[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"strategy-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:strategy-training":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100655772","real-world-study-of-obstructive-upper-urinary-tract-stones-and-acute-pyelonephritis-100655772",false,"NCT07816991","Real-World Study of Obstructive Upper Urinary Tract Stones and Acute Pyelonephritis","Real-World Study on Management Strategies for Upper Urinary Tract Stone Obstruction Complicated by Acute Pyelonephritis","Inclusion Criteria:\n\n* Informed consent has been obtained from the patient.\n* Unilateral upper urinary tract stone obstruction (accompanied by dilatation of the renal pelvis and\u002For ureter) confirmed by non-contrast CT (NCCT).\n* Presence of fever (body temperature ≥38.0°C) and\u002For chills.\n* Meet at least one of the following conditions:\n* SIRS Criteria: Meeting at least two of the following: heart rate \\>90 bpm; respiratory rate \\>20 breaths\u002Fmin; white blood cell count \\>12×10⁹\u002FL or \\\u003C4×10⁹\u002FL.\n* Flank or Abdominal Pain: Persistent dull pain or colic in the flank or upper abdomen on the affected side.\n* qSOFA Abnormality: Meeting at least one of the following: altered mental status; systolic blood pressure \\\u003C100 mmHg; respiratory rate ≥22 breaths\u002Fmin.\n\nExclusion Criteria:\n\n* Pregnant or lactating women.\n* Non-calculous obstruction (e.g., tumors, retroperitoneal fibrosis, congenital stenosis).\n* Any form of drainage or surgical treatment performed on the affected kidney for the target stone prior to admission.\n* Concurrent abdominal or pelvic emergency requiring urgent surgery.\n* Non-functional affected kidney (preoperative imaging suggesting renal cortical thickness \\\u003C5 mm or clinical assessment of no renal function).","ALL","18 Years",{"count":19,"type":20},1650,"ESTIMATED","OBSERVATIONAL","Upper urinary tract stone obstruction complicated by acute pyelonephritis is a critical urological emergency requiring urgent decompression and infection control, yet real-world clinical decisions regarding the choice between retrograde ureteral stenting, percutaneous nephrostomy, or initial antibiotic therapy often vary based on physician experience and resource availability. This prospective, multi-center, observational study aims to enroll 1,650 patients across more than 30 hospitals in China to systematically evaluate the technical success rates, infection control efficacy, and safety profiles of these different management strategies. By analyzing natural clinical cohorts without intervening in routine practice, the study seeks to define the optimal application boundaries for retrograde stenting, evaluate the role of nephrostomy as a primary or salvage treatment, and establish risk models to predict the failure of conservative antibiotic therapy, ultimately providing high-level evidence for individualized and precise clinical decision-making.",[24,25,26,27],"Urolithiasis","Strategy Training","Observation","Pyelonephritis Acute","NOT_YET_RECRUITING","2026-09-10",{"date":31,"type":32},"2026-09-14","ACTUAL",{"date":34,"type":20},"2026-10-01",{"date":36,"type":20},"2029-11-01",{"name":38,"class":39},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER"]