[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sufentanil\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sufentanil":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100651086","oliceridine-versus-sufentanil-analgesia-for-postoperative-patients-with-obstructive-sleep-apnea-100651086",false,"NCT07753785","Oliceridine Versus Sufentanil Analgesia for Postoperative Patients With Obstructive Sleep Apnea","Effects of Oliceridine Versus Sufentanil Analgesia on Incidence of Postoperative Respiratory Depression in Patients at High-Risk of Obstructive Sleep Apnea: A Prospective Cohort Study","OSA","Inclusion Criteria:\n\n* Aged 18 to 90 years.\n* Diagnosed with obstructive sleep apnea according to polysomnography, or suspected to be at high risk of moderate-to-severe OSA according to the STOP-Bang questionnaire: (1) STOP-Bang score ≥ 5; (2) STOP-Bang score ≥ 3 with serum bicarbonate \\[HCO₃-\\] ≥ 28 mmol\u002FL; (3) STOP score ≥ 2 and male sex; (4) STOP score ≥ 2 and body mass index (BMI) \\> 35 kg\u002Fm²; or (5) STOP score ≥ 2 and neck circumference \\> 40 cm.\n* Scheduled to undergo elective non-cardiac surgery under general anesthesia.\n* Required patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n* Pregnant or lactating women.\n* Scheduled to undergo pulmonary\u002Fthoracic surgery in the current admission;\n* Planning to receive use of epidural analgesia.\n* Preplanned postoperative admission to the intensive care unit (ICU) or requirement for mechanical ventilation.","ALL","18 Years","90 Years",{"count":21,"type":22},851,"ESTIMATED","OBSERVATIONAL","Opioids are frequently used for postoperative analgesia but may induce side effects. Opioid-induced respiratory depression is the most dangerous side effect of opioids. Patients with obstructive sleep apnea (OSA) are at higher risk for opioid-induced respiratory depression. Oliceridine is a novel biased μ-opioid receptor agonist that selectively engages the G-protein pathway while reducing β-arrestin recruitment and thus may lower the risk of respiratory depression. The goal of this observational study is to compare the effects of oliceridine versus sufentanil analgesia on the incidence of postoperative respiratory depression in patients with known or suspected OSA in the postoperative period following elective surgery.",[26,27,28,29,30],"Obstructive Sleep Apnea","Postoperative Analgesia","Oliceridine","Sufentanil","Respiratory Depression",[32,33,28,29,34],"Obstructive sleep apnea","Postoperative analgesia","Respiratory depression","NOT_YET_RECRUITING","2026-08-07",{"date":38,"type":39},"2026-08-11","ACTUAL",{"date":41,"type":22},"2026-09",{"date":43,"type":22},"2029-12",{"name":45,"class":46},"Peking University First Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100592243","comparison-of-the-analgesic-effect-of-oliceridine-versus-morphine-or-sufentanil-for-postoperative-analgesia-in-lumbar-surgeries-a-randomized-control-trial-100592243","NCT06990893","Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial","Inclusion Criteria:\n\n* Lumbar spine surgery with ASA grades I-III\n* Aged 18-65 years\n* Ethically, the patient voluntarily accepted this trial and signed the informed consent form\n\nExclusion Criteria:\n\n* Severe respiratory and circulatory system diseases\n* Nervous system disease\n* Mental and psychological disorders\n* Abnormal liver and kidney functions\n* Participated in another drug clinical research within the past 30 days","65 Years",{"count":56,"type":22},90,"INTERVENTIONAL",[59],"NA","Objective: This study aimed to compare the efficacy and safety of oliceridine versus morphine and sufentanil for postoperative analgesia following elective lumbar spine surgery.\n\nMethods: In this randomized, controlled trial, 90 patients scheduled for lumbar spine surgery were allocated in a 1:1:1 ratio to receive postoperative intravenous patient-controlled analgesia (PCIA) with either oliceridine (Group O，1.5mg oliceridine for loading dose， 0.5mg\u002Fkg oliceridine for PICA), morphine (Group M，4mg morphine for loading dose，1.5mg\u002Fkg morphine for PICA), or sufentanil (Group S，4ug sufentanil for loading dose，1.5ug\u002Fkg sufentanil for PICA). The primary outcome was the movement Visual Analogue Scale (VAS) score at 6 hours postoperatively. Secondary outcomes included resting and movement VAS scores, ramsay sation score at 0.5, 2, 6, 12, 24, and 48 hours postoperatively (excluding the motor VAS score at 6 hours postoperatively); number of PCIA demands and rescue analgesic requirements within 48 hours; hemodynamic parameters at 5, 10, 15, 30, and 60 minutes after administration of the initial loading dose. The incidence of adverse events within 48 hours postoperatively, such as nausea and vomiting, somnolence, respiratory depression, or pruritus.",[29,62,63,64,28],"Morphine","Validity","Safety",[29,64,62,66],"oliceridine","RECRUITING","2026-05-28",{"date":70,"type":39},"2026-06-01",{"date":72,"type":39},"2025-06-01",{"date":74,"type":22},"2026-10-01",{"name":76,"class":46},"Anqing Municipal Hospital"]