair-and-nail-health-100650168","NCT07746076","A Clinical Trial to Evaluate the Effects of Naila's Collagen Marine Plus Food Supplement on Skin Hydration, Elasticity, Fine Lines and Wrinkles, and Hair and Nail Health","Inclusion Criteria:\n\n* Healthy adults aged 40-60 years at the time of enrollment.\n* Self-reported visible signs of skin aging, including at least one of the following: fine lines, wrinkles, reduced skin firmness or elasticity, or skin dryness.\n* Self-reports hair shedding and a desire to improve hair health.\n* Willing to take one sachet of the study product daily for 12 weeks as directed.\n* Willing to avoid taking any other collagen-containing dietary supplements for the duration of the study.\n* Willing to maintain current diet, skincare routine, sleep patterns, and physical activity levels for the duration of the trial.\n* Willing and able to submit standardized facial and hair photographs at Baseline and Week 12.\n* Has access to a smartphone or digital camera capable of producing photographs.\n* Resides in the United States.\n* Willing to follow the study protocol and complete all required questionnaires.\n\nExclusion Criteria:\n\n* Known allergy or sensitivity to fish, marine-derived products, or any of the study product ingredients (marine collagen, hyaluronic acid, ascorbic acid, biotin).\n* Previous diagnosis of a hair loss condition such as alopecia areata, androgenetic alopecia, or telogen effluvium.\n* Currently taking any collagen-containing dietary supplements, or planning to start taking any collagen supplements in the next 12 weeks.\n* Any current uncontrolled chronic medical condition that would prevent the participant from safely completing the study protocol.\n* History of a diagnosed dermatological condition that significantly affects facial skin appearance (e.g., severe eczema, psoriasis, rosacea, or active acne) and could confound assessment of skin aging outcomes.\n* Use of prescription retinoids, injectable dermal fillers, botulinum toxin, chemical peels, laser skin treatments, or other professional aesthetic procedures on the face within 3 months prior to enrollment or planned during the study period.\n* Currently pregnant, breastfeeding, or planning to become pregnant during the study period.\n* Currently participating in another research study or planning to participate in another study during this study's duration.\n* Any condition that, in the judgment of the investigator, would make the participant unsuitable for inclusion in the study.","ALL","30 Years","60 Years",{"count":62,"type":23},40,"INTERVENTIONAL",[65],"NA","This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail health over 12 weeks. Forty healthy adults aged 40-60 years with self-reported mature skin showing early signs of aging will take one sachet of the supplement daily and complete questionnaires at Baseline, Week 4, Week 8, and Week 12.\n\nParticipants will also submit standardized facial and hair photographs at Baseline and Week 12 for evaluation by a board-certified dermatologist. The primary objectives are to assess changes in skin aging parameters and hair health. Secondary objectives include evaluation of nail health, hair shedding and density, participant-reported satisfaction, and product safety and tolerability.",[68,29,69,70,71,72],"Skin Aging","Skin Elasticity","Fine Lines and Wrinkles","Hair Health","Nail Health","2026-08-03",{"date":75,"type":43},"2026-08-04",{"date":77,"type":23},"2026-08",{"date":79,"type":23},"2026-11",{"name":81,"class":50},"Gulf Bird",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":17,"sex":58,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":63,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":51},"100635110","study-of-a-peptide-creams-effect-on-the-facial-skin-barrier-using-a-side-by-side-comparison-100635110","NCT07548424","Study of a Peptide Cream's Effect on the Facial Skin Barrier Using a Side-by-Side Comparison","Evaluation of the Effect of a Topical Formulation Containing Acetyl Hexapeptide-37 on Objective Skin Barrier Parameters of the Face in a Randomized Controlled Split-Face Design","Inclusion Criteria:\n\n* healthy volunteers who gave written informed consent\n\nExclusion Criteria:\n\n* presence of active skin diseases or dermatological conditions\n* known allergy or hypersensitivity to any ingredient of the study products\n* pregnancy or breastfeeding\n* use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines prior to or during the study","18 Years","50 Years",{"count":92,"type":23},30,[65],"The goal of this clinical trial is to evaluate whether a topical face cream containing the peptide Acetyl Hexapeptide-37 improves skin hydration and strengthens the skin barrier compared to a placebo cream in healthy adult participants. The study uses a split-face design, in which one side of the face is treated with the peptide cream and the other side with a placebo (a cream without the active ingredient).\n\nThe main questions it aims to answer are:\n\n* Does the peptide cream improve skin hydration and reduce transepidermal water loss compared to placebo?\n* Does the peptide cream affect skin erythema or cause irritation?\n* How do participants rate the comfort and tolerability of the peptide cream?\n\nResearchers will compare the treated and placebo sides of the face to assess differences in skin barrier function and tolerability.\n\nParticipants will:\n\n* Attend a baseline visit for assessment of facial skin parameters, including hydration, transepidermal water loss, and erythema\n* Apply the peptide cream to one side of the face and the placebo cream to the other side once daily for 4 weeks\n* Attend weekly follow-up visits for non-invasive skin measurements\n* Record any skin sensations (e.g., stinging, tightness) or adverse effects throughout the study",[96,29,97],"Skin Barrier Function","Topical Peptide Effects on Facial Skin Barrier Function","RECRUITING","2026-06-15",{"date":101,"type":43},"2026-06-17",{"date":103,"type":43},"2026-05-04",{"date":105,"type":23},"2027-01",{"name":107,"class":108},"University of Split, School of Medicine","OTHER",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":17,"sex":58,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":63,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":51},"100611142","evaluation-of-spm-topical-cosmetic-application-on-skin-appearance-hydration-and-barrier-support-in-healthy-adults-100611142","NCT07236736","Evaluation of SPM™ Topical Cosmetic Application on Skin Appearance, Hydration, and Barrier Support in Healthy Adults","SPMT","Inclusion Criteria:\n\n1. Generally healthy with no systemic or active dermatologic diseases.\n2. Willing and able to apply topical product daily for 6 weeks.\n3. Able to provide written informed consent.\n4. Willing to undergo skin biopsies and follow study procedures.\n\nExclusion Criteria:\n\n1. History of skin cancer or other malignancy within the past 10 years.\n2. Active or chronic dermatologic conditions (e.g., eczema, psoriasis, acne, rosacea).\n3. Known allergy or sensitivity to components of the investigational product.\n4. Current use of systemic corticosteroids or immunosuppressants.\n5. Pregnancy or breastfeeding.\n6. Any condition that, in the investigator's opinion, would interfere with study participation or pose additional risk.","20 Years","75 Years",{"count":119,"type":23},10,[65],"This is an exploratory, cosmetic-use study evaluating the effects of Super Protein Multifunction (SPM™), a topical peptide-based formulation, on skin appearance, hydration, and barrier-related characteristics in healthy adults. The study aims to collect preliminary biophysical and histologic data on cosmetic skin changes following six weeks of SPM™ use. Participants will apply the product to a designated skin area while a matched contralateral area serves as the untreated comparison site. Skin hydration, transepidermal water loss (TEWL), and tissue markers of skin structure and barrier integrity will be assessed before and after product use. The study includes noninvasive measurements and small punch biopsies at two timepoints.",[123,29],"Healthy Skin","2025-12-17",{"date":126,"type":43},"2025-12-19",{"date":128,"type":23},"2026-01-30",{"date":130,"type":23},"2027-06-30",{"name":132,"class":50},"Biocoz Global Pte. Ltd."]