[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spontaneous-breathing-trial-in-icu\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spontaneous-breathing-trial-in-icu":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,38,64,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":35,"locationsCount":4},"100648783","effect-of-high-flow-humidified-oxygen-on-ventilatory-work-during-the-spontaneous-breathing-trial-100648783",false,"NCT07724392","Effect of High-Flow Humidified Oxygen on Ventilatory Work During the Spontaneous Breathing Trial","OTRAVAIL","Inclusion Criteria:\n\n* Adult patient, of legal age\n* On invasive mechanical ventilation for more than 48 hours\n* With at least one criterion indicating a high risk of extubation failure:\n\n  * Age \\> 65 years\n  * Chronic respiratory disease\n  * Chronic cardiac disease\n* Capable of undergoing a mechanical ventilation weaning test (\"weaning criterion\"):\n\n  * Respiratory rate \\\u003C 35 bpm\n  * Adequate oxygenation:\n\n    * SpO₂ ≥ 90% with FiO₂ ≤ 40% and PEEP ≤ 8 cm H₂O\n    * Or PaO₂\u002FFiO₂ ≥ 150 with PEEP ≤ 8 cm H₂O\n  * Effective cough\n  * Patient is alert (RASS score -2 to +1), without sedation\n  * Hemodynamically stable or on the minimum effective dose\n* Patient has an invasive arterial pressure catheter for arterial blood sampling\n* Informed consent signed by a family member\n* Patient is enrolled in or eligible for a social security program\n\nExclusion Criteria:\n\n* Resuscitation-associated neuromyopathy\n* History of neuromuscular disease\n* Admission for a neurological condition\n* Subjects currently excluded from another study,\n* Persons referred to in Articles L1121-5 through L1121-8 of the CSP (corresponding to all protected persons: pregnant women, women in labor, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of Article L. 1121-8, persons admitted to a health or social care facility for purposes other than research, minors, and persons subject to a legal protection order or unable to give informed consent).\n* Staff members who report to the principal investigator","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","Weaning from mechanical ventilation (MV) accounts for a significant portion of the total MV duration, and failure to extubate or delayed extubation increases complications (particularly Ventilator-Associated Pneumonia (VAP)) and mortality. Standard tests (T-piece, Spontaneous Ventilation with Inspiratory Assistance (SV-IA)) have not demonstrated clear superiority, and the T-piece is still widely used despite its limitations. High-flow oxygen (HFO) may reduce ventilatory work and facilitate secretion clearance; however, there is a lack of physiological data in humans with an endotracheal tube in place. This study aims to address this gap prior to a subsequent clinical evaluation.\n\nAn experimental, prospective, single-center, 3-period crossover study with randomized sequence order and single-blind design (primary endpoint assessment and statistical analysis were conducted in a blinded manner).",[26],"Spontaneous Breathing Trial in ICU","NOT_YET_RECRUITING","2026-07-20",{"date":30,"type":31},"2026-07-24","ACTUAL",{"date":33,"type":20},"2027-01",{"date":33,"type":20},{"name":36,"class":37},"University Hospital, Grenoble","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":45,"targetDuration":4,"studyType":21,"phases":47,"briefSummary":48,"conditions":49,"keywords":50,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":63},"100593366","automatic-tube-compensation-vs-pressure-support-ventilation-during-spontaneous-breathing-trials-in-adults-100593366","NCT07005505","Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults","Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Critically Ill Adults: A Cluster-Randomized, Cluster-Crossover Trial","Inclusion Criteria:\n\n* Admitted to intensive care unit (ICU)\n* Age 18 years or older\n* Requiring invasive mechanical ventilation for at least 24 hours\n* Pass spontaneous breathing trial screen criteria\n\nExclusion Criteria:\n\n* Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results\n* Do not intubate (DNI) order\n* Presence of tracheostomy\n* Pregnancy\n* Known prisoner\n* Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures\n* Enrolled in another clinical trial that impacts ventilator weaning or liberation",{"count":46,"type":20},880,[23],"For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.",[26],[51,52],"Ventilator liberation","Spontaneous breathing trial","RECRUITING","2026-06-30",{"date":56,"type":31},"2026-07-02",{"date":58,"type":31},"2025-06-01",{"date":60,"type":20},"2027-08",{"name":62,"class":37},"Rush University Medical Center",1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":71,"targetDuration":4,"studyType":21,"phases":73,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":63},"100605494","effectiveness-of-pet-robotic-intervention-in-intensive-care-unit-patients-100605494","NCT07163247","Effectiveness of Pet-Robotic Intervention in Intensive Care Unit Patients","Effectiveness of Using Pet-Robotic Intervention to Enhance Spontaneous Breathing Trial Success in Intensive Care Unit Patients","Inclusion Criteria:\n\n* Aged 18 years or older with clear consciousness.\n* Mechanical ventilation for more than 72 hours.\n* Previously failed the first spontaneous breathing trial and is clinically ready to undergo a second spontaneous breathing trial.\n\nExclusion Criteria:\n\n* Multidrug-resistant organism infection.\n* Requiring airborne infection isolation precautions (e.g., COVID-19).\n* Immunodeficiency (absolute neutrophil count \\\u003C 500 cells\u002FmL).\n* Richmond Agitation-Sedation Scale (RASS) less than -1.\n* Patient with a tracheostomy.\n* Subjects with implanted cardiac devices (e.g., permanent pacemaker, implantable cardioverter defibrillators)\n* Known allergy to the fur of the robotic pet.",{"count":72,"type":20},24,[23],"This study aims to develop a novel nursing intervention involving robotic pet companionship to reduce anxiety in patients undergoing spontaneous breathing trials.",[26,76],"Spontaneous Breathing Trial",[78,79,80,81],"spontaneous breathing trials","Pet-robotic intervention","anxiety","Robot assisted intervention","2025-09-02",{"date":84,"type":31},"2025-09-09",{"date":86,"type":20},"2025-09",{"date":88,"type":20},"2026-01",{"name":90,"class":37},"National Taiwan University Hospital",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":100,"briefSummary":101,"conditions":102,"keywords":103,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":112,"locationsCount":4},"100549445","benefits-of-immersive-virtual-reality-on-dyspnoea-during-a-weaning-test-in-the-intensive-care-unit-100549445","NCT06434116","Benefits of Immersive Virtual Reality on Dyspnoea During a Weaning Test in the Intensive Care Unit.","Benefits of Immersive Virtual Reality on Dyspnoea During a Weaning Test in the Intensive Care Unit","RVI-ERS","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Patients intubated and on mechanical ventilation for more than 24 hours\n3. Patients eligible for a weaning trial (resolution of acute phase of pathology, low bronchial congestion, effective cough, SpO2 \\> 90% with Fio2 \\\u003C 40%, PEEP \\\u003C 8 cmH20, respiratory rate \\\u003C 40\u002Fmin, haemodynamically stable)\n4. Decision by the doctor in charge to initiate a respiratory weaning trial as part of treatment\n5. RASS score between -1 and +1\n6. Patient able to answer questionnaires\n7. Informed of the study and whose free and informed written consent has been obtained\n8. Beneficiary of a social security plan (excluding AME)\n\nExclusion Criteria:\n\n1. Non french speaker\n2. Acute confusion or cognitive disorders\n3. No reliable assessment of dyspnea\n4. Acrophobia\n5. Claustrophobia\n6. Photophobia\n7. Hearing loss\n8. Visual impairment\n9. Subject under guardianship or curatorship",{"count":19,"type":20},[23],"A weaning trial is a test that simulates physiological respiratory conditions after extubation in order to assess the patient's ability to breathe without the assistance of a ventilator.\n\nThis test is highly susceptible to induce dyspnea, with 62% of patients reporting a dyspnea score on VAS greater than 3.\n\nSimilarly, the prevalence of anxiety is high during weaning trials. 60% of patients treated in a respiratory weaning unit report psychological symptoms.\n\nDyspnea can be a traumatic experience for patients. In intensive care, up to half of patients suffer from dyspnea, which is described by patients as one of the worst memories of their stay in intensive care.\n\nThe virtual reality headset is a device that simulates a realistic, three-dimensional environment, allowing the patient to be totally immersed, so that they feel as if they are really present in a virtual world. This environment can be combined with hypnotic verbal support.\n\nThe research hypothesis is that virtual reality during a spontaneous breathing trial would relieve the respiratory discomfort induced by the weaning trial.\n\nThe secondary hypotheses are that virtual reality could reduce the anxiety associated with spontaneous breathing trials. These benefits could be associated to a reduction in ventilatory drive.\n\nTo assess dyspnea a VAS scale will be used, as the MV-RDOS scale, and the amplitude of EMG activity of inspiratory muscles.",[26],[52,104,105,80],"dyspnea","virtual reality","2025-06-30",{"date":108,"type":31},"2025-07-03",{"date":110,"type":20},"2025-10-03",{"date":110,"type":20},{"name":113,"class":37},"Assistance Publique - Hôpitaux de Paris"]