[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stress-psychology\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stress-psychology":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,43,71,98,127,163,193,223,251,302,333,375,400,426,454],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100635237","caring-for-dementia-caregivers-in-ethnic-immigrant-communities-100635237",false,"NCT07550075","Caring for Dementia Caregivers in Ethnic Immigrant Communities","Inclusion Criteria:\n\nSelf-identified Korean American adults aged 18 or older Provide care for a family member with dementia as a primary caregiver Primary caregiver defined as providing a minimum of 10 hours per week of in-home caregiving to a family member Speak English less than \"very well\" Able to attend virtual classes using an electronic device with Internet access\n\nExclusion Criteria:\n\nIndividuals with severe depression (Patient Health Questionnaire \\[PHQ-9\\] score ≥ 20), as K-Savvy is not a mental health treatment program",true,"ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"NA","Many caregivers of people with Alzheimer's disease or other dementias-especially those in immigrant communities who don't speak English well-don't get access to helpful, proven support programs.\n\nTo address this, the investigative team adapted an existing caregiver support program (called the Savvy Caregiver Program) to better fit target group's culture and language. This new version, called K-Savvy, is a 6-week online program taught in Korean. In an earlier small study, K-Savvy worked well: caregivers found it helpful, were willing to use it, and showed fewer symptoms of depression.\n\nNow, the investigative team wants to study it more carefully to see how well it really works and why.\n\nThe study has two main goals:\n\nGoal 1:\n\nThe investigative team will measure whether K-Savvy improves caregivers' well-being-specifically whether it reduces stress and depression and helps them feel more positive about caregiving. The investigative team will also look at why it works, focusing on whether it changes how caregivers think about their situation (for example, feeling less overwhelmed and more confident).\n\nGoal 2:\n\nThe investigative team will talk directly with caregivers and program instructors to understand their experiences with K-Savvy. This will help the investigative team learn what worked well, what didn't, and why.",[26,27],"No Disease or Condition is Being Studied","Stress (Psychology)",[29],"K-Savvy","RECRUITING","2026-08-18",{"date":33,"type":34},"2026-08-20","ACTUAL",{"date":36,"type":34},"2026-06-01",{"date":38,"type":20},"2030-12-30",{"name":40,"class":41},"University of Southern California","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":42},"100649381","effectiveness-of-a-mindfulness-centered-stress-management-ai-chatbot-to-reduce-stress-and-enhance-mental-health-among-men-who-have-sex-with-men-in-china-100649381","NCT07732621","Effectiveness of A Mindfulness-centered Stress Management AI Chatbot to Reduce Stress and Enhance Mental Health Among Men Who Have Sex With Men in China","Effectiveness of A Mindfulness-centered Stress Management AI Chatbot to Reduce Stress and Enhance Mental Health Among Men Who Have Sex With Men in China: A Randomized Controlled Trial Study","MSM","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. Chinese\n3. Self-identify as MSM.\n4. Own a smartphone to ensure compatibility with the intervention platform.\n5. Mild to moderate perceived stress, defined as Chinese Perceived Stress Scale (PSS-14) score \\\u003C 43.\n\nExclusion Criteria:\n\n1. Diagnosed with an acute severe mental disorder, such as psychosis, major depressive disorder, or anxiety disorder;\n2. Currently receiving psychotherapy at enrollment.\n3. Report moderately severe to severe depressive symptoms, defined as a PHQ-9 total score greater than 14.\n4. Unable to provide online informed consent or complete study procedures.","MALE",{"count":53,"type":20},76,[23],"The goal of this randomized controlled trial is to evaluate the effectiveness of a mindfulness-centered stress management AI chatbot in reducing perceived stress and enhancing mental health among Chinese men who have sex with men (MSM).\n\nThe main questions it aims to answer are:\n\n1. Does the AI chatbot show a greater reduction in perceived stress compared to standardized psychoeducational materials?\n2. Does the AI chatbot improve mental health outcomes, including depressive and anxiety symptoms, subjective well-being, and emotion regulation?\n\nResearchers will compare the AI chatbot to a control group receiving psychoeducational materials to see if the chatbot works to reduce stress and improve mental health.\n\nParticipants will:\n\n1. Be randomized to use the AI chatbot (recommended at least 2 sessions per week, 10-15 minutes per session) or read psychoeducational materials (2 times per week) for 4 weeks.\n2. Complete online self-report questionnaires at baseline, post-intervention (Week 4), and 4-week follow-up.",[27],[58,59,60],"stress","sexual minority","mindfulness","NOT_YET_RECRUITING","2026-08-17",{"date":64,"type":34},"2026-08-19",{"date":66,"type":20},"2026-07-31",{"date":68,"type":20},"2027-03-31",{"name":70,"class":41},"The University of Hong Kong",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":42},"100646293","mindfulness-intervention-for-emotional-distress-an-eeg-study-100646293","NCT07692269","Mindfulness Intervention for Emotional Distress: An EEG Study","Effects and Multimodal EEG Mechanisms of an 8-week Mindfulness Intervention for Emotional Distress: A Randomized Controlled Trial","MIED-RCT","Inclusion Criteria:\n\n* Adults aged 18-50 years Kessler Psychological Distress Scale (K10) score \\> 21 No systematic mindfulness or progressive muscle relaxation practice in the past 6 months (frequency \\\u003C 1 time per week) Normal or corrected-to-normal vision Voluntary participation with signed informed consent\n\nExclusion Criteria:\n\n* Prior diagnosis of schizophrenia, bipolar disorder, or other severe mental disorders by a psychiatrist Suicidal plan, self-injury, or need for emergency psychological crisis intervention in the past month Currently receiving systematic psychotherapy or participating in other psychological intervention programs Started psychiatric medication within the past 3 months or on an unstable medication dosage History of epilepsy, severe brain injury, or other neurological disorders that may affect EEG measurement Severe vision or hearing impairment or other conditions preventing completion of study procedures","50 Years",{"count":81,"type":20},160,[23],"This is a randomized controlled trial examining the efficacy and neural mechanisms of a standardized Mindfulness Intervention for Emotional Distress (MIED) in adults with subclinical emotional distress. One hundred and sixty participants will be randomly assigned to either an 8-week MIED program or an 8-week Progressive Muscle Relaxation (PMR) active control. The primary aim is to evaluate whether MIED reduces anxiety symptoms and reshapes multilevel emotional processing as measured by multimodal EEG (resting-state FAA\u002Ftheta, Fast Periodic Visual Stimulation, and event-related potentials). Assessments occur at baseline (T1), post-intervention (T2), and 1-month follow-up.",[85,86,87,27,88],"Emotional Distress","Anxiety","Depression","Psychological","2026-07-25",{"date":91,"type":34},"2026-07-28",{"date":93,"type":34},"2026-07-04",{"date":95,"type":20},"2027-02",{"name":97,"class":41},"Peking University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":42},"100647092","sanamente-a-peer-led-program-to-reduce-health-disparities-in-rural-latinoa-communities-100647092","NCT07705776","SanaMente: A Peer-Led Program to Reduce Health Disparities in Rural Latino\u002Fa Communities","SanaMente: A Peer-Led, Evidence-Based Mental Health and Lifestyle Program to Reduce Health Disparities in Rural Latino\u002Fa Communities","SanaMente","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Identify as Hispanic\u002FLatino\u002Fa.\n* Patients of La Clínica del Pueblo in Carbondale, Colorado.\n* Spanish-speaking (bilingual Spanish-English speakers are eligible).\n* Interest in improving your physical and emotional well-being.\n* Are currently managing or are at risk for chronic medical or metabolic conditions (e.g., diabetes, cardiovascular disease, liver, or kidney conditions), but a diagnosis is not required.\n* Experiencing or at risk for stress, low mood, or anxiety (formal diagnosis not required)\n* Willingness and ability to participate in the SanaMente program.\n* Willing to provide a release of information authorizing study staff to communicate with La Clínica del Pueblo in the event that a participant endorses suicidality or if it becomes necessary to share relevant medical information to ensure participant safety and appropriate care.\n\nExclusion Criteria:\n\n* Individuals who are unable to provide informed consent.\n* Individuals who are unwilling or unable to participate in the group-based or one-to-one SanaMente sessions.",{"count":107,"type":20},40,[23],"The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effectiveness of the SanaMente peer-led mental health and lifestyle program for rural Latino\u002Fa adults with chronic medical conditions and mental health concerns. The main questions it aims to answer are:\n\n* Is the SanaMente program feasible and acceptable for rural Latino\u002Fa adults with chronic medical conditions and mental health concerns?\n* Does participation in the SanaMente program improve mental health outcomes (depression, anxiety, and stress), healthy lifestyle behaviors (sleep, physical activity, and nutrition), and overall well-being?\n\nThis is a single-arm pilot study without comparison group.\n\nParticipants will:\n\n* Participate in the 6-8 week SanaMente peer-led group program.\n* Complete surveys at baseline, mid-program, and post-program assessing mental health, lifestyle behaviors, overall well-being, and program satisfaction.\n* Complete an exit survey and have the option to participate in a focus group to provide feedback on the program's usability, acceptability, perceived impact, and suggestions for improvement.",[111,27,112],"Depression and\u002For Anxiety in the Mild-to-moderate Range","Chronic Medical Illness",[114,115,116,117],"rural","Peer-led intervention","Chronic disease","Latino\u002Fa mental health","2026-07-10",{"date":120,"type":34},"2026-07-15",{"date":122,"type":34},"2026-03-06",{"date":124,"type":20},"2026-12-10",{"name":126,"class":41},"University of Colorado, Boulder",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":21,"phases":137,"briefSummary":138,"conditions":139,"keywords":147,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100646084","immersive-vr-to-reduce-stress-anxiety-and-pain-during-piccmidline-placement-100646084","NCT07696156","Immersive VR to Reduce Stress, Anxiety, and Pain During PICC\u002FMidline Placement","ESTAR-VR Project: Randomized Controlled Trial on the Impact of Virtual Reality on Reducing Stress, Anxiety, and Pain During Invasive Procedures","PICC","Inclusion Criteria:\n\n* Patients ≥ 18 years old\n* Patients undergoing first-time CVC or Midline catheter insertion\n\nExclusion Criteria:\n\n* Patients with cognitive impairment\n* Communication barriers\n* Acute pain (VAS \\> 3)\n* Epilepsy\n* Brain neoplasm or brain metastases\n* Previous or simultaneous invasive procedures",{"count":136,"type":20},202,[23],"Medical and technological advancements allow increasingly complex invasive procedures to be performed on hospitalized patients, improving their survival rates and prognosis. However, these interventions impact physical, emotional, and psychological health. In this scenario, post-hospitalization syndrome (PHS) emerges as a concerning phenomenon characterized by functional, emotional, and social decline after discharge. Invasive procedures such as surgeries or prolonged use of catheters not only compromise physical integrity but also contribute to disorders like anxiety, depression, and post-traumatic stress. In fact, between 20% and 30% of patients admitted to the Intensive Care Unit (ICU) develop symptoms compatible with post-traumatic stress disorder. This underscores the need for a comprehensive approach focused on psychological and social well-being during and after the hospital stay. Despite humanization initiatives, few hospitals successfully implement them due to a lack of objective evaluations and clinical recommendations that justify their necessity.\n\nIn this regard, venous catheterization (VC) is the most prevalent invasive procedure. The pain, anxiety, or fear caused by this technique triggers physiological and psychological alterations that can interfere with the successful insertion of the device. This stress response induces vasoconstriction, reducing the caliber of the vein, which increases technical difficulty, elevates the risk of complications, raises healthcare costs, and negatively impacts patient satisfaction.\n\nNatural outdoor environments have been shown to reduce stress, enhancing well-being and health in the general population. In this sense, the use of immersive virtual reality (IVR) to achieve immersion in virtual nature could help not only by diverting attention away from the painful or anxiety-inducing stimulus during invasive procedures but also by providing pleasant stimuli that could have a physiological impact.\n\nThe objective of this study is to evaluate the impact of IVR on stress and anxiety during VC using validated clinical scales, measuring the caliber of the vessel to be punctured, and determining salivary biomarkers of stress, well-being, and pain. Confirming this hypothesis will provide the evidence to integrate virtual reality into the National Health System as a standard tool for more humanized and innovative care.",[140,141,142,143,144,86,145,146,27],"Vasoconstriction","Biomarkers","Central Venous Catheters","Midline Catheter","Pain","Catheterization","Peripheral Venous Catheterization",[148,149,150,133,151,152,153],"anxiety","pain","Virtual Reality","Invasive Procedures","Metabolomics","HPA Axis","2026-07-08",{"date":118,"type":34},{"date":157,"type":20},"2027-01-15",{"date":159,"type":20},"2029-01-12",{"name":161,"class":41},"diana garcia",4,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":15,"sex":16,"minAge":171,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":21,"phases":175,"briefSummary":176,"conditions":177,"keywords":181,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":42},"100630118","bonding-before-birth-a-mhealth-intervention-for-first-time-expectant-couples-100630118","NCT07483515","Bonding Before Birth: A mHealth Intervention for First-time Expectant Couples","Bonding Before Birth: A Cluster-randomized, Controlled, mHealth Trial for Developing Mindfulness and Emotional Regulation in Expectant Couples","B³","Inclusion Criteria:\n\nMothers:\n\n1. 21-50 years of age\n2. Less than 20 weeks of pregnancy, confirmed by ultrasonography upon enrolment\n3. Singleton pregnancy\n4. Nulliparous\n5. Plan to deliver in Singapore\n6. Proficient and able to respond to questionnaires in English\n7. Intends for herself and her child to stay in Singapore for the next 2 years\n8. Access to a smartphone\n9. Willing to download the study app\n10. Score of 7 or more in the Edinburgh Postnatal Depression Scale\n\nFathers:\n\n1. 21-75 years of age\n2. Proficient and able to respond to questionnaires in English\n3. Intends for himself and his child to stay in Singapore for the next 2 years\n4. Access to a smartphone\n5. Willing to download the study app\n\nExclusion Criteria:\n\nMothers:\n\n1. Any pre-existing or history of psychotic depression, schizophrenia, and bipolar disorders\n2. Currently on oral\u002FIV steroids and\u002For thyroid medication\n3. History of thyroid disease\n4. Pregnant using assisted reproductive technologies\n5. Multiple pregnancies\n6. Currently enrolled in interventional randomised controlled trials\n7. Responded \"Yes, quite often\" to EPDS item 10 (\"The thought of harming myself has occurred to me\")\n\nFathers:\n\n1\\. Currently enrolled in interventional randomised controlled trials","21 Years","75 Years",{"count":174,"type":20},572,[23],"Emotional regulation is a key component of reducing parenting stress, a sense of self-efficacy, and thus successful parenting, child outcomes, and productivity amongst working parents. However, few interventions begin building these necessary components in pregnancy prior to the extremely stressful period immediately post-partum, where little trait and behavioural modification occurs. More importantly, most interventions overlook the importance of having both partners, despite fathers\u002Fpartners playing a significant role in influencing maternal stress and mood symptoms.\n\nThis goal of this study is to examine whether short weekly exercises delivered through a mobile app can help first-time parents feel better emotionally during pregnancy. These exercises are designed to help people manage their emotions and stress. Researchers want to know if doing these exercises, along with getting weekly feedback and encouragement, can reduce signs of depression and improve emotional control.\n\nExpecting mothers and fathers who are having their first child may be able to join the study if they meet certain conditions. Participants should be planning to stay in Singapore for the next two years and be comfortable using a smartphone and answering questions in English. Participants may benefit from learning new ways to manage stress and emotions, which could help improve their mental health.\n\nParticipants will wear a Fitbit watch to track activity. They will complete a short weekly survey about their well-being during pregnancy and a monthly survey about their work productivity until six months after the baby is born. They will also answer online surveys about their health, relationships, and background at the start, three times during pregnancy, and three times after birth. In addition, they will visit the research lab twice to take part in tasks that measure thinking and behaviour.",[86,178,179,27,87,180],"Pregnancy","Parenting Self-efficacy","Emotion Regulation",[182,183,180,87,178,86],"Reinforcement Learning","Micro-randomization","2026-06-28",{"date":186,"type":34},"2026-06-30",{"date":188,"type":20},"2026-07-06",{"date":190,"type":20},"2028-12-31",{"name":192,"class":41},"Institute for Human Development and Potential (IHDP), Singapore",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":21,"phases":203,"briefSummary":204,"conditions":205,"keywords":208,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":42},"100641660","the-green-room-virtual-nature-for-mental-well-being-in-the-acute-psychiatry-ward-100641660","NCT07655063","The Green Room: Virtual Nature for Mental Well-being in the Acute Psychiatry Ward","The Green Room: A Mixed-Methods Randomized Controlled Trial Evaluating Virtual Reality-Based Nature Exposure in an Acute Psychiatry Ward","GREEN ROOM","Inclusion Criteria:\n\nAdults aged 18 to 65 years. Admitted to the Acute Psychiatry Ward (regardless of voluntary or involuntary legal status).\n\nSufficient cognitive and clinical stability to provide informed consent and engage with the VR equipment, as determined by the clinical team.\n\nAbility to communicate effectively in Spanish.\n\nExclusion Criteria:\n\nHistory of photosensitive epilepsy or severe seizure disorders. Presence of active facial injuries, infections, or skin conditions that prevent the hygienic use of the VR headset.\n\nPre-existing severe vertigo, balance disorders, or high susceptibility to motion sickness.\n\nAcute clinical state involving high risk of agitation or behavioral dysregulation that could compromise participant or equipment safety.\n\nSevere visual or hearing impairments that cannot be corrected and would hinder the VR experience.\n\nPatients who have previously participated in the study during a prior admission are not eligible for re-enrolment.",{"count":202,"type":20},120,[23],"This study evaluates the feasibility, acceptability and clinical impact of a virtual reality (VR)- based nature intervention in an acute psychiatric inpatient unit. Participants are randomly assigned to recieve VR nature sessions (using Nature Treks VR on Meta Quest 3) in addition to standard care, or standard care alone. The primary outcome is change in percieved stress (PSS-19) from admission to discharge. The study uses a mixed-methods design combining randomized controlled trial with a qualitative phase.",[206,207,27],"Mental Disorders","Psychiatric Hospitalization",[209,210,211,212,213],"virtual reality","nature exposure","Acute psychiatry","Inpatient","Mental health","2026-06-12",{"date":216,"type":34},"2026-06-17",{"date":218,"type":20},"2026-06-10",{"date":220,"type":20},"2026-12",{"name":222,"class":41},"Hospital Clinic of Barcelona",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":21,"phases":233,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":4},"100638590","metacognitive-bibliotherapy-for-anxiety-depression-and-metacognitions-in-university-students-100638590","NCT07627139","Metacognitive Bibliotherapy for Anxiety, Depression, and Metacognitions in University Students","The Effects of a Metacognitive Bibliotherapy Intervention on Anxiety, Depression, and Metacognitions Among University Students: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Active enrollment in the Faculties of Medicine, Nursing, Pharmacy, Dentistry, or Psychology at Istanbul Nisantasi University\n* Aged between 18 and 25 years\n* Provision of voluntary digital informed consent\n\nExclusion Criteria:\n\n* Currently receiving active psychiatric treatment (psychotherapy or pharmacotherapy)\n* Change in psychopharmacological medication within the past 6 months\n* Prior reading of either of the study books\n* Presence of acute psychotic symptoms or suicidal risk","25 Years",{"count":232,"type":20},110,[23],"The goal of this clinical trial is to learn if a self-help reading program, called metacognitive bibliotherapy, can reduce anxiety and depression in university students studying medicine and health sciences. It will also examine whether the program changes unhelpful thinking patterns about worry and rumination.\n\nThe main questions it aims to answer are:\n\nDoes metacognitive bibliotherapy lower anxiety and depression symptoms in university students? Does it reduce unhelpful thinking patterns, such as excessive worry and rumination?\n\nResearchers will compare two different self-help books with a waiting list group to see if reading these books helps reduce anxiety and depression.\n\nParticipants will:\n\n* Be randomly assigned to one of three groups: read The Art of Letting Go - How to Stop Rumination, read Anchored: How to Befriend Your Nervous System Using Polyvagal Theory, or join a waiting list\n* Read the assigned book at their own pace over 8 weeks\n* Complete online questionnaires at the start of the study, after 4 weeks, and after 8 weeks\n* Participants in the waiting list group will receive both books for free after the 8-week study period ends",[86,87,27,236],"Rumination",[238,239,240,241],"Metacognition","Psychological Distress","self-help","rumination","2026-05-30",{"date":244,"type":34},"2026-06-04",{"date":246,"type":20},"2026-06-15",{"date":248,"type":20},"2026-10-31",{"name":250,"class":41},"Istanbul Nisantasi University",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":261,"phases":4,"briefSummary":262,"conditions":263,"keywords":277,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":301},"100585203","health-surveillance-at-constructor-university-bremen-cub-and-among-haw-hamburg-employees-100585203","NCT06899308","Health Surveillance at Constructor University Bremen (CUB) and Among HAW-Hamburg Employees","Health Surveillance at Constructor University Bremen (CUB) to Assess Students' and HAW-Hamburg Employees' Health and Wellbeing - Explanatory Sequential Mixed-Methods Approach","CUB-HS2025","Inclusion Criteria:\n\n* English language skills\n* Reading and writing skills\n* Internet access\n* Student status\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* Illiteracy\n* Massively limited cognitive abilities ( i.e. linguistic components of the digital offerings must be able to be used, and questionnaires completed, or interviews participated in) and severe psychiatric disorders (e.g., severe depression)",{"count":260,"type":20},363,"OBSERVATIONAL","The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.",[264,86,265,266,267,268,269,270,271,272,27,273,274,275,276],"Social Isolation or Loneliness","Anxiety Depression (Mild or Not Persistent)","Health Behavior","Observational Study","Stress, Psychological","Emotional Stress","Life Stress","Psychological Stress","Stress, Emotional","Substance Abuse","Substance Addiction","Substance Dependence","Substance Use",[278,279,280,281,282,283,284,285,286,287,288,289,290,291],"Healthy students","Health literacy","Disability","Age","Gender","Study characteristics","PHQ-4","Self-efficacy","Satisfaction with Life Scale (SWLS)","Subjective health status","Student satisfaction","UCLA-LS","HEI-Stress","Mixed Method","2026-04-25",{"date":294,"type":34},"2026-05-01",{"date":296,"type":34},"2025-03-17",{"date":298,"type":20},"2026-12-31",{"name":300,"class":41},"Jacobs University Bremen gGmbH",2,{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":308,"eligibilityCriteria":309,"healthyVolunteers":15,"sex":310,"minAge":17,"maxAge":311,"enrollmentInfo":312,"targetDuration":4,"studyType":21,"phases":314,"briefSummary":315,"conditions":316,"keywords":318,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":42},"100635170","hbm-based-solution-focused-birth-program-on-fear-of-childbirth-in-primigravidas-100635170","NCT07549204","HBM-Based Solution-Focused Birth Program on Fear of Childbirth in Primigravidas","The Effect of a Health Belief Model-Based Solution-Focused Childbirth Preparation Program on Fear of Childbirth, Belief in Normal Birth, Pregnancy Stress, and Mode of Delivery in Primigravid Women","Primigravida","Inclusion Criteria:\n\n* Being 18 years of age or older\n* Having at least a primary school level of education\n* Being able to understand and speak Turkish\n* Having a singleton pregnancy\n* Being a primigravida\n* Being between 28 and 32 weeks of gestation at the time of the intervention.\n\nExclusion Criteria:\n\n* Having a high-risk pregnancy (e.g., preeclampsia, diabetes, cardiovascular disease, placenta previa, oligohydramnios)\n* Having a chronic and\u002For psychiatric disorder\n* Having conceived through infertility treatment","FEMALE","49 Years",{"count":313,"type":20},72,[23],"Pregnancy is a period characterized by significant physiological and psychosocial changes, during which women adapt to new roles. While some women experience this period with excitement and hope, others may experience anxiety, uncertainty, and fear. Fear of childbirth (tokophobia) is a common condition that can negatively affect women's quality of life, birth preferences, and childbirth experiences. High levels of fear of childbirth have been associated with increased cesarean section rates, negative birth perceptions, and postpartum psychological problems.\n\nThis randomized controlled trial aims to evaluate the effect of a solution-focused childbirth preparation education program based on the Health Belief Model on fear of childbirth and belief in normal birth among primigravida women. Secondary outcomes include pregnancy-related stress and mode of delivery.\n\nParticipants will be randomly assigned to either an intervention group receiving structured education or a control group receiving routine prenatal care. Data will be collected before and after the intervention using validated measurement tools, and delivery outcomes will be recorded after birth. The findings are expected to contribute to improving maternal psychological well-being and promoting positive childbirth experiences.",[317,27,178],"Fear",[178,317,319,320,321,322,323],"Health Belief Model","Solution-Focused Approach","Antenatal Education","Mode of Delivery","Randomized Controlled Trial","2026-04-17",{"date":326,"type":34},"2026-04-24",{"date":328,"type":20},"2026-05-15",{"date":330,"type":20},"2026-12-15",{"name":332,"class":41},"Ordu University",{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":340,"targetDuration":342,"studyType":261,"phases":4,"briefSummary":343,"conditions":344,"keywords":356,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":371,"leadSponsor":373,"locationsCount":4},"100630769","development-and-multicenter-validation-of-an-ai-based-remote-photoplethysmography-rppg-facial-scan-for-multimodal-health-assessment-100630769","NCT07491978","Development and Multicenter Validation of an AI-Based Remote Photoplethysmography (rPPG) Facial Scan for Multimodal Health Assessment","Development and Multicenter Validation of an AI-Based Remote Photoplethysmography (rPPG) Facial Scan for Multimodal Health Assessment: Agreement With Clinical, Laboratory, and Psychological Parameters in an Urban Population","Inclusion Criteria:\n\n1. Adults aged ≥18 years.\n2. Able and willing to provide written informed consent.\n3. Able to comply with study procedures, including face scan, physical examination, blood sampling, and questionnaire completion.\n4. Clinically stable at the time of assessment.\n\nExclusion Criteria:\n\n1. Facial conditions affecting the region of interest (ROI), such as injury, deformity, or impaired circulation, that may interfere with rPPG signal acquisition.\n2. Presence of facial tattoos or coverings that obstruct optical signal detection.\n3. Inability to remain still or comply with measurement procedures during data acquisition.\n4. Severe medical conditions that preclude safe participation, as judged by the investigator.\n5. Incomplete data or withdrawal of consent during the study.\n\n   \\-",{"count":341,"type":20},1000,"1 Day","The goal of this observational study is to learn if a non-contact facial scan using artificial intelligence (AI) can be used to check health status in adults living in urban areas such as Jakarta. The facial scan uses a method called remote photoplethysmography (rPPG), which measures small changes in blood flow from the face using a camera.\n\nThe main questions this study aims to answer are:\n\n1. How close are the results from the facial scan to standard medical measurements, such as heart rate, breathing rate, blood pressure, and oxygen levels?\n2. Can the facial scan estimate other health indicators, such as blood sugar, lipid profile, HbA1c, and hemoglobin levels?\n3. Is there a relationship between the facial scan results and mental health, such as stress, anxiety, and depression?\n\nParticipants will take part in several simple and mostly non-invasive procedures:\n\n1. Answer questionnaires about their mental health and daily habits\n2. Have basic health checks, such as blood pressure, heart rate, and body measurements\n3. Provide a blood sample for laboratory testing\n4. Complete a facial scan using a camera for about 1 to 3 minutes\n\nResearchers will compare the results from the facial scan with standard clinical and laboratory tests to see how well the technology works.\n\nThis study may help develop a simple and accessible screening tool that can be used for early detection of health risks. It may also support the use of digital health and telemedicine in community and clinical settings.",[345,346,347,348,349,350,86,27,351,352,353,354,355],"Metabolic Syndrome","Hypertension","Diabetes (DM)","Tachycardia","ASCVD","Depression Disorder","Obesity & Overweight","Cardiometabolic Risk Factors","Cardiometabolic Health Indicators","Sleep","Wellness",[357,358,359,360,361,362,363,364,365,366],"remote photoplethysmography","rPPG","artificial intelligence","digital biomarker","telemedicine","vital signs","cardiometabolic risk","machine learning","facial scan","screening tool","2026-04-15",{"date":369,"type":34},"2026-04-20",{"date":326,"type":20},{"date":372,"type":20},"2027-03-30",{"name":374,"class":41},"Tarumanagara University",{"id":376,"slug":377,"hasResults":11,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":381,"eligibilityCriteria":382,"healthyVolunteers":11,"sex":16,"minAge":383,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":21,"phases":386,"briefSummary":387,"conditions":388,"keywords":390,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":398,"locationsCount":4},"100622902","map-pilot-randomized-controlled-trial-for-older-adults-with-mild-cognitive-impairment-and-elevated-stress-100622902","NCT07389655","(MAP) Pilot Randomized Controlled Trial for Older Adults With Mild Cognitive Impairment and Elevated Stress","Mindful Awareness Practice (MAP) Pilot Randomized Controlled Trial for Older Adults With Mild Cognitive Impairment and Elevated Stress","CohnMAP-RCT","Inclusion Criteria:\n\n* MCI participant: Community-dwelling, ≥65 years old, and diagnosed with MCI within the past 12 months, consented to participate in the trial, and have Wi-Fi access; Diagnosed with chronic stress-related conditions based on ICD-10 codes. No prior experience in mindfulness or other mind-body practices (e.g., yoga, Qi Gong, and Tai Chi) within the past year for \\>10 minutes per day28.\n\nIf taking medications with significant cholinergic, anticholinergic effects, anti-depressants, corticosteroid, or non-steroidal anti-inflammatory drug (NSAID), stabilized dose for ≥6 months.\n\n* Ability to speak and read English\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Diagnosed major psychiatric disorder, e.g., psychosis, bipolar disorder, and schizophrenia.Those with depression and anxiety will not be excluded, as they may be the prime targets for such an intervention and to avoid floor effects on measures that we suspected with our previous trial.\n\nDiagnosed major neurological disorders, e.g., large vessel stroke, brain tumor, and severe brain injury.\n\nDiagnosed terminal illness, including cancer, requiring palliative care, and organ failure, including hepatic or renal failure.\n\nSensory impairment, e.g., visual\u002Fhearing impairment impacting abilities to participate in the study.\n\nParticipating in other intervention(s) concurrently, either a research study or for self-interest (e.g., lifelong learning programs).which may improve memory for \\>2 days\u002Fweek, 30 minutes a session in the past 3 months. After a wash-out period of ≥6 months, potential participants will be allowed to join this present study.","65 Years",{"count":385,"type":20},30,[23],"The purpose of this study is to test whether a tailored mindfulness program, called the Mindful Awareness Practice (MAP) or a Health Education Program (HEP) can reduce stress and improve memory, mood, and well-being in older adults with Mild Cognitive Impairment (MCI) and elevated stress.",[389,27],"Mild Cognitive Impairment (MCI)",[391],"mindfulness; stress; MCI","2026-01-29",{"date":394,"type":34},"2026-02-05",{"date":396,"type":20},"2026-10",{"date":396,"type":20},{"name":399,"class":41},"Rush University Medical Center",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":15,"sex":310,"minAge":17,"maxAge":407,"enrollmentInfo":408,"targetDuration":4,"studyType":21,"phases":410,"briefSummary":411,"conditions":412,"keywords":413,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":4},"100620400","stress-management-intervention-for-young-turkish-women-100620400","NCT07357129","Stress Management Intervention for Young Turkish Women","A Psychosocial Intervention Program to Improve Stress Management Among Young Women: A Pilot Study","Inclusion Criteria:\n\n1. being a woman\n2. being ages between 18 and 29\n3. being fluent in Turkish\n4. having high levels of psychological distress (scoring above 15 on the Turkish version of the Kessler Psychological Distress Scale (K-10)\n\nExclusion Criteria:\n\n1. having an imminent risk of suicide (measured by WHO PM+ assessment tool)\n2. having a diagnosis for severe mental disorder (e.g., psychotic disorders or substance dependence)\n3. having cognitive impairment (e.g., received a diagnosis of dementia or severe intellectual disability)\n4. currently receiving psychological treatment, e.g., therapy.","29 Years",{"count":409,"type":20},60,[23],"This pilot study aims to evaluate the feasibility and probable impact of a low intensity psychosocial intervention program designed to help individuals to manage their stress levels. Consequently, this study will implement and measure the feasibility, randomization, retention, assessment procedures, and preliminary effects of the Self-Help Plus (SH+) program developed by the World Health Organization. This intervention, which has been used among immigrants and has proven to be effective, is intended to be implemented for the first time among distressed young Turkish-speaking women in Türkiye (ages between 18 and 29). Participants who will receive this intervention program will be compared with others in the control group who experience similar stress levels but will not receive SH+ during the trial period. Participants in the control group will receive SH+ after the completion of follow-up assessments at 3 months.",[27],[414,415,416],"Stress management","pilot study","Self-Help Plus","2026-01-21",{"date":419,"type":34},"2026-01-23",{"date":421,"type":20},"2026-01-15",{"date":423,"type":20},"2026-09-30",{"name":425,"class":41},"Bogazici University",{"id":427,"slug":428,"hasResults":11,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":432,"eligibilityCriteria":433,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":21,"phases":436,"briefSummary":437,"conditions":438,"keywords":441,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":445,"lastUpdatePostDateStruct":446,"startDateStruct":448,"completionDateStruct":450,"leadSponsor":452,"locationsCount":42},"100614757","a-mindfulness-based-intervention-to-reduce-stress-through-the-cultivation-of-loving-kindness-compassion-joy-and-equanimity-in-healthcare-professionals-100614757","NCT07283744","A Mindfulness-Based Intervention to Reduce Stress Through the Cultivation of Loving-Kindness, Compassion, Joy, and Equanimity in Healthcare Professionals","Project FIERCE - Fostering Internal and External Respect, Compassion, and Equanimity: A Mindfulness-Based Intervention to Reduce Stress Through the Cultivation of Loving-Kindness, Compassion, Joy, and Equanimity in Healthcare Professionals","FIERCE","Inclusion Criteria: 1) full-time physician (M.D. or D.O.), 2) at least 18 years of age, 3) able to attend the six-week intervention, 4) fluent in English, and 5) access to the internet and email.\n\nExclusion Criteria. 1) having a current and consistent meditation practice (i.e., engaging in a formal meditation practice at least three days per week for five minutes each day), 2) previous participation in a Four Immeasurable course (e.g., attending a Brahmaviharas meditation retreat), 3) absence of at least mild levels of perceived stress as determined by a score less than five on the four-item Perceived Stress Scale (PSS-4; 92), 4) regular tobacco use (given its impact on immune function; 90), and 5) failure to agree to the informed consent. The presence or absence of perceived stress will be assessed using the PSS-4 during the initial phone screening.",{"count":435,"type":20},80,[23],"Nearly 50% of the adult workforce experience adverse psychological symptoms (e.g., stress, depression, burnout, etc.) stemming from workplace stressors, with healthcare workers experiencing rates as high as 80%. Some common complaints and downstream consequences of working in high-stress healthcare occupations are elevated levels of perceived stress, depression, and burnout. These conditions have been associated with unfavorable occupational (e.g., increased medical errors), patient (e.g., increased mortality rates), and provider-related outcomes (e.g., increased rates of cardiovascular disease), imposing a heavy burden on an already stretched system. Given the impact of perceived stress, depression, and burnout on employee and patient health, a clear need exists to develop effective interventions to reduce distress and promote well-being among healthcare professionals. In particular, interventions that target processes particularly vulnerable to provider stress (e.g., compassion) are needed.\n\nThe present study will evaluate the feasibility and efficacy of a mindfulness-based intervention inspired by the Buddhist Four Immeasurables practice on reducing perceived stress (primary outcome), depressive symptoms, burnout, and biological markers of inflammation, and enhancing psychological well-being and sleep quality (secondary outcomes) in 80 healthcare workers. Additionally, we will investigate several mediators (compassion, positive emotions, equanimity, and mindfulness) of intervention effects. Participants will be healthcare employees of UCLA Health. They will be enrolled in a six-week, two-arm randomized controlled trial. Participants will complete self-report questionnaires at baseline, mid-course, and post-intervention to assess study outcomes and mediators. We aim to advance the study of interventions that reduce distress and promote well-being using practices that cultivate kind feelings toward oneself and others.",[27,439,440],"Inflamation","Psychosocial Functioning",[60,442,443,444,58],"compassion","loving-kindness","healthcare professional","2025-12-04",{"date":447,"type":34},"2025-12-16",{"date":449,"type":34},"2025-10-10",{"date":451,"type":20},"2027-01",{"name":453,"class":41},"University of California, Los Angeles",{"id":455,"slug":456,"hasResults":11,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":461,"targetDuration":4,"studyType":21,"phases":463,"briefSummary":464,"conditions":465,"keywords":467,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":476,"startDateStruct":478,"completionDateStruct":480,"leadSponsor":481,"locationsCount":301},"100604912","evaluating-healthcare-professionals-satisfaction-and-stress-mitigation-using-virtual-reality-intervention-in-surgical-ward-100604912","NCT07155681","Evaluating Healthcare Professionals' Satisfaction and Stress Mitigation Using Virtual Reality Intervention in Surgical Ward","Evaluating Healthcare Professionals' Satisfaction and Stress Mitigation Using Virtual Reality Intervention in Surgical Ward: a Multination Feasibility Study","Inclusion Criteria:\n\n* Volunteering healthcare professionals (≥18 years old) working in direct patient care, such as nurses, residents, physician assistants, and surgeons, on the surgical ward.\n\nExclusion Criteria:\n\n* Diagnosed with epilepsy\n* Experienced VR as a trigger for their migraines\n* Severe dizziness, nausea or physical disabilities will be excluded.\n* Diagnosed with arrythmias, bradycardia or tachycardia\n* Not able to wear the VR headset due to physical or psychological conditions",{"count":462,"type":20},75,[23],"The goal of this feasibility study is to learn whether a VR intervention is feasible, acceptable, and satisfactory for healthcare workers in surgical wards to help mitigate stress. Secondary objectives include assessing its potential contribution to stress reduction, user comfort, and practical integration into daily workflows.\n\nParticipants will take part in a single 10-minute VR intervention session.",[466,27],"Stress",[468,150,466,469,470,471,472,473,474],"VR","Resilience","Healthcare professionals","healthcare workers","nurses","hospital","surgical ward","2025-08-26",{"date":477,"type":34},"2025-09-04",{"date":479,"type":20},"2025-11-01",{"date":36,"type":20},{"name":482,"class":41},"Amsterdam UMC, location VUmc"]