[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stress":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,242,0,25,[9,57,89,111,143,164,203,231,256,278,303,323,348,374,399,424,450,473,492,511,543,568,604,627,645],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":21,"enrollmentInfo":22,"targetDuration":4,"studyType":25,"phases":26,"briefSummary":28,"conditions":29,"keywords":34,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100652854","how-does-the-opioid-system-shape-stress-and-social-behaviour-in-men-and-women-and-what-role-does-childhood-unpredictability-play-100652854",false,"NCT07778511","How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play?","Randomized, Double-blind, Placebo-controlled, Crossover Study Investigating Sex-specific Effects of Mu-opioid Receptor Activation on Stress and Social Interaction and Its Modulation by Early Life Stress","MOR-SAFE","Inclusion Criteria:\n\n* Age 18-40 years\n* Ability to read, understand, and provide written informed consent in German\n* Proficiency in German\n* Able to give blood samples (no blood- or needle-related phobia)\n* Good health as determined by medical history, ECG, and clinical assessment of lab tests. Lab tests will include potassium, creatinine, hemoglobin, glucose, calcium, BUN, complete blood count, total bilirubin, AST, ALT, and GGT. The final decision will be according to the judgment of the study physician.\n* Females must have a negative urine pregnancy test (hCG) at inclusion and at the start of each study session. Females of childbearing potential who are sexually active and have not been surgically sterilized must agree to use an adequate method of birth control during the study.\n* Prior experience with medical opioids (at least one experience with prescription opioids such as oxycodone, morphine, hydromorphone, fentanyl, hydrocodone, codeine, or dihydrocodeine) and paracetamol.\n* Body mass index (BMI) between 19 and 30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Any current instable medical or neurological condition\n* Any clinically significant psychiatric disorder (i.e., psychotic and stress-related disorders) including a diagnosis of substance use disorder (defined in DSM-5 terms as Moderate or Severe). Participants will be screened using the Structured Clinical Interview - SCID for DSM-5). If indication is obtained that a clinically significant psychiatric disorder may be present, a full SCID will be carried out by appropriately trained staff.\n* Significant adverse reaction to prior opioid or paracetamol exposure\n* Reporting any illegal drug use \\>15 life-time occasions and regular drug use during the last three months incl. the test period (except for nicotine and alcohol)\n* Any current use of CNS-active medications.\n* Current use of opioid analgesics, opioid use for \\> 6 weeks (lifetime), or within the three months prior to study enrollment.\n* Fagerström Test of Nicotine Dependence (FTND) Score \\> 5 (strong nicotine dependence)\n* Heavy alcohol use based on the Alcohol Use Disorder Identification Test (AUDIT)\n* Lifetime diagnosis of cardiac disease.\n* Clinically significant laboratory or ECG abnormality that could be a safety issue in the study\n* Acute or chronic respiratory issues (e.g., cold, flu, asthma, etc.)\n* Lifetime diagnosis of liver or kidney disease including moderate or severe renal impairment (creatinine clearance \\\u003C 50 ml\u002Fmin)\n* Lifetime diagnosis of schizophrenia, bipolar disorder, obsessive-compulsive disorder, or autism spectrum disorder according to DSM-5\n* Diagnosis of a current episode of depression based on DSM-5 criteria\n* Current diagnosis of a moderate or severe substance use disorder according to DSM-5\n* Daily cannabis consumption in the past three months\n* Use of psychotropic medication within the last 7 days\n* Participation in other pharmacological studies within the last 2 months\n* Alcohol use within the last 24 hours controlled by breathalyzer\n* Unable to provide a negative urine drug screen (cannabinoids, amphetamines, opiates and opioids, benzodiazepines, and cocaine).\n* Positive pregnancy test or nursing (self-report)\n* For women: irregular menstrual cycle or menopause",true,"ALL","18 Years","40 Years",{"count":23,"type":24},72,"ESTIMATED","INTERVENTIONAL",[27],"NA","The study aims to investigate sex differences in the effect of mu-opioid receptor (MOR) activation on stress response and social behaviour modulated by early life stress.",[30,31,32,33],"Stress","Early Life Stress","Sex Differences","Opioid",[35,36,37,38,39,40,41,42,43],"mu opioid receptor","stress","early life stress","social behaviour","affiliative behaviour","sex differences","endocannabinoid system","morphine","opioid use disorder","NOT_YET_RECRUITING","2026-08-19",{"date":47,"type":48},"2026-08-21","ACTUAL",{"date":50,"type":24},"2026-09",{"date":52,"type":24},"2028-03",{"name":54,"class":55},"Sara L. Kroll","OTHER",1,{"id":58,"slug":59,"hasResults":12,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":18,"sex":64,"minAge":20,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":25,"phases":68,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":82,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":56},"100648034","mindfulness-based-education-for-women-with-polycystic-ovary-syndrome-100648034","NCT07718217","Mindfulness-Based Education For Women With Polycystic Ovary Syndrome","The Effect Of Mindfulness-Based Education For Women With Polycystic Ovary Syndrome On Menstrual Symptoms, Stress, And Quality of Life: A Randomized Controlled Study","Inclusion Criteria:\n\n* Self-identify as female.\n* Be of reproductive age (18-49 years).\n* Have a confirmed diagnosis of Polycystic Ovary Syndrome (PCOS) based on the Rotterdam criteria.\n* Be able to read, understand, and communicate in Turkish.\n* Have access to the internet and a device capable of participating in online education sessions.\n\n  * Be willing to attend the four-week online education program and complete all study assessments.\n  * Provide written informed consent before participation.\n\nExclusion Criteria:\n\n* Currently pregnant or breastfeeding.\n* Having a severe psychiatric disorder or cognitive impairment that may interfere with participation.\n* Having a serious chronic medical condition that could affect study outcomes or prevent participation in the intervention.\n* Currently participating in another interventional research study.\n* Having previously received structured mindfulness training or participated in a mindfulness-based program during the study period.\n* Being unable to attend the online education sessions or complete the study assessments.\n* Declining or withdrawing informed consent at any stage of the study.","FEMALE","49 Years",{"count":67,"type":24},78,[27],"Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the disease's pathophysiology remains unclear. This has hindered the diagnosis of the disease and the appropriate treatment for millions of individuals. The long-term health sequelae associated with PCOS, future directions, and areas of needed research in this often-overlooked disease. Women with PCOS may experience menstrual symptoms, increased stress, and difficulties in managing the physical and emotional effects of the condition. Supportive approaches that improve symptom management and quality of life may be beneficial in addition to routine care.\n\nThe aim of this randomized controlled study is to evaluate the effect of mindfulness-based PCOS education on menstrual symptoms, stress levels, and quality of life in women with PCOS. The study will examine whether a structured mindfulness-based education program can support women in managing PCOS-related symptoms and improving their overall well-being.\n\nWomen diagnosed with PCOS who meet the study eligibility criteria will be invited to participate. Participants will be randomly assigned to either the intervention group or the control group. Participants in the intervention group will receive a mindfulness-based PCOS education program, while those in the control group will receive routine care without it.\n\nResearchers will assess participants' menstrual symptoms, stress levels, and quality of life using validated measurement tools before and after the intervention. The findings of this study will provide information about the potential role of mindfulness-based education as a supportive approach in the management of PCOS and may contribute to the development of patient-centered education programs for women with PCOS.",[71,72,30,73],"Polycystic Ovary Syndrome (PCOS)","Menstrual Symptoms","Quality of Life",[75,76,77,78,72,79,80,73],"Polycystic Ovary Syndrome","PCOS","Mindfulness-Based Education","Mindfulness","Menstrual Pain","PCOS-Specific Quality of Life","RECRUITING",{"date":47,"type":48},{"date":84,"type":48},"2026-07-20",{"date":86,"type":24},"2026-12",{"name":88,"class":55},"Aydin Adnan Menderes University",{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":25,"phases":96,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":56},"100649138","aromatherapy-and-music-impact-on-nurses-stress-at-work-100649138","NCT07732179","Aromatherapy and Music Impact on Nurses' Stress at Work","Inclusion Criteria:\n\n-CCU nurses at NM AMC providing direct patient care.\n\nExclusion Criteria:\n\n* currently pregnant\n* allergic to essential oils",{"count":7,"type":24},[27],"The purpose of the Doctor of Nursing Practice research project is to determine if nurses who receive chamomile-lavender aromatherapy and listen to music during a 20-minute break once per shift for 8 weeks, will experience report decreased work stress (measured by self-reported symptoms of anxiety) compared to before the aromatherapy and music intervention during breaks.\n\nThe investigators know nurses are at high risk for stress and anxiety. Despite the current processes and policies in place at Northwestern Memorial Hospital that support nurses to take breaks during their shifts, nurses continue to share feeling stressed and anxious. Included in this Doctor of Nursing Practice research project is an evidence synthesis of fourteen studies supporting the idea that combining aromatherapy and music can reduce anxiety in both adults and children.\n\nThe evidence-based intervention being studied is administering lavender-chamomile essential oil aromatherapy and listening to music during 20-minute non-meal breaks once a shift for 8 weeks. Participants will go to a quiet breakroom, pour 3 drops of lavender-chamomile essential oil onto a non-adhesive 2X2 gauze pad, and place the pad about 20 centimeters from their noses while also listening to their preferred calming music through their personal phones and wireless earbuds or headphones for twenty minutes.",[30],[100,101,102],"nurse","aromatherapy","music","2026-08-17",{"date":45,"type":48},{"date":106,"type":48},"2026-07-01",{"date":108,"type":24},"2026-09-30",{"name":110,"class":55},"Northwestern University",{"id":112,"slug":113,"hasResults":12,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":25,"phases":121,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":56},"100649368","impact-of-peanut-consumption-on-stress-immune-function-inflammation-and-cardiovascular-health-in-high-stress-individuals-100649368","NCT07735221","Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals","Effects of Peanut Consumption on Physiological and Psychosocial Stress, Circulating Immune Cell Status, Markers of Inflammation and Cardiovascular Disease Risk, and Gastrointestinal Health in High-Stress Individuals","Inclusion Criteria:\n\n* Males and females\n* 18-65 years old\n* BMI ≥ 18.5 kg\u002Fm2 and ≤ 39.9 kg\u002F m2\n* Recruitment will be based on Perceived Stress Scale - 4 (PSS-4) score\n\nExclusion Criteria:\n\n* Less than 18 and over 65 years old\n* Pregnant or lactating women\n* Adults who rely on prescription medication that may influence study variables, apart from birth control\n* BMI \\\u003C 18.5 kg\u002Fm2 and \\> 39.9 kg\u002Fm2\n* Smokers who currently use tobacco- or marijuana-containing products including e-cigarettes, vape pens, pod mods, tanks, and electronic nicotine delivery devices (ENDS)\n* Habitual consumption of nuts, nut butters, nut powders, nut side dishes, nut bars or other nut products\n* Known food allergies (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, sesame, corn) due to samples not prepared in a hypoallergenic environment\n* Currently living in close contact with individuals who have an allergy to peanuts, in order to avoid exposing these individuals to an allergen\n* Self-reported history of difficulties with blood drawing procedures including prior fainting or dizziness, or veins assessed as not suitable for four separate venipunctures by licensed phlebotomist\n* Diagnosed active chronic diseases for which the individual is currently taking daily medication, including but not limited to:\n\n  * Diabetes mellitus, cardiovascular disease, cancer, gastrointestinal disorders, kidney disease, liver disease, bleeding disorders, asthma, autoimmune disorders, hypertension, osteoporosis\n* Recent minor surgery (within 4 weeks) or major surgery (within 16 weeks)\n* Known gallbladder disease or history of cholecystectomy\n* History of gastrointestinal surgery, including gastric bypass surgery or resection\n* Diagnosis of irritable bowel syndrome\n* Recent antibiotic therapy (within 4 weeks)\n* Recent hospitalization (within 4 weeks)\n* Current participation in another research study\n* Has HIV\u002FAIDS, hepatitis, or another disease that affects the immune system\n* Gives regular blood donations and is unwilling to stop during the study\n* Blood Pressure ≥ 140 mmHg systolic or 90 mmHg diastolic\n* Current diagnoses of an eating disorder (ex. anorexia, bulimia, etc.)\n* High - very high triglyceride levels: ≥ 300 mg\u002FdL\n* Adults who are unable to consent, individuals who are not yet adults (infants, children and teenagers), pregnant women and prisoners will be excluded from participation in the study\n* Participants who are unwilling to collect and transport urine, stool and saliva samples\n* Abnormal hemoglobin and\u002For hematocrit levels\n* Abnormal liver function (defined as liver enzymes that are \\>200% of upper limit (ALT upper limit is 43 U\u002FL or Aspartate transaminase (AST) upper limit is 54 U\u002FL)\n* Unwillingness to discontinue probiotic, prebiotic, fiber, or other supplements (except RDA-level vitamin and mineral supplements) during the study\n* Unwilling to consume study foods\n* Alcohol consumption \\> 20 g\u002Fday","65 Years",{"count":120,"type":24},70,[27],"The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.",[124,30,125,126],"Immune System","Chronic Stress","Cardiovascular Health",[128,36,129,130,131,132,133,134],"peanut","immune function","cardiovascular health","chronic stress","pss10","inflammation","gut microbiota","2026-08-13",{"date":103,"type":48},{"date":50,"type":24},{"date":139,"type":24},"2028-08",{"name":141,"class":142},"USDA, Western Human Nutrition Research Center","FED",{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":12,"sex":64,"minAge":20,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":25,"phases":152,"briefSummary":153,"conditions":154,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":162,"locationsCount":56},"100613856","office-massage-effects-on-hrv-and-stress-100613856","NCT07272031","Office Massage Effects on HRV and Stress","Randomized Controlled Trial to Evaluate the Effectiveness of Three Different 15-Minute Office Massage Types (Head, Cervical Area, Hand) on Autonomic Nervous System Balance and Chronic Stress Reduction Using Heart Rate Variability (HRV)","Inclusion Criteria:\n\nBiological females aged 18 years or older. Currently working in an office job with at least 75% of the working day spent sitting (sedentary work).\n\nSelf-reported regular menstrual cycle (cycle length 21-35 days). Able to attend all scheduled intervention sessions (8 sessions over 4 weeks). Able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\nCurrent pregnancy or breastfeeding. Diagnosis of cardiovascular diseases (e.g., heart failure, cardiac arrhythmias, deep vein thrombosis) or presence of a pacemaker Endocrine or metabolic disorders (e.g., insulin-dependent diabetes, hyperthyroidism, or other thyroid dysfunctions) Active cancer or receiving active cancer treatment (e.g., chemotherapy, radiation therapy) History of major surgery or trauma in the head, neck, or upper extremities within the last 3 months Current diagnosis of a major psychiatric disorder (e.g., major depressive disorder, bipolar disorder) Regular use of medications affecting heart rate or the nervous system (e.g., beta-blockers, ACE inhibitors, antidepressants, anxiolytics, or asthma inhalers) Current participation in another interventional clinical trial",{"count":151,"type":24},140,[27],"This study is a randomized controlled trial designed to investigate which of three short office massage types (head, neck\u002Fshoulder area, or hand) is most effective for reducing chronic stress in women who perform sedentary office work.\n\nMany sedentary female office employees experience long-term tension and work-related strain, which can affect the body's ability to recover. The investigators are testing whether a 15-minute massage, performed twice a week for four weeks, can help restore balance within the body.\n\nThe investigators will evaluate the impact of these massages using Heart Rate Variability (HRV)-an objective measure that shows how well the body manages stress (autonomic nervous system balance)-as well as analyzing participants' self-reported levels of perceived stress, sleep quality, and overall well-being. Participants receiving massage will be compared to a control group engaging in quiet rest.",[155,156,30],"Occupational Health","Autonomic Nervous System (ANS) Functioning and Mood State","2026-08-12",{"date":135,"type":48},{"date":160,"type":48},"2026-01-05",{"date":108,"type":24},{"name":163,"class":55},"Riga Stradins University",{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":18,"sex":19,"minAge":171,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":25,"phases":175,"briefSummary":176,"conditions":177,"keywords":183,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":56},"100650926","latin-dance-and-psychological-health-in-primary-school-children-100650926","NCT07755995","Latin Dance and Psychological Health in Primary School Children","Effects of Latin Dance Intervention on Psychologic Health, Loneliness, Enjoyment and Well-being Among Primary School Children in Gansu, China","Inclusion Criteria:\n\n* Primary school children aged 6-12 years.\n* Currently enrolled in a participating primary school in Gansu, China.\n* Able to participate safely in school-based physical activities and Latin dance sessions.\n* Able to understand and complete the study questionnaires.\n* Willing to participate in the 12-week intervention and study assessments.\n* Written informed consent provided by a parent or legal guardian.\n* Assent provided by the child.\n\nExclusion Criteria：\n\n* A medical condition, physical disability, or musculoskeletal injury that would make participation in physical activity or Latin dance unsafe.\n* A health condition for which a physician or school health professional advises against participation in moderate-intensity physical activity.\n* Current participation in regular Latin dance training or another structured dance intervention.\n* Participation in another psychological or physical activity intervention that may affect the study outcomes.\n* Inability to participate regularly in the intervention sessions or complete the study assessments.","6 Years","12 Years",{"count":174,"type":24},60,[27],"This study aims to examine the effects of a 12-week Latin dance intervention on loneliness, anxiety, depression, perceived stress, physical activity enjoyment, and well-being among primary school children in Gansu, China. Eligible participants will be randomly assigned to either a Latin dance intervention group or a control group. The intervention group will participate in two supervised Latin dance sessions per week, including Rumba, Cha-cha, and Jive, while the control group will participate in regular physical education activities. The outcomes will be assessed before and after the 12-week intervention using validated questionnaires. The findings may provide evidence regarding the effectiveness of school-based Latin dance as a strategy for promoting children's psychological health and well-being.",[178,179,180,30,181,182],"Loneliness","Anxiety","Depression","Well-Being","Enjoyment",[184,185,186,187,188,189,190,181,191,192,193],"Latin Dance","Primary School Children","School-Based Intervention","Physical Activity","Physical Activity Enjoyment","Psychological Health","Mental Health","Rumba","Cha-Cha","Jive","2026-08-06",{"date":196,"type":48},"2026-08-10",{"date":198,"type":24},"2026-09-01",{"date":200,"type":24},"2026-11-30",{"name":202,"class":55},"Xu Shuishui",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":12,"sex":19,"minAge":211,"maxAge":212,"enrollmentInfo":213,"targetDuration":4,"studyType":25,"phases":215,"briefSummary":217,"conditions":218,"keywords":222,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":224,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":56},"100593091","effects-of-cannabidiol-on-stress-and-nicotine-withdrawal-100593091","NCT07001930","Effects of Cannabidiol on Stress and Nicotine Withdrawal","Pharmacological Effects of Cannabidiol on Responses to Stress and Nicotine Withdrawal","CREWS","Inclusion Criteria:\n\n1. Healthy non-treatment seeking adults aged 21-70 (inclusive).\n2. Use of \\> 5 cigarettes per day for \\> 2 years. (Use of other tobacco\u002Fnicotine products in addition to cigarettes will be acceptable).\n3. Biological confirmation of cigarette use: have an expired carbon monoxide (CO) level \\>= 5 ppm.\n4. Alcohol Use: \\\u003C 2 drinks\u002Fday on average (\\\u003C 14 drinks\u002Fweek).\n5. Sleep schedule: No graveyard or third shift work (i.e., participants must report a normal nighttime sleep schedule).\n6. For women of children bearing potential and men with female partners of child-bearing potential, must be willing to use an effective form of contraception during the study and for at least 30 days after the last study drug administration.\n\nExclusion Criteria:\n\n1. Report current intention to reduce or quit cannabis or tobacco use within the next 30 days\n2. Meet Diagnostic and Statistical Manual (DSM-5) criteria for a substance use disorder other than alcohol, cannabis, or nicotine\n3. Test positive for illicit drugs other than cannabis\n4. Positive breath alcohol test (\\>.01 g\u002F210L) at study admission\n5. Have a current physical or mental illness or takes a medication judged by the study team to negatively impact participant safety or scientific integrity\n6. Have a resting heart rate \\>100, systolic blood pressure \\>160mmHg or \\\u003C100mmHg, or diastolic blood pressure \\>100mmHg or \\\u003C50mmHg at screening.\n7. Have cold intolerance or a medical condition that might be exacerbated by exposure to cold (e.g. Reynaud's, peripheral neuropathy, trigeminal neuralgia, poorly controlled\u002Funcontrolled hypothyroidism).\n8. Are currently pregnant, planning to become pregnant in the next three months, or are currently breastfeeding\n9. Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina, Raynaud's).\n10. Have a history of and\u002For current liver disease, or elevated serum liver transaminase (AST or ALT) above 3 x Upper Limit of Normal (ULN), or elevated bilirubin above 2 x ULN at screening.\n11. Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.","21 Years","70 Years",{"count":214,"type":24},90,[216],"PHASE1","The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between these types of stress. Participants will be administered CBD and exposed to stress. Biological and subjective measures will be collected. Participants may be asked to stop use for 24 hours. Researchers will also investigate withdrawal effects between participants who have not smoked nicotine in 24 hours and those who have continued to smoke before each session.",[219,30,220,221],"CBD","Nicotine Dependence","Tobacco Smoking",[219,30,223,221],"Nicotine",{"date":196,"type":48},{"date":226,"type":48},"2025-08-25",{"date":228,"type":24},"2029-09-01",{"name":230,"class":55},"Johns Hopkins University",{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":12,"sex":19,"minAge":238,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":242,"phases":4,"briefSummary":243,"conditions":244,"keywords":245,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":4},"100651174","2d4d-ratio-in-relation-to-anxiety-and-stress-among-anesthesiology-residents-100651174","NCT07757971","2D:4D Ratio in Relation to Anxiety and Stress Among Anesthesiology Residents","Association of Second-to-Fourth Digit Ratio (2D:4D) With Trait Anxiety and Occupational Stress Among Anesthesiology Residents: A Cross Sectional Observational Study","Inclusion Criteria:\n\n* Any anesthesiologists who voluntarily agreed to participate in the study.\n* Age: 20-35 years\n* Both genders\n\nExclusion Criteria:\n\n* Incomplete questionnaires and\u002For irrelevant responses.\n* Injuries to the 2nd or 4th digits,\n* Unclear or inaccurate digit photocopy,\n* If the participant is a twin\n* Cumulative leave (e.g., maternity\u002Fsick leave) exceeding 6 months during the study period;\n* Pre-existing diagnosis of psychiatric disorders prior to the study","20 Years","35 Years",{"count":241,"type":24},116,"OBSERVATIONAL","Anesthesiologists are exposed to substantial occupational stress, making their psychological well-being essential for both personal health and optimal patient care. Early identification of mental health disorders among healthcare professionals is important for improving well-being and maintaining healthcare quality.",[179,30],[246,36],"anxiety","2026-08-05",{"date":249,"type":48},"2026-08-11",{"date":251,"type":24},"2026-09-15",{"date":253,"type":24},"2026-12-30",{"name":255,"class":55},"Ain Shams University",{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":25,"phases":266,"briefSummary":267,"conditions":268,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":271,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":56},"100645593","diaphragmatic-and-box-breathing-on-heart-rate-variability-and-perceived-stress-100645593","NCT07698652","Diaphragmatic and Box Breathing on Heart Rate Variability and Perceived Stress","Enhancing Physiological and Psychological Resilience: A Comparative Study of Diaphragmatic and Box Breathing in Physical Therapy Students.","HRV DB BB PSS","Inclusion Criteria:\n\n* Academic Status: Currently enrolled, full-time undergraduate Physical Therapy students\n* Age Range: 18-25 years\n* Health Status: Generally healthy individuals with no known chronic respiratory or cardiovascular diseases.\n* Informed Consent: Ability and willingness to provide written informed consent and commit to the 4-week protocol (6 sessions\u002Fweek).\n* Stress Level: A baseline score on the Perceived Stress Scale (PSS) indicating at least moderate stress.\n\nExclusion Criteria:\n\n* Pre-existing Breathing Expertise: Individuals with professional training in yoga (Pranayama), formal meditation, or advanced breath work that might bias the baseline results.\n* Medical Conditions: Diagnosed respiratory conditions (e.g., Asthma, COPD).\n* Cardiovascular issues (e.g., Arrhythmias, Hypertension).\n* Clinical psychological disorders (e.g., Generalized Anxiety Disorder or Panic Disorder) that may require medication.\n* Pharmacological Factors: Use of medications that influence the Autonomic Nervous System (e.g., Beta-blockers, antidepressants, or heavy use of stimulants\u002Fsedatives).\n* Substance Use: Smokers\u002FVapers\n* Excessive Caffeine \"Participants consuming more than 400 mg of caffeine per day (equivalent to approximately 4 standard cups of brewed coffee) will be excluded.\n* Recent Acute Illness: Any respiratory tract infection or fever within two weeks prior to the start of the study","25 Years",{"count":174,"type":24},[27],"The goal of this clinical trial is to learn if diaphragmatic breathing and box breathing work to enhance resilience and manage stress in physical therapy students. It will also learn about their effects on overall physiological and psychological parameters. The main questions it aims to answer are:\n\nDo these breathing techniques improve heart rate variability (HRV)?\n\nHow do these interventions affect participants' perceived stress levels, cognitive performance, and academic achievement?\n\nResearchers will compare diaphragmatic breathing and box breathing to a control group to see if these non-invasive methods work to improve physiological adaptation and manage stress.\n\nParticipants will:\n\nBe randomly assigned to practice diaphragmatic breathing, practice box breathing, or join a control group Have their heart rate variability (HRV) measured as a primary sign of physiological adaptation Complete assessments to evaluate their perceived stress, cognitive performance, and academic achievement",[30,269,270],"Psychological Resilience","Healthy Students",{"date":194,"type":48},{"date":273,"type":24},"2026-09-20",{"date":275,"type":24},"2027-03-01",{"name":277,"class":55},"Cairo University",{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":18,"sex":19,"minAge":211,"maxAge":285,"enrollmentInfo":286,"targetDuration":4,"studyType":25,"phases":288,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":56},"100650758","gut-feelings-using-citizen-science-for-large-scale-prebiotic-clinical-trials-for-mental-health-in-adults-100650758","NCT07752823","GUT-FEELINGS: Using Citizen Science for Large-Scale Prebiotic Clinical Trials for Mental Health in Adults","GUT-FEELINGS: Using Citizen Science for Large-Scale Prebiotic Clinical Trials for Mental Health in Adults, Wave 1","Criteria: 3.1 Inclusion\n\nParticipants must meet all of the following criteria:\n\n* Adults aged 21-80 years (inclusive) at the time of electronic informed consent, of any ethnicity, race, or gender identity\n* Assigned sex at birth determines sex-specific PRO branching (e.g., menstrual interference) where applicable\n* Reside in the contiguous 48 states in the United States and is able to provide a valid US shipping address and and 10-digit mobile phone number\n* Per state regulations, individuals residing in New York, New Jersey, and Rhode Island will be excluded\n* Capable of providing voluntary, electronic informed consent and willing to comply with study procedures, including remote biospecimen collection\n* PROMIS Anxiety 8A T-score between 55.0 and 69.9 (inclusive) at screening, corresponding to mild-to-moderate anxiety symptoms.\n* On a stable medication regimen for ≥30 days prior to screening and willing to maintain that regimen for the duration of the trial, unless changes are deemed medically necessary by the participant's healthcare provider. Stable, prescribed psychotropic medications (including SSRIs, SNRIs, and other antidepressants or anxiolytics) are not exclusionary.\n* Willing to take a study product and not know the intervention arm assignment (active or placebo) or the product identity.\n* Reliable daily access to the internet via mobile device or computer\n\n3.2 Exclusion\n\nIndividuals who report any of the following during screening may be excluded from participation:\n\n* Currently pregnant, planning to become pregnant during the trial, or breastfeeding\n* Unable to read and understand English at a 7th-grade reading level\n* Currently enrolled in another interventional clinical trial or planning to enroll in one during the trial timeline\n* Heavy alcohol consumption (defined for female sex assigned at birth \\>\u002F= 2 alcoholic beverages\u002Fday, male sex assigned at birth \\>\u002F=3\u002Fday) or use of recreational or illicit drugs other than cannabis\n* History of bariatric or weight-loss surgery (e.g., Roux-en-Y gastric bypass, sleeve gastrectomy, adjustable gastric banding, or biliopancreatic diversion).\n* Reports a current diagnosis of inflammatory bowel disease (ulcerative colitis or Crohn's disease).\n* Current or recent (within 3 months) major illness, surgery, or hospitalization posing a known significant safety risk\n* Diagnosis of cardiac dysfunction, severe liver disease, or severe kidney disease that presents a known contraindication to study product ingredients or substantial safety risk:\n* NYHA Class III or IV congestive heart failure, atrial fibrillation, uncontrolled arrhythmias, cirrhosis, end-stage liver disease, stage 3b or 4 chronic kidney disease, or kidney failure\n* Significant immunocompromise, including diagnosed primary or acquired immunodeficiency, current chemotherapy, current immunotherapy, current use of immunosuppressive medications, or daily corticosteroid dose \\>5 mg prednisone-equivalent\n* Antibiotic use (oral, IV) currently or within 30 days prior to screening\n* Plans to start a new structured dietary regimen (including new probiotic or prebiotic supplementation outside the study product) during the trial period\n* Use of medications with a well-established interaction posing a substantial safety risk with study product ingredients\n* Active suicidality as determined by a response of 3 in item 9 of the PHQ-9 score at screening\n* Known hypersensitivity to any component of the study products\n* Wave-specific exclusion criteria per Subprotocol A (Wave 1) or Subprotocol B (Wave 2)\n\nNote on medication exclusions: routine prescription medications (including antihypertensives, anticoagulants at standard outpatient doses, antiseizure medications, and medications carrying a grapefruit-consumption warning) are not categorically excluded. Specific medications posing a documented safety risk in combination with the food ingredients (products) are addressed by the study screening Q-bank.\n\n* Participants residing in the states of New York, New Jersey, or Rhode Island are not eligible to participate in the study. This restriction is due to state regulatory requirements governing direct-to-consumer at-home laboratory specimen collection and processing that cannot be accommodated within the fully decentralized design of the study. No alternative collection pathway is available under the current protocol.\n* To ensure compliance, state-of-residence logic is built into the enrollment platform. Participants who indicate a residential address in New York, New Jersey, or Rhode Island will not be eligible. This automated screening ensures that ineligible participants are not inadvertently enrolled in the study.","80 Years",{"count":287,"type":24},1000,[27],"The goal of this study is to evaluate the effects of different products in participants experiencing feelings of anxiety. The main question it aims to answer is:\n\n\\- Do these products affect feelings of anxiety and related wellness outcomes compared with a placebo?\n\nResearchers will compare participants taking active products to those taking a placebo to see whether the active products influence feelings of anxiety and related outcomes, and to monitor safety.\n\nParticipants will:\n\n* Be randomly assigned to receive either an active product or a placebo (an inactive look-alike).\n* Take their assigned product or placebo without knowing which group they are in until the study is completed.\n* Complete evaluations and tasks to track safety, feelings of anxiety, and related health outcomes.",[291,30,292],"Sleep Disturbance","Feeling Anxious","2026-08-04",{"date":295,"type":48},"2026-08-07",{"date":297,"type":24},"2026-08-20",{"date":299,"type":24},"2027-08",{"name":301,"class":302},"Holobiome, Inc.","INDUSTRY",{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":239,"enrollmentInfo":310,"targetDuration":4,"studyType":25,"phases":312,"briefSummary":313,"conditions":314,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":319,"leadSponsor":321,"locationsCount":56},"100622129","effects-of-moderate-exercise-and-cyclic-sighing-on-stress-cognition-and-physiological-markers-in-young-adults-100622129","NCT07379606","Effects of Moderate Exercise and Cyclic Sighing on Stress, Cognition and Physiological Markers in Young Adults","A Comparison of Psychophysiological Effects Between Relaxation Techniques and Physical Exercise in Young Adults","Inclusion Criteria:\n\n* male or female participants,\n* age 18-35,\n* without chronic somatic diseases,\n* no current episode of psychiatric disorder (no active depression, mania, or psychosis),\n* regular sleep schedule in the week prior to the study,\n* not taking psychotropic drugs or medications,\n* non-smoker,\n* not working nightshifts.\n\nExclusion Criteria:\n\n* consumption of alcohol or psychoactive substances the day before or on the day of the study,\n* intense physical activity less than 2 hours before the study,\n* consuming coffee, black tee, energy drinks less than 2 hours before the study,\n* contraindications to moderate-intensity physical activity on cycle ergometer (e.g., recent injuries),\n* contraindications to EEG (e.g., scalp skin conditions preventing proper electrode placement, hypersensitivity to conductive gels or pastes).",{"count":311,"type":24},30,[27],"This study investigates the effects of moderate physical exercise and cyclic sighing (breathing training) on stress, cognition, and physiological markers in young adults. It is a randomized cross-over trial with two interventions. Each participant will take part in two intervention sessions:\n\n1. Moderate-intensity physical activity (PA): 15 minutes of stationary cycling at 65-75% of maximum heart rate (HRmax).\n2. Breathing training (CS): 15 minutes of cyclic sighing, a technique involving inhaling, pausing briefly, taking a deeper breath, and exhaling slowly.\n\nA one-week washout period between sessions is planned to minimise carry-over effects and to ensure participants' physiological state is similar before the next session. During this week, participants will wear Polar Ignite wrist-worn devices to monitor physical activity and sleep.\n\nA total of 30 participants (you adults) will be enrolled.\n\nMeasurements performed before and after each intervention include:\n\n* EEG using Emotiv EPOC Flex Gel (32-channel device): 2 minutes with eyes open, 2 minutes with eyes closed, during the interventions, and while performing cognitive test (N-back).\n* Heart rate variability (HRV) using the Polar H10 sensor.\n* SUDS - Subjective Units of Disress Scale for perceived stress.\n* N-back test for cognitive performance using Emotiv App.\n* Blood pressure (systolic and diastolic) and heart rate.\n* Pain threshold measured with a dolorimeter.\n* PANAS-SF - Positive and Negative Affect Schedule.\n\nBaseline questionnaires completed by participants the day before the study:\n\n* PSS-10 - Perceived Stress Scale (Cohen, Kamarck, Mermelstein).\n* MAAS - Mindful Attention Awareness Scale\n* Psychological well-being - short version\n* Mini-COPE - Coping with Stress Inventory\n* Sleep quality and average sleep duration\n* Chronotype questionnaire (morningness-eveningness)\n* GPAQ - Global Physical Activity Questionnaire\n* Pittsburgh Sleep Quality Index\n\nThe study aims to understand how brief interventions like moderate exercise and breathing techniques affect stress, cognitive performance, and physiological responses in young adults.",[30],"2026-07-31",{"date":317,"type":48},"2026-08-03",{"date":315,"type":48},{"date":320,"type":24},"2026-10-30",{"name":322,"class":55},"Poznan University of Physical Education",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":19,"minAge":330,"maxAge":331,"enrollmentInfo":332,"targetDuration":4,"studyType":25,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":56},"100618718","effects-of-swaddling-and-nesting-on-pain-and-stress-in-newborns-100618718","NCT07335263","Effects of Swaddling and Nesting on Pain and Stress in Newborns","The Effect of Swaddling and Nesting Methods on Pain and Stress Levels in Newborns Undergoing Noninvasive Mechanical Ventilation","Inclusion Criteria:\n\n* Birth week greater than 35 weeks and birth weight greater than 2000 grams\n* Requirement for nasal CPAP\u002Fnoninvasive mechanical ventilation\n* Legal guardians' consent to participate in the study\n* Postnatal diagnosis of transient tachypnea of the newborn\n\nExclusion Criteria:\n\nMother:\n\n* Taking cortisol-containing medication during the antenatal period\n* Taking narcotics during the antenatal period\n* Having chorioamnionitis\n* Having a metabolic disorder (adrenal insufficiency, etc.)\n\nNewborn:\n\n* Amniotic fluid stained with meconium\n* Being intubated\n* Having an Apgar score below 6\n* Receiving analgesic or narcotic drugs for sedation\n* The newborn receiving cortisol-containing medication\n* Being unable to obtain a saliva sample or the sample being contaminated with blood\n* Signs of nasal injury during noninvasive mechanical ventilation\n* Congenital defects (spina bifida, gastroschisis, etc.) that prevent positioning using the swaddling or cradling methods\n* Resuscitation\n* Cerebral hypoxia-ischemia\n* Non-respiratory causes (congenital pneumonia, respiratory distress syndrome, congenital heart disease, hypocalcemia, persistent hypoglycemia, development of sepsis)\n* Hypocalcemia (low calcium level detected in blood gas sample taken while establishing an intravenous line prior to nCPAP)","0 Days","28 Days",{"count":333,"type":24},100,[27],"This study aims to investigate the effects of swaddling and cradling methods on pain and stress levels in newborn infants receiving respiratory support.\n\nInfants receiving respiratory support in the neonatal intensive care unit may experience stress and discomfort during treatment. In this study, two different care methods that help infants feel more comfortable and secure will be scientifically compared. Only one of the Swaddling or Nesting methods will be applied to the newborns participating in the study. These methods are comfort-enhancing care practices routinely used in neonatal intensive care that do not harm the baby. The newborn's heart rate, respiratory rate, oxygen level, pain and stress symptoms will be closely and safely monitored by the healthcare team. A pain-free saliva sample will be collected to assess the newborn's stress level. It does not involve needles, does not hurt, and takes approximately 2 minutes. Pain and stress levels will be assessed in a multifaceted manner using clinical observation, physiological parameters, and saliva cortisol levels. The study aims to contribute to the strengthening of evidence-based non-pharmacological care practices in neonatal intensive care.",[30,337,338],"Non Pharmacological Intervention","Newborn Diseases","2026-07-25",{"date":341,"type":48},"2026-07-28",{"date":343,"type":48},"2025-02-17",{"date":345,"type":24},"2026-12-13",{"name":347,"class":55},"Kutahya Health Sciences University",{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":355,"targetDuration":4,"studyType":25,"phases":357,"briefSummary":358,"conditions":359,"keywords":362,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":370,"leadSponsor":372,"locationsCount":56},"100648086","supporting-mental-health-and-reducing-care-stress-in-caregivers-of-persons-with-cardiovascular-disease-100648086","NCT07717723","Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease","Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease: A Hybrid Effectiveness-Implementation Study of Caregiving Support in Cardiac Rehabilitation","Inclusion Criteria:\n\n* 18 years of age or older\n* Is a caregiver for a patient receiving care in our UC Davis Cardiac Rehabilitation Clinic. A caregiver is defined as someone who provides support to the patient with one or more basic or instrumental activities of daily living.\n* Has one or more caregiving-related challenges or issues that they would like support with\n* Is able to read and speak in English\n\nExclusion Criteria:\n\n* Is a paid professional caregiver with no family or fictive kin relationship with the care recipient\n* Has a diagnosis of major cognitive impairment or Alzheimer's or related dementias\n* Is unable to complete the protocol or participate in the intervention (e.g., unavailable during the intervention period, unable to access or use virtual meeting technology)",{"count":356,"type":24},40,[27],"The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilitators to implementation of the Confident Caregiver intervention among family caregivers of persons with cardiovascular disease participating in cardiac rehabilitation. Caregivers receive four individualized intervention sessions focused on assessment of caregiving challenges, tailored coaching, stress reduction, education, and referrals to supportive resources. Outcomes include reductions in caregiving-related challenges, improvements in mental health, and reductions in stress.",[360,30,180,179,361],"Caregiver Burden","Cardiovascular Diseases",[363,364,365],"Cardiac Rehabilitation","Caregiver Support","Confident Caregiver","2026-07-23",{"date":368,"type":48},"2026-07-27",{"date":366,"type":48},{"date":371,"type":24},"2027-12",{"name":373,"class":55},"University of California, Davis",{"id":375,"slug":376,"hasResults":12,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":381,"enrollmentInfo":382,"targetDuration":4,"studyType":25,"phases":384,"briefSummary":385,"conditions":386,"keywords":388,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":392,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":56},"100564314","exercise-effects-on-the-neurobiology-underlying-stress-related-eating-behaviors-in-veterans-100564314","NCT06627569","Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans","Exercise Effects on the Neurobiology Underlying Stress-Related Eating Behaviors in Veterans","Inclusion Criteria:\n\n* Veterans 18-75 years old\n* BMI of 25 or greater\n* Physically inactive\n* Able to attend study visits in person in Aurora, CO\n\nExclusion Criteria:\n\n* Currently pregnant\n* History of bariatric surgery\n* Current eating disorder\n* Current treatment with appetite-altering medications (e.g., GLP-1 agonists)\n* Contraindication to MRI (weight \\> 500 lbs; claustrophobia; metal or electronic devices in the body)\n* Cardiovascular disease, chronic kidney disease, pulmonary disease, or diabetes\n* Unable to exercise due to cardiac, pulmonary, neurologic, or orthopedic reasons","75 Years",{"count":383,"type":24},132,[27],"The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.",[387,30],"Overweight\u002FObesity",[389,390,30,391],"Overweight","Obesity","Eating",{"date":368,"type":48},{"date":394,"type":24},"2026-08-01",{"date":396,"type":24},"2030-08-30",{"name":398,"class":142},"VA Office of Research and Development",{"id":400,"slug":401,"hasResults":12,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":4,"eligibilityCriteria":405,"healthyVolunteers":18,"sex":19,"minAge":239,"maxAge":212,"enrollmentInfo":406,"targetDuration":4,"studyType":25,"phases":407,"briefSummary":408,"conditions":409,"keywords":411,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":418,"completionDateStruct":419,"leadSponsor":421,"locationsCount":423},"100636942","a-clinical-trial-to-assess-the-effect-of-ap-brain-collagen-peptides-on-the-improvement-of-attention-focus-and-memory-in-stressed-but-otherwise-healthy-individuals-100636942","NCT07572240","A Clinical Trial to Assess the Effect of AP-Brain Collagen Peptides on the Improvement of Attention, Focus, and Memory in Stressed But Otherwise Healthy Individuals","A Randomized, Open-Label, Parallel Proof-of-Concept Study to Assess the Effect of AP-Brain Collagen Peptides on the Improvement of Attention, Focus, and Memory in Stressed But Otherwise Healthy Individuals","Inclusion Criteria:\n\n* Individuals ready to give voluntary, written informed consent to participate in the study.\n* Male and female individuals of age between 35 to 70 years (both values included).\n* Individuals with body mass index (BMI) between 18.5 kg\u002Fm\\^2 to 29.9 kg\u002Fm\\^2 (both values included).\n* Perceived Stress Scale (PSS) scores between 14 to 26 (both values included).\n* Individuals with mild cognitive impairment as indicated by Addenbrooke's Cognitive Examination (ACE) III scores between 75 to 88 (both values included).\n* Self-reported mild difficulties in focus, attention, or memory.\n* Progressive cognitive complaints like stress, disturbed sleep etc. reported by participant.\n* Individuals willing to consume an investigational product from bovine source.\n* Individuals willing to complete all study-related and clinical study visits as per protocol.\n\nExclusion Criteria:\n\n* Clinically diagnosed with Attention Deficit Hyperactivity Disorder (ADHD).\n* Clinically diagnosed with mental disorders (diagnostic and statistical manual of mental disorders: DSM-5-TR), namely but not limited to epilepsy, anxiety, depression or Alzheimer's disease.\n* Individuals with a medical history of cardiac disease, respiratory disorders, kidney disorder, liver disorder, or seizure disorders or other chronic health conditions requiring medication.\n* Individuals with uncontrolled hypertension (systolic blood pressure greater than or equal to 140 mmHg or diastolic blood pressure greater than or equal to 90 mmHg).\n* Individuals with uncontrolled diabetes (fasting blood glucose (FBG) greater than equal to 126 mg\u002Fdl).\n* Individuals with history of hypersensitivity to any components of the investigational product.\n* Those taking prescription medication or dietary supplements that affect cognitive function within 30 days prior to screening.\n* Head injury immediately preceding cognitive deterioration.\n* Consumption of excessive amounts of caffeine (more than 4-5 cups per day) and caffeine-containing foods or beverages.\n* Current smokers.\n* Those who are deemed unable to comply with the test requirements or otherwise deemed unsuitable according to the Investigator's opinion.\n* Females who are pregnant\u002Fplanning to be pregnant\u002Flactating or taking any oral contraceptives.\n* History of drug or alcohol addiction or abuse with the past 12 months.",{"count":23,"type":24},[27],"The goal of this clinical trial is to learn about the effects of AP-Brain collagen peptide on attention, focus, and memory in adults who are stressed but otherwise healthy.\n\nThe main questions it aims to answer are:\n\n* How does AP-Brain affect a participant's attention, focus, stress, and memory?\n* Is there a difference in the effects between a higher dose and a lower dose?\n* What are the side effects, if any, for participants taking AP-Brain?\n\nResearchers will compare two different doses of AP-Brain to see how they affect brain function and stress levels.\n\nParticipants in this study will be asked to:\n\n* Take one of two the doses of AP-Brain once a day for 56 days.\n* Visit the study center for regular checkups.\n* Complete tasks that measure memory, focus, and attention.\n* Answer survey questions about their stress levels.\n* Provide blood samples and have vital signs checked.\n* Have the brain's response to tasks monitored to see how it affects attention and alertness.",[410,30],"Healthy",[412,413,414,415],"Collagen Peptides","Memory","Attention","Focus","2026-07-22",{"date":366,"type":48},{"date":368,"type":24},{"date":420,"type":24},"2026-11",{"name":422,"class":302},"Rousselot BVBA",9,{"id":425,"slug":426,"hasResults":12,"nctId":427,"briefTitle":428,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":431,"enrollmentInfo":432,"targetDuration":4,"studyType":25,"phases":434,"briefSummary":435,"conditions":436,"keywords":438,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":442,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":449},"100597174","an-iso-principle-based-music-intervention-for-reducing-stress-anxiety-and-depression-100597174","NCT07055061","An ISO Principle-Based Music Intervention for Reducing Stress, Anxiety, and Depression","ISO4SAD","Inclusion Criteria:\n\n\\- Minimum of a secondary specialized school degree (vocational college) or higher\n\nExclusion Criteria:\n\n* Self-reported current or recent use of medication or history of surgical treatment\n* Self-reported history of psychiatric disorders\n* Self-reported hearing impairments\n* Female participants who are self-reported currently pregnant or breastfeeding","60 Years",{"count":433,"type":24},2000,[27],"This study aims to evaluate the effectiveness of a music-based intervention, guided by the ISO principle, in reducing stress, anxiety and depression induced by work, family or others among adults. The ISO principle suggests that emotional regulation can be supported by gradually modifying the emotional characteristics of music to help individuals transition to a desired emotional state.\n\nParticipants in this study will be randomly assigned to either a music intervention group or a control group. The intervention group will receive personalized music playlists designed to help reduce stress, anxiety and depression. The control group will not receive any music intervention during the same period.\n\nOutcomes will be measured using self-report questionnaires assessing stress, emotional state, and well-being. The study is designed to contribute to the development of accessible, non-invasive stress management tools using music as a behavioral intervention.",[30,179,437],"Depression in Adults",[439,440,441],"music intervention","emotion regulation","ISO principle",{"date":366,"type":48},{"date":444,"type":48},"2024-04-23",{"date":446,"type":24},"2026-12-31",{"name":448,"class":55},"Shanghai Mental Health Center",2,{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":456,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":25,"phases":460,"briefSummary":461,"conditions":462,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":466,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":471,"locationsCount":56},"100557448","adaptive-coping-skills-training-to-improve-psychological-distress-among-cardiorespiratory-failure-survivors-100557448","NCT06538246","Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors","Self-directed Mobile Adaptive Coping Skills Intervention to Improve Psychological Distress Symptoms Among Cardiorespiratory Failure Survivors: Blueprint 2","Blueprint 2","Inclusion Criteria Inclusion criteria present in the hospital\n\n1. Adult (age ≥18)\n2. Managed in an ICU or stepdown unit for ≥24 hours during the time inclusion criterion #3 is met\n3. Serious acute cardiorespiratory condition, defined as ≥1 of the following:\n\n   * mechanical ventilation via endotracheal tube for ≥4 hours\n   * non-invasive ventilation (CPAP, BiPAP) for ≥4 hours in a 24-hour period provided for acute respiratory failure\n   * new use of supplemental oxygen ≥6 liters per minute (or increase in baseline continuous oxygen)\n   * use of vasopressors for shock of any etiology\n   * use of inotropes for shock of any etiology\n   * use of pulmonary vasodilators\n   * use of aortic balloon pump or cardiac assist device for cardiogenic shock\n   * use of diuretic intravenous drip\n   * evidence of acute coronary ischemia (i.e., elevated troponin level, supporting EKG changes, unstable angina symptoms documented)\n   * urgent cardiac catheterization\n4. Cognitive status intact\n\n   • No history of pre-existing significant cognitive impairment (e.g., dementia) as per medical chart\n5. Absence of severe mental illness\n\n   * Treatment for severe mental illness (e.g., psychosis, bipolar affective disorder, schizoaffective disorder, schizoid personality disorder, schizophrenia \\[as per medical record\\], hospitalization for any psychiatric disorder) within the 6 months preceding the current hospital admission\n   * Evidence of poorly managed severe mental illness\n   * No endorsement of suicidality at time of admission or informed consent\n6. Functional fluency in English or Spanish (i.e., sufficient knowledge of English or Spanish to complete study tasks like watch videos, complete surveys)\n\nInclusion criteria present after hospital discharge (i.e., at the time of arrival home after discharge from the hospital)\n\n1\\. Elevated baseline psychological distress symptoms, defined as a Hospital Anxiety and Distress Scale (HADS) total score ≥8\n\nExclusion Criteria Exclusion criteria present in the hospital\n\n1. Active alcohol or drug abuse (e.g., admission for alcohol withdrawal, drug-related complication, positive toxicology screening at admission, endorsement of active addiction)\n2. Anticipated complex medical needs after discharge that would be disruptive to intervention and follow up; for example:\n\n   * Anticipated surgical procedures\n   * Anticipated complex medical regiment (e.g., new chemotherapy, new dialysis, need for repeat surgery, pregnant and near term)\n   * Plan for comfort care\n3. Other complex needs anticipated that could interfere with the ability to complete study procedures. Examples include:\n\n   * Anticipated disruptive travel\n   * Inability to use mobile app\n   * Anticipated unstable living situation\n4. Anticipated or actual discharge to a location other than independent in a home setting (e.g., nursing home, long-term acute care facility, inpatient rehabilitation facility, home hospice)\n5. Persistently impaired cognition as a result of illness (Impairment defined as ≥3 errors on the Callahan cognitive status screen and\u002For the lack of decisional capacity (i.e., patient could be consented by medical team for a procedure if necessary)\n6. Currently imprisoned or incarcerated or in home detention\n7. Lack a reliable smartphone with cellular data plan or access to the internet\n8. Currently enrolled in another study involving an intervention whose objectives conflict with the objectives of this study\n9. Previously enrolled in the trial\n\nExclusion criteria present after hospital discharge (i.e., at T1 Data Collection conducted at the time of arrival home from the hospital)\n\n1. Failure to randomize within 14 days from planned start date (planned start date is within 3 days post-discharge from the hospital to home to accommodate weekends)\n2. Readmission to hospital before randomization completed",{"count":459,"type":24},400,[27],"Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategies able to overcome barriers of limited access to mental health care. Even less is known about the experiences of patients from racially and ethnically minoritized populations because of they haven't been included well in past research.\n\nTo address this problem, the investigators developed Blueprint, a mobile app that coaches people to use adaptive coping skills to self-manage their symptoms. The investigators found that it reduced depression symptoms and improved quality of life compared to placebo.\n\nTo confirm these promising findings, the investigators are doing a formal test of Blueprint. The investigators will enroll 400 people who received ICU care from 4 hospitals (Duke, UCLA, Colorado, and Oregon). These patients will be randomized to receive either the Blueprint mobile app or a special Education Program mobile app the investigators developed. -both delivered through similar mobile app platforms. Our specific aims are to see which program improves symptoms better across 6 months of follow up.\n\nThis project addresses national research priorities and could advance the field with a personalizable yet population-focused therapy that could be scaled broadly and efficiently to enhance mental health equity.",[180,179,463,30,464,465],"Post-traumatic Stress Disorder","Worries; Pain or Disability","Breath Shortness",{"date":366,"type":48},{"date":468,"type":48},"2024-10-15",{"date":470,"type":24},"2028-04-15",{"name":472,"class":55},"Duke University",{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":477,"acronym":4,"eligibilityCriteria":478,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":479,"targetDuration":4,"studyType":25,"phases":481,"briefSummary":482,"conditions":483,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":485,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":56},"100264771","internet-based-psychological-support-100264771","NCT02726061","Internet Based Psychological Support","Inclusion Criteria:\n\n* Adult employees (age 18 and older) and faculty attending the EAP programs of DHMC and Dartmouth College complaining of depression.\n* Any Adult (age 18 or older)\n\nExclusion Criteria:\n\n* None",{"count":480,"type":24},500,[27],"The investigators have developed interactive, multimedia-intensive, computer-based treatment programs that include depression (Problem-Solving Therapy), stress management, and conflict management. Together the three modules are called PATH.\n\nThe problem-solving module is based on an evidence-based psychotherapy called Problem-Solving Therapy in which depressed patients identify problems in their lives and work through a structured format for solving these problems. We have subjected the problem-solving module to Phase 1-3 feasibility, acceptability and efficacy trials which have been positive and without adverse events.\n\nThe conflict program uses a cognitive-behavioral-therapy-based approach. The program includes a conflict briefing, an interactive conflict simulation, a conflict assessment tool, an interactive training exercise in interest-based negotiation, and a cognitive restructuring exercise.\n\nThe stress program also uses a cognitive behavioral therapy (CBT) approach. In the program, the mentor introduces the \"stress pyramid\", which demonstrates how stress triggers can lead to different feelings, actions and thoughts, which are analogs to the CBT realms of dysfunctional emotions, maladaptive behaviors, and faulty cognitive processes. The stress management content is delivered over 6 sessions, with each session including exercises in the 3 domains of thoughts, feelings, and actions. The program includes briefings, cognitive restructuring exercises, interactive scenarios, and self-assessments. This program has been evaluated with law and business students and was shown effective in reducing stress levels.\n\nThe purpose of the current study is to make the problem-solving, stress, and the conflict modules available through the internet for any adult 18 or older in order to assess their feasibility, acceptability and effectiveness under naturalistic conditions.",[180,30,484],"Conflict Resolution",{"date":366,"type":48},{"date":487,"type":48},"2016-02",{"date":489,"type":24},"2031-02",{"name":491,"class":55},"Dartmouth-Hitchcock Medical Center",{"id":493,"slug":494,"hasResults":12,"nctId":495,"briefTitle":496,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":118,"enrollmentInfo":498,"targetDuration":4,"studyType":25,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":507,"completionDateStruct":508,"leadSponsor":510,"locationsCount":4},"100627199","racism-related-stress-and-objective-short-sleep-as-moderators-of-treatment-effect-in-cognitive-behavioral-therapy-for-insomnia-100627199","NCT07445529","Racism-related Stress and Objective Short-sleep as Moderators of Treatment Effect in Cognitive Behavioral Therapy for Insomnia","Inclusion Criteria:\n\n* Non-Hispanic Black adults\n* aged 18-65 years with\n* Clinically Significant \\[Insomnia Severity Index (ISI) score \\> 1048\\] insomnia symptoms and\n* clinically significant depressive symptoms \\[PHQ-9 total score \\>9\\].\n\nExclusion Criteria:\n\n* Current alcohol or substance use issues,\n* Current active suicidal ideation\n* Current shift-worker or frequent time zone travel\n* Severe psychiatric morbidity within 6 months or lifetime history of bipolar disorder, mania, psychotic disorder\n* delirium or dementia, which would interfere with participation\n* major medical comorbidities\n* history of seizures\n* sleep apnea\n* Lastly, people using antidepressant or psychiatric medications may be included if on a stable dosage for the last 1-month prior to the study and intend to remain on the medication during the study.",{"count":333,"type":24},[27],"The purpose of this study is to understand whether Black participants with insomnia with objective short-sleep (ISSD) experience less symptom improvement in response to Cognitive Behavioral Therapy for Insomnia (CBTi) than Insomnia with Normal Sleep Duration (INSD) and whether this difference is driven by downstream racism-related stress and experiences. The investigators propose an innovative pragmatic open-label design in which Black participants with insomnia undergo a standard 6-week protocol of digital CBTi. The investigators will quantify ISSD using wireless EEG and will gather high-resolution naturalistic data of racism-related stress using random smartphone prompts and Ecological Momentary Assessments (EMA).",[502,30,503,504],"Insomnia","Short Sleep Phenotype","Race","2026-07-21",{"date":416,"type":48},{"date":198,"type":24},{"date":509,"type":24},"2030-01",{"name":230,"class":55},{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":517,"eligibilityCriteria":518,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":519,"targetDuration":4,"studyType":25,"phases":521,"briefSummary":522,"conditions":523,"keywords":528,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":534,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":542},"100623441","operating-room-black-box-supported-debriefings-and-their-effect-on-healthcare-professionals-effectiveness-and-psychological-safety-100623441","NCT07396675","Operating Room Black Box Supported Debriefings and Their Effect on Healthcare Professionals Effectiveness and Psychological Safety.","Improving Postoperative Debriefings: the Added Value of Operating Room Black Box Supported Debriefings and Their Effect on Healthcare Professionals Perceived Effectiveness and Psychological Safety.","ORBLACKBOX","Inclusion Criteria:\n\n* Participants work in an OR-team at RIGS, AUMC or UKE.\n* Participants must have given informed written consent to participate in the study.\n* Participants must be in the OR for the majority of the procedure or\u002Fand have a central role in the teamwork.\n* At RIGS and AUMC participants for the ORBB debriefings must also be part of teams conducting surgeries in the OR where ORBB is installed (not all ORs have ORBB).\n* Participants can either be surgeons, anesthesiologist, anesthesia nurses, residents, OR-nurses, perfusionists, interns, nurse students or other OR-staff.\n\nExclusion Criteria:\n\n* Visitors, guests, and other staff only watching the surgery, are excluded from participation.\n* Individuals who are unable or unwilling to provide written informed consent.",{"count":520,"type":24},135,[27],"This study is enrolled in the European KEEPCARING Project. KEEPCARING aims to (re-)build wellbeing and resilience of healthcare workforce in EU hospitals by co-creating a multi-faceted non-digital, digital, and AI-supported solution package to prevent burnout among (aspirant) healthcare professionals on the individual, team, and organizational level.\n\nThis study specifically investigate the operating room staff wellbeing and resilience. The healthcare system is currently struggling to retain and attract operating room personnel. A factor of importance to consider here is occupational stress. If not recognized or mitigated well, occupational stress and personal efficacy can eventually evolve into a syndrome labelled as 'burnout'. In addition, communication and resilience patterns between operating room staff members are of influence, poor and\u002For inadequate communication among staff may be a factor of stress, compromising their work and wellbeing. In contrast, communication patterns that have a high standard and clarity may support resilience. The ability to speak up and being able to advocate concerns of all team members is of the highest importance here. Indeed, psychological safety and effective teamwork patterns are key for the working environment, performance, patient safety, and job satisfaction. To prevent mistakes during surgery, a safe space where team members can freely speak up is vital.\n\nTo improve psychological safety, and teamwork among OR staff, team debriefing after surgery is known to be effective. What is not known; is whether team debriefing with the additional support derived from audio- and video recordings of the surgery is equally effective as debriefing without.\n\nThe objective of this study is to evaluate the impact of structured postoperative debriefings with and without procedural, structured audio- and video recordings, on team performance, psychological safety, and non-technical skills in the operating room. Specifically, this study aims to compare augmented debriefings with non-augmented debriefings, to assess differences in perceived usefulness, psychological safety, and observed improvements in teams' non-technical skills.\n\nThis is an international quasi-experimental comparative study. The intervention consists of postoperative team debriefing using audio and video recordings ('augmented debriefing') from Operating Room Black Box system provided by Surgical Safety Technologies. The control group will have a postoperative team debriefing that is not augmented with Operating Room Black Box derived data. An identical debriefing template will be designed for both groups.",[30,524,525,526,527],"Resilience","Psychological Safety","Burnout, Healthcare Workers","Teamwork",[529,530,531,532,533],"debriefing","teamwork","psychological safety","operating room","operating room black box",{"date":366,"type":48},{"date":536,"type":48},"2026-03-01",{"date":538,"type":24},"2027-10-01",{"name":540,"class":541},"ORNND - Operating Room Nurse Network Denmark","NETWORK",3,{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":547,"acronym":4,"eligibilityCriteria":548,"healthyVolunteers":18,"sex":19,"minAge":211,"maxAge":212,"enrollmentInfo":549,"targetDuration":4,"studyType":25,"phases":551,"briefSummary":552,"conditions":553,"keywords":556,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":56},"100598283","cannabidiol-cbd-and-stress-response-psychobiological-mechanisms-100598283","NCT07069478","Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms","Inclusion Criteria:\n\n* Adults who are relatively healthy and aged 21-70 years.\n* Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).\n* Must either (1) use CBD daily\u002Fregularly or (2) not use CBD regularly.\n\nExclusion Criteria:\n\n* Participated in previous acute stress studies that included a similar stress induction.\n* Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160\u002F100).\n* Self-reported current pregnancy.\n* Self-reported current use of illicit substances (other than cannabis).\n* Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)\n* Students of the principal researcher",{"count":550,"type":24},125,[27],"The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.",[219,554,30,555],"Cannabidiol","Acute Stress Reaction",[557,558,36,559,560],"cardiovascular reactivity, , , ,","hypothalamic-pituitary-adrenal axis","mood","CBD use",{"date":416,"type":48},{"date":563,"type":48},"2025-06-16",{"date":565,"type":24},"2028-12-31",{"name":567,"class":55},"University of Minnesota",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":25,"phases":577,"briefSummary":578,"conditions":579,"keywords":583,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":56},"100592128","implementation-of-the-ascend-training-for-supervisors-in-dutch-small-and-medium-sized-enterprises-smes-100592128","NCT06989398","Implementation of the ASCEND Training for Supervisors in Dutch Small and Medium-sized Enterprises (SMEs)","Cluster RCT of the WHO's Advancing Supervisor Capabilities for Mental Health at Work (ASCEND) in Dutch Small and Medium-sized Enterprises (SMEs)","Inclusion for SMEs:\n\n* Having 10 to 250 employees\n* Being located in the Netherlands\n\nIn case of insufficient recruitment among SMEs, a mitigation strategy is to recruit public and non-profit organizations with 10 to 250 employees, and units of larger organizations employing between 10 and 250 employees\n\nEligibility criteria for individual participants:\n\nSupervisors are included if they fit the following inclusion criteria:\n\n* 18 years or older\n* Working in an organization in the Netherlands\n* Sufficient mastery (written and spoken) of the language in which the ASCEND intervention is being delivered (i.e., Dutch or English)\n* Written informed consent before entering the study\n* Supervise at least 1 supervisee within the same organization\n\nSupervisees are included if they fit the following inclusion criteria:\n\n* 18 years or older\n* Have a direct supervisor who is participating in ASCEND (either intervention or control group)\n* Sufficient mastery of English or Dutch\n* Written informed consent before entering the study",{"count":576,"type":24},148,[27],"This cluster randomized controlled trial (cRCT) aims to evaluate the effectiveness of the Dutch adaptation of an in-person group intervention for workplace supervisors - Advancing Supervisors' Capacity for Mental Health at Work (ASCEND) - in Dutch Small and Medium-sized Enterprises (SMEs). The ASCEND intervention is designed to equip supervisors with the skills to: i) know when to support their workers; ii) how to direct workers to support, and iii) advocate for action on mental health at work.\n\nThe primary objectives of this project are to:\n\n* Assess to what extent the Dutch adaptation of the WHO-developed ASCEND intervention is effective in enhancing supervisors' confidence, responsiveness, mental health literacy, and self-care practices, and in reducing supervisor stigma towards mental health conditions within Dutch SMEs.\n* Evaluate the impact of the ASCEND intervention on employee outcomes, including mental health and work-related outcomes among supervisees (i.e., subordinates), as well as overall organizational absenteeism rates.\n* Identify barriers, facilitators, and key implementation and adoption indicators to support future opportunities for scaling up the ASCEND intervention.\n\nResearchers will compare two groups to evaluate the effectiveness of the ASCEND intervention. One group will receive the training (the intervention group), while the other group will receive the training after the final follow-up period (the control group).\n\nData will be collected from both supervisors and their supervisees (i.e., subordinates) via online questionnaires at various time points. In addition, general organizational information, including absenteeism rates, will be gathered through a representative from each participating organization.\n\nTo further explore the feasibility of scaling up the ASCEND intervention within the Netherlands, qualitative data will be collected through interviews and\u002For focus group discussions.",[155,30,580,581,582],"Burnout","Mental Health Conditions","Sickness Absence",[584,585,586,587,588,589,590,591,592,593,594,595],"Workplace mental health","Occupational stress","Sickness absence","Supervisors","Line managers","Absenteeism","Presenteeism","Employee well-being","Workplace intervention","Manager training","ASCEND","Advancing Supervisors' Capacity for Mental Health at Work","2026-07-17",{"date":505,"type":48},{"date":599,"type":48},"2025-05-14",{"date":601,"type":24},"2027-02",{"name":603,"class":55},"VU University of Amsterdam",{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":4,"eligibilityCriteria":610,"healthyVolunteers":12,"sex":19,"minAge":611,"maxAge":612,"enrollmentInfo":613,"targetDuration":4,"studyType":25,"phases":614,"briefSummary":615,"conditions":616,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":620,"startDateStruct":621,"completionDateStruct":623,"leadSponsor":625,"locationsCount":56},"100648084","ecological-momentary-intervention-e-breathing-to-reduce-psychological-distress-in-adolescents-100648084","NCT07717112","Ecological Momentary Intervention (E-Breathing) to Reduce Psychological Distress in Adolescents","Effect of Slow-Paced Breathing Via Ecological Momentary Intervention on Reducing Psychological Distress in Adolescents: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged between 11 to17 years;\n2. With at least one mild mental health state as reported by Depression, Anxiety, and Stress Scale-21;\n3. Able to read and understand Chinese;\n4. Have access to a mobile phone and data plan.\n\nExclusion Criteria:\n\n1. With a diagnosis of hearing, visual, or physical impairments that may hinder study participation;\n2. With a diagnosed history of major mental illnesses or other diagnosed medical conditions that may affect study participation.","11 Years","17 Years",{"count":333,"type":24},[27],"A two-arm randomized controlled trial (RCT) will be conducted to test a mobile-based intervention, E-breathing, for early detection and intervention to address psychological distress in at-risk adolescents in Hong Kong. E-breathing harnesses the science of real-time, in-situ assessment approach - Ecological Momentary Assessment (EMA) - to capture the psychological symptoms and needs of adolescents. Based on the real-time data collected via smartphone, the mobile application prompts the practice of slow-paced breathing as an Ecological Momentary Intervention (EMI) to reduce psychological distress. This RCT will recruit a total of 100 participants who will be randomly allocated to either (1) an intervention group (EMI group), where they will receive a feedback prompt when they score high on negative affect (i.e., E-breathing) or (2) the control group (EMA group), where they will only complete EMAs without feedback. This project aims to investigate the feasibility and effectiveness of E-breathing in improving psychological symptoms in Hong Kong adolescents. This project also examine the underlying physio-mechanisms of the effects of E-breathing on psychological outcomes in this target population.",[617,618,179,30],"Psychological Distress","Depressed Mood","2026-07-16",{"date":505,"type":48},{"date":622,"type":24},"2026-10-01",{"date":624,"type":24},"2027-05-31",{"name":626,"class":55},"The Hong Kong Polytechnic University",{"id":628,"slug":629,"hasResults":12,"nctId":630,"briefTitle":631,"officialTitle":631,"acronym":632,"eligibilityCriteria":633,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":634,"targetDuration":4,"studyType":242,"phases":4,"briefSummary":635,"conditions":636,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":638,"lastUpdatePostDateStruct":639,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":643,"locationsCount":542},"100641700","preoperative-stress-assessment-in-patients-undergoing-surgery-for-rotator-cuff-tendinopathy-100641700","NCT07658326","Preoperative Stress Assessment in Patients Undergoing Surgery for Rotator Cuff Tendinopathy","Tendistress","Inclusion Criteria:\n\n* Patient, male or female, over 18 years of age\n* First-line surgery for rotator cuff tendinopathy (torn and untorn)\n* Subject affiliated with or covered by a social security scheme\n* Collection of the patient's non-opposition to participate in the study\n\nExclusion Criteria:\n\n* Patients with medical history of adhesive capsulitis or complex regional pain syndrome (CRPS)\n* Patients with a history of diabetes or thyroid dysfunction\n* Patients with a history of fibromyalgia\n* Patients with a history of mental illness (PMD, schizophrenia)\n* Patients taking antidepressants or similar medications\n* Patients participating in another clinical trial\n* Protected patients: adults under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision;\n* Pregnant, breastfeeding, or parturient women;\n* Patients hospitalized without their consent.",{"count":333,"type":24},"Orthopedic surgery of the limbs presents a unpredictable postoperative course, which can be more or less lengthy in terms of functional recovery and resumption of personal or professional activities. Not uncommon, convalescence can require many months with dramatic personal and\u002For socio-professional consequences (disability, unemployment, etc.), particularly in the postoperative development of complex regional pain syndrome (CRPS) and\u002For adhesive capsulitis.\n\nAmong the suspected contributing factors, the existence of an unfavorable preoperative psychological context in patients is often mentioned.\n\nThis research is based on the hypothesis that a high level of preoperative stress in patients could contribute to the occurrence of more significant postoperative complications in patients who have undergone shoulder surgery.\n\nThe main objective is to measure the level of preoperative stress in patients undergoing surgery for rotator cuff tendinopathy.",[30,637],"Tendinopathy Rotator Cuff","2026-07-15",{"date":619,"type":48},{"date":641,"type":48},"2023-09-28",{"date":50,"type":24},{"name":644,"class":55},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":646,"slug":647,"hasResults":12,"nctId":648,"briefTitle":649,"officialTitle":650,"acronym":4,"eligibilityCriteria":651,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":652,"enrollmentInfo":653,"targetDuration":4,"studyType":25,"phases":655,"briefSummary":656,"conditions":657,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":638,"lastUpdatePostDateStruct":660,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":56},"100632584","a-mindfulness-based-intervention-for-sexual-assault-survivors-100632584","NCT07515586","A Mindfulness-based Intervention for Sexual Assault Survivors","Leveraging Implementation Science to Develop a Mindfulness-Based Intervention to Reduce Alcohol Misuse and Tobacco Use Among Sexual Violence Survivors","Inclusion Criteria:\n\n* 18-24 years of age\n* currently enrolled as a full-time undergraduate at GSU\n* self-reported lifetime SV victimization\n* self-reported SV victimization in the past 6 months\n* drank alcohol within the last 30 days\n* must own a smartphone\n\nExclusion Criteria:\n\n* not applicable","24 Years",{"count":654,"type":24},120,[27],"The goal is this pilot randomized trial is to learn if intervention 1 is feasible and acceptable. A secondary aim is to learn if intervention 1 reduces alcohol misuse and tobacco use in sexual assault survivors. The main questions it aims to answer are:\n\n* Is intervention 1 feasible to implement?\n* Is intervention 1 an acceptable intervention among the primary population, sexual assault survivors?\n* Does intervention 1 reduce alcohol misuse and tobacco use?\n\nResearchers will compare intervention 1 to an attention-placebo control group (e.g., online resources on healthy eating and nutrition).\n\nParticipants will:\n\n* take online surveys at baseline, 1 month follow-up, and 3-month follow-up\n* answer text-message questions at baseline and post-test\n* view and engage in an educational program",[658,659,78,30],"Alcohol Misuse","Tobacco Use",{"date":619,"type":48},{"date":662,"type":24},"2027-10-04",{"date":664,"type":24},"2029-03-30",{"name":666,"class":55},"Georgia State University"]