[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spastic-cerebral-palsy-scp\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spastic-cerebral-palsy-scp":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,74,107,138,164,188],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100652639","bilateral-asymmetry-of-respiratory-muscle-activity-during-breathing-in-children-with-spastic-cerebral-palsy-100652639",false,"NCT07777809","Bilateral Asymmetry of Respiratory Muscle Activity During Breathing in Children With Spastic Cerebral Palsy","A Cross-Sectional Study on Bilateral Asymmetry of Respiratory Muscle Activity During Breathing in Children With Spastic Cerebral Palsy: Surface Electromyography Analysis","Inclusion Criteria:\n\n* Children with Gross Motor Function Classification System (GMFCS) Level I or II\n* Children with sufficient cognitive ability to understand instructions and voluntarily perform tasks\n* Children with a Trunk Appearance Clinical Evaluation (TRACE) score of 4 or higher out of a total of 12 points\n\nExclusion Criteria:\n\n* Children who have undergone orthopedic surgery of the spine or lower extremities, or received botulinum toxin injection treatment within the past 6 months\n* Children with acute or chronic respiratory diseases, such as asthma or acute pneumonia\n* Children with severe cardiac disorders, intellectual disabilities, or visual and auditory impairments that may interfere with the experiment","ALL","4 Years","12 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","This observational cross-sectional study investigates the bilateral asymmetry of respiratory muscle activity during breathing in children with spastic cerebral palsy (CP). Children with CP often exhibit structural deformities, which may lead to impaired chest mobility and asymmetric respiratory function. The primary objective is to objectively evaluate the imbalance in the activation of bilateral respiratory muscles (intercostal, external oblique, and sternocleidomastoid) using non-invasive surface electromyography (sEMG). Muscle activity will be measured during resting breathing and active breathing tasks. The findings aim to provide clinical evidence for developing selective respiratory muscle training programs for this population.",[25],"Spastic Cerebral Palsy (sCP)",[27,28,29],"Surface Electromyography","Respiratory Muscle","Asymmetry","NOT_YET_RECRUITING","2026-08-17",{"date":33,"type":34},"2026-08-20","ACTUAL",{"date":36,"type":21},"2026-08",{"date":38,"type":21},"2027-08",{"name":40,"class":41},"Sahmyook University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":42},"100639612","tdcs-and-bi-manual-training-in-cerebral-palsy-100639612","NCT07573865","tDCS and Bi-manual Training in Cerebral Palsy","AI-Assisted Anodal tDCS Combined With Bimanual Motor Training in Children With Unilateral Spastic Cerebral Palsy: A Pilot Feasibility Study at Riphah Hospital","Inclusion Criteria:\n\n1. Children aged 6-17 years with unilateral spastic CP\n2. Wrist extension ≥ 20°, MCP\u002FPIP joints ≥ 10°\n\nExclusion Criteria:\n\n1. Any other neurological disorders\n2. An orthopedic condition affecting the participation in UE activities.\n3. Unable to understand the command.","6 Years","17 Years",{"count":53,"type":21},15,"INTERVENTIONAL",[56],"NA","Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function. Traditional therapies such as constraint-induced movement therapy (CIMT) and bimanual intensive training offer limited benefits. Pharmacologic treatments often produce behavioral side effects and do not address underlying neuro-plastic deficits. There is an unmet need for safe, effective, non-invasive interventions targeting motor recovery through cortical modulation.",[59,60,25],"Cerebral Palsy (CP)","Unilateral Cerebral Palsy",[62,63,64],"Cerebral Palsy","Spasticity","tDCS","2026-05-04",{"date":67,"type":34},"2026-05-07",{"date":69,"type":21},"2026-04-30",{"date":71,"type":21},"2026-08-31",{"name":73,"class":41},"Riphah International University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":42},"100592307","botulinum-neurotoxin-for-children-with-cp-a-delicate-balance-between-clinical-benefits-and-muscular-harm-100592307","NCT06991725","Botulinum Neurotoxin for Children With CP: a Delicate Balance Between Clinical Benefits and Muscular Harm","Botulinum Neurotoxin for Children With Cerebral Palsy: a Delicate Balance Between Clinical Benefits and Muscular Harm","Bo-Balance","\\- Children with spastic cerebral palsy\n\nInclusion criteria:\n\n* Children (boys\u002Fgirls) with congenital brain lesion, confirmed with neuro-imaging such as MRI\n* At high-risk for CP or diagnosed spastic type of CP\n* (Suspected) Gross Motor Function Classification Scale (GMFCS) Level I-III\n* Uni or bilateral involvement\n* Aged between 2-16 years\n\nExclusion criteria:\n\n* Presence of dyskinesia or ataxia\n* Severe co-morbidities (cognitive problems)\n* BTX treatment in the gastrocnemius in the past 10 months\n* Previous surgery at the investigated muscles.\n* Previous orthopedic or neurosurgery\n* Severe ankle deformities\n* Weight for height values \\>2SD or \\\u003C-2SD from mean\n\n  * Typically developing children\n\nInclusion criteria:\n\n• Aged between 2-16 years\n\nExclusion criteria:\n\n* History of neurological, orthopedic or muscular problems\n* Involvement in an elite or high-performance sporting program (Children performing the same sports for \\> 5 hours\u002Fweek will be excluded)",true,"2 Years","16 Years",{"count":86,"type":21},51,"A cross-sectional design study will be carried out to explore the morphological muscle properties and alterations in muscle composition on a macroscopic level in children with spastic cerebral palsy (CP). Muscle composition will be assessed using quantitative Magnetic Resonance Imaging (qMRI) and shear wave elastography (SWE), while macroscopic muscle size properties will be evaluated through 'Three-dimensional freehand ultrasound (3DfUS).",[25],[90,91,92,93,94,95,96,63],"Spastic Cerebral Palsy","Muscle composition","3D freehand ultrasound","Shear wave elastography","Muscle morphology","Range of motion","Stiffness","RECRUITING","2026-04-28",{"date":100,"type":34},"2026-04-29",{"date":102,"type":34},"2025-02-03",{"date":104,"type":21},"2028-12",{"name":106,"class":41},"Universitaire Ziekenhuizen KU Leuven",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":54,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":42},"100623112","virtual-reality-combined-with-bobath-therapy-for-spastic-cerebral-palsy-100623112","NCT07392398","Virtual Reality Combined With Bobath Therapy for Spastic Cerebral Palsy","Effects of Virtual Reality Combined With Bobath Technique on Lower Limb Muscle Activity, Balance, and Motor Function in Patients With Spastic Cerebral Palsy: A Randomized Controlled Trial","VR-BOBATH-CP","Inclusion Criteria:\n\n* Aged 2 to 14 years at the time of enrollment.\n* Diagnosed with spastic cerebral palsy (spastic diplegia or spastic hemiplegia) by a qualified clinician.\n* Classified as Gross Motor Function Classification System (GMFCS) levels I to III.\n* Presence of lower limb spasticity with a Modified Ashworth Scale (MAS) score of at least 1.\n* Ability to understand and follow simple instructions appropriate for age and cognitive level.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Presence of severe cognitive impairment that prevents participation in the intervention or assessments.\n* Uncontrolled epilepsy or a history of frequent seizures that may interfere with the intervention.\n* Severe visual, vestibular, or auditory impairments that limit safe participation in virtual reality training.\n* Orthopedic surgery or botulinum toxin injection involving the lower limbs within the previous 6 months.\n* Participation in other interventional clinical studies during the study period.","14 Years",{"count":117,"type":21},30,[56],"Spastic cerebral palsy is a common neurodevelopmental disorder characterized by increased muscle tone, impaired balance, and limitations in motor function, particularly in the lower limbs. Conventional rehabilitation approaches such as the Bobath technique are widely used to improve posture control and movement patterns; however, patient engagement and task variability may be limited.\n\nThis randomized controlled trial aims to evaluate the effectiveness of virtual reality (VR) combined with Bobath therapy on lower limb muscle activity, balance, and gross motor function in patients with spastic cerebral palsy. Eligible participants will be randomly assigned to either a VR plus Bobath intervention group or a conventional Bobath therapy group.\n\nThe intervention will be delivered over a 6-week period, with sessions conducted five times per week. Outcome measures, including surface electromyography (sEMG), center of pressure (COP) parameters, and the Gross Motor Function Measure-88 (GMFM-88), will be assessed before and after the intervention. This study seeks to provide evidence on whether integrating VR into conventional rehabilitation can improve functional outcomes in children with spastic cerebral palsy.",[25],[122,123,124,125,126,27,127,128],"Virtual Reality Rehabilitation","Bobath Technique","Pediatric Rehabilitation","Lower Limb Function","Balance Training","Gross Motor Function Measure","Randomized Controlled Trial","2026-02-02",{"date":131,"type":34},"2026-02-06",{"date":133,"type":21},"2026-03-01",{"date":135,"type":21},"2026-06-01",{"name":137,"class":41},"Tongren Hongxin Kangxin Traditional Chinese Medicine Hospital, Guizhou Province",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":54,"phases":149,"briefSummary":150,"conditions":151,"keywords":152,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":42},"100562091","talocrural-mobilization-with-movement-in-spastic-cerebral-palsy-100562091","NCT06598657","Talocrural Mobilization With Movement in Spastic Cerebral Palsy","Effects of Talocrural Joint Mobilization With Movement in Spastic Cerebral Palsy Patients","Inclusion Criteria:\n\n* Both genders\n* Age group 8-18 years\n* Diagnosis of spastic Cerebral Palsy\n* CP to follow verbal directions\n* Modified Ashworth Scale score of '1' or '1+'\n* Function classification system (GMFCS) level I or II ability to walk\n* 10 m or more independently\n\nExclusion Criteria:\n\n* visual, hearing disorders\n* verbal and cognitive disorders (unable to comprehend commands)\n* recent lower extremity surgery\n* botulinum toxin injection","8 Years","18 Years",{"count":148,"type":21},40,[56],"The aim of this randomized controlled trial is to find the effect of Mulligan's Mobilization with Movement of Talocrural joint in Cerebral Palsy Patients having spasticity on improving Ankle Range of Motion, improving balance and its effect on Gait speed.",[25],[153,154,155],"Talocrural joint","Mobilization with Movement","Spasticity cerebral palsy","2025-02-20",{"date":158,"type":34},"2025-02-21",{"date":160,"type":34},"2024-10-02",{"date":162,"type":21},"2025-10-25",{"name":73,"class":41},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":171,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":54,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":4},"100576432","the-effects-of-oral-facial-facilitation-and-oral-motor-therapy-in-dysphagia-100576432","NCT06785220","The Effects of Oral Facial Facilitation and Oral Motor Therapy in Dysphagia","The Effects of Oral Facial Facilitation and Oral Motor Therapy in Dysphagia with Spastic Cerebral Palsy","Inclusion Criteria:\n\n* 1\\. Confirmed diagnosis of spastic cerebral palsy (CP) by a qualified medical professional.\n\n  2\\. Participants aged 3 to 7 years, as this is a common demographic affected by spastic CP.\n\n  3\\. Clinical diagnosis of dysphagia, confirmed by a speech-language pathologist or related healthcare provider.\n\n  4\\. No recent significant changes in neurological status or medical condition within the last six months.\n\n  5\\. Sufficient cognitive ability to follow simple instructions during therapy sessions, as assessed by a qualified professional.\n\n  6\\. Parental or guardian consent obtained for participants under 18, along with assent from participants when appropriate.\n\n  7\\. No recent (within the last three months) oral motor therapy interventions that could confound results.\n\n  8\\. Willingness and ability of the participant to engage in therapy sessions consistently.\n\n  9\\. Clearance from a physician to participate in oral motor therapy and related interventions.\n\nExclusion Criteria:\n\n* 1\\. Diagnosis of other neurological disorders or conditions that may affect swallowing or motor skills.\n\n  2\\. Serious medical conditions or comorbidities that could interfere with therapy (e.g., severe respiratory issues).\n\n  3\\. Any surgical interventions affecting the oral or pharyngeal region within the last year.\n\n  4\\. Concurrent participation in other clinical trials or interventions that could affect swallowing outcomes.","3 Years","7 Years",{"count":174,"type":21},13,[56],"The objective of this research is to investigate the impact of oral facial facilitation and oral motor therapy dysphagia in individuals with spastic cerebral palsy. Specifically, the study aims to:\n\n* Evaluate changes in dysphagia and severity following a regimen of oral motor therapy and oral facial facilitation.\n* Assess improvements in swallowing function, including ease of swallowing and reduction in dysphagia symptoms, after implementing oral motor therapy and oral facial facilitation.",[178,25],"Dysphagia","2025-01-17",{"date":181,"type":34},"2025-01-21",{"date":183,"type":21},"2025-02-01",{"date":185,"type":21},"2025-08-30",{"name":187,"class":41},"Kafrelsheikh University",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":18,"enrollmentInfo":195,"targetDuration":4,"studyType":54,"phases":197,"briefSummary":198,"conditions":199,"keywords":200,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":42},"100567873","rhythmic-stabilization-versus-ball-balancing-100567873","NCT06673849","Rhythmic Stabilization Versus Ball Balancing","Effects of Rhythmic Stabilization Versus Ball Balancing on Upper Extremity Function in Children With Spastic Cerebral Palsy","Inclusion Criteria:\n\n* Spastic diplegic CP children age 6 to 12 years,\n* Each gender included\n* Grade 1 of spasticity according to modified Ashworth scale (21)\n* With normal I.Q. greater than 70 (assessed by psychologist),\n* Can follow commands(\n\nExclusion Criteria:\n\n* Children with any other neurological impairment\n* Children with audio visual impairment",{"count":196,"type":21},36,[56],"Spastic Cerebral Palsy (CP) is the leading cause of upper motor neuron syndrome (UMN) in children. The primary factors contributing to motor behavior disorders in these children are impairments in motor control and muscle strength. These impairments result in changes in muscle growth and hinder the development of motor skills, leading to reduced muscle force generation and decreased flexibility. Spastic cerebral palsy is the most prevalent type, affecting 77% of individuals with CP, and is caused by damage to the motor cortex and pyramidal tracts. The motor cortex is responsible for transmitting voluntary movement signals from the brain to the muscles. Characteristics of spastic cerebral palsy include stiff muscles (hypertonia), which can cause jerky and repetitive limb movements (spasticity). Additionally, individuals with CP often have difficulties in processing somatosensory and proprioceptive information. Proprioceptive training refers to interventions aimed at enhancing proprioceptive function to ultimately improve motor performance, a concept that has been explored in studies focused on sports injuries. In this study, we will utilize two proprioceptive exercises-rhythmic stabilization and ball balancing-to promote functional improvement in the upper extremities of children with spastic CP.",[25],[201,202,203,204,205,206],"Ball Balancing","Corticobulbar tracts","Corticospinal tracts","Epilepsy","Rhythmic Stabilization","Spastic CP","2024-11-03",{"date":209,"type":34},"2024-11-05",{"date":211,"type":34},"2024-09-25",{"date":213,"type":21},"2025-01-02",{"name":73,"class":41}]