[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-aneshtesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-aneshtesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,55,93,128,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100649737","phase-4-routine-antiemetic-prophylaxis-for-nonfasted-parturients-undergoing-cesarean-sections-under-spinal-anesthesia-100649737",false,"NCT07740577","Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia","Comparative Effectiveness of Routine Antiemetic Prophylaxis in Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women scheduled for emergency cesarean delivery under spinal anesthesia\n* Non-fasted (full-stomach) parturients\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Age ≥ 18 years\n* Singleton pregnancy\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* ASA physical status III or higher\n* Refusal to participate\n* Elective cesarean delivery (non-emergency cases)\n* Preoperative antiemetic use within 24 hours before surgery\n* Known allergy or contraindication to study drugs (ondansetron or metoclopramide)\n* Pre-existing gastrointestinal disorders (e.g., severe GERD, gastroparesis, bowel obstruction)\n* Psychiatric illness or current use of psychotropic medications\n* Preoperative anemia (as defined by institutional threshold, e.g., Hb \\\u003C 10 g\u002FdL)\n* Intraoperative conversion to general anesthesia\n* Massive intraoperative hemorrhage (\\>1000-1500 mL or requiring transfusion, depending on your protocol definition)\n* Intraoperative administration of additional sedative or antiemetic agents outside study protocol\n* Multiple gestation pregnancies","FEMALE","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing emergency cesarean section under spinal anesthesia.\n\nNausea and vomiting are common complications during cesarean delivery performed under spinal anesthesia and may negatively affect maternal comfort and perioperative safety. The incidence of these symptoms may be particularly increased in emergency cesarean sections involving non-fasted (full-stomach) parturients. This study compares two commonly used antiemetic strategies, namely 5-hydroxytryptamine-3 (5-HT3) receptor antagonists and dopamine receptor antagonists, to determine their relative effectiveness in preventing IONV during surgery.\n\nThe findings are expected to contribute to optimization of antiemetic prophylaxis protocols, improvement of maternal comfort, and reduction of perioperative complications associated with nausea and vomiting during emergency cesarean delivery.",[26,27,28,29,30,31],"Intraoperative Nausea-retching-vomiting Episodes","Spinal Aneshtesia","Ceserean Section","Antiemetic Therapy","Ondansetron","Metoclopramide",[33,34,35,36,37,38,39,40,41],"Cesarean Section","Emergency Cesarean Delivery","Non-fasted Parturients","Full Stomach","Spinal Anesthesia","Antiemetic Prophylaxis","Intraoperative Nausea and Vomiting","Obstetric Anesthesia","Maternal Outcomes","RECRUITING","2026-08-16",{"date":45,"type":46},"2026-08-18","ACTUAL",{"date":48,"type":46},"2026-07-30",{"date":50,"type":20},"2027-01-02",{"name":52,"class":53},"Sanliurfa Education and Research Hospital","OTHER_GOV",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":62,"minAge":63,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":21,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100638990","effect-of-lateral-decubitus-position-after-spinal-anesthesia-on-hemodynamic-stability-in-high-risk-geriatric-patients-100638990","NCT07597148","Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients","The Effects of Lateral Decubitus Positioning After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients Undergoing Lower Extremity Orthopedic Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 65 years or older\n* ASA physical status classification III or IV\n* Scheduled for unilateral lower extremity orthopedic surgery (hip fracture, femur fracture, knee arthroplasty, tibia-fibula fracture, or similar procedures)\n* Eligible for spinal anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (coagulopathy, recent anticoagulant or antiplatelet use without adequate washout period, local infection at injection site)\n* Severe neurological disease or pre-existing motor or sensory deficit\n* Significant spinal deformity (severe scoliosis, kyphosis) or history of previous spinal surgery\n* Known allergy to local anesthetics\n* Decompensated heart failure (ejection fraction below 30%)\n* Uncontrolled hypertension (systolic blood pressure above 180 mmHg or diastolic blood pressure above 110 mmHg)\n* Emergency surgery\n* Severe hypovolemia or active bleeding\n* Advanced dementia or inability to communicate\n* Body mass index above 40 kg\u002Fm²\n* Refusal to participate","ALL","65 Years",{"count":65,"type":20},70,[67],"NA","Spinal anesthesia is a common and preferred anesthetic technique for lower extremity orthopedic surgery in elderly patients. However, it can cause a significant drop in blood pressure (hypotension), especially in high-risk older patients with multiple medical conditions. This complication can lead to serious consequences such as heart attack, stroke, or death in vulnerable patients.\n\nThis study investigates whether keeping patients in a lateral (side-lying) position for 15 minutes after spinal anesthesia - instead of immediately turning them onto their back (supine position) - can reduce the risk of hypotension. When a patient lies on their side after receiving spinal anesthesia with a heavy (hyperbaric) local anesthetic, the medication tends to stay concentrated on the lower (operative) side, resulting in a more limited nerve block. This may help preserve blood pressure stability.\n\nWe will enroll 70 patients aged 65 years or older with high anesthetic risk (ASA physical status III or IV) scheduled for unilateral lower extremity orthopedic surgery under spinal anesthesia. Patients will be randomly assigned to two groups: one group will be kept in the lateral decubitus position (operative side down) for 15 minutes before being turned supine, and the other group will be turned supine immediately after spinal anesthesia. Blood pressure, heart rate, and oxygen saturation will be monitored continuously. The primary outcome is the incidence of hypotension during the first 15 minutes after spinal anesthesia.",[70,27,71,72],"Hypotension Drug-Induced","Geriatric","Orthopedic Surgery Patients",[74,75,76,77,78,79,80,81,82],"hypotension","spinal anesthesia","lateral decubitus position","geriatric","hyperbaric bupivacaine","unilateral spinal block","hemodynamic stability","orthopedic surgery","ASA III-IV","NOT_YET_RECRUITING","2026-05-12",{"date":86,"type":46},"2026-05-19",{"date":88,"type":20},"2026-06-01",{"date":90,"type":20},"2026-08-10",{"name":92,"class":53},"University of Health Sciences Balikesir Hospital Eduation and Research",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":62,"minAge":17,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":102,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":54},"100592612","ketamine-for-preventing-post-spinal-hypotension-in-orthopedic-surgery-100592612","NCT06995690","Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery","Impact of Sub-anesthetic Dose of Ketamine in the Prevention of Post Spinal Hypotension in Patients Undergoing Orthopedic Surgeries","Inclusion Criteria:\n\n* Patients American Society of Anesthesiologists Physical Status (ASA) I to II undergoing orthopedic surgeries under spinal anesthesia.\n* Both Sexes.\n* Patients aged equal to or above 18 years.\n* Body mass index \\\u003C35 kg\u002Fm2\n* Duration of operation from 1 hour to 3 hours\n\nExclusion Criteria:\n\n* Patients' refusal of procedure or participation in the study.\n* Patients with contraindication to spinal anesthesia.\n* Patients with cardiovascular or pulmonary disease.\n* Patients with pre-procedural hypotension (systolic arterial pressure less than 90 mmHg and\u002For mean arterial pressure less than 60 mmHg).\n* Patients aged below 18 years.\n* Duration of operation below 1 hour or above 3 hours.",{"count":101,"type":20},30,[67],"This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg\u002Fkg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries under spinal anesthesia. The study compares ketamine with placebo (normal saline) in terms of blood pressure stability and incidence of hypotensive episodes following spinal anesthesia.",[105,106,27],"Post-spinal Hypotension","Orthopedic Surgery",[108,109,110,111,112,113,114,115,116,117],"Ketamine","Sub-anesthetic dose","Hypotension prevention","Neuraxial anesthesia","Hemodynamic stability","regional anesthesia","ASA I-II","Double-blind randomized trial","Blood pressure monitoring","Ephedrine use","2025-06-15",{"date":120,"type":46},"2025-06-18",{"date":122,"type":46},"2025-06-01",{"date":124,"type":20},"2025-11-01",{"name":126,"class":127},"Ain Shams University","OTHER",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":62,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":21,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":54},"100595648","a-comparative-study-between-age-based-and-weight-based-bupivacaine-dosing-for-pediatric-spinal-anesthesia-in-children-undergoing-elective-infra-umbilical-surgeries-100595648","NCT07035184","A Comparative Study Between Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia in Children Undergoing Elective Infra-Umbilical Surgeries","A Comparative Study Between Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia in Children Undergoing Elective Infra-Umbilical Surgeries: A Randomized Double-Blinded Controlled Trial","Inclusion Criteria:\n\n* Children aged 1-6 years\n\n  * Both genders.\n  * American Society of Anesthesiologists (ASA) physical status I or II.\n  * Elective infra-umbilical surgeries with anticipated duration ≤ 90 minutes.\n\nExclusion Criteria:\n\n* Guardian refusal.\n\n  * Children with significant congenital heart disease (e.g., septal defects requiring surgical intervention)\n  * Children with neuromuscular disorders or high intracranial pressure.\n  * Children with spinal deformities or morbid obesity (body mass index (BMI) above the 99th percentile).\n  * Children with a history or family history of coagulation disorders.\n  * Children with local infection at the site of skin puncture for spinal anesthesia.\n  * Children with known allergy to Bupivacaine.\n  * Surgeries requiring Trendelenburg or prone position.\n  * Unexpected prolongation of surgery \\> 90 minutes","1 Year","6 Years",{"count":138,"type":20},60,[67],"This prospective randomized double-blinded controlled trial will include 60 pediatric patients aged 1 - 6 years old, both sexes, with American society of anesthesiologists (I and II) and undergoing elective infra-umbilical surgeries with anticipated duration ≤ 90 minutes. Patients will be randomly divided into two equal groups: Weight-based dosing (Group A) and age-based dosing group (Group B). Both groups will receive hyperbaric bupivacaine 0.5%. The aim of the study is to evaluate the effectiveness of using age based dosing of Bupivacaine compared with standard method of weight based dosing in pediatric spinal anesthesia.",[142,27,143],"Pediatrics","Infraumbilical Surgeries","2025-06-14",{"date":146,"type":46},"2025-06-25",{"date":148,"type":20},"2025-08-01",{"date":150,"type":20},"2025-10-15",{"name":152,"class":127},"Cairo University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":160,"enrollmentInfo":161,"targetDuration":163,"studyType":164,"phases":4,"briefSummary":165,"conditions":166,"keywords":171,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":181,"leadSponsor":183,"locationsCount":54},"100594124","renal-functions-in-preeclamptic-pregnant-women-using-neutrophil-gelatinase-associated-lipocalin-ngal-and-standard-renal-function-tests-100594124","NCT07015359","Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests","Evaluation of the Effect of Spinal Anesthesia-Induced Hypotension on Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests","Inclusion Criteria:\n\n* Patients classified as ASA physical status II-III\n* Pregnant women aged 18-45 years, diagnosed with preeclampsia and scheduled for elective cesarean section, will be included in the study.\n\nExclusion Criteria:\n\n* Patients who are unable to read, understand, or sign the informed consent form\n* Patients with a diagnosed renal disease\n* Patients who do not wish to participate in the study\n* Patients with ASA physical status greater than III\n* Patients younger than 18 or older than 45 years\n* Patients requiring sedation or undergoing general anesthesia\n* Patients with cardiac instability\n* Patients with known arrhythmias","45 Years",{"count":162,"type":20},46,"6 Months","OBSERVATIONAL","Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes mellitus, renovascular disease and congestive heart failure. Mean arterial pressure (MAP) below 55-60 mmHg has been associated with postoperative AKI. Traditional diagnostic criteria for AKI include increased serum creatinine levels and oliguria. However, creatinine levels do not rise until more than half of renal function is lost. Serum and urine NGAL levels rise earlier-within 24-48 hours-making it a promising early biomarker.\n\nIn our study, hypotension is defined as systolic blood pressure \\\u003C100 mmHg or a \\>30% decrease in MAP. Patients requiring ephedrine under these conditions will be evaluated as the hypotension group and compared with non-hypotensive patients in terms of NGAL, BUN (blood urea nitrogen), creatinine, and GFR (Glomerular Filtration Rate) values at baseline and at the 4th postoperative hour.",[167,27,168,169,170],"Anesthesia","Acute Kidney Failure","Spinal Anesthesia Induced Hypotension","Preeclampsia (PE)",[172,173,174,175,176],"Preeclampsia","Hypotension","NGAL","Creatinine","AKI","2025-06-08",{"date":179,"type":46},"2025-06-11",{"date":177,"type":20},{"date":182,"type":20},"2025-10-20",{"name":184,"class":127},"Nihan Aydin Guzey"]