[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"suicidal-ideation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:suicidal-ideation":31},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,105,0,25,[9,50,77,105,143,175,208,236,263,291,326,349,378,398,425,446,479,509,529,550,569,589,620,647,678],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100647938","empowerment-self-defense-program-for-adult-native-women-survivors-of-sexual-violence-100647938",false,"NCT07712796","Empowerment Self Defense Program for Adult Native Women Survivors of Sexual Violence","Development and Evaluation of a Culturally Grounded Empowerment Self Defense Program for Adult Native Women Survivors of Sexual Violence: Open Pilot Trial","ESD","Inclusion Criteria:\n\n* Identify as Indigenous (including American Indian or Alaska Native), including individuals who identify as multiracial and Indigenous.\n* Identify as a woman, trans woman, and\u002For Two Spirit..\n* Be 18 years of age or older.\n* Have experienced sexual violence or unwanted sexual experiences.\n* Report moderate to high levels of Meet criteria for depression and\u002For PTSD.\n* NOT report high risk for suicidality\n* NOT report active psychosis\n* Live on or near the Pine Ridge Indian Reservation.\n* Be able to read and speak English.\n* Report an ability and willingness to participate in the program sessions and related research activities, including surveys and potential exit interviews.","FEMALE","18 Years",{"count":21,"type":22},14,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to culturally adapt and evaluate an empowerment self-defense (ESD) program (i.e., IMpower) for AI\u002FAN women who have experienced SV in their lifetime and currently experiencing moderate to severe levels of depression and\u002For PTSD symptoms (primary outcomes). Previous research with non-AI\u002FAN women finds that ESD reduces depression and PTSD symptoms, but no research has examined ESD among AI\u002FAN survivors despite calls from our tribal partners to implement ESD with AI\u002FAN adult women survivors. The investigators have assembled an interdisciplinary expert team and Elders\u002FTraditional Knowledge Keepers (TKKs) as well as Survivor Advisory Board (SAB) in the proposed work.",[28,29,30,31,32],"Depression and Quality of Life","Sexual Violence","PTSD","Suicidal Ideation","Problem Drinking",[34,35,36],"Native American","Sexual violence","Depression","NOT_YET_RECRUITING","2026-08-19",{"date":40,"type":41},"2026-08-21","ACTUAL",{"date":43,"type":22},"2026-09-30",{"date":45,"type":22},"2028-06-14",{"name":47,"class":48},"University of Michigan","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":49},"100502712","pilot-study-of-health-systemcommunity-partnership-for-enhanced-outreach-to-prevent-suicide-attempts-100502712","NCT05825820","Pilot Study of Health System\u002FCommunity Partnership for Enhanced Outreach to Prevent Suicide Attempts","Pilot Study Health System\u002FCommunity Partnership for Enhanced Outreach to Prevent Suicide Attempts","Inclusion Criteria:\n\n1. Currently a patient being treated and evaluated by psychiatry service in an MGB ED\n2. Participants enrolled in another study (NCT05671133; PI Nock) conducted by the research team who fall into the top 50% of risk based on the suicide risk prediction algorithm used in that study\n3. Able to read English\n4. Ownership of a smartphone (iOS or Android) and consistent access to their smartphone following discharge from the current treatment unit or program; ability to be reliably contacted\n5. Willing to provide contact information for collateral contact\n6. Willing to share contact information and key clinical information with Samaritans of Boston\n7. Consent to unencrypted text or email communications\n8. Willing to provide social security number (SSN) or individual taxpayer identification number (ITIN) for study compensation\n\nExclusion Criteria:\n\n1. Any factor that impairs an individual's ability to comprehend and effectively participate in informed consent, including the presence of gross cognitive impairment due to florid psychosis, intellectual disability, dementia, or acute intoxication\n2. Presence of extremely agitated or violent behavior at the time of consent or enrollment","ALL",{"count":59,"type":22},20,[25],"The goal of this clinical trial is to test an enhanced outreach intervention (EOI) delivered by Samaritans of Boston (a community organization that provides support during mental health crises) for people after they leave an emergency department (ED) visit for suicidal thoughts. The main questions the trial aims to answer are:\n\n* Is the EOI feasible and acceptable?\n* Can the EOI be delivered with fidelity by Samaritans staff?\n\nParticipants will:\n\n* Receive outreach (by call or text) once per week for 12 weeks after ED visit. During these conversations, Samaritans staff will ask participants questions about their suicidal thoughts and behaviors, develop and review a list of coping skills to use if they have suicidal thoughts, and discuss plans for receiving mental health care.\n* Receive caring messages from Samaritans staff at least once per week.\n* Be asked to complete monthly self-report questionnaires, and participate in a phone interview with study staff at the end of the study.",[63,64,31],"Suicide","Suicide, Attempted",[63,66],"Suicidal Thoughts","RECRUITING","2026-08-14",{"date":70,"type":41},"2026-08-17",{"date":72,"type":41},"2026-07-31",{"date":74,"type":22},"2027-02",{"name":76,"class":48},"Massachusetts General Hospital",{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":49},"100652043","effectiveness-of-the-mindbridge-mobile-health-module-for-young-adults-at-risk-of-suicide-100652043","NCT07767604","Effectiveness of the MindBridge Mobile Health Module for Young Adults at Risk of Suicide","Development and Effectiveness of the MindBridge Mobile Health Module for Chinese Young Adults at Risk of Suicide: A Sequential Mixed Methods Study","MindBridge","Inclusion Criteria:\n\nAged 18-24 years. Mild-to-moderate suicide risk, defined as a Suicide and Self-Injury Behavior Inventory (SSBI) past-year or recent suicide-related or self-harm composite score of 17-51.\n\nAble to understand the study procedures and complete questionnaires independently.\n\nOwn a smartphone and are able to use WeChat and the relevant study application. Able and willing to provide voluntary informed consent. Have not participated in earlier phases of this research.\n\nExclusion Criteria:\n\nCurrent acute suicide crisis requiring immediate clinical intervention, operationally defined as a Columbia-Suicide Severity Rating Scale (C-SSRS) ideation level of 4-5 and\u002For recent suicidal behavior (any actual, aborted, or interrupted attempt or preparatory act within the past month), assessed at screening\u002Fbaseline.\n\nSerious physical illness or other condition that, in the judgment of the research or clinical safety team, makes participation inappropriate.\n\nCurrently receiving intensive psychiatric crisis intervention that would make trial participation unsafe.\n\nExpected to be unable to complete the 8-week intervention or 1-month follow-up.","24 Years",{"count":87,"type":22},84,[25],"This study will evaluate the effectiveness of MindBridge, a dialectical behavior therapy (DBT)-informed mobile health module delivered through a WeChat mini-program, among Chinese young adults aged 18 to 24 years with mild-to-moderate suicide risk. In the randomized controlled trial, 84 participants will be randomized 1:1 to receive MindBridge plus treatment as usual or an attention-matched general well-being program plus treatment as usual for 8 weeks. Assessments will be conducted at baseline, week 4, week 8, and 1-month follow-up. The primary outcome is suicide-related thoughts and behaviors. Secondary outcomes include depression, anxiety, emotion regulation, sleep quality, perceived social support, academic self-efficacy, and problematic internet use. This randomized controlled trial is the effectiveness-evaluation component of a broader sequential mixed methods study involving the development and evaluation of MindBridge.",[31],[92,93,94,95,96],"Suicide Prevention","Mobile Health","Dialectical Behavior Therapy","Digital Mental Health","Young Adults","2026-08-12",{"date":70,"type":41},{"date":100,"type":22},"2027-03",{"date":102,"type":22},"2027-11",{"name":104,"class":48},"Jiangsu Medical College",{"id":106,"slug":107,"hasResults":12,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":57,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":142},"100651117","developing-a-recovery-oriented-suicide-prevention-program-for-young-people-at-clinical-high-risk-for-psychosis-100651117","NCT07756567","Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis","Development of a Recovery-Oriented Suicide Prevention Intervention With Peers for Clinical High Risk for Psychosis","Young Person Inclusion Criteria:\n\n* symptoms of clinical high risk for psychosis in the last two years\n* lifetime active suicide ideation and\u002For lifetime suicide behavior\n* has a caregiver willing to participate\n\nYoung Person Exclusion Criterion:\n\n* not able to read and write in English\n\nCaregiver Inclusion Criteria:\n\n* has a familial relationship with the young person participant\n* has at least 4 hours of face-to-face contact with the patient participant every week, even if they do not live together\n\nCaregiver Exclusion Criteria: None\n\n\\*\\*\\*\n\nAdministrator\u002FClinician Inclusion Criteria:\n\n* employed at the University of California, San Diego or University of California, Los Angeles early psychosis program\n\nAdministrator\u002FClinician Exclusion Criteria: None","12 Years","30 Years",{"count":115,"type":22},108,[25],"Young people at clinical high risk for psychosis are more likely to experience suicide thoughts than the general population, but there are few suicide prevention programs designed specifically for them. This study will develop and evaluate a recovery-oriented suicide prevention group program for young people at clinical high risk for psychosis.\n\nThe program will be led by a clinician and a peer with lived experience. It will help participants identify reasons for living, build hope, set meaningful recovery goals, strengthen social connections, and learn strategies to better remember and use suicide prevention strategies developed during the program. Caregivers will also be invited to participate in a session to learn ways to support their young person.\n\nThe study will first gather feedback from participants, caregivers, clinicians, and community advisors to refine the program. Researchers will then compare the program plus standard care with standard care alone to determine whether it improves personal recovery and increases participants' ability to remember and use suicide prevention strategies. Researchers will also collect feedback from participants and program staff to better understand how the program can be integrated into early psychosis services.",[119,31,120,121],"Clinical High Risk for Psychosis (CHR)","Psychosis","Suicidal Behavior",[123,124,125,126,127,128,129,130,131,132,133],"clinical high risk for psychosis","psychosis","early intervention","peer support","suicidal ideation","suicide","suicidal behavior","recovery","group intervention","implementation science","Hybrid Effectiveness-Implementation Trial","2026-08-10",{"date":97,"type":41},{"date":137,"type":22},"2026-08",{"date":139,"type":22},"2028-12",{"name":141,"class":48},"University of California, San Diego",2,{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":157,"conditions":158,"keywords":162,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":49},"100556739","phase-2-low-amplitude-pulse-seizure-therapy-versus-standard-ultra-brief-right-unilateral-electroconvulsive-therapy-100556739","NCT06529029","Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy","Efficacy of Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy in Remission of Suicidal Ideation","LAP-ST vs ECT","Inclusion Criteria:\n\n1. Patients in whom ECT is clinically indicated: The referrals to ECT by the primary psychiatrist (before a consult by the ECT consultant) will serve to both increase the feasibility of the study and address any ethical concerns that the patient would not undergo ECT without having a valid full indication for the procedure as well as increase the external validity and generalizability of the study.\n2. Male or female patients 18 to 90 years of age\n3. Current DSM-5 criteria for MDE with any SI of major depressive, bipolar, or schizoaffective disorders\n4. Montgomery-Asberg depression rating scale (MADRS) with 2 or more on SI item\n5. Use of effective method of birth control for women of child-bearing capacity\n6. Patient is medically stable\n7. No anticipated need to alter psychotropic medications for the duration of the study (except for urgent\u002Femergent situations)\n8. Ability of patient to fully participate in the informed consent process\n\nExclusion Criteria:\n\n1. Unstable or serious medical condition that substantially increases risks of ECT or cognitive impairment\n2. Female patients who are pregnant or plan to be pregnant during the study or are breast-feeding\n3. History of neurological disorder if deemed by the treating ECT physician or PI to pose a significant risk with ECT, or if there is any metal in the head or history of known structural brain lesion or skull defect that is deemed to affect cognition or safe ECT treatment\n4. Implanted devices that make ECT unsafe\n5. Clinical presentation of delirium or dementia\n6. Active substance use disorders within 1 week of randomization\n7. ECT in the past 1 month or prior failure to respond to an adequate course of ECT as deemed by the ECT physician treating the patient or the PI","90 Years",{"count":153,"type":22},30,[155,156],"PHASE2","PHASE3","This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse - Seizure Therapy (RUL LAP-ST) treatment has more magnitude and rate of remission of SI as conventional pulse amplitude Right Unilateral Electroconvulsive Therapy (RUL ECT) (based on our prior secondary analysis). Our central hypothesis is that RUL LAP-ST has significantly less cognitive\u002Fmemory side effects (no memory side effects were noted in our prior studies for 500mA and 600mA) and thus is more favorable in terms of side effects compared to RUL conventional pulse amplitude ECT, while maintaining better anti-suicidal effect.",[31,159,160,161],"Major Depressive Disorder","Schizo Affective Disorder","Bipolar Disorder",[31,63,36,159,160,161,163,164,165,166],"Low Amplitude Seizure Therapy","Electroconvulsive Therapy","Neuromodulation","Brain Stimulation","2026-08-09",{"date":97,"type":41},{"date":170,"type":41},"2024-07-03",{"date":172,"type":22},"2026-12-01",{"name":174,"class":48},"Michigan State University",{"id":176,"slug":177,"hasResults":12,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":183,"sex":184,"minAge":19,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":23,"phases":187,"briefSummary":188,"conditions":189,"keywords":194,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":49},"100651615","gwan-enjoy-life-a-peer-supported-mental-health-mentoring-intervention-to-improve-engagement-in-care-among-sexual-minority-men-living-with-hiv-in-jamaica-100651615","NCT07762612","\"Gwan Enjoy Life:\" A Peer-Supported Mental Health Mentoring Intervention to Improve Engagement in Care Among Sexual Minority Men Living With HIV in Jamaica","\"Gwan Enjoy Life:\" Protocol for a Randomized Controlled Trial to Test a Peer-Supported Mental Health Intervention to Improve Engagement in Care for High-Priority Sexual Minority Men Living With HIV","GwanEnjoyLife","Inclusion Criteria:\n\n* Self-identified as a cisgender man who have sex with men\n* Age 18 and older,\n* Living in one of the 14 parishes\n* Able to offer informed consent\n* Living with HIV (currently engaged, marginally engaged, and not engaged in care)\n* Provide consent to clinic staff to review medical records.\n\nExclusion Criteria:\n\n* Self-reported participation in another HIV care engagement study\n* Unable to understand the consent process\n* Planning on relocating out of Jamaica over the next 12 months.",true,"MALE",{"count":186,"type":22},60,[25],"Sexual minority men (SMM) in Jamaica face many challenges that affect their health and well-being. Although they make up a relatively small part of the population, they are much more likely to be living with HIV than the general public. Many also experience discrimination because of their sexual orientation, HIV-related stigma, violence, poverty, unstable housing, limited educational opportunities, and barriers created by laws and social attitudes. These experiences can have a serious impact on mental health, leading to problems such as depression, anxiety, trauma, and thoughts of suicide. Many people also face barriers to getting mental health care because of stigma or a lack of services that are welcoming and appropriate for their needs. These challenges can make it difficult for people living with HIV to stay connected to medical care and take their HIV medications consistently. Missing appointments or stopping treatment can make it harder to keep the virus under control and can lead to poorer health over time. While researchers know that stigma, discrimination, and violence affect health, we still do not fully understand how these experiences work together to influence HIV care among sexual minority men in Jamaica.\n\nTo help address these challenges, we developed the Gwan Enjoy Life program, a culturally relevant program designed specifically for sexual minority men living with HIV in Jamaica. The program combines practical coping skills, emotional support, and strategies for managing the effects of trauma and stress. It is led by trained peer mentors who are also living with HIV, allowing participants to learn from people who understand their experiences. The six-session program gives participants the option of meeting one-on-one with a peer mentor or participating in a small group, depending on what they find most comfortable. The program will be tested in partnership with Jamaica AIDS Support for Life (JASL), one of Jamaica's leading HIV service organizations. Sixty participants from JASL clinics in Kingston and St. Andrew, St. James, and St. Ann will take part in the intervention. Participants will be randomly assigned to either receive the Gwan Enjoy Life program or continue with their usual care, and they will be followed for one year. Researchers will examine whether the program improves mental health, strengthens social support, helps participants stay engaged in HIV care, and improves medication adherence.\n\nThe goal of the intervention is to determine whether the Gwan Enjoy Life intervention is a practical and effective program that can be expanded to reach more people across Jamaica. The findings will help researchers, healthcare providers, and policymakers better understand how stigma, violence, and mental health affect HIV care and will support the development of programs that improve the health and well-being of sexual minority men living with HIV.",[190,191,192,31,193],"Mental Health","HIV","Pyschological Distress","Engagement in HIV Care",[190,191,195,196,197,198],"Engagement in Care","Jamaica","Sexual Minority Men","Psychological Distress","2026-08-07",{"date":201,"type":41},"2026-08-13",{"date":203,"type":22},"2026-08-25",{"date":205,"type":22},"2027-08-30",{"name":207,"class":48},"University of California, San Francisco",{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":217,"phases":4,"briefSummary":218,"conditions":219,"keywords":222,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":49},"100648337","qualitative-study-of-student-financial-insecurity-and-psychiatry-100648337","NCT07719816","Qualitative Study of Student Financial Insecurity and Psychiatry","A Qualitative Exploration of the Impact of Financial Insecurity on the Development of Psychiatric Disorders and the Use of Healthcare Services Among Students","QUALIPEPSY","Inclusion Criteria:\n\n* A student enrolled at Paris Sciences et Lettres (PSL) University or the Faculty of Health Sciences at Université Paris Cité (UPC),\n* Aged 18 or over,\n* Fluent in French,\n* be a student,\n* have used the PPOP scheme,\n* not object to participating after receiving clear information.\n\nExclusion Criteria:\n\n* Participants under the age of 18,\n* not enrolled at PSL universities or the UPCS Faculty of Health Sciences,\n* insufficient proficiency in French to conduct an interview,\n* refusal to participate,\n* clinical vulnerability deemed incompatible by the referring consultant.",{"count":153,"type":22},"OBSERVATIONAL","Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and 2021. This phenomenon particularly affects students, who are already identified as being at greater risk of mental health disorders than the general population. Medical students seem to be particularly vulnerable: in 2021, a national study showed very high rates of depression and suicidal thoughts in this population. The main factor associated with depression was the feeling of financial hardship.\n\nStudents often face multiple forms of insecurity. Financially, they have limited resources and struggle to cover their basic needs such as housing, food and healthcare. Socially, many experience significant isolation, particularly when they are away from their families or under pressure from their studies. All of this has a significant impact on their mental health. Unfortunately, many students do not seek help due to lack of time, resources, or awareness of support services. The 2021 study showed that only one-third of medical students suffering from depression received appropriate treatment.\n\nThe aim of the study is to explore the lived experiences of the students concerned in order to identify what they perceive as the various aspects of student precarity (housing, transport, isolation, financial difficulties, etc.) and the links they perceive between these and their psychological distress. This study will deepen our understanding of these factors by exploring students' lived experiences, and will bring to light elements not identified by quantitative studies.",[220,221,31],"Depressive Disorder","Generalized Anxiety Disorder",[223,36,224,225,226],"Students","Use of care","Qualitative study","Precarity","2026-08-03",{"date":229,"type":41},"2026-08-05",{"date":231,"type":22},"2027-01-01",{"date":233,"type":22},"2027-06",{"name":235,"class":48},"Assistance Publique - Hôpitaux de Paris",{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":23,"phases":244,"briefSummary":245,"conditions":246,"keywords":247,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":257,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":4},"100574809","multimodality-adaptive-intervention-for-post-inpatient-hospitalization-suicide-risk-reduction-100574809","NCT06764108","Multimodality Adaptive Intervention for Post-Inpatient Hospitalization Suicide Risk Reduction","Inclusion Criteria:\n\n* Adult status (18+ years-old)\n* Ownership of a smartphone (iOS or Android)\n* Inpatient admission due to suicidal thoughts or suicide attempt\n\nExclusion Criteria:\n\n\\- Presence of any factor that impairs an individual's ability to comprehend and effectively participate in the study, including an inability to speak or write English fluently, the presence of gross cognitive impairment due to florid psychosis, intellectual disability, dementia, acute intoxication, or the presence of extremely agitated or violent behavior",{"count":243,"type":22},360,[25],"The goal of this clinical trial is to learn whether a combination of brief digital and clinician-delivered interventions can help adults leaving a psychiatric hospitalization cope with suicidal thoughts and prevent suicide-related events.\n\nThe main questions it aims to answer are:\n\n* Are people who receive automated smartphone messages when they report suicidal thoughts after leaving the hospital less likely to have a suicide-related event than those who do smartphone self-monitoring alone?\n* Are people who have additional session(s) with a clinician in the four weeks after leaving the hospital less likely to have a suicide-related event than those who receive additional brief self-guided intervention(s)?\n\nParticipants will be asked to:\n\n* Make a personalized safety plan (of coping strategies to use when feeling suicidal) before leaving the hospital\n* Do self-monitoring of suicidal thoughts and related experiences on their smartphone for four weeks after leaving the hospital\n* Complete a longer set of research questionnaires at the start of the study and five more times during the 12 weeks after leaving the hospital\n\nDepending on which study group they are in and whether they benefit from initial smartphone interventions, participants may or may not:\n\n* Receive automated smartphone messages reminding them of coping strategies to use for suicidal thoughts\n* Receive up to three additional sessions with a study clinician\n* Receive up to three brief online self-guided interventions\n\nThe study interventions last for the four weeks after leaving the hospital. Participants will also be asked permission to share information from their health records about care received for 12 weeks after leaving the hospital.",[31,121],[248,249,250,251,252,253,254,255,256],"just-in-time adaptive intervention","JITAI","micro-randomized trial","MRT","Sequential Multiple Assignment Randomized Trial","SMART","single-session intervention","SSI","hybrid experimental design",{"date":227,"type":41},{"date":259,"type":22},"2026-10",{"date":261,"type":22},"2030-01",{"name":76,"class":48},{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":269,"eligibilityCriteria":270,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":271,"enrollmentInfo":272,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":277,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":142},"100625085","preliminary-trial-of-an-avatar-guided-digital-intervention-for-emerging-adults-100625085","NCT07418047","Preliminary Trial of an Avatar Guided Digital Intervention for Emerging Adults","Randomized Controlled Feasibility Trial of an Avatar Guided Intervention for Young Adults Seen in the Emergency Department With Alcohol Use Problems and Suicidal Thoughts","EA-Avatar","Inclusion Criteria:\n\n* (1) emergency department admission for alcohol- or suicide-related reason since turning 18, OR treated for incidental suicide risk in the emergency department\n* (2) aged 18-29\n* (3) speak, read, and understand English\n* (4) binge drinking in the past month OR alcohol use problems (Alcohol Use Disorders Identification Test score \\> 5)\n* (5) active suicidal ideation in the past month\n* (6) owning and having access to a personal smartphone\n* (7) willingness to be randomized to an avatar guided intervention for alcohol use problems and suicidal thoughts OR a freely available suicide safety planning app\n* (8) for remote MyChart-based recruitment only, have MyChart activated\n\nExclusion Criteria:\n\n* (1) severe cognitive delay, active psychosis, or heavy intoxication that precludes research participation\n* (2) imminent safety risk and have been recently unsafe to themselves or others\n* (3) prisoner or are under arrest\n* (4) not interested or not willing to be randomized to receive the avatar-guided digital intervention or safety plan app\n* (5) under the care of a legal guardian","29 Years",{"count":186,"type":22},[25],"The goal of this clinical trial is to learn whether a novel digital avatar (virtual coach) support program can help emerging adults ages 18-29 who present to the emergency department with suicidal thoughts and alcohol misuse (EA-Avatar). The study also aims to learn whether people find the program easy to use and whether daily surveys and the study design are able to be completed by the majority of emerging adult participants.\n\nThe main questions this study aims to answer are:\n\n* Do participants use the digital program and find it helpful?\n* Is it possible for participants to complete daily surveys for twenty-eight days and follow-up surveys over twelve weeks?\n* Are there early signs that the program may help lower alcohol use and suicidal thoughts?\n\nResearchers will compare participants who receive the new digital avatar program plus supportive text messages to participants who receive a freely available suicide safety planning app to see if there are differences in use, engagement, and early signs of benefit.\n\nParticipants will:\n\n* Receive standard care from the emergency department\n* Be randomly put into one of two groups (EA-Avatar or a free suicide prevention app)\n* Depending on their group, use a new avatar-guided digital support program with text message reminders OR use a free suicide safety planning app\n* Complete surveys at the start of the study and again at four, eight, and twelve weeks\n* Complete short daily surveys for twenty-eight days",[276,31],"Binge Alcohol Consumption",[127,278,279,280,281,282],"binge drinking","emerging adults","feasibility","emergency department","digital health","2026-07-30",{"date":227,"type":41},{"date":286,"type":41},"2026-06-10",{"date":288,"type":22},"2027-08-31",{"name":290,"class":48},"University of Massachusetts, Worcester",{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":299,"enrollmentInfo":300,"targetDuration":4,"studyType":23,"phases":302,"briefSummary":303,"conditions":304,"keywords":311,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":49},"100636708","phase-2-ketamine-with-dialectical-behavioural-therapy-dbt-for-suicidality-in-individuals-with-treatment-resistant-depression-and-borderline-personality-disorder-ket-dbt-100636708","NCT07569198","Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)","Combining Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder: A Phase II Randomized, Midazolam-Controlled Clinical Trial (KET-DBT)","KET-DBT","Inclusion Criteria:\n\n1. Adults between the age of 18 to 70, inclusive;\n2. Meets criteria for BPD, as determined by clinical assessment by a psychiatrist or psychologist and confirmed by the International Personality Disorder Examination (IPDE);\n3. Meets DSM-5 criteria for MDD or BD (I or II), currently experiencing a MDE without psychotic features, as diagnosed by a study psychiatrist or psychologist. Diagnosis will be confirmed using the Mini- International Neuropsychiatric Interview (MINI);\n4. Current MDE must be moderate to severe, as determined by the MADRS score \\>20 with an inadequate response to two or more guideline-concordant treatment trials as defined by the Antidepressant Treatment History Form-Short Form (ATHF- SF);\n5. No changes in pharmacotherapy for MDD\u002FBD in the last month or changes in psychotherapy in the past month;\n6. Baseline SI as shown by two consecutive MSSI scores \\> 10 two weeks apart.\n\nExclusion Criteria:\n\n1. Past or current history of a psychotic disorder as determined by clinical assessment and MINI;\n2. Current or recent (within the past 3 months) manic or hypomanic episode as determined by clinical assessment via YMRS (score \\> 12) and the MINI;\n3. Meeting criteria for Moderate to Severe Alcohol or substance use disorders currently or within the past 3 months;\n4. Lifetime history of ketamine use disorder or illicit ketamine use.\n5. Acute suicide risk requiring involuntary inpatient treatment under the Mental Health Act (MHA).\n6. Presence of a relative or absolute contraindication to ketamine or midazolam, including a drug allergy, lifetime history of stroke, uncontrolled hypertension (Systolic BP \\> 160 or Diastolic BP \\> 100), low or labile blood pressure (Systolic BP \\\u003C 100 or Diastolic BP \\\u003C 60), recent (within the past 6 months) myocardial infarction, severe coronary artery disease (ascertained through participant's medical history), or moderate to severe renal (GFR scores ≤ 44) or hepatic impairment (A Child-Pugh score of ≥ 7);\n7. Currently pregnant or breastfeeding or planning on getting pregnant within the first two months of the trial or planning on getting someone else pregnant within the first two months of trial. Participants who are sexually active must agree to use a highly effective contraceptive method (please see exhaustive list in Section 3.6.1);\n8. Current use of prohibited concomitant medications, including other forms of ketamine or esketamine, high dose daily benzodiazepines (greater than 4 mg lorazepam equivalent daily) or monoamine oxidase inhibitors;\n9. Currently engaged (or completed within the past year) in DBT treatment. NOTE: Individuals who have received only DBT skills training in the past year will be considered eligible to participate;\n10. Those engaged in other forms of psychotherapy must be willing to discontinue for the duration of the 6-month DBT intervention (standard for DBT). There should be no changes in psychotherapy 30 days prior to baseline (i.e., Screening Visit 2).","70 Years",{"count":301,"type":22},120,[155],"The goal of this clinical trial is to learn if intravenous (IV) ketamine with Dialectical Behavioural Therapy (DBT) reduces suicidal ideation in individuals with suicidality who have been diagnosed with Borderline Personality Disorder and either Major Depressive Disorder or Bipolar Disorder. The main question it aims to answer is:\n\nDoes IV ketamine and DBT produce more rapid and robust improvements in suicidal ideation (SI) severity between baseline and Day 35 compared to IV midazolam and DBT, as measured by changes in the Modified Scale for Suicidal Ideation (MSSI) scores ?\n\nResearchers will compare six IV ketamine infusions and DBT to an active placebo (a look-alike substance that mimics some of ketamine's effects and not others) and DBT to see if IV ketamine with DBT is more effective at reducing SI severity.\n\nParticipants will:\n\n* Complete six infusions of either IV ketamine or IV midazolam\n* Take part in 6 months of DBT (includes both weekly one-on-one sessions, and group sessions, starting week 5 of the trial)\n* Visit the hospital for scheduled in-person visits\n* Join a call or videocall for scheduled remote visits\n* Complete a variety of different mood, cognitive and behavioral assessments",[305,306,307,308,309,310,31],"Borderline Personality Disorder (BPD)","Treatment-Resistant Major Depressive Disorder","Treatment-resistant Bipolar Depression","Major Depressive Disorder (MDD)","Bipolar Disorder (BD)","Bipolar Disorder I or II",[312,313,314,315,309,308,316],"Dialectical Behavioural Therapy (DBT)","ketamine","Borderline Personality Disorder","Treatment-Resistant Depression","Suicidality","2026-07-27",{"date":319,"type":41},"2026-07-29",{"date":321,"type":22},"2026-07-16",{"date":323,"type":22},"2029-08",{"name":325,"class":48},"Joshua Rosenblat",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":57,"minAge":112,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":23,"phases":336,"briefSummary":337,"conditions":338,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":49},"100622454","task-shifting-adapted-ipt-a-for-youth-suicide-prevention-100622454","NCT07383831","Task-Shifting Adapted IPT-A for Youth Suicide Prevention","Youth Mentor-Led Brief Interpersonal Psychotherapy for Youth Suicide Prevention","Inclusion Criteria:\n\n1. Parent consent\n2. Adolescent consent\n3. Enrolled in youth community centers\n4. Self-identified as Hispanic or Latine\n5. Between 12 and 17 years old.\n6. Scoring threshold for depression (4-9) as indicated in the PHQ-A.\n7. No current report of suicide ideation with plan or self-harming behaviors\n\nExclusion Criteria:\n\n1. Not consented to participate in the study\n2. Scoring 10 or higher in the PHQ-A, indicating depressive disorder\n3. Active suicide ideation (i.e., having thoughts of killing oneself, thinking about how in the past month).","17 Years",{"count":335,"type":22},46,[25],"The goal of this randomized pragmatic clinical trial is to examine the feasibility, acceptability, and mechanisms of change of a brief adaptation of Interpersonal Psychotherapy for Adolescents (BIPT-A), adapted and task-shifted to lay providers (mentors, youth trusted adults) in youth community centers (YCCs) as an upstream approach to suicide.\n\nIt focuses on Hispanic adolescents ages 12-17 enrolled in these YCCs. The pragmatic clinical trial will evaluate the acceptability and feasibility of adapted IPT-A delivered by mentors in YCCs and whether adapted BIPT-A impacts mechanisms of change (depressive symptoms, belongingness, and burdensomeness or feeling like a burden to others).\n\nThe main questions to answer are:\n\n* Is adapted BIPT-A, when delivered by trained lay providers (youth mentors), feasible and acceptable in youth community centers?\n* Does adapted BIPT-A, delivered by lay providers, change key risk factors (i.e., key mechanisms: depressive symptoms, low belongingness, and perceived burdensomeness) associated with suicide ideation? The investigators will compare adolescents randomized to adapted BIPT-A (6 sessions) delivered by a trained youth mentor with those receiving usual services at the community center (one individual session focused on active listening).\n\nParticipants will:\n\n1. Be screened for subthreshold depression using the Patient Health Questionnaire Adolescent version (PHQ-A). Adolescent participants will be included if they score between 4 and 9 (mild depression). Participants with a PHQ-A score of 10 or higher (severe depression) will not be eligible and will be referred to a licensed mental health provider for appropriate care.\n2. Be randomized to adapted BIPT-A or usual care. Adolescent participants in the intervention arm will participate in 6 weekly, adapted BIPT-A sessions with a trained youth mentor. Intervention focuses on education, affect identification, and interpersonal skills.",[31,339,340],"Depressive Symptoms","Adolescent Mental Health",{"date":342,"type":41},"2026-07-28",{"date":344,"type":22},"2026-10-01",{"date":346,"type":22},"2028-07-31",{"name":348,"class":48},"Boston College",{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":183,"sex":57,"minAge":19,"maxAge":356,"enrollmentInfo":357,"targetDuration":4,"studyType":23,"phases":358,"briefSummary":359,"conditions":360,"keywords":361,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":49},"100514357","recovers---realigning-emotion-and-cognition-via-precision-regulation-networks-100514357","NCT05977439","RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS","A Multiphase Program of Multimodal Computational Modeling and Hybrid Interventions Including EEG-Synchronized Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy","Study 1 (Healthy Participants)\n\nInclusion Criteria:\n\n* Age 18-65 years\n* Medically and psychiatrically healthy with no history of psychiatric or neurological disorders\n* English-speaking\n* Capacity to provide informed consent\n* Willingness and ability to complete study procedures\n* Negative pregnancy test for participants of childbearing potential\n\nExclusion Criteria:\n\n* Any current or past psychiatric diagnosis\n* Neurological disorders or history of central nervous system disease\n* History of seizure or epilepsy or use of medications that lower seizure threshold\n* Significant head injury or loss of consciousness\n* Implanted metal or contraindications to MRI or TMS\n* Substance use disorder (excluding nicotine or caffeine)\n* Pregnancy or plans to become pregnant during study participation\n* Inability to complete study procedures\n\nStudies 2, 3, and 4 (Participants With Depression)\n\nInclusion Criteria:\n\n* Age 18-65 years\n* Current diagnosis of Major Depressive Disorder (MDD)\n* Depression severity consistent with study criteria (e.g., HAM-D ≥17)\n* No history of psychotic or bipolar disorders\n* English-speaking\n* Capacity to provide informed consent\n* Willingness and ability to complete study procedures\n* Negative pregnancy test for participants of childbearing potential\n\nExclusion Criteria:\n\n* Neurological disorders or history of central nervous system disease\n* History of seizure or epilepsy or use of medications that lower seizure threshold\n* Significant head injury or loss of consciousness\n* Implanted metal or contraindications to MRI or TMS\n* Substance use disorder (excluding nicotine or caffeine)\n* Current participation in another interventional clinical trial\n* Pregnancy or plans to become pregnant during study participation\n* Any condition that would interfere with safe participation or completion of study procedures","65 Years",{"count":301,"type":22},[25],"In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation.\n\nThe study includes multiple related sub-studies involving healthy participants and participants with depression. Some study components focus on mechanistic modeling using non-therapeutic neurostimulation in healthy participants, while other components include interventional approaches such as individualized EEG-synchronized repetitive TMS (rTMS), cognitive tasks, and brief cognitive behavioral therapy (CBT) in participants with depression. Certain study components also evaluate CBT alone without TMS to assess behavioral intervention effects.",[36,159,31],[362,363,364,365,366,367,368],"transcranial magnetic stimulation","EEG-synchronized rTMS","closed-loop neurostimulation","depression","suicide prevention","cognitive behavioral therapy (CBT)","neuroplasticity","2026-07-17",{"date":371,"type":41},"2026-07-21",{"date":373,"type":41},"2024-02-01",{"date":375,"type":22},"2028-10-01",{"name":377,"class":48},"Medical University of South Carolina",{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":356,"enrollmentInfo":385,"targetDuration":4,"studyType":23,"phases":386,"briefSummary":387,"conditions":388,"keywords":390,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":397,"locationsCount":49},"100563344","improving-coping-to-reduce-suicide-risk-following-ed-discharge-100563344","NCT06614946","Improving Coping to Reduce Suicide Risk Following ED Discharge","Facilitating Effective Coping to Reduce Suicide Risk Following ED Discharge: A Micro-randomized Trial to Develop an Adaptive Text-based Intervention","Inclusion Criteria:\n\nIndividuals presenting to an ED with either:\n\n1. actual, interrupted, or aborted attempt in the last 4 weeks\n2. suicidal ideation within the last week\n\nExclusion Criteria:\n\n* Severe cognitive impairment or altered mental status (psychosis, manic state)\n* Severe aggression\u002Fagitation,\n* Being admitted or transferred into inpatient care,\n* Patient not owning a cell phone with text messaging capability",{"count":301,"type":22},[25],"The researchers hope to learn whether an electronic safety plan (ESP) and a supportive text messaging program are feasible and acceptable to adult patients with recent suicidal thoughts or behavior after emergency department (ED) discharge. From this study, the researchers also hope to learn how to best carry out the ESP and text messaging program to improve outcomes for patients after ED discharge.",[389,64,31],"Suicidal",[391],"Emergency Department","2026-07-14",{"date":321,"type":41},{"date":395,"type":41},"2026-05-12",{"date":74,"type":22},{"name":47,"class":48},{"id":399,"slug":400,"hasResults":12,"nctId":401,"briefTitle":402,"officialTitle":402,"acronym":403,"eligibilityCriteria":404,"healthyVolunteers":183,"sex":57,"minAge":405,"maxAge":4,"enrollmentInfo":406,"targetDuration":4,"studyType":23,"phases":408,"briefSummary":409,"conditions":410,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":422,"locationsCount":142},"100593861","walk-with-me-wwm-for-perinatal-grief-100593861","NCT07011940","Walk With Me (WWM) for Perinatal Grief","PeriGrief-II","Inclusion Criteria:\n\n* Within the first month of pregnancy or early infant loss\n* Reside in the United State\n* Speak and read either English or Spanish at a 6th grade reading level\n* 15 or older\n\nExclusion Criteria:\n\n* Not pregnant or has not experienced an early infant loss\n* Does not reside in the United State\n* Does not speak and read either English or Spanish at a 6th grade reading level\n* 14 or younger","15 Years",{"count":407,"type":22},300,[25],"The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss. It will also learn whether peer guides provide additional improvements on these outcomes.\n\nThe main questions it aims to answer are:\n\n• Do people who receive Along With Me or Along With Me plus a Peer Guide compared to services as usual have lower posttraumatic stress symptoms and suicidal ideation than those who do not receive the intervention?\n\nResearchers will compare Along With Me and Along With Me plus a Peer Guide to services as usual (referrals made in the hospital setting) to see if Along With Me works to prevent and address posttraumatic stress symptoms and suicidal ideation.\n\nParticipants will:\n\n* Receive access to a mobile app with approximately 10 therapeutic modules about how to manage grief and other symptoms.\n* Receive check-ins with a Peer Guide (in the Peer Guide condition only)",[411,412,31,413,414,415],"Grief","Post Traumatic Stress Disorder","Miscarriage","Stillbirth","Infant Death","2026-07-13",{"date":418,"type":41},"2026-07-15",{"date":420,"type":41},"2025-07-13",{"date":288,"type":22},{"name":423,"class":424},"Oregon Research Behavioral Intervention Strategies, Inc.","INDUSTRY",{"id":426,"slug":427,"hasResults":12,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":23,"phases":432,"briefSummary":433,"conditions":434,"keywords":436,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":49},"100568874","a-randomized-controlled-trial-of-a-smartphone-delivered-treatment-for-suicidal-thoughts-and-behavior-100568874","NCT06686901","A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior","Inclusion Criteria:\n\n* Adults ages 18+\n* Relatively frequent and recent (≥5 days within the past-month) active suicidal thoughts as assessed via SITBI-R.\n* Willing and able to provide at least one emergency contact (name, phone number, relation).\n* Owns an Android or iOS smartphone.\n* Possesses at least occasional access to Wi-Fi-enabled internet for data down\u002Fuploads.\n* Fluent in English and willing to provide informed consent.\n* Living in the Boston metropolitan area (i.e., \\~50 mile radius around Boston, MA)\n\nExclusion Criteria:\n\n* Recent (past 3-month) hypo\u002Fmanic symptoms or homicidal ideation or lifetime psychosis spectrum diagnosis as assessed via MINI 7.0.2.\n* Recent acute suicide risk operationalized as affirmative responses to BOTH below items during structured clinical interview AND evaluation by the PI in consultation with Mentors\u002FAdvisor Drs. Wilhelm, Kleiman, and\u002For Bentley:\n* At any time in past week: ≥ 8\u002F10 current intent to act on suicidal thoughts (0 \\[\"not at all\"\\] to 10 \\[\"extremely strong\"\\]); AND\n* At any time in past week: thought of a specific suicide plan (i.e, known method\u002Fmeans and\u002For location) with access to lethal means\n* Impaired vision (e.g., legal blindness), technological illiteracy, or intellectual disability that might impair ability to provide valid data and\u002For informed consent.",{"count":186,"type":22},[25],"This study aims to evaluate the acceptability, safety, and efficacy of a smartphone-delivered intervention called Therapeutic Evaluative Conditioning for Suicide (TEC-S) in reducing suicidal thoughts and behaviors (STB) among adults with recent and frequent suicide ideation.",[31,435],"Suicide Attempt",[63,437,438],"ecological momentary assessment (EMA)","Therapeutic Evaluative Conditioning (TEC)","2026-07-10",{"date":416,"type":41},{"date":442,"type":22},"2027-01-30",{"date":444,"type":22},"2029-08-31",{"name":76,"class":48},{"id":447,"slug":448,"hasResults":12,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":452,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":454,"targetDuration":4,"studyType":23,"phases":456,"briefSummary":457,"conditions":458,"keywords":461,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":478},"100636169","phase-2-inhaled-dmt-for-major-depressive-disorder-100636169","NCT07562191","Inhaled DMT for Major Depressive Disorder","Randomized, Double-Blind, Placebo-Controlled Phase IIb Trial of Inhaled N,N-Dimethyltryptamine (DMT) for Major Depressive Disorder","DMT-MDD","Inclusion Criteria:\n\n* 18 years or older, capable of making decisions, and able to provide informed consent.\n* Major Depressive Disorder (MDD) according to DSM-5 criteria\n* Current depressive episode of moderate to severe intensity\n* Episode duration of at least two weeks\n* Baseline MADRS score ≥ 20\n* No treatment changes (including antidepressants) in the 4 weeks prior to the study\n* Abstain from psychedelics ≥14 days before dosing (D0)\n\nExclusion criteria:\n\n* Major cardiac, hepatic, or renal disease; unstable cardiovascular conditions\n* Uncontrolled hypertension, QTc prolongation, arrhythmias, or valvular disease COPD or asthma\n* Severe obesity, uncontrolled diabetes, coagulopathy, thyroid disease, or glaucoma\n* Neurological risk (e.g., aneurysm, ↑ICP, epilepsy\u002Fseizures, severe disorders)\n* MAO deficiency or history of serotonin syndrome\n* Pregnant, breastfeeding, positive test, or no effective contraception\n* Secondary depression\n* Cluster B personality disorders (incl. borderline with ≥2 suicidal behaviors in past 12 months) or poor therapeutic rapport\n* Psychotic disorders, MDD with psychotic features, or first-degree family history of psychosis\u002Fbipolar disorder\n* Mania\u002Fhypomania\n* OCD, dissociative disorders, active PTSD, or decompensated eating disorders\n* Moderate-severe use disorder (past 6 months; except nicotine\u002Fcaffeine)\n* Lifetime ketamine, PCP, psychedelics, or MDMA use disorder\n* Current use of MAO inhibitors, unless discontinued at least 14 days prior to dosing\n* Psychedelic trial participation in past 12 months\n* Cognitive impairment affecting valid assessment",{"count":455,"type":22},140,[155],"This Phase 2b, randomized, double-blind, active-controlled clinical trial will evaluate the efficacy and safety of inhaled N,N-dimethyltryptamine (DMT) in adults with Major Depressive Disorder (MDD).\n\nThe study will test whether inhaled DMT can rapidly reduce depressive symptoms and suicide risk compared with a low-dose active comparator. A total of 140 participants will be randomized 1:1 to receive either 15 mg followed 1 hour later by 60 mg of inhaled DMT, or 1 mg followed 1 hour later by 4 mg of inhaled DMT.\n\nParticipants who do not achieve remission at Day 7 will enter an open-label extension and receive a high-dose DMT session on Day 14 (±3 days). All participants will be followed for up to 12 months to evaluate the durability of response, safety, functioning, and quality of life.",[459,308,460,31,63],"MDD","Major Depression",[462,463,464,465,466,467,468,469],"DMT","major depressive disorder","N,N-dimethyltryptamine","psychedelic therapy","inhaled DMT","vaporized DMT","suicidality","non invasive","2026-07-09",{"date":416,"type":41},{"date":473,"type":22},"2026-08-01",{"date":475,"type":22},"2027-08-01",{"name":477,"class":48},"Universidade Federal do Rio Grande do Norte",5,{"id":480,"slug":481,"hasResults":12,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":183,"sex":57,"minAge":486,"maxAge":85,"enrollmentInfo":487,"targetDuration":4,"studyType":23,"phases":488,"briefSummary":489,"conditions":490,"keywords":494,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":49},"100636620","neural-correlates-of-suicidal-behavior-in-youth-100636620","NCT07568054","Neural Correlates of Suicidal Behavior in Youth","Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study","Inclusion Criteria:\n\n* Subjects must be 14-24 years old\n* Subjects must be:\n\n  * High Risk Subjects: Psychiatrically admitted due to a suicide attempt or history of 2 previous suicide attempts\n  * Medium Risk Subjects: Suicide ideation for the past year with no suicide attempt\n  * Minimal Risk Subjects: No previous history of suicidal ideation or behavior, not taking any psychiatric history or medication, and no family history of suicide\n* Subjects must have the ability to understand and the willingness to sign a written informed consent\u002Fassent document\n* Subjects must be English speaking\n\nExclusion Criteria:\n\n* Subjects with known history of Autism Spectrum Disorder; non-verbal patients\n* Subjects with moderate or severe intellectual disability (IQ less than 70 and those patients in special education classes full time)\n* Subjects with Schizophrenia or history of any type of psychosis including mood related psychosis and brief reactive psychosis\n* Within 6 months before initial screening, urine toxicology positive for phencyclidine, cocaine or amphetamines (subjects prescribed amphetamines for the management of ADHD will not be excluded)\n* Subjects with a history of moderate or severe substance or alcohol use per DSM-5 criteria in the past 6 months\n* Subjects who are currently pregnant or breastfeeding\n* Subjects in custody of Children's Services\n* Subjects with recent bone, tendon, spine or joint surgery\n* Subjects with recent metallic dental implants\n* Subjects weighing less than 30 kg or more than 200 kg","14 Years",{"count":186,"type":22},[25],"This study, titled \"Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study,\" aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and young adults (ages 14-24). Suicide is a leading cause of death in this population, and current clinical approaches often fail to accurately predict or prevent suicidal behavior. This study seeks to identify objective neurobiological markers associated with suicide risk and treatment response.\n\nParticipants will be divided into three groups: (1) high-risk individuals recently hospitalized following a suicide attempt, (2) medium-risk individuals with chronic suicidal ideation but no attempts, and (3) low-risk healthy controls. All participants will undergo advanced neuroimaging, including magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with comprehensive psychiatric assessments.\n\nThe study focuses on brain regions and networks implicated in suicidality, including the anterior cingulate cortex and salience network, as well as neurochemical markers such as glutamate. It also examines electrophysiological activity and functional connectivity patterns associated with suicidal thoughts and behaviors.\n\nHigh-risk participants will receive an evidence-based psychotherapy called the Collaborative Assessment and Management of Suicidality (CAMS). This therapeutic approach emphasizes collaboration between patient and clinician to identify and address the underlying drivers of suicidal thoughts, with a focus on increasing hope and reducing psychological distress. Neuroimaging and clinical assessments will be repeated after completion of CAMS to evaluate treatment-related changes.\n\nThe study's primary goals are to:\n\n* Identify neural and electrophysiological correlates of suicide risk.\n* Distinguish biological differences between individuals with suicidal ideation and those who have attempted suicide.\n* Determine how CAMS therapy affects brain function and neurochemistry.\n\nBy integrating clinical and neurobiological data, this research aims to improve understanding of suicidality, enhance risk prediction, and inform more effective, personalized interventions for at-risk youth.",[31,435,121,491,492,493],"Depression \u002F Major Depressive Disorder","Hopelessness","Neurobiological",[495,496,497,498,36,492,499,500],"Suicidal ideation","Suicide attempt","Suicidal behavior","Youth suicide","CAMS therapy","Neuroimaging","2026-07-08",{"date":439,"type":41},{"date":504,"type":22},"2026-06-30",{"date":506,"type":22},"2031-10-01",{"name":508,"class":48},"The Cleveland Clinic",{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":57,"minAge":486,"maxAge":19,"enrollmentInfo":516,"targetDuration":4,"studyType":23,"phases":518,"briefSummary":519,"conditions":520,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":522,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":142},"100616311","sleep-treatment-for-teens-rct-phase-100616311","NCT07303959","Sleep Treatment for Teens (RCT Phase)","Sleep Treatment for Teens","Inclusion:\n\n1. Age 14-18 years old.\n2. Recent hospitalization due to suicide risk (i.e., suicide attempts, aborted\u002Finterrupted attempts, or suicide ideation with intent and\u002For a plan) using an abbreviated version of the semi-structured and well-validated Columbia Suicide Severity Rating Scale (C-SSRS; Posner et al., 2011). Regarding recency, adolescents will need to complete the baseline within three months (Study 1) or 45 days (Study 2) of discharge in order to capture the high-risk post-discharge period, which is up to 3 months following discharge from acute psychiatric hospitalization (Chung et al., 2017).\n3. Clinically significant insomnia symptoms: SCI scores ≤16 will be used to recruit a sample with clinically significant insomnia symptoms. The ISI will also be administered to gain additional information about the nature of adolescents' sleep problems in order to confirm primary insomnia. ISI scores may also be obtained via chart review when applicable\n4. Access to or willingness to use a compatible Smart Device. SleepioTM works with any internet connection (cellular or Wifi) on any iOS device running iOS 10.3 or later or on any Android device running Android OS 8.0 or later. Metricwire is compatible with all devices that SleepioTM is compatible with. If an interested adolescent does not have access to their own smart device, the research team will offer them a loaner device for the duration of the treatment\u002Ffollow-up phase.\n\nAdolescents will be excluded based on the following exclusion criteria:\n\n1. Prior CBT-I treatment, which would indicate lack of response to a prior reasonable dose of this treatment.\n2. Bipolar disorder given that certain components of CBT-I (e.g., sleep restriction) may be risky for this population.\n3. Substance use disorder that is primary to insomnia which would require alternative treatment.\n4. Presence of factors that may reduce participants' ability to consent or complete the study procedures (e.g., current psychosis, other-directed violence; severe cognitive impairment, non-English speaking).\n5. Unwillingness to wear wrist actigraphy or complete the EMA surveys.\n6. Not having a parent willing to provide permission (if participant is a minor) or to consent to their own participation (required for all adolescents). Eligibility will not be based on biological sex, gender identity, race, or ethnicity. These variables will be assessed during screening to compare those who are and are not eligible.\n7. Having a sibling who has enrolled in the study.",{"count":517,"type":22},80,[25],"The purpose of this research study is to compare (vs. treatment as usual) a brief (6-session), empirically supported, and highly disseminable version of digital (i.e., smartphone or web-based) cognitive behavioral therapy for insomnia (dCBT-I), called SleepioTM, in suicidal adolescents with co-occurring insomnia during the high-risk post-hospitalization period. Suicide is the 2nd leading cause of death among adolescents. Sleep problems, such as insomnia symptoms-the most common sleep problem in youth-may be a particularly promising treatment target to reduce suicide risk in adolescents. The investigators propose to test the feasibility, acceptability, and effectiveness of dCBT-I in a two-site (Rutgers and Old Dominion University) pilot study trial. Adolescents, 14-18 years-old, recently hospitalized for suicide risk with co-occurring insomnia (n=80, 50% at each site), will receive either dCBT-I (six weekly, 20-minute sessions) plus post-hospitalization treatment-as-usual (TAU) or TAU alone. Adolescents will complete assessments pre-treatment, during the treatment phase including at the end of treatment, and 1-month follow-up post-treatment.",[521,31,121],"Sleep Problems",{"date":439,"type":41},{"date":524,"type":41},"2025-06-02",{"date":526,"type":22},"2026-12-31",{"name":528,"class":48},"Rutgers, The State University of New Jersey",{"id":530,"slug":531,"hasResults":12,"nctId":532,"briefTitle":533,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":535,"targetDuration":4,"studyType":23,"phases":537,"briefSummary":538,"conditions":539,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":542,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":49},"100480545","a-novel-peer-delivered-recovery-focused-suicide-prevention-intervention-for-veterans-with-serious-mental-illness-100480545","NCT05537376","A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental Illness","Inclusion Criteria:\n\nVeteran Inclusion Criteria:\n\n1. Veterans who report present suicidal ideation (i.e., Columbia-Suicide Severity Rating Scale (C-SSRS) \\> 2 (\"Active thoughts of killing oneself\") in past 1 month and\u002For a suicide attempt in the prior 3 months as identified by the C-SSRS\n2. Current SMI diagnosis (i.e., schizophrenia and other psychotic disorders, mood disorders with psychotic features, bipolar disorders)\n3. Capable of informed consent via the University of California San Diego Brief Assessment of Capacity to Consent (UBACC)\n\nPeer Specialist Inclusion Criteria:\n\n1. Certified Peer Specialist employed at VA San Diego Healthcare System (VASDHS) in the Mental Health Care Line (individuals must demonstrate competency in basic suicide screening and referral procedures to be certified)\n2. 2-3 years of experience post certification as a Certified Peer Specialist\n3. Interest in being trained in SUPPORT\n4. Provide verbal or written consent for the research staff to discuss ability to participate in the study with the Peer Specialist's direct clinical supervisor\n5. Direct clinical supervisor agreement to allow the Peer Specialist to participate. This includes the Peer Specialist's direct clinical supervisor agreement to allow the Peer Specialist time as part of their current scope of practice to 1) participate in the full day (8-hour) SUPPORT training, 2) participate in weekly 1-hour group supervision for the duration of the Peer Specialist's time in the study, and 3) take on a case load of at least one SUPPORT Veteran at a given time.\n\nExclusion Criteria:\n\nVeteran Exclusion Criteria:\n\n1. Cannot complete the assessment battery\n2. Current intoxication requiring immediate detoxification or outpatient plan directed specifically to residential substance use disorder (not mental health) services\n3. Imminent psychiatric hospitalization",{"count":536,"type":22},69,[25],"Suicide is a major public health concern, particularly among Veterans with serious mental illness (SMI, i.e., psychotic disorders or bipolar disorders). Wellness Recovery Action Plan (WRAP) is a well-established evidence-based practice for those with SMI that centers on identifying warning signs of mental illness, developing wellness tools for functional independence, planning for day-to-day effective living within one's community, and building an action plan to create a valued life worth living. This proposed study will refine and pilot SUicide Prevention by Peers Offering Recovery Tactics (SUPPORT), a novel integrated recovery program that is an adaptation of peer-delivered WRAP for Veterans with SMI. In SUPPORT, a Peer Specialist leads a Veteran at increased risk for suicide through recovery planning that is tailored to the Veteran's suicidal experiences with cognitive learning strategies to enhance safety plan recall and improve functioning.",[540,541,31,64],"Psychotic Disorders","Bipolar Disorders",{"date":439,"type":41},{"date":544,"type":41},"2023-09-12",{"date":546,"type":22},"2027-10-31",{"name":548,"class":549},"VA Office of Research and Development","FED",{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":554,"acronym":4,"eligibilityCriteria":555,"healthyVolunteers":12,"sex":57,"minAge":112,"maxAge":333,"enrollmentInfo":556,"targetDuration":4,"studyType":23,"phases":557,"briefSummary":558,"conditions":559,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":567,"locationsCount":49},"100516259","development-and-testing-of-imhere4u-a-digital-suicide-prevention-intervention-for-cyberbullied-adolescents-100516259","NCT06002191","Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents","Inclusion Criteria:\n\n* English-speaking\n* access to a phone or device capable of text messaging\n* past 3-month history of cyberbullying assessed by the cybervictimization subscale of the Traditional Bullying and Cyberbullying Victimization and Perpetration Scale and\u002For presence of online discrimination measured by a modified version of a discrimination measured developed as part of the Adolescent Brain and Cognitive Development (ABCD) study\n* past 3-month history of suicidal risk, including: psychological distress (\\>13 on the 6-item Kessler Psychological Distress Scale) and\u002For suicidal ideation or behavior (via the Columbia Suicide Severity Rating Scale)\n\nExclusion Criteria:\n\n* intellectual challenges, low literacy levels, or other conditions that might inhibit adolescents' ability to effectively engage with Flourish (reported by parents and, if needed, confirmed through the age-appropriate Wechsler Intelligence scale)\n* acuity levels suggesting need for a higher level of care (e.g., inpatient hospitalization) or referral for emergency services",{"count":517,"type":22},[25],"The objective of this study is to test the feasibility and preliminary efficacy of Flourish (formerly referred to as imHere4U), a digital suicide prevention intervention for cyberbullied adolescents.\n\nThe specific aims are to:\n\nAim #1: Conduct a randomized controlled trial (RCT) comparing Flourish+Questionnaires vs. Questionnaires Alone among cyberbullied youth at-risk for suicide ages 12-17 (N=80, \\>35% underserved youth).\n\nH2a. Primary outcome: Feasibility will be evidenced by recruitment\u002Fretention rates \\> 80% and imHere4U engagement \\> 70%.\n\nH2b. Secondary outcomes: Youth assigned to Flourish+Questionnaires will report improved problem-solving capacity, distress tolerance, and motivation and reduced distress and suicidal ideation than youth assigned to Questionnaires Alone over the 6-month follow-up period.\n\nExploratory Aim: Examine the feasibility of delivering feedback on online interactions from machine learning algorithms. All youth assigned to Flourish may optionally provide their social media data to receive feedback from machine learning algorithms. H3a. Feedback from algorithms will have high acceptability (identified via qualitative themes and \\>70% acceptance rates) and usability, defined by mean scores on Post-Study System and Usability Questionnaire (PSSUQ) \\> 6.",[198,31],"2026-07-01",{"date":562,"type":41},"2026-07-06",{"date":564,"type":41},"2023-11-21",{"date":566,"type":22},"2027-08",{"name":568,"class":48},"University of Pittsburgh",{"id":570,"slug":571,"hasResults":12,"nctId":572,"briefTitle":573,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":23,"phases":577,"briefSummary":578,"conditions":579,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":587,"locationsCount":49},"100538044","enhancing-the-effectiveness-of-prolonged-exposure-among-suicidal-individuals-with-ptsd-100538044","NCT06285708","Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD","Inclusion Criteria:\n\n* Current diagnosis of PTSD or subthreshold PTSD; ability to speak and understand the English language; and ability to complete the informed consent process.\n\nExclusion Criteria:\n\n* Substance use disorder requiring medical management; imminent suicide risk warranting inpatient hospitalization or suicide-focused treatment; and impaired mental status that precludes the ability to provide informed consent (e.g., intoxication, psychosis, mania).",{"count":576,"type":22},100,[25],"The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared to treatment as usual. However, no studies to date have assessed their effectiveness when used in combination. In light of this knowledge gap, the primary objective of this study will be to test the effectiveness of PE augmented with CRP as compared to PE with care as usual (self-guided treatment plan), an active comparator, for the reduction of suicide ideations and attempts for individuals with comorbid PTSD.",[30,31,64,580],"Trauma, Psychological","2026-06-24",{"date":583,"type":41},"2026-06-29",{"date":585,"type":41},"2024-02-26",{"date":233,"type":22},{"name":588,"class":48},"Ohio State University",{"id":590,"slug":591,"hasResults":12,"nctId":592,"briefTitle":593,"officialTitle":593,"acronym":594,"eligibilityCriteria":595,"healthyVolunteers":12,"sex":57,"minAge":19,"maxAge":596,"enrollmentInfo":597,"targetDuration":4,"studyType":23,"phases":599,"briefSummary":600,"conditions":601,"keywords":604,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":618,"locationsCount":49},"100596878","recovery-through-inspiration-support-and-empowerment-100596878","NCT07051200","Recovery Through Inspiration, Support, and Empowerment","RISE","Inclusion Criteria:\n\n* Chief complaint of suicidal ideation, suicide attempt, depression, and\u002For anxiety\n* discharged from inpatient care or from emergency department\n* men and women ages 18-27\n\nExclusion Criteria:\n\n* primary diagnosis of: substance use disorder, schizophrenia spectrum, intellectual development disorder, autism spectrum disorder (level II or III)","27 Years",{"count":598,"type":22},40,[25],"The goal of this pilot study is to test the effectiveness of a novel intervention for young adults (ages 18-27) with mental health conditions who have been released from an acute care psychiatric facility. The intervention aims to reduce suicidality, depression, anxiety, re-hospitalization, and improve mental health recovery by using outpatient services.\n\nThe current standard of care (SOC) for these patients at discharge includes a discharge plan with a list of their medications, anticipated outpatient appointments, and information on when and where to find community resources.\n\nThe intervention being tested involves the implementation of a mental health recovery education and support program, involving one-on-one and small group meetings led by Peer Support Specialists (PSS) and Recovery Community Organizations (RCO).\n\nParticipants will be assigned to either Cohort A or B for 8 weeks.\n\nCohort A will be the intervention group with PSS and RCOs.\n\n* Weeks 1-4: One-on-one meetings with PSS for education and support. Assessments will be completed at weeks 2 and 4.\n* Weeks 5 and 7: One-on-one meetings with PSS for education and support.\n* Week 6 and 8: Group meetings with PSS and other participants from RCOs. Assessments will be completed during these weeks.\n\nCohort B will be the SOC group with no PSS or RCOs.\n\n* Weeks 1-4: Weekly check in phone calls with a member of the research team. Assessments will be completed at weeks 2 and 4.\n* Weeks 5-8: Check in phone calls with a member of the research team every other week. Assessments will be completed at weeks 6 and 8.\n\nData collected from participant assessments, adherence to medication, and re-admittance to a psychiatric facility will be used to compare the intervention to the SOC.",[31,435,602,603],"Anxiety","Depression Disorders",[605,606,607,608,609,610],"Peer Support Specialist (PSS)","Recovery Community Organization (RCO)","Mental Health Recovery","Transitional Age Youth (TAY)","UT Southwestern Medical Center","Young Adult","2026-06-22",{"date":613,"type":41},"2026-06-25",{"date":615,"type":41},"2025-04-01",{"date":617,"type":22},"2027-12-01",{"name":619,"class":48},"University of Texas Southwestern Medical Center",{"id":621,"slug":622,"hasResults":12,"nctId":623,"briefTitle":624,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":57,"minAge":626,"maxAge":627,"enrollmentInfo":628,"targetDuration":4,"studyType":23,"phases":629,"briefSummary":630,"conditions":631,"keywords":634,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":638,"lastUpdatePostDateStruct":639,"startDateStruct":641,"completionDateStruct":643,"leadSponsor":645,"locationsCount":49},"100489364","inhibitory-mechanisms-of-negative-urgency-in-adolescent-suicidal-behavior-100489364","NCT05652153","Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior","Inclusion Criteria:\n\n* Ages 13-21 years (inclusive)\n* Any sex, gender, race, or ethnicity\n* For participants 18 years of age or older, ability to provide written informed consent\n* For participants under 18 years of age, ability to provide written assent, with legal guardian's ability to provide written informed consent\n* Ability of participant (and parent\u002Fguardian, if applicable) to read and to communicate verbally and in writing in English (in order to permit comprehensive assessment of suicide risk by study team, and to facilitate safety planning and mitigation of suicide-related risks as necessary)\n* Current diagnosis of a unipolar depressive episode (major depressive episode, unspecified depressive disorder, or adjustment disorder with depressed mood), confirmed on the structured diagnostic interview (MINI or MINI-Kid)\n* For participants in the Dep\u002FSI group:\n\n  * Any lifetime history of suicidal ideation, as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)\n  * No prior history of suicidal behavior (interrupted attempt, aborted attempt, or suicide attempt) as assessed by the C-SSRS\n* For participants in the Dep\u002FSB group:\n\n  \\-- Any lifetime history of suicidal behavior (interrupted attempt, aborted attempt, or suicide attempt) as assessed by the C-SSRS\n* If the study participant will be completing any of the assessments remotely through the use of video teleconferencing, access to a reliable internet connection will be required\n\nExclusion Criteria:\n\n* Imminent suicide risk as determined by the PI or other study board-certified child and adolescent psychiatrist (based on review of C-SSRS and SSI scales and clinical assessment of participant)\n* Current substance use meeting diagnostic criteria for a substance use disorder within the last month on the MINI or MINI-KID diagnostic interview (with the exceptions of caffeine and nicotine)\n* Lifetime history of psychosis, hypomania, or mania\n* Historical diagnosis of autism spectrum disorder or intellectual disability\n* Antiepileptic medication use or chronic benzodiazepine use (as-needed benzodiazepine use will be permitted if it can be held on day of study visit with TMS-EEG testing)\n* Pregnancy or suspected pregnancy in participants capable of becoming pregnant (assessed with urine pregnancy test)\n* Medical\u002Fneurologic history that would pose increased risks for transcranial magnetic stimulation (TMS) or magnetic resonance imaging (MRI), or factors that would impede completion of study procedures, including:\n\n  * Neurological disorders including seizure disorder, history of anoxia, history of head injuries with loss of consciousness for greater than 5 minutes\n  * Suicide attempt by hanging or strangulation (asphyxiation) leading to anoxia\n  * Any personal history of seizure or family history of epilepsy\n  * Any metallic implants, fragments, or devices\n  * Any cardiac pacemaker, medication pump, neural stimulator, or other implanted medical device\n  * Risk for increased intracranial pressure (e.g., history of intracranial mass)\n  * History of intracranial surgical procedure\n  * Any contraindication to TMS determined by the TMS Adult Safety Screen (TASS)\n  * Any contraindication to MRI identified on imaging center screening form\n* Any non-removable hair, head, or neck body modifications that would impede TMS and proper EEG recording","13 Years","21 Years",{"count":517,"type":22},[25],"The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure negative urgency and brain signals in adolescents aged 13-21 years with depression and suicidal thoughts and behaviors.\n\nThe main questions it aims to answer are:\n\n* Whether a type of brain signaling called cortical inhibition is related to negative urgency\n* Whether depressed adolescents with suicidal behavior have more problems with cortical inhibition than depressed adolescents with suicidal thoughts only\n* Whether the relationship between negative urgency and cortical inhibition changes over time\n\nAdolescents who participate in the study will complete the following activities at the time they join the study, as well as 6 months and 12 months later:\n\n* Interviews with researchers and questionnaires to learn about their thoughts, emotions, and symptoms\n* A questionnaire about impulsive behaviors and negative urgency\n* Computerized games that measure brain functions\n* An MRI scan of the brain\n* Transcranial magnetic stimulation with electroencephalography (TMS-EEG), a way to measure how brain cells communicate (cortical inhibition) using a magnet placed outside of the head and recording brain signals",[121,31,632,633,36],"Negative Urgency","Cortical Inhibition",[121,31,632,633,36,635,636,637],"Adolescent","Transcranial Magnetic Stimulation","Electroencephalography","2026-06-18",{"date":640,"type":41},"2026-06-23",{"date":642,"type":41},"2024-05-25",{"date":644,"type":22},"2028-01",{"name":646,"class":48},"University of Minnesota",{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":652,"acronym":653,"eligibilityCriteria":654,"healthyVolunteers":12,"sex":57,"minAge":626,"maxAge":333,"enrollmentInfo":655,"targetDuration":4,"studyType":23,"phases":656,"briefSummary":657,"conditions":658,"keywords":662,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":670,"lastUpdatePostDateStruct":671,"startDateStruct":672,"completionDateStruct":674,"leadSponsor":676,"locationsCount":49},"100642005","reward-sensitivity-digital-intervention-for-suicide-risk-100642005","NCT07661901","Reward Sensitivity Digital Intervention for Suicide Risk","Pilot Development of a Youth-Focused Digital Just-in-Time Adaptive Intervention to Enhance Reward Sensitivity and Reduce Suicidal Ideation","DIGIReward","Inclusion Criteria:\n\nADOLESCENTS\n\n* Aged 13-17 years old\n* Recent suicidal ideation\n* Access to a smartphone device\n* Residing in the Philadelphia metropolitan area\n\nLEGALGUARDIANS\n\n* They are the legal guardian of an adolescent that meets all study criteria (see above)\n* They can read, write, and speak English\n\nExclusion Criteria:\n\nADOLESCENTS\n\n* Psychotic disorder, including schizophrenia, schizoaffective disorder, or psychotic disorder not otherwise specified, with a past year psychotic episode prior to baseline\n* Bipolar disorder I diagnosis, with a past year manic episode prior to baseline\n* Imminent suicide risk (e.g., active suicidal ideation with a specific plan and intent)\n\nLEGALGUARDIANS\n\n\\- There are no exclusion criteria for legal guardians",{"count":59,"type":22},[25],"The goal of this clinical trial is to develop and test an app designed to reduce suicide risk and improve emotional well-being in adolescents. The study will test if the app's daily check ins and recommended mood boosting skills will improve the adolescent's overall mood and suicidality. The main question it aims to answer is:\n\n• Is the app practical and acceptable to use daily?\n\nIn the study, adolescents will:\n\n* Participate in a focus group with other adolescents and provide feedback on the app itself (design, ease of use, etc.).\n* Complete surveys and assessments on their mood, thoughts, and experiences.\n* Complete assessments about their app experience.\n\nIn the study, the legal guardian of the adolescent will:\n\n* Participate in a focus group with other adolescents and provide feedback on the app itself (design, ease of use, etc.).\n* Complete assessments about their app experience.",[31,389,66,659,660,661],"Digital Health Intervention","Reward Sensitivity","Anhedonia",[663,664,665,666,63,667,668,669,660,661],"Adolescents","Legal Guardians","Digital","Philadelphia","Intervention","Prevention","Dyads","2026-06-16",{"date":611,"type":41},{"date":673,"type":22},"2026-06",{"date":675,"type":22},"2027-09",{"name":677,"class":48},"University of Pennsylvania",{"id":679,"slug":680,"hasResults":12,"nctId":681,"briefTitle":682,"officialTitle":683,"acronym":4,"eligibilityCriteria":684,"healthyVolunteers":183,"sex":57,"minAge":19,"maxAge":4,"enrollmentInfo":685,"targetDuration":4,"studyType":217,"phases":4,"briefSummary":687,"conditions":688,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":690,"lastUpdatePostDateStruct":691,"startDateStruct":693,"completionDateStruct":695,"leadSponsor":697,"locationsCount":49},"100642300","user-evaluation-think-life-100642300","NCT07654127","User Evaluation Think Life","Evaluation of User Experiences With the Online Self-help Course Think Life","Inclusion Criteria:\n\n* age: 18 years or older\n* user of the online self-help course Think Life\n\nExclusion Criteria:\n\n* not meeting the inclusion criteria",{"count":686,"type":22},1000,"This study aims to evaluate user experiences with the online self-help course Think Life, a suicide prevention intervention for individuals experiencing suicidal thoughts. Think Life was developed by the Flemish Centre of Expertise in Suicide Prevention (VLESP) and is freely available via Zelfmoord1813.be. The course was originally developed in 2014 and updated in 2025 to improve its look and feel, usability, and inclusiveness, without fundamental changes to its core content.\n\nThe researchers seek to better understand how users experience the updated version of Think Life, including perceived strengths, usability, and overall satisfaction with the course.\n\nUsers of the Think Life self-help course will be invited through a call displayed on the course homepage to voluntarily participate in an online user evaluation study. Interested individuals can access an online informed consent form via a public internet link hosted on REDCap. Participants who provide online informed consent and meet the inclusion criteria will automatically be redirected to the online questionnaire, which is also hosted on REDCap.\n\nApproximately 1000 participants aged 18 years or older can be included in this study. Participants are invited to complete a one-time online questionnaire with an estimated completion time of approximately 10 minutes.",[31,92,689],"mHealth Intervention","2026-06-11",{"date":692,"type":41},"2026-06-17",{"date":694,"type":22},"2026-06-01",{"date":696,"type":22},"2031-06-01",{"name":698,"class":48},"University Ghent"]