[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"supplement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:supplement":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100652400","skeletal-muscle-adaptations-to-peptide-supplemented-resistance-exercise-training-100652400",false,"NCT07773142","Skeletal Muscle Adaptations to Peptide-Supplemented Resistance Exercise Training","The Effects of an Innovative Novel Bioactive Peptide Supplement on Skeletal Muscle Anabolism, Autophagy, and Adaptations to Long Term Full Body Resistance Exercise Training in Young Healthy Individuals","Inclusion Criteria:\n\n* Aged 18-35 years\n* Body Mass Index (BMI, calculated by research team based on height and weight) between 18.5-27.4 kg.m-2\n* Meeting UK physical activity guidelines (150 mins moderate or 75 mins vigorous activity\u002Fweek)\n* Not currently participating in structured progressive resistance exercise training or have regularly participated in previous 6 months\n* In good health, being free from disease or conditions (e.g., Type-II diabetes, hyper\u002Fhypothyroidism, irritable bowel syndrome, polycystic ovary syndrome) which influence skeletal muscle metabolism or digestion (self-declared)\n\nExclusion Criteria:\n\n* Have an allergy to ingredients of the supplement or placebo supplement (e.g., legume\u002Fbean, corn allergies)\n* Have used dietary supplements which are known to affect skeletal muscle recovery and exercise adaptations (e.g., creatine) within the previous month\n* Are a smoker\u002Fvaper or have a history of smoking\u002Fvaping in previous year\n* Have a respiratory condition (e.g., asthma, chronic obstructive pulmonary disease)\n* Using hormone therapy (not including birth control), anabolic steroids, or recreational drugs\n* Are pregnant or currently breastfeeding\n* Are currently trying to conceive a child\n* Have any injury or body weakness which prevents participation in full body resistance exercise\n* Have a known allergy to lidocaine",true,"ALL","18 Years","35 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","Skeletal muscle size, an important metabolic tissue, is governed by the balance between two opposing processes, muscle protein synthesis and muscle protein breakdown. In response to long-term resistance exercise (weightlifting), skeletal muscle growth is commonly observed and it is believed that this is due to increases in muscle protein synthesis which leads to a positive net protein balance stimulating muscle growth. Due to its links to overall metabolic health, maximising muscle growth in response to resistance exercise training has become a significant focus in recent times, with various dietary supplements proposed due to their additive effects on muscle growth with resistance training. Protein supplementation, most commonly whey protein, is the most popular dietary supplement utilised by individuals completing resistance exercise training, however, more recent research has suggested that specific components of whey protein, as well as other foodstuffs, have the potential to individually activate growth pathways within skeletal muscle.\n\nThis study will investigate whether daily supplementation with a combination of these compounds is able to produce greater muscle growth, compared to a placebo, when combined with resistance exercise training. We will also investigate whether this supplement can also produce greater increase in strength as well as studying the potential mechanisms behind any of these preferential adaptations in muscle samples which will be collected before and after the training period.",[28,29],"Supplement","Resistance Training Adaptation",[31,32,33,34,35,36],"skeletal muscle","hypertrophy","autophagy","resistance exercise","resistance training","supplementation","RECRUITING","2026-08-19",{"date":40,"type":41},"2026-08-21","ACTUAL",{"date":43,"type":41},"2026-07-14",{"date":45,"type":22},"2027-12",{"name":47,"class":48},"University of Birmingham","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":16,"sex":58,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":70,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":49},"100623758","assessing-health-system-readiness-for-scaling-antenatal-mms-in-cambodia-100623758","NCT07400796","Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia","Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia: A Mixed-Methods Assessment","TIPS-Cambodia","For the cohort of pregnant individuals consuming MMS:\n\nInclusion Criteria:\n\n* Current pregnant\n* At least 18 years of age\n* Have attended at least one ANC visit at a health center or hospital in Takeo during the study period\n* Can provide a functioning phone number for follow-up contact\n* Willingness to participate and provide consent\n\nExclusion Criteria:\n\n* Individuals with diagnosed anemia who require iron and folic acid (IFA) supplementation instead of MMS\n* Individuals unable to communicate via telephone,;(3) individuals who withdraw consent at any point","FEMALE",{"count":60,"type":22},710,"OBSERVATIONAL","Malnutrition among pregnant women in low- and middle-income countries (LMICs) can cause micronutrient deficiencies that result in adverse maternal and neonatal health outcomes. The World Health Organization has recently recommended antenatal multiple micronutrient supplementation (MMS) that includes iron and folic acid (IFA) to improve maternal and neonatal health outcomes. MMS likely provides additional antenatal benefits over IFA supplementation alone. The Cambodian government, in partnership with Helen Keller International, is piloting MMS implementation in Takeo Province, which will inform nationwide scale-up of MMS.\n\nStudy Purpose: The Takeo implementation must be evaluated to understand context-specific implementation of MMS and health system readiness for scale-up. This study assesses system readiness through four domains from the Intervention Scalability Assessment Tool (ISAT): (1) fidelity and adaptation, (2) reach and acceptability, (3) delivery setting and workforce capacity, and (4) implementation infrastructure.\n\nPopulation: The pilot involves transitioning to MMS from IFA across all 86 health centers, all 6 referral hospitals, and the provincial hospital in Takeo province. This study includes pregnant women receiving antenatal care, antenatal healthcare providers and facilities, and hospital managers in Takeo. The study also includes national governing bodies for MMS delivery.\n\nMethods: This mixed-methods study uses ISAT as a framework for developing data collection methods. Sampling strategies emphasize urban and rural representation across all operational districts in Takeo and diverse stakeholder perspectives at multiple levels of the health system. Data collection includes:\n\n* 12 focus group discussions (FGDs) with health center providers to assess provider adherence to MMS delivery guidelines, perspectives on the transition to MMS, and additional resources needed for MMS delivery\n* Workload assessment surveys at FGDs to quantify any burden on providers and resource gaps to deliver MMS\n* MMS stockout monitoring at 18 health centers and 7 hospitals to assess supply chain reliability\n* 15 key informant interviews with hospital managers to assess perspectives on the integration of MMS into antenatal services and facility readiness for MMS delivery\n* Phone surveys with 630 pregnant women to assess acceptability and adherence to MMS at 90- and 180-days after MMS distribution\n* One FGD with national-level stakeholders to assess national-level readiness, economic planning, and resource planning for sustainable MMS implementation and scale-up\n* Rapid economic evaluation to estimate the cost of nationwide scale-up Potential Impact: This study will generate insights into real-world implementation of MMS in Cambodia. It will identify context-specific adaptations, implementation gaps, and resource planning frameworks needed for nationwide scale-up of MMS. Successful scale-up is anticipated to improve maternal and neonatal health in Cambodia. Findings can also be used to guide other LMICs seeking to transition to and sustainably implement MMS.",[64,65,66,28,67,68,69],"Anemia","Pregnancy","Micronutrients","Health Systems","Supply Chain Vulnerabilities","Adherence",[71,72,73,74,75,76,77],"anemia","nutrition","micronutrient","supplement","dietary supplement","Cambodia","policy","2026-02-12",{"date":80,"type":41},"2026-02-17",{"date":82,"type":41},"2025-12-01",{"date":84,"type":22},"2026-06-30",{"name":86,"class":48},"University of British Columbia"]