[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinal-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinal-injury":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100646408","transcutaneous-spinal-electrical-stimulation-to-improve-exercise-function-after-spinal-cord-injury-100646408",false,"NCT07692191","Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.","Inclusion Criteria:\n\n* traumatic or non-traumatic spinal cord injury\n* Spinal cord injury of at least one year duration, C5 or lower, AIS A - D\n* medically stable and healthy enough to engage in and complete exercise requirements\n* willing and able to complete the exercise protocols and testing requirements\n* able to understand and follow written and verbal instructions from study staff\n* able to communicate with study staff about their exercise capabilities and preferences\n\nExclusion Criteria:\n\n* current serious injury (ies) of the upper extremities\n* known cardiovascular disease\n* unsatisfactory results of EKG screening\n* implanted electronic cardiac devices (e.g., pacemaker, defibrillator, etc.)\n* current pressure ulcer(s)\n* morbid obesity\n* known thyroid dysfunction\n* current cancer\n* current uncontrolled high blood pressure\n* uncontrolled epilepsy\n* current deep vein thrombosis\n* ventilator dependency\n* cognitive impairment",true,"ALL","18 Years","70 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI). SCI affects motor, sensory and autonomic systems and can cause very limited exercise capacity which then leads to very high rates of obesity, metabolic syndrome, type II diabetes and cardiovascular disease.\n\nThis randomized controlled study aims to determine whether and how transcutaneous spinal electrical stimulation (TSES) alters acute (immediate) exercise responses in people living with SCI. Exercise responses will be tested during incremental tests to fatigue, and during steady state tests. Testing will occur over several study visits and results will be compared within each individual as well as between groups (tetraplegia and paraplegia) and to a group of reference controls. A number of outcomes will be monitored, including whole-body metabolic responses using a metabolic cart, muscle responses using EMG sensors and muscle oxygenation using near infrared spectroscopy (NIRS) sensors, time to fatigue, power output, as well as perceptions about fatigue and effort.\n\nThe findings of this study are expected to provide evidence regarding whether and how TSES might improve acute exercise responses in people living with SCI.",[27,28,29],"Spinal Cord Injuries (SCI)","Spinal Cord Injury","Spinal Injury",[31,32,33,34,35,36,37],"exercise","spinal cord injury","sympathetic nervous system","autonomic nervous system","arm ergometry","obesity","cardiovascular disease","RECRUITING","2026-07-02",{"date":41,"type":42},"2026-07-09","ACTUAL",{"date":44,"type":42},"2024-06-10",{"date":46,"type":21},"2026-10",{"name":48,"class":49},"University of Manitoba","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":4,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":50},"100222205","mri-changes-in-morphometry-and-cerebro-spinale-fluid-csf-flow-in-spinal-cord-disorders-100222205","NCT02170155","MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders","Inclusion Criteria:\n\n* Cervical injury\n* Informed consent\n* Age 18-80\n* CSM\n\nExclusion Criteria:\n\n* No other neurologic disorder and psychiatric disorder\n* Seizure\n* MRI incompatibility\n* Pregnancy","80 Years",{"count":59,"type":21},350,"OBSERVATIONAL","Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology.\n\nIn some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.",[29],"2025-12-15",{"date":65,"type":42},"2025-12-22",{"date":67,"type":4},"2012-12",{"date":69,"type":21},"2026-12",{"name":71,"class":49},"University of Zurich"]