[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"subjective-cognitive-complaints\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:subjective-cognitive-complaints":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100650035","cogot-telerehabilitation-for-adults-with-subjective-cognitive-complaints-100650035",false,"NCT07743229","COG+OT Telerehabilitation for Adults With Subjective Cognitive Complaints","A Comprehensive Cognitive Assessment Protocol and Innovative Neurocognitive Telerehabilitation Pilot Program for Adults With Subjective Cognitive Complaints","CogSCC","Inclusion Criteria:\n\n* Endorsement of subjective cognitive complaints as indicated by a score ≥4 on the Healthy Brain 9 (HB9)\n* Community-dwelling adult aged 60 years or older, or adult aged 21 years or older with a diagnosis of Ehlers-Danlos Syndrome (EDS)\n* English as the primary language\n* Access to and ability to use a smartphone compatible with the NeuroUX platform\n* Access to a device capable of supporting a telerehabilitation visit, such as a phone, tablet, or laptop, and a reliable Wi-Fi or cellular internet connection\n* Able to participate in study assessment sessions as determined by the licensed, experienced telerehabilitation occupational therapist\n\nExclusion Criteria:\n\n* Diagnosis of dementia or mild cognitive impairment\n* Significant or unstable conditions or treatments for medical conditions that may impact cognition, such as traumatic brain injury or brain tumor\n* Inability to engage in study-related procedures as determined by the study team","MALE","21 Years",{"count":20,"type":21},16,"ESTIMATED","INTERVENTIONAL",[24],"NA","This pilot study will evaluate a comprehensive cognitive assessment approach and personalized neurocognitive telerehabilitation intervention for adults with subjective cognitive complaints (SCC). The study includes older adults with SCC and adults with Ehlers-Danlos Syndrome (EDS) and SCC. Participants will complete pre- and post-treatment assessments and receive a 6-week COG+OT telerehabilitation intervention that combines cognitive rehabilitation and occupational therapy strategies to support everyday functional cognition.",[27,28,29],"Subjective Cognitive Complaints","Ehlers-Danlos Syndrome","Cognitive Dysfunction",[31,32,33,34,35,28],"Subjective cognitive complaints","Brain fog","Functional cognition","Occupational therapy","Cognitive rehabilitation","NOT_YET_RECRUITING","2026-07-29",{"date":39,"type":40},"2026-08-03","ACTUAL",{"date":42,"type":21},"2026-09-01",{"date":44,"type":21},"2027-05-01",{"name":46,"class":47},"Medical University of South Carolina","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100613867","exercise-in-perimenopause-to-improve-cognitive-health-100613867","NCT07272174","Exercise in Perimenopause to Improve Cognitive Health","Resistance Training and Cognitive Health in Perimenopause","EPIC","Inclusion Criteria:\n\n* Are biological females, as assigned at birth\n* Are aged between 40 and 55 years\n* Had at least 1 menstrual period in the last 10 months\n* Are perimenopausal based on STRAW +10 Staging System, or answer \"yes\" to MQ6 questions of changes in periods, having hot flashes, or vaginal dryness, pain, or sexual concerns\n* Have an intact uterus\n* Have a Montreal Cognitive Assessment (MoCA) score \\>26\u002F30, indicating normal cognition\n* Have subjective cognitive complaints defined as responding \"yes\" to \"Do you feel like your memory or thinking is becoming worse?\"\n* Completed high school education\n* Read and speak English with acceptable visual and auditory acuity\n* Are able to safely engage in moderate-intensity PRT as indicated by the PAR-Q+; and\n* Are able to provide informed consent.\n\nExclusion Criteria:\n\n* Are engaged in regular PRT (i.e., 2x\u002Fweek) in the prior three months\n* Are diagnosed with cognitive impairment or dementia of any type\n* Are at high risk for cardiac complications during exercise\n* Have clinically important peripheral neuropathy or severe musculoskeletal or joint disease that impairs mobility\n* Are taking medications that negatively affect cognitive function, such as anticholinergics, major tranquilizers, and anticonvulsants\n* Have a BMI \\\u003C15 or anorexia nervosa; g) had surgical menopause\n* Had endometrial ablation that resulted in the loss of menstruation\n* Have polycystic ovarian syndrome\n* Currently undergoing chemo\n* Are using estrogen-containing contraception in the last 12 months\n* Had premature ovarian failure; or\n* Are already enrolled in a drug or exercise trial",true,"FEMALE","40 Years","55 Years",{"count":61,"type":21},50,[24],"Perimenopause is now considered a possible risk factor for dementia and may contribute to the fact that 2\u002F3 of those living with Alzheimer's disease are females. Indeed, research studies show that middle-aged females demonstrate significant declines in their thinking abilities and detrimental changes in their brains as they go through perimenopause. Thus, perimenopausal females need strategies to bolster their brain health.\n\nThe World Health Organization strongly recommends physical activity interventions to reduce the risk of decline in thinking abilities. However, whether exercise can improve thinking abilities and brain health in perimenopausal females has not been examined. Our research aims to address this important knowledge gap in female brain health.\n\nWe will study the effects of a 6-month resistance exercise training (e.g., lifting free weights, exercise with weight machine) program on thinking abilities in 50 physically inactive perimenopausal females, aged 40 to 55 years, who are experiencing difficulties with their thinking abilities. In addition to measuring thinking abilities, we will determine if exercise benefits muscle health, heart health, sleep quality, psychological well-being, menopausal symptoms, and quality of life. We will also explore how resistance exercise training improves thinking abilities as such information can lead to new discoveries and therapies for brain health in females.",[65,27],"Perimenopause",[67],"progressive resistance training, perimenopause","RECRUITING","2026-04-13",{"date":71,"type":40},"2026-04-16",{"date":73,"type":40},"2026-03-30",{"date":75,"type":21},"2027-01-30",{"name":77,"class":47},"University of British Columbia",1]