[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"soft-tissue-augmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:soft-tissue-augmentation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100652656","evaluation-of-the-effect-of-smoking-on-palatal-donor-site-tissue-profile-in-the-success-of-connective-tissue-grafts-100652656",false,"NCT07777185","Evaluation of the Effect of Smoking on Palatal Donor Site Tissue Profile in the Success of Connective Tissue Grafts","Evaluation of the Effect of Smoking on the Palatal Donor Site Tissue Profile in the Success of Connective Tissue Grafts","Inclusion Criteria\n\nParticipants must be aged 18 years or older and systemically healthy, with no systemic disease that could directly affect inflammatory status or wound healing. Eligible patients must present with an isolated facial recession greater than 2 mm and less than 5 mm (up to a maximum of 5 mm) on non-molar maxillary teeth, classified as Cairo Type 1 (RT1 = Miller Class I and II), meaning gingival recession without interproximal attachment loss. Patients must have had no previous soft tissue surgery at the surgical site, must demonstrate good oral hygiene (full-mouth bleeding on probing below 10%), and must not have had a soft tissue graft previously harvested from the palatal donor site. Finally, participants must be able to comply with all study-related procedures, including attendance at all follow-up visits.\n\nExclusion Criteria\n\nPatients are excluded if they have untreated periodontitis or peri-implantitis, or any systemic disease that could potentially impair wound healing, such as diabetes or connective tissue disorders. Pregnancy or breastfeeding, as well as previous or concurrent use of medications affecting mucosal healing (e.g., steroids or high-dose anti-inflammatory drugs), are also grounds for exclusion. Additional exclusion criteria include coagulation or bleeding disorders, cleft palate, active orthodontic treatment with fixed or removable appliances, a history of malignancy, radiotherapy, or chemotherapy for malignancy within the past 5 years, and antibiotic therapy within the past 6 months. Patients who have previously had a connective tissue graft harvested from the palatal donor site, or who have undergone any other surgical procedure at the palatal donor or recipient site (e.g., apical resection or crown lengthening), are also excluded.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","This single-center prospective clinical study investigates how smoking affects palatal donor site tissue biology and, in turn, the success of connective tissue grafts used in root coverage surgery. A total of 24 systemically healthy patients with Cairo Type 1 (RT1) gingival recession will be enrolled: 12 smokers and 12 non-smokers. All participants will receive a coronally advanced flap combined with a subepithelial connective tissue graft (CAF + CTG) harvested from the palatal donor site.\n\nBoth donor and recipient sites will be assessed at baseline and postoperatively (2 weeks, 1 month, and 3 months) using ultra-high frequency ultrasonography (UHFUS) to measure tissue thickness, echogenicity, structural integrity, and vascularization. Residual connective tissue fragments obtained during routine graft preparation will undergo histological, histochemical, and immunohistochemical analysis (including COL1A1, COL1A2, COL3A1, α-SMA, CD31, Factor XIIIa, and IL-33). Smoking status will be biochemically confirmed via salivary cotinine ELISA. Clinical outcomes (recession depth, clinical attachment level, keratinized tissue height, percentage of root coverage) and patient-reported outcome measures (PROMs) will be compared between groups.\n\nPrimary Hypothesis: Smoking negatively affects palatal donor site biology, impairing the clinical and ultrasonographic healing outcomes of CAF + CTG procedures.",[28,29,30],"Soft Tissue Augmentation","Gingival Recession Localized Moderate","Palatal Morphology","NOT_YET_RECRUITING","2026-08-17",{"date":34,"type":35},"2026-08-20","ACTUAL",{"date":37,"type":22},"2026-08-18",{"date":39,"type":22},"2027-02-17",{"name":41,"class":42},"Ankara University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100563945","phase-2-the-use-of-a-porcine-collagen-matrix-for-the-prevention-of-buccal-bone-wall-resorption-during-implant-placement-in-the-aesthetic-zone-100563945","NCT06622759","The Use of a Porcine Collagen Matrix for the Prevention of Buccal Bone Wall Resorption During Implant Placement in the Aesthetic Zone.","The Use of a Porcine Collagen Matrix for the Prevention of Buccal Bone Wall During Implant Placement in the Aesthetic Zone. A Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\n1. Generally healthy adult patients.\n2. 18 years or older.\n3. Need for replacement of single implant in the upper aesthetic zone (second premolar to second premolar)\n4. Ridge width (bucco-lingual) no greater than 6 mm at its narrowest point.\n5. Minimum 2mm of attached gingiva.\n6. Ability to comply with the study related procedures such as exercising good oral hygiene and attending all follow-up examinations.\n7. Ability to fully understand the nature of the proposed surgery and ability to sign the informed consent form\n\nExclusion Criteria:\n\n1. Poor oral hygiene (FMPS \\\u003C 20%, FMBS \\\u003C 15%) and poor motivation\n2. Heavy smokers (\\>10 cigarettes per day)\n3. Need for bone augmentation\n4. Untreated periodontitis\n5. General contraindications for dental and\u002For surgical treatment\n6. History of malignancy, radiotherapy, or chemotherapy for malignancy within the past 5 years\n7. Women of child bearing age, not using a standard accepted method for contraception\n8. Pregnancy or breast feeding\n9. Previous and concurrent medication affecting mucosal healing in general (e.g. steroids, large doses of anti-inflammatory drugs\n10. Disease affecting connective tissue metabolism (e.g. collagenases)\n11. Allergy to collagen","75 Years",{"count":53,"type":22},36,[55],"PHASE2","Aim:\n\nTo provide a comparative assessment of the clinical and radiographic effect of porcine collagen matrix when placed buccally at the time of single implant placement in the aesthetic zone vs autogenous connective tissue graft in terms of buccal bone resorption and soft tissue augmentation 6 months post operative. Histological assessment and patient reported outcomes were reported",[28],[59,60,61,62,63,64,65],"Implants","Esthetic zone","Soft tissue augmentation","Collagen matrix","Soft tissue grafts","Connetive Tissue Graft","Porcine collagen matrix","RECRUITING","2025-08-03",{"date":69,"type":35},"2025-08-07",{"date":71,"type":35},"2023-03-24",{"date":73,"type":22},"2025-08-30",{"name":75,"class":42},"Aristotle University Of Thessaloniki",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":43},"100390733","management-of-the-fresh-extraction-socket-in-the-aesthetic-area-100390733","NCT04367766","Management of the Fresh Extraction Socket in the Aesthetic Area","Management of the Fresh Extraction Socket in the Aesthetic Area: Alveolar Ridge Preservation vs Immediate Implant Placement vs Delayed Implant Placement","IIP\u002FARP\u002FSH","Inclusion Criteria:\n\n* single tooth extraction in the anterior region of the dentition (including premolars) to be extracted\n* smoking no more than 10 cigarettes\u002Fday,\n* periodontal health (BoP \\\u003C 10%) and good plaque control (\\\u003C 20%)\n* absence of symptomatic periapical radiolucencies, acute abscesses at the site of extraction,\n* extraction sites with less than 30% loss of one or more walls\n* adequate quantity and quality of native bone to achieve primary stability\n\nExclusion Criteria:\n\n* growing patients\n* patients with autoimmune disease, uncontrolled diabetes or immunocompromised\n* history of head and neck radiation for cancer treatment,\n* pregnancy",{"count":85,"type":22},60,[25],"After atraumatic tooth extraction and the assessment of the feasibility of immediate implant placement, patients will be randomly assigned to one of three treatment concepts:\n\n1. Immediate Implant Placement and Immediate Provisionalization\n2. Alveolar Ridge Preservation. After 4 months of healing an implant will be placed with simultaneous GBR and\u002For Soft Tissue Augmentation procedures, if needed.\n3. Spontaneous Healing of the socket. After 4 months of healing, an implant will be placedwith simultaneous GBR and\u002For Soft Tissue Augmentation procedures, if needed.\n\nIn all groups, four months after implant placement, a prosthesis will be delivered. From this experimental period onward, patients will be scheduled for maintenance. Clinical, radiographic and volumetric assessment will be performed by clinicians not involved in the surgery and blind with respect to treatment assignment at 1, 3 and 5 years post loading.",[89,90,91,28],"Tooth Extraction Status Nos","Dental Implant","Bone Augmentation",[93,94,95,96,97,98,99],"Immediate implant placement","alveolar ridge preservation","delayed implant placement","PROMs","implant health","volumetric analysis","tissue augmentation","2023-12-06",{"date":102,"type":35},"2023-12-12",{"date":104,"type":35},"2023-09-27",{"date":106,"type":22},"2026-08",{"name":108,"class":109},"Centro Specialistico Odontoiatrico, Rome","NETWORK"]