[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-cord-injurysci\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-cord-injurysci":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100649293","multilevel-multimodal-neurophysiological-integration-for-investigating-the-network-modulatory-mechanisms-of-epidural-spinal-cord-stimulation-100649293",false,"NCT07732972","Multilevel Multimodal Neurophysiological Integration for Investigating the Network Modulatory Mechanisms of Epidural Spinal Cord Stimulation","Inclusion Criteria:\n\nA. Non-Spinal Cord Injury (Non-SCI) Group\n\n* Individuals without spinal cord injury.\n* Patients diagnosed with chronic neuropathic pain who meet the criteria for routine temporary epidural spinal cord stimulation (EES) implantation therapy.\n* Patients who have undergone temporary epidural spinal cord stimulation (EES) implantation.\n* Ability to understand and follow motor instructions.\n* Age between 20 and 70 years. B. Spinal Cord Injury (SCI) Group\n* Patients with chronic spinal cord injury.\n* Patients who have undergone temporary epidural spinal cord stimulation (EES) implantation.\n* American Spinal Injury Association Impairment Scale (AIS) grades A-D.\n* Spinal cord injury levels between C3 and L1.\n* Ability to understand and follow motor instructions.\n* Age between 20 and 70 years.\n\nExclusion Criteria:\n\n* Individuals with severe psychiatric disorders or cognitive impairments, including major depressive disorder, schizophrenia, or dementia, that may affect their ability to understand the study procedures or comply with study instructions.\n* Individuals who are unable to maintain consciousness, follow instructions, or complete study tasks, including motor tasks, isometric contractions, or resting-state tasks.\n* Individuals with severe medical conditions and unstable clinical status, such as uncontrolled cardiovascular disease, severe infection, respiratory failure, or other conditions deemed unsuitable for study participation by the attending physician.\n* Individuals with abnormal positioning, inadequate fixation, or complications related to temporary epidural spinal cord stimulation (EES) leads, including infection, significant pain, or neurological deterioration, as determined by clinical evaluation to be unsuitable for study recordings.\n* Individuals currently using medications that may significantly affect neurophysiological signals, such as high-dose sedatives, anesthetic agents, or other medications considered by the research team to interfere with data interpretation.","ALL","20 Years","70 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","This study will examine how the brain, spinal cord, and muscles communicate in people with spinal cord injury. Researchers will use noninvasive brain and muscle recordings together with spinal electrical recordings to better understand how epidural spinal cord stimulation (EES) affects nerve function. The results may help develop more effective and personalized rehabilitation treatments for people with spinal cord injury.",[24],"Spinal Cord Injury(SCI)","RECRUITING","2026-07-23",{"date":28,"type":29},"2026-07-29","ACTUAL",{"date":31,"type":20},"2026-08-01",{"date":33,"type":20},"2030-12-31",{"name":35,"class":36},"Buddhist Tzu Chi General Hospital","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":11,"sex":15,"minAge":44,"maxAge":17,"enrollmentInfo":45,"targetDuration":4,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":52,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":37},"100648576","exploration-of-the-effectiveness-and-mechanism-of-personalized-epidural-electrical-stimulation-in-improving-upper-limb-function-in-participants-with-spinal-cord-injury-100648576","NCT07722429","Exploration of the Effectiveness and Mechanism of Personalized Epidural Electrical Stimulation in Improving Upper Limb Function in Participants With Spinal Cord Injury","Inclusion Criteria:\n\n* Age between 18 and 70 years.\n* Duration since spinal cord injury ranging from 1 to 10 years.\n* Spinal cord injury level at or above T4.\n* MRI and\u002For CT imaging confirms adequate spinal cord decompression and spinal stability.\n* Stable vital signs and no dependence on mechanical ventilation.\n* Stable neurological and psychological status, with no history of neurological deterioration within the past 6 months (e.g., acute worsening of motor or sensory function, new-onset seizures, acute changes in muscle tone, or other neurological symptoms). Participants must be conscious, able to understand, and comply with study instructions. Clinical neurological examinations and imaging findings (MRI or CT) should demonstrate no new abnormalities.\n* Willingness to participate in and comply with rehabilitation programs.\n* Participants who have completed spinal cord electrical stimulation implantation surgery and\u002For are currently undergoing conventional rehabilitation therapy.\n\nExclusion Criteria:\n\n* Patients with untreated fractures of the upper extremities.\n* Patients with severe skin lesions or wounds that interfere with EMG electrode placement or the surgical sites for electrical stimulation implantation (e.g., chest\u002Fback, upper extremities, posterior cervical region, or subclavicular area).\n* Patients with a history of other neurological diseases.\n* Patients with known allergy or hypersensitivity to silver (Ag).","18 Years",{"count":46,"type":20},20,"INTERVENTIONAL",[49],"NA","This study aimed to determine whether cervical spinal cord epidural electrical stimulation (EES) can activate upper-limb muscles in individuals with spinal cord injury.",[24],{"date":53,"type":29},"2026-07-24",{"date":55,"type":29},"2025-11-17",{"date":57,"type":20},"2027-12-31",{"name":35,"class":36}]