[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgery":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,278,0,25,[9,52,85,108,136,164,194,218,248,271,299,322,349,371,399,429,450,469,502,523,544,567,586,610,638],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100450669","phase-4-tes-rct-fleet-enema-vs-oral-mechanical-bowel-prep-100450669",false,"NCT05148494","TES RCT Fleet Enema vs Oral Mechanical Bowel Prep","Transanal Endoscopic Surgery: a Randomized Controlled Trial Comparing Fleet Enema vs Oral Mechanical Bowel Prep (TESEO Trial)","TESEO","Inclusion Criteria:\n\n* undergoing transanal endoscopic surgery at the QEII Health Sciences Center in Halifax by one of the colorectal trained surgeons\n\nExclusion Criteria:\n\n* chronic constipation not well controlled with diet or stool softening agents\n* previous pelvic radiation\n* inflammatory bowel disease\n* repeat transanal surgery for the same lesion\n* patient unable to self-administer enemas\n* patient unable to tolerate either of the 2 bowel preps due to medical reasons\n* age over 75\n* clear diagnosis of congestive heart failure\n* daily use of Lasix or similar loop diuretic\n* chronic steroid use\n* Transanal Endoscopic Surgery combined with another surgical procedure","ALL","18 Years","75 Years",{"count":22,"type":23},66,"ESTIMATED","INTERVENTIONAL",[26],"PHASE4","There is no consensus about the best bowel preparation prior to transanal endoscopic surgery TES). Cleanliness and visibility in the rectosigmoid and rectum are of utmost importance, possibly even more so than during colonoscopy, to facilitate safe, precise and efficient resection of the rectal lesion and potentially adequate closure of the defect. Both Fleet enemas and oral mechanical bowel preparation are considered standard of care in preparation for TES. This single center two arm single blinded randomized controlled trial will compare the effectiveness of Fleet enemas in comparison to Pico Salax oral mechanical bowel preparation in cleansing the rectum as measured by a modified version of the Ottawa Bowel Prep Scale.",[29,30],"Colorectal Neoplasms","Surgery",[32,33,34,35,36,37,38],"transanal endoscopic surgery","TEM","TAMIS","rectal neoplasm","oral mechanical bowel preparation","fleet enema","Ottawa bowel prep score","RECRUITING","2026-08-20",{"date":42,"type":43},"2026-08-21","ACTUAL",{"date":45,"type":43},"2022-03-16",{"date":47,"type":23},"2027-10-01",{"name":49,"class":50},"Nova Scotia Health Authority","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":51},"100604584","phase-2-use-of-corticosteroid-in-intraopertive-injections-in-total-knee-replacement-surgery-100604584","NCT07151417","Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.","Adjunctive Use of Corticosteroid in Periarticular Injections in Primary Total Knee Arthroplasty","TKACSI","Inclusion Criteria:\n\n* Patients within the MHS who are DEERS eligible undergoing primary TKA at Walter Reed National Military Medical Center (WRNMMC), Surgery Center of Chevy Chase or District Surgery Center\n* Age 18 or older\n* successful surgical intervention\n\nExclusion Criteria:\n\n* Unicompartmental knee arthroplasty (UKA)\n* Revision total knee arthroplasty (rTKA)\n* Females who are pregnant or nursing\n* Allergic to ingredients in PAI or previous adverse reaction to steroids being used in this study\n* Diabetics will be excluded from Group 2 (standard PAI + methylprednisolone)",{"count":61,"type":23},240,[63,64],"PHASE2","PHASE3","The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury.\n\nThe main questions it aims to answer are:\n\nDoes adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)?\n\nResearchers will compare:\n\nStandard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function.\n\n(Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.)\n\nParticipants will:\n\nBe randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint\n\nBe followed after surgery to measure:\n\nPain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function",[67,68,30],"Knee Osteoarthritis","Musculoskeletal Disease",[70,71,72,73,74],"total knee arthroplasty (TKA)","manipulation under anesthesia (MUA)","corticosteroid","periarticular injection\u002Fpericapsular injection (PAI)","zilretta","2026-08-17",{"date":77,"type":43},"2026-08-19",{"date":79,"type":23},"2026-09-01",{"date":81,"type":23},"2027-08-31",{"name":83,"class":84},"Walter Reed National Military Medical Center","FED",{"id":86,"slug":87,"hasResults":12,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":24,"phases":94,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":51},"100519030","optimizing-pain-self-management-in-total-knee-arthroplasty-100519030","NCT06038240","Optimizing Pain Self-Management in Total Knee Arthroplasty","Inclusion Criteria:\n\n* 18-85 years old.\n* Have a physician-confirmed treatment plan to undergo unilateral TKA along with physician-confirmed knee osteoarthritis diagnosis.\n* Willingness and ability to comply with scheduled sessions and study procedures\n\nExclusion Criteria:\n\n* Member of a vulnerable population including pregnant women, children, prisoners, cognitively impaired, and non-English-speaking subjects.\n* Current unstable, severe medical comorbidity.\n* Current severe psychiatric comorbidity (e.g., schizophrenia, psychosis, or other unstable psychiatric disorder).\n* Current severe alcohol or substance use disorder.\n* Weekly or more frequent use of opioids in the past 30 days (other than tramadol and\u002For codeine) for therapeutic or non-therapeutic purposes.\n* Other surgery of the affected knee in the last 6 months.\n* Previous TKA.","85 Years",{"count":93,"type":23},150,[95],"NA","The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward system dysfunction as a chronic pain mechanism - is optimally suited to reduce postsurgical pain and augment reward system functioning relative to a Pain Self-Management and Education (PSME) condition. We will randomize 150 patients with KOA undergoing unilateral TKA to a brief, 4-session (20-30 minutes each) course of Savoring Meditation (SM; n = 75) or PSME (n = 75) delivered remotely by trained interventionists in a one-on-one format. We will assess pain and as well as pain-related risk and protective factors both via questionnaire and via weeklong ecological momentary assessment (EMA) data bursts on the following schedule: baseline, post-surgery, and 3-month follow-up. In addition, participants will attend laboratory testing sessions at baseline and 6-weeks post-surgery, during which affective pain modulation and electroencephalographic (EEG) brain biomarkers associated with pain and affect will be recorded. Participants in SM be encouraged to practice their savoring for 5 minutes\u002Fday during the week following surgery, as well as to use it to manage pain flares in a self-directed manner.",[98,99,30],"Osteo Arthritis Knee","Knee Pain Chronic","2026-08-13",{"date":75,"type":43},{"date":103,"type":43},"2023-11-27",{"date":105,"type":23},"2027-09",{"name":107,"class":50},"University of Virginia",{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":115,"minAge":19,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":24,"phases":119,"briefSummary":120,"conditions":121,"keywords":122,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":51},"100652053","lapbox-manual-containment-system-100652053","NCT07767968","LapBox® Manual Containment System","Evaluation of Leak Integrity of the LapBox® Manual Containment System During Laparoscopic Surgery","Inclusion Criteria:\n\n* Participants who require laparoscopic hysterectomy or myomectomy for management of uterine fibroids\n\nExclusion Criteria:\n\n\\-","FEMALE","65 Years",{"count":118,"type":23},24,[95],"This study to evaluate the leak integrity of the LapBox Manual Containment System for laparoscopic hysterectomy and myomectomy. The goal is to determine the integrity of this containment system in order to increase surgical safety. 30 adult females who require laparoscopic hysterectomy or myomectomy for management of uterine fibroids will be enrolled and will be on study the day of surgery.",[30],[123,124,125,126],"laparoscopic hysterectomy","laparoscopic myomectomy","uterine fibroids","morcellation","NOT_YET_RECRUITING","2026-08-11",{"date":75,"type":43},{"date":131,"type":23},"2026-09",{"date":133,"type":23},"2027-07",{"name":135,"class":50},"University of Wisconsin, Madison",{"id":137,"slug":138,"hasResults":12,"nctId":139,"briefTitle":140,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":145,"phases":4,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":51},"100637996","perioperative-predictive-value-of-physical-activity-on-short--and-long-term-morbidity-and-mortality-100637996","NCT07603622","Perioperative Predictive Value of Physical Activity on Short- and Long-term Morbidity and Mortality","PeriopPrePA","Inclusion Criteria:\n\n* Elective non-cardiac surgery patients (equal to or over 18 years) at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge\n\nExclusion Criteria:\n\n* Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.",{"count":144,"type":23},50000,"OBSERVATIONAL","Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.\n\nAge and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity has added predicted value, beyond established risk factors, for predicting perioperative morbidity and mortality.",[148,30,149],"Anesthesia","Surgery Complications",[151,152,153,154],"Perioperative medicine","Outcome","Mortality","Morbidity","2026-08-09",{"date":157,"type":43},"2026-08-12",{"date":159,"type":43},"2026-05-01",{"date":161,"type":23},"2026-11-30",{"name":163,"class":50},"Karolinska Institutet",{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":171,"sex":18,"minAge":116,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":24,"phases":174,"briefSummary":175,"conditions":176,"keywords":181,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":192,"locationsCount":51},"100649604","perioperative-transcranial-photobiomodulation-and-delayed-neurocognitive-recovery-in-older-patients-100649604","NCT07736092","Perioperative Transcranial Photobiomodulation and Delayed Neurocognitive Recovery in Older Patients","Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial","Inclusion Criteria:\n\n* Aged 65 years or older.\n* Preoperative Mini-Mental State Examination (MMSE) \\\u003C27.\n* Scheduled to undergo non-cardiac, non-neurosurgical surgery under general anesthesia, with an expected surgical duration \\>1 hour.\n* Planned hospital stay of at least 1 day before surgery and at least 2 days after surgery.\n\nExclusion Criteria:\n\n* Communication barriers before surgery due to coma, severe dementia, or language disorders.\n* History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, or delirium before surgery.\n* History of brain injury, tumors, or surgery, or intracranial metal implants, or skin or soft tissue injuries on the head or face.\n* History of ischemic or hemorrhagic stroke within 3 months before surgery.\n* An American Society of Anesthesiologists class ≥ IV.\n* Enrolled in other interventional studies.\n* Other conditions deemed unsuitable for study participation.",true,{"count":173,"type":23},130,[95],"Delayed neurocognitive recovery is a common neurocognitive complication in older patients after surgery, especially those with preoperative neurocognitive decline. Transcranial photobiomodulation therapy is a novel neuromodulation technique using transcranial low-power light to modulate brain biological functions. This technique has been used to treat various neurological or psychiatric conditions, including ischemic stroke, traumatic brain injury, and major depression. This study is designed to explore whether using transcranial photobiomodulation therapy during the perioperative period can reduce the incidence of delayed neurocognitive recovery in older patients with pre-existing neurocognitive impairment.",[177,30,178,179,180],"Older Adults","Transcranial Photobiomodulation","Delayed Neurocognitive Recovery","Postoperative Delirium",[182,30,183,184,185],"Older adults","Transcranial photobiomodulation","Delayed neurocognitive recovery","Postoperative delirium","2026-08-07",{"date":188,"type":43},"2026-08-10",{"date":190,"type":43},"2026-08-05",{"date":133,"type":23},{"name":193,"class":50},"Peking University First Hospital",{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":145,"phases":4,"briefSummary":203,"conditions":204,"keywords":205,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":51},"100306807","to-evaluate-the-performance-and-efficiency-of-robotic-surgery-in-children-and-adults-100306807","NCT03274050","To Evaluate the Performance and Efficiency of Robotic Surgery in Children and Adults","PECRoP","Inclusion Criteria :\n\n* child or adult\n* with an indication for a robotic surgery\n* non-opposition of patient or non-opposition of parents for minor patient\n\nExclusion Criteria :\n\n* anatomic or anesthetic contraindication for the mini-invasive surgery",{"count":202,"type":23},16000,"Robotic minimally invasive surgery has been rapidly adopted for a wide variety of surgical procedures in adult patients across a broad spectrum of surgical specialties. This has occurred despite the high costs and uncertain benefits of surgical robots.\n\nIn contrast, Children's Hospitals and pediatric surgical disciplines have been much slower to embrace the surgical robot. Many children's hospitals do not even possess a surgical robot, and many of those that do borrow them from the adult operating room within the same medical facility.\n\nSince the first case of robotic minimally invasive surgery in children in 2000, robotic procedures have been slowly adopted by select pediatric surgical specialists.\n\nAdvocates of robotic minimally invasive surgical systems add many useful features that include improved dexterity, motion scaling, tremor filtration, greater optical magnification (up to 10x), stereoscopic vision, operator-controlled camera movement, and the elimination of the fulcrum effect when compared to conventional laparoscopy. The wristed laparoscopic instruments used in robotic surgery provide seven degrees of freedom.\n\nFor the surgeon, these features may allow for more precise dissection with increased magnification and visibility. The intuitive controls of the robot are purported as providing the ability to perform laparoscopic procedures in an \"open\" fashion. In pediatric surgical procedures, these technical abilities may have the potential to surpass the physical capabilities of human performance in the tight operative fields encountered in children.\n\nThis study aims to evaluate the clinical safety, effectiveness, and cost-effectiveness of robot-assisted minimally invasive surgery in both pediatric and adult patients. Robotic surgery was developed to overcome key limitations of conventional laparoscopy, including 2D visualization, limited instrument mobility, poor ergonomics, and long learning curves. The trial will assess clinical outcomes, postoperative pain, length of stay, return to daily activities, access to minimally invasive surgery, and the impact of robotic surgery on surgical training. Specific indications, such as pyeloplasty, will also be compared with open and conventional laparoscopic approaches.",[30],[206,207,208,209],"robot","surgery","pediatry (0-20 years included)","adults","2026-08-06",{"date":188,"type":43},{"date":213,"type":43},"2018-02-28",{"date":215,"type":23},"2029-08",{"name":217,"class":50},"Assistance Publique - Hôpitaux de Paris",{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":12,"sex":18,"minAge":225,"maxAge":226,"enrollmentInfo":227,"targetDuration":4,"studyType":24,"phases":229,"briefSummary":230,"conditions":231,"keywords":237,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":51},"100641453","transcriptional-pathways-of-surgical-pain-modulated-by-music-therapy-exposure-transpose-100641453","NCT07653594","TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)","TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE): A Single Arm Pilot Study","Inclusion Criteria:\n\n* Age 50 to 80\n* Able to speak and understand English\n* Scheduled to undergo a surgery meeting the following criteria: (1) traditional open surgery (not laparoscopic or robotic) via laparotomy (midline or subcostal incisions), (2) length of surgery \\>3 hours, and (3) curative-intent surgical resection of a cancer in the stomach, pancreas, bile ducts, liver, or peritoneal surfaces\n* Participant reports pain intensity of 4\u002F10 or above to study staff on day 1 post-surgery or any other day post-surgery through discharge\n\nExclusion Criteria:\n\n* Significant visual impairment that has not been corrected\n* Significant hearing impairment that has not been corrected\n* Significant cognitive impairment that would prevent participant from participating in the study","50 Years","80 Years",{"count":228,"type":23},20,[95],"Participants may take part in this study if they are scheduled to undergo a surgery that meets the following: (1) traditional open surgery via laparotomy, (2) length of surgery \\>3 hours, and (3) curative-intent surgical resection of a cancer in the stomach, pancreas, bile ducts, liver, or peritoneal surfaces. The purpose of this study is (1) to evaluate the feasibility of collecting blood samples prior to surgery, post-surgery and pre- music-assisted relaxation and imagery (MARI) intervention, and immediately post-MARI intervention and (2) to identify gene expression changes associated with MARI and explore their relationship with immediate changes in pain intensity. Participants will be in this study for the duration of their hospital admission for surgery.",[30,232,233,234,235,236],"Stomach Cancer","Pancreas Cancer","Bile Duct Cancer","Liver Cancer","Peritoneal Cancer",[238,239],"Music therapy","Music-assisted relaxation and imagery","2026-08-03",{"date":190,"type":43},{"date":243,"type":23},"2027-01",{"date":245,"type":23},"2027-12",{"name":247,"class":50},"Case Comprehensive Cancer Center",{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":18,"minAge":255,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":24,"phases":259,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":264,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":51},"100379157","phase-3-no-during-cpb-in-neonates-to-reduce-risk-of-aki-100379157","NCT04216927","NO During CPB in Neonates to Reduce Risk of AKI","Efficacy of Nitric Oxide Administration During Cardiopulmonary Bypass in Neonates at Reducing the Risk of Acute Kidney Injury","Inclusion Criteria:\n\n* All neonates (≤31 days) undergoing cardiac surgery with CPB for CHD will be deemed eligible for enrollment.\n\nExclusion Criteria:\n\n1. Failure to obtain informed consent from parent\u002Fguardian\n2. Clinical signs of preoperative persistent elevated pulmonary vascular resistance,\n3. Emergency surgery,\n4. Episode of cardiac arrest within 1 week before surgery,\n5. Recent treatment with steroids and\u002For a condition that may require treatment with steroids (excluding steroid administration specifically for CPB),\n6. Use of inhaled NO (iNO) immediately prior to surgery,\n7. Structural renal abnormalities by ultrasound,\n8. Preoperative AKI,\n9. Use of other investigational drugs,\n10. Weight less than \\\u003C2 kg,\n11. Gestational age \\\u003C36 weeks,\n12. Major extracardiac congenital anomalies,\n13. Non-English speakers.","1 Day","31 Days",{"count":258,"type":23},40,[64],"Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread success in preventing this postoperative decline in renal function. Nitric oxide is an intricate regulator of acute inflammation and coagulation and is a potent vasodilator. The investigators hypothesize that nitric oxide, administered during cardiopulmonary bypass (CPB), may reduce the incidence of AKI.",[262,263,30],"AKI","CHD - Congenital Heart Disease",{"date":190,"type":43},{"date":266,"type":43},"2023-01-10",{"date":268,"type":23},"2027-06-30",{"name":270,"class":50},"Children's Hospital Medical Center, Cincinnati",{"id":272,"slug":273,"hasResults":12,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":278,"targetDuration":4,"studyType":24,"phases":279,"briefSummary":280,"conditions":281,"keywords":286,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":51},"100648355","developing-pilot-postoperative-guidelines-for-improved-functional-outcomes-after-high-risk-cancer-surgery-100648355","NCT07720089","Developing Pilot Postoperative Guidelines for Improved Functional Outcomes After High-Risk Cancer Surgery","Development and Implementation of Pilot Postoperative Guidelines to Improve Functional Outcomes Following High-Risk Surgery for Cancer: A North American Prospective Feasibility Study","Inclusion Criteria:\n\n* Surgeons who perform abdominal surgery for cancer at the study institution\n\nExclusion Criteria:\n\n* Surgeons who do not perform abdominal surgery for cancer\n* Surgeons who are external to the study institution",{"count":22,"type":23},[95],"The objective of this study is to develop and evaluate the implementation of novel timeline-specific National Comprehensive Cancer Network (NCCN)-style clinical guidelines designed to improve functional outcomes after high-risk abdominal surgery for cancer.",[282,283,30,284,285],"Cancer","Abdominal Cancer Surgery","Recovery Outcomes","Functional Outcomes",[287,288,207,289,290],"cancer","abdominal cancer surgery","recovery outcomes","functional outcomes","2026-07-31",{"date":240,"type":43},{"date":294,"type":23},"2026-07",{"date":296,"type":23},"2027-08",{"name":298,"class":50},"University of Alabama at Birmingham",{"id":300,"slug":301,"hasResults":12,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":12,"sex":18,"minAge":306,"maxAge":91,"enrollmentInfo":307,"targetDuration":4,"studyType":24,"phases":309,"briefSummary":310,"conditions":311,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":51},"100581318","tubeless-surgery-with-impaired-pulmonary-function-100581318","NCT06848751","Tubeless Surgery With Impaired Pulmonary Function","Non-intubated Thoracoscopic Surgery for Lung Leision in Patients With Impaired Pulmonary Function","Inclusion Criteria:\n\n1. Patients with impaired lung function (who may require postoperative intubation and transfer to the surgical ICU after preoperative and MDT discussions).\n2. Patients requiring minimally invasive lung resection due to lung cancer, pulmonary nodules, benign lung tumors, pneumothorax, lung volume reduction surgery, etc.\n3. Patients with normal mental status who can cooperate with perioperative examinations, exercises, and physical rehabilitation measures.\n4. Patients who agree to participate in the clinical trial after communication.\n\nExclusion Criteria:\n\n1. Patients with severe impairment of cardiopulmonary function or other organ systems, who are deemed unable to tolerate any form of anesthesia or minimally invasive surgery after preoperative and MDT discussions.\n2. Patients with abnormal mental status or who are unable to adequately cooperate with perioperative examinations, exercises, and physical rehabilitation measures.\n3. Patients who refuse to participate in the clinical trial or decline the use of non-intubated anesthesia with preserved spontaneous breathing.\n4. Patients who refuse to undergo surgery.","14 Years",{"count":308,"type":23},45,[95],"Some patients with impaired lung function require minimally invasive surgical treatment, including those with lung cancer, benign lung tumors, pneumothorax, or lung volume reduction surgery. Patients with borderline lung function often cannot be extubated immediately postoperatively under conventional treatment models. These patients typically need to be transferred to the surgical ICU for close monitoring. However, positive-pressure mechanical ventilation with an endotracheal tube carries risks of further airway injury and persistent air leakage from the lung surface, leading to a high incidence of postoperative respiratory failure.\n\nNon-intubated minimally invasive surgery (tubeless), which preserves spontaneous breathing without endotracheal intubation, avoids the physical stimulation of intubation and the airway damage caused by mechanical ventilation. This approach may reduce the incidence of postoperative airway injury and respiratory failure, potentially expanding the indications for minimally invasive lung surgery, lowering postoperative complication and mortality rates.\n\nThe aim is to further clarify the surgical indications for non-intubated single-port minimally invasive surgery in patients with impaired lung function, the decision-making criteria for postoperative ICU transfer, and the safety and feasibility of this comprehensive management approach.",[312,30],"Lung Function Decreased","2026-07-22",{"date":315,"type":43},"2026-07-23",{"date":317,"type":43},"2021-04-10",{"date":319,"type":23},"2026-12-31",{"name":321,"class":50},"The Second Hospital of Shandong University",{"id":323,"slug":324,"hasResults":12,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":328,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":18,"minAge":330,"maxAge":4,"enrollmentInfo":331,"targetDuration":4,"studyType":24,"phases":333,"briefSummary":334,"conditions":335,"keywords":337,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":342,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":51},"100471936","phase-4-intravenous-vs-oral-acetaminophen-in-postoperative-hip-fracture-adult-patients-100471936","NCT05425355","Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients","INTACT-HIP: INTravenous Acetaminophen vs. Oral Randomized Controlled Trial in HIP Fracture Patients - a Feasibility Trial","INTACT-HIP","Inclusion Criteria:\n\n* 60 years of age and older\n* Patients who were ambulating without human assistance before fracture, with any type of non-neoplastic hip fracture\n* Patients undergoing surgical treatment as an inpatient\n\nExclusion Criteria:\n\n* Patients with neoplastic hip fracture\n* Severe cognitive impairment (Montreal Cognitive Assessment (MoCA) \\\u003C10)\n* Pre-existing delirium\n* Known hypersensitivity or allergy to acetaminophen\n* Severe or chronic liver or kidney dysfunction\n* Planned postoperative ventilation\n* Swallowing issues and\u002For dysphagia\n* English language limitation\n* Weight \\\u003C50kg","60 Years",{"count":332,"type":23},42,[26],"The INTACT-HIP trial study will evaluate feasibility of conducting a randomized, double-blinded controlled trial comparing postoperative treatment with intravenous (IV) acetaminophen versus oral acetaminophen, in older adults undergoing hip fracture surgery.\n\nThe results of this feasibility trial will be used to inform designing a larger, multi-center, randomized controlled trial to assess the efficacy of IV acetaminophen compared to oral acetaminophen to reduce delirium and improve other clinical and patient-centered outcomes after hip fracture surgery. It will randomize 42 older adults to receive either oral or IV acetaminophen after hip fracture surgery.",[336,30],"Hip-fracture",[338,339,340,341],"elderly","acetaminophen","oral vs intravenous","hip fracture surgery",{"date":315,"type":43},{"date":344,"type":43},"2023-01-23",{"date":346,"type":23},"2026-12-30",{"name":348,"class":50},"University Health Network, Toronto",{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":355,"targetDuration":4,"studyType":24,"phases":357,"briefSummary":359,"conditions":360,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":369,"locationsCount":51},"100642940","phase-1-research-on-the-efficacy-and-mechanism-of-shouhui-tongbian-capsules-in-treating-postoperative-constipation-of-benign-anal-and-rectal-diseases-based-on-gut-microbiota-analysis-100642940","NCT07648394","Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota Analysis","Inclusion Criteria:\n\nSurgical indication for a benign anorectal disease, including hemorrhoids or anal fistula Diagnosis of postoperative constipation after benign anorectal surgery Postoperative constipation symptoms such as difficulty defecating, reduced bowel movement frequency, hard or lumpy stools, incomplete evacuation, anorectal obstruction, or abdominal distension Ability to tolerate the planned anorectal surgical procedure without related contraindications Consciousness and ability to cooperate with treatment, follow-up, and questionnaire assessments Written informed consent provided by the participant or legally authorized representative Age 18 to 75 years, inclusive\n\nExclusion Criteria:\n\nSevere systemic disease, including serious psychiatric or immune disorders Severe infection Malignant tumor Severe organic disease of a major organ, including the heart, liver, or kidneys Pregnancy Breastfeeding Postpartum period Coagulation dysfunction Other anorectal disease that may affect outcome assessment Known allergy to either study treatment or any treatment component Any other condition considered by the investigators to make participation unsuitable",{"count":356,"type":23},120,[358,63],"PHASE1","The goal of this clinical trial is to evaluate whether Shouhui Tongbian Capsule can improve postoperative constipation in adults aged 18 to 75 years after surgery for benign anorectal diseases, including hemorrhoids and anal fistula. The clinical trial will also evaluate the safety of Shouhui Tongbian Capsule and explore associations between treatment effects and changes in gut microbiota, metabolic profiles, and inflammatory indicators.\n\nThe main questions are:\n\nDoes Shouhui Tongbian Capsule improve constipation symptoms after benign anorectal surgery? Does Shouhui Tongbian Capsule reduce postoperative and defecation-related pain? Does Shouhui Tongbian Capsule improve quality of life and anorectal function? What adverse events occur during treatment? Are clinical improvements associated with changes in gut microbiota, metabolic profiles, or inflammatory indicators?\n\nResearchers will compare Shouhui Tongbian Capsule with lactulose to evaluate differences in efficacy and safety for postoperative constipation.\n\nParticipants will:\n\nReceive either Shouhui Tongbian Capsule three times daily or lactulose once daily for 14 days Complete assessments of constipation symptoms, pain, quality of life, and anorectal function Provide stool and blood samples before treatment and on Day 14 Attend assessments during treatment and approximately 1 month after surgery Report adverse events and other medical problems during participation",[361,362,30,363],"Intestinal Flora","Anorectal Diseases","Constipation","2026-07-21",{"date":313,"type":43},{"date":367,"type":23},"2026-08-01",{"date":268,"type":23},{"name":370,"class":50},"China-Japan Friendship Hospital",{"id":372,"slug":373,"hasResults":12,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":24,"phases":381,"briefSummary":382,"conditions":383,"keywords":384,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":51},"100647977","patient-safety-checklist-pasc-in-surgical-patients-100647977","NCT07713147","Patient Safety Checklist (PASC) in Surgical Patients","The Effect of the Patient Safety Checklist (PASC) on Surgical Patients' Satisfaction With Discharge Education and Communication Problems: A Randomized Controlled Trial","(PASC)","Inclusion Criteria:\n\n* Willing to participate in the study.\n* Scheduled to undergo elective primary major surgery.\n* Aged 18 years or older.\n* Undergoing a surgical procedure classified as a Category A, B, C, or D (major surgery) according to the Interventional Procedures List of the Turkish Ministry of Health.\n* Able to understand and complete the checklist, with adequate cognitive ability and no impairment that would interfere with participation.\n* Able to provide written informed consent in Turkish.\n\nExclusion Criteria:\n\n* Undergoing a surgical procedure classified as Category E according to the Interventional Procedures List published by the Turkish Public Hospitals Institution.\n* Belonging to vulnerable groups, including individuals who are legally restricted, prisoners, or residents of nursing homes.\n* Being scheduled for day surgery.",{"count":380,"type":23},264,[95],"This study aims to examine the effect of using the Patient Safety Checklist (PASC) on surgical patients' satisfaction with discharge education and their communication-related issues.\n\nThis study is designed as a post-test control group randomized trial. The main questions it aims to answer are:\n\nH₀₁: There is no difference in discharge education satisfaction levels between surgical patients who use the PASC and those in the control group.\n\nH₀₂: There is no difference in communication problems between surgical patients who use the PASC and those in the control group.\n\n•H₁₁: There is a difference in discharge education satisfaction levels between surgical patients who use the PASC and those in the control group.\n\nH₁₂: There is a difference in communication problems between surgical patients who use the PASC and those in the control group. Research Question:• What are the adherence rates for each item of the PASC Checklist and the overall adherence rate among participants?\n\nParticipants will:\n\n* From the day the decision for surgery is made until hospital discharge, participants will either use the Patient Safety Checklist (PASC) or receive standard perioperative care, according to their group allocation.\n* On the day of discharge, participants will complete the Surgical Patients' Discharge Education Satisfaction Scale, the Healthcare Communication Questionnaire, and the Health Communication Problems Scale.",[30],[207,385,386,387,388,389],"checklist","patient safety","PASC","Communication","discharge","2026-07-17",{"date":392,"type":43},"2026-07-20",{"date":394,"type":23},"2026-09-20",{"date":396,"type":23},"2027-01-30",{"name":398,"class":50},"Ondokuz Mayıs University",{"id":400,"slug":401,"hasResults":12,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":4,"eligibilityCriteria":405,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":330,"enrollmentInfo":406,"targetDuration":4,"studyType":24,"phases":408,"briefSummary":409,"conditions":410,"keywords":414,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":425,"leadSponsor":427,"locationsCount":51},"100647292","effectiveness-of-wechat-supported-neck-rehabilitation-exercises-on-early-recovery-after-thyroidectomy-100647292","NCT07707401","Effectiveness of WeChat-Supported Neck Rehabilitation Exercises on Early Recovery After Thyroidectomy","Effectiveness of WeChat-Supported Neck Rehabilitation Exercises on Early Recovery After Thyroidectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Undergoing thyroid surgery\n* Postoperative condition stable, with the attending physician assessing the patient as fit for neck movement\n* Willing to participate in the study, complete scheduled follow-ups, and sign a written informed consent form\n\nExclusion Criteria:\n\n* History of prior thyroid or neck surgery\n* History of cervical spondylosis, cervical spine surgery, neck trauma, or other conditions affecting neck mobility\n* Postoperative complications rendering the patient unsuitable for neck movement training, such as confirmed recurrent laryngeal nerve injury, chyle leak, or complications requiring reoperation or prolonged drainage, or incision infection\n* Persistent postoperative dizziness or other conditions unsuitable for exercise\n* Unable to use WeChat and lacking assistance from family members",{"count":407,"type":23},200,[95],"This study aimed to evaluate the effectiveness, safety, and implementation outcomes of a WeChat mini program-supported tele-neck rehabilitation exercises for improving early postoperative neck recovery after thyroidectomy.",[411,412,30,413],"Thyroid Diseases","Thyroid Cancer","Postoperative Pain",[415,416,417,418,419,420],"Tele-exercise program","Telehealth","Health-related quality of life","Postoperative rehabilitation","Thyroidectomy","Neck exercise","2026-07-13",{"date":423,"type":43},"2026-07-16",{"date":421,"type":43},{"date":426,"type":23},"2029-06-30",{"name":428,"class":50},"Shanghai 6th People's Hospital",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":433,"acronym":4,"eligibilityCriteria":434,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":116,"enrollmentInfo":435,"targetDuration":4,"studyType":24,"phases":437,"briefSummary":438,"conditions":439,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":447,"locationsCount":449},"100538350","phase-4-rotator-cuff-repairs-with-or-without-bioenthesis-augmentation-100538350","NCT06289686","Rotator Cuff Repairs With or Without BioEnthesis™ Augmentation","Inclusion Criteria:\n\n* DEERS-eligible\n* Adults, between the ages of 18-65 (inclusive)\n* Presenting with a rotator cuff tear that is reparable surgically (a reparable tear is defined as tear of the RC where it is possible to bring the retracted tendon edge back to the greater tuberosity of the humerus under minimal tension)\n* Ability to undergo surgery to repair rotator cuff tear\n* Willingness to commit to study procedures including study intervention and a 12-month follow-up\n* Fluency in speaking, reading, comprehending English\n* 1-2 tendon full thickness reparable RC tear (full thickness tear is defined as a tear that involves the majority of supraspinatus and less than half of the infraspinatus under minimal tension, with no subscapularis involvement beyond the upper border)\n* Patients who have high-grade partial thickness tears where the surgeon elects to complete the tear during surgery before repairing the tendon(s)\n\nExclusion Criteria:\n\n* Previous shoulder surgery (excluding acromioplasty or diagnostic arthroscopy)\n* Inability to receive an MRI\n* Current (within the past 6 months) tobacco user\n* Unwilling to remain tobacco free for the duration of the study\n* Current lower limb injuries requiring walking assist devices such as crutches and walkers\n* Diagnosed with systemic arthritis\n* Significant neck pathology\n* Active joint or systemic infection\n* Currently enrolled, or plans to enroll, in another clinical trial during this study (that would affect the patient's safety or results of this trial)\n* Significant muscle paralysis of the shoulder girdle\n* Currently pregnant or plans to become pregnant during this study\n* Inability of the surgeon to repair the tear with remaining defect no greater than 10 mm in diameter\n* Inability of the surgeon to repair the tear with less than 1cm of medialization\n* Evidence of other significant shoulder pathology (such as Grade III osteoarthritis)\n* Has a history of alcohol abuse, illicit drug use, significant mental illness, physical dependence to any opioid, or drug abuse or addiction\n* Major medical illness that would preclude undergoing surgery\n* Major psychiatric illness or developmental handicap\n* Goutallier III classification and above",{"count":436,"type":23},100,[26],"Rotator cuff (RC) injuries are particularly prevalent, difficult to repair, and attachment between the bone and tendon is notoriously difficult to achieve. The most common method and current standard of care (SOC) for reattaching connective tissues (e.g., ligaments, tendons) to bone typically involves suture anchor-based techniques, but this is fraught with problems. More specifically, re-tearing of the connective tissue after this procedure occurs in 30-60% of cases, and can be even higher in patients who engage in smoking, have a diagnosis of diabetes, etc. To address these clinical challenges, Sparta Biopharma Inc. (Sparta) developed a unique technology, called BioEnthesis, to improve the connection between the tendon and bone. Pre-clinical in vivo studies demonstrated that the biphasic bovine cancellous matrix regenerated at the bone-soft tissue interface-thereby leading to high structural integrity and will likely lead to reduced re-tear rates over time. The investigators hypothesize that patients in this interventional cohort will experience enhanced mobility, reduced pain, and less re-tears after RC procedures versus a standard suture anchor-based repair.",[440,441,30],"Rotator Cuff Tears","Rotator Cuff Injuries","2026-07-10",{"date":421,"type":43},{"date":445,"type":43},"2023-07-28",{"date":296,"type":23},{"name":448,"class":84},"Brooke Army Medical Center",5,{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":457,"targetDuration":4,"studyType":24,"phases":458,"briefSummary":459,"conditions":460,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":464,"completionDateStruct":465,"leadSponsor":467,"locationsCount":51},"100646168","the-proaktive-trial-100646168","NCT07696624","The PROAKTIVE Trial","PRO-Active Rehabilitation Prior to Kidney Transplantation to ImproVe Patient-centered Recovery Evaluation","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled, or on the pathway, for kidney transplant surgery\n* Expected surgery date between at least 4 weeks from enrollment\n* Access to internet-enabled device\n* Email address\n\nExclusion Criteria:\n\n* Inability to read and communicate in English\n* Cognitive impairment preventing ability to provide informed consent independently\n* No telephone\u002Fcell phone\n* Any of the following cardiovascular conditions:\n\n  1. Severe valvular heart disease that limits a patient's ability to ambulate on level ground, or is associated with syncope or dyspnea\n  2. Severe cardiac dysrhythmias that limit a patient's ability to ambulate on level ground, or is associated with syncope or dyspnea\n  3. Recent myocardial infarction (within 6 weeks prior to enrollment - based on the Heart and Stroke Foundation's HeartWalk program)",{"count":308,"type":23},[95],"The PRO-Active rehabilitation prior to Kidney Transplantation to ImproVe patient-centered recovery Evaluation trial tests an approach where people are supported to exercise, improve diet, and receive emotional support at home before and after kidney transplant surgery to understand the ideal process and benefits.",[461,30],"Kidney Transplant; Complications","2026-07-06",{"date":442,"type":43},{"date":243,"type":23},{"date":466,"type":23},"2029-03",{"name":468,"class":50},"Ottawa Hospital Research Institute",{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":476,"minAge":477,"maxAge":478,"enrollmentInfo":479,"targetDuration":4,"studyType":24,"phases":481,"briefSummary":482,"conditions":483,"keywords":488,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":496,"completionDateStruct":498,"leadSponsor":500,"locationsCount":51},"100633338","the-effect-of-progressive-relaxation-exercises-with-therapeutic-clown-100633338","NCT07525388","The Effect of Progressive Relaxation Exercises With Therapeutic Clown","The Effect of Progressive Relaxation Exercises With Therapeutic Clown in Preoperative Period on Fear Anxiety and Physiological Parameters in Children","Inclusion Criteria:\n\n* Aged between 6 and 10 years,\n* Willing to participate in the study,\n* Admitted to the clinic for elective circumcision surgery,\n* Accessible prior to surgery,\n* With no cognitive impairments,\n* With no vision or hearing problems were included in the study.\n\nExclusion Criteria:\n\n* Children who wished to withdraw from the study during the study period were excluded.","MALE","6 Years","10 Years",{"count":480,"type":23},162,[95],"This study was conducted to investigate the effects of progressive relaxation exercises, performed with the assistance of a therapeutic clown during the pre-operative period, on fear, anxiety and physiological parameters in children. This randomised controlled trial included children aged 6-10 years undergoing circumcision surgery. The children were randomised into three groups: a progressive relaxation exercise group led by a therapeutic clown, a progressive relaxation group led by a nurse, and a control group. Fear, anxiety and physiological parameters (heart rate, respiratory rate, blood pressure, oxygen saturation) were assessed before and after the procedure.",[484,485,486,487,30],"Therapeutic Clown","Relaxation Exercise","Anxiety","Fear",[489,490,491,492,207],"therapeutic clown","relaxation exercise","fear","anxiety","2026-07-03",{"date":495,"type":43},"2026-07-07",{"date":497,"type":43},"2025-03-25",{"date":499,"type":23},"2026-06-30",{"name":501,"class":50},"Ataturk University",{"id":503,"slug":504,"hasResults":12,"nctId":505,"briefTitle":506,"officialTitle":507,"acronym":508,"eligibilityCriteria":509,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":510,"targetDuration":4,"studyType":24,"phases":512,"briefSummary":513,"conditions":514,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":519,"leadSponsor":521,"locationsCount":51},"100598834","phase-3-efficacy-and-safety-of-intravenous-lidocaine-versus-placebo-in-patients-receiving-morphine-rachi-analgesia-100598834","NCT07076641","Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia","Phase III, Randomized, Double-blind Study to Assess the Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Analgesic Morphine Rachi Anesthesia for Major Digestive or Abdominal Surgery by Laparotomy.","LIDORACHI","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Major digestive or abdominal surgery (pancreatic, hepatic, colorectal, gynecological, esophageal, gastric, duodenal, small intestine...);\n* Scheduled surgery;\n* Laparotomy;\n* Patient in agreement with morphine rachi anesthesia;\n* Social security affiliation;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Emergency surgery;\n* Contraindication to non-steroidal anti-inflammatory drugs: history of gastro duodenal ulcer, renal failure from stage 3 A or higher;\n* History of bradycardia and\u002For known conduction disorder (atrioventricular block) \u002F Pacemaker ;\n* Unstable coronary ;\n* Myocardial infarction \\\u003C6 months;\n* Severe cardiocirculatory insufficiency;\n* Severe hepatic insufficiency;\n* Allergy to morphine ;\n* Allergy to lidocaine;\n* Rhythm disorders at risk of sudden death (e.g. Brugada syndrome);\n* Flecaine as usual treatment;\n* Chronic pain with level II or III analgesics;\n* Gabapentinoids: pregabalin (Lyrica), gabapentin;\n* Drug addiction and substitute drugs;\n* Epileptic disorders ;\n* Myasthenia gravis;\n* Creatinine clearance below 10 mL\u002Fmin;\n* Hypokalemia, hypoxia or acid-base disorders;\n* Patient participating in another clinical trial, or in a period of exclusion from another clinical trial;\n* Inability to understand study information (due to linguistic, psychological, cognitive or literacy problems);\n* Women who are or may become pregnant\\* (of childbearing age, without effective contraception) or who are breast-feeding;\n* Patient deprived of liberty, under guardianship or unable to give consent.",{"count":511,"type":23},76,[64],"The purpose of this study is to evaluate the superiority of IV lidocaine combined with morphine spinal anesthesia versus placebo combined with morphine spinal anesthesia, in reducing postoperative morphine consumption at 48 hours, in patients undergoing major digestive or abdominal surgery by laparotomy.",[515,30],"Digestive System Disease",{"date":517,"type":43},"2026-07-01",{"date":294,"type":23},{"date":520,"type":23},"2027-07-30",{"name":522,"class":50},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":530,"enrollmentInfo":531,"targetDuration":4,"studyType":24,"phases":533,"briefSummary":534,"conditions":535,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":539,"completionDateStruct":540,"leadSponsor":542,"locationsCount":51},"100633588","intraoperative-neuromonitoring-ionm-and-bipolar-electrocautery-be-during-axillary-lymph-node-dissection-alnd-100633588","NCT07528638","Intraoperative Neuromonitoring (IONM) and Bipolar Electrocautery (BE) During Axillary Lymph Node Dissection (ALND)","Feasibility of Using Intraoperative Neuromonitoring (IONM) and Bipolar Electrocautery (BE) During Axillary Lymph Node Dissection (ALND) to Provide Early Identification and Protection of the Intercostalbrachial Nerve (ICBN), Medial Branch Cutaneous Nerve (MBCN), and Their Branches","Inclusion Criteria:\n\n1. Patients ages 18-70 years old.\n2. Pathologically confirmed diagnosis of breast cancer.\n3. Undergoing ALND by one of the breast surgeon Sub-Investigators on this study.\n\nExclusion Criteria:\n\n1. Patients having any previous axillary surgery other than percutaneous breast biopsy and\u002For SLNB.\n2. Prior breast radiation with neuropathy clearly developing after radiation.\n3. Patients who have undergone prior chemotherapy and developed post-chemotherapy neuropathy prior to ALND.\n4. Patients with any pre-existing neurological conditions affecting nerves, such as neuropathy (peripheral neuropathy, neuropathic pain or nerve injury to upper extremity).\n5. Patients taking medications that are known to modify neuropathic pain (eg, gabapentin, pregabalin, duloxetine, venlafaxine, lidocaine patches, capsaicin, opioids, tramadol, NMDA receptor antagonists, clonidine, cannabis, botox).\n6. Patients with prior spinal surgery or spinal pathology (cervical spinal stenosis or cervical radiculopathy).\n7. Patients with limb-dysfunction.\n8. Patients with demyelinating disease.\n9. Patients with significant co-morbidities (clotting disorders on anticoagulation, cardiac issues, other conditions that could impact long-term follow-up).\n10. Patients that present with pre-operative breast, arm or chest pain ipsilateral to anticipated ALND.\n11. Patients who have had prior procedures where IONM failed intraoperatively.\n12. Presence of parietal cortical lesion.","70 Years",{"count":532,"type":23},6,[95],"The purpose of this study is to determine whether the implementation of existing neurosurgical techniques of intraoperative neuromonitoring (IONM) and the replacement of monopolar electrocautery with bipolar electrocautery (BE), during ALND, will improve the early identification of nerves that have been implicated in the cause of neuropathically-mediated post-surgical pain syndrome (PSPS).",[536,30],"Breast Cancer","2026-06-29",{"date":517,"type":43},{"date":537,"type":43},{"date":541,"type":23},"2027-12-01",{"name":543,"class":50},"University of Cincinnati",{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":548,"acronym":4,"eligibilityCriteria":549,"healthyVolunteers":171,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":550,"targetDuration":4,"studyType":24,"phases":552,"briefSummary":553,"conditions":554,"keywords":557,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":51},"100543491","adapting-enhanced-recovery-programs-for-low-health-literacy-patients-100543491","NCT06356558","Adapting Enhanced Recovery Programs for Low Health Literacy Patients","Inclusion Criteria:\n\n* Adult patients \\>= 18 years of age undergoing surgery under an enhanced recovery program (ERPs)\n* Adult caregivers\u002Fproviders, organizational leaders, \\>= 18 years of age with direct or indirect involvement with ERP implementation\n* All genders\n* All race\u002Fethnicities\n* Able to consent\n* English-speaking\n\nExclusion Criteria:\n\n* Child (\\\u003C18 years of age)\n* Patients undergoing operations not included under ERPs\n* Participants unable to consent for the study\n* Participants whose mental state excludes them from being able to understand contents of the informed consent form and\u002For patients whose family members or patient representative do not wish for them to participate in the study",{"count":551,"type":23},1050,[95],"Low health literacy patients are a vulnerable population at high-risk for surgical disparities including longer hospital stays, more complications, and more readmissions. This study will adapt enhanced recovery programs (ERPs) to low health literacy patients with a multilevel, health literacy-based implementation strategy (called VISACT - VISuAl aids, Coach providers in communication, and Train organizations in health literacy) to improve ERP fidelity and thereby outcomes. In the final aim of this project (Specific Aim 3), the VISACT intervention will be tested in a pilot trial. Findings from this study will lay the foundation for a multi-institutional stepped-wedge trial and establish key principles for adapting interventions to eliminate disparities.",[30,555,556],"Health Knowledge, Attitudes, Practice","Colorectal Disorders",[30,558,559],"Health Literacy","Enhanced Recovery","2026-06-25",{"date":537,"type":43},{"date":563,"type":43},"2026-06-15",{"date":565,"type":23},"2028-05-01",{"name":298,"class":50},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":476,"minAge":19,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":145,"phases":4,"briefSummary":575,"conditions":576,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":579,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":51},"100392456","inflatable-penile-prostheses--which-patients-can-correctly-use-the-scrotal-pump--100392456","NCT04390230","Inflatable Penile Prostheses : Which Patients Can Correctly Use the Scrotal Pump ?","Inflatable Penile Prostheses : Predicting Factors of Pump Misuse and Unsatisfaction","All cases included were discussed and approved by a multidisciplinary team. Patients who underwent prosthesis replacement or second implantation were not included. We excluded patients who refused or were not able to answer our questionnaire, patients who provided unreliable answers, and patients that experimented a secondary malfunction of their IP.",{"count":356,"type":23},"Sexual health and satisfaction are well know as critical critera to assess quality of life, at any age. Among the multiple aspects of sexual health, erectile dysfunction (ED) is not anymore a fate, mainly thanks to the advent of phosphodiesterase type 5 (PDE5) inhibitors in 1998. Nevertheless, a significant part of patients are intolerant or does not respond to PDE5 inhibitors and thus are looking for other treatment options.\n\nSince the first implantation of foreign material intracarvernosally in 1966 by Beheri, multiple modifications and enhancements were achieved in order to produce devices more reliable with a more natural appearance. First introduced in 1973 by Scott et al., inflatable prosthesis provides now high general satisfaction rates (69-94%), better than in malleable prostheses, except for few authors.\n\nIn addition to changes in materials and construction, the two main manufacturers of IPP, Boston scientific AMS (Marlborough, MA, USA) and Coloplast (Minneapolis, MN, USA), modernized the pump mechanism of their devices. Since the introduction of AMS IPP, three main pump formats have been used : the standard pump has been replaced in 2004 by the \" Tactile \" pump and then the \" Momentary Squeeze \" (MS) pump in 2006, smaller and easier to deflate by not requiring the patient to hold the deflation button throughout deflation. Coloplast also replaced in 2008 their \" Genesis \" pump by a \" One Touch Release \" (OTR) pump, and finally in 2014 by the current \" Touch \" pump, smaller, and presenting a biconcave deflation button, easier to find.\n\nDespite all technological advances, appropriate pre-operative counselling and careful post-operative teachning, a significant part of patients has still difficulties to handle the pump and thus, does not use their IPP, regardless of any material malfunction. That situation obviously leads to patient's dissatisfaction and highlights the operating risks of a useless surgical procedure.\n\nThe purposes of this study were:to identify the risks factors, modifiable and non-modifiable, for patients' difficulty to inflate and\u002For deflate their device after IPP implantation, then to show a correlation between easy handling and post-operative satisfaction. And last but not least, to show an association between pre-operative pump pattern viewing and handling and post-operative easy handling. That information could help the physicians to improve the pre-operative selection of patients and to adapt the peri-operative care in order to improve patients satisfaction.",[30,577,578],"Satisfaction","Penile Prosthesis; Complications",{"date":537,"type":43},{"date":581,"type":43},"2014-01-24",{"date":583,"type":23},"2027-06-25",{"name":585,"class":50},"Centre Hospitalier Universitaire de Nice",{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":4,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":593,"targetDuration":4,"studyType":24,"phases":595,"briefSummary":596,"conditions":597,"keywords":598,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":602,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":4},"100644297","focus-pre-post-study-100644297","NCT07664514","FOCUS Pre-Post Study","Facilitating Goal-based Conversations for Understanding Surgery (FOCUS) Guide: Pre-Post Study","Inclusion Criteria:\n\nFor surgeons\n\n1\\. Surgeons who have regular outpatient clinics at the University of Utah and Huntsman Cancer Institute\n\nFor patients:\n\n1. Age ≥65 years.\n2. Presenting for in-person outpatient consultation regarding major non-urgent surgery with an enrolled surgeon.\n3. Ability to provide informed consent.\n4. English-speaking.\n\nExclusion Criteria:\n\nFor surgeons\n\n1. Surgeons with a predominantly pediatric practice\n2. Transplant surgeons\n\nFor patients\n\n1. Anticipated life expectancy \\\u003C3 months.\n2. Inability to complete study procedures.\n3. Patients presenting for minor procedures or non-operative consultations.\n4. Telehealth consultation\n5. Any clinical, cognitive, communication, or logistical factor that, in the opinion of the treating surgeon or investigator, would substantially interfere with participation or completion of study procedures.",{"count":594,"type":23},180,[95],"The Facilitating Goal-based Conversations for Understanding Surgery (FOCUS) Guide is a communication intervention designed to support discussion and documentation of the goal for surgery during outpatient surgical consultations. The purpose of this study is to assess the efficacy of the FOCUS guide in prompting discussion of the goal for surgery.",[30],[30,599,600],"Goals","Communication guide","2026-06-23",{"date":603,"type":43},"2026-06-26",{"date":605,"type":23},"2026-08-15",{"date":607,"type":23},"2029-05",{"name":609,"class":50},"University of Utah",{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":615,"acronym":4,"eligibilityCriteria":616,"healthyVolunteers":171,"sex":115,"minAge":617,"maxAge":4,"enrollmentInfo":618,"targetDuration":4,"studyType":24,"phases":620,"briefSummary":621,"conditions":622,"keywords":623,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":634,"leadSponsor":636,"locationsCount":637},"100540075","a-study-of-opportunistic-salpingectomy-to-prevent-ovarian-cancer-100540075","NCT06312124","A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer","A Multi-Disciplinary Approach to the Opportunistic Salpingectomy for Primary Prevention of Ovarian Cancer","Inclusion Criteria:\n\nPart I\n\n* Age ≥45 years\n* Scheduled visit with a nongynecologic surgeon\n* Female or assigned female at birth\n\nPart II\n\n* Age ≥45 years\n* At least one in situ fallopian tube\n* No desire or plan to have children in the future\n* Average risk of developing ovarian cancer\n\n  ° Note: Average risk patients are defined as patients with no known genetic risk factor for developing ovarian cancer. Patients who, after obtaining family history, are suspected to have a hereditary ovarian cancer syndrome but have not yet been tested, will be referred for genetic evaluation.\n* Planned nongynecologic, intraabdominal, or pelvic surgery\n* Deemed to be a suitable candidate by gynecologic surgeon and primary nongynecologic surgeon (for example, on the basis of surgical history and current malignancy status)\n* Approved and signed informed consent\n\nExclusion Criteria:\n\nPart I\n\n* Not fluent in English or Spanish\n\n  ° If there is a non-english or non-spanish speaking participant who is a strong candidate and meets all other criteria for Part 2, they are able to go directly onto Part 2 without completing Part 1. (Please see additional details in section 4.1 and 7.0.)\n* Known inherited ovarian cancer susceptibility\n\nPart II\n\n* Personal history of a gynecologic malignancy\n* Carrier of a hereditary breast or ovarian cancer variant (e.g., BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2)\n* Suspicious ovarian, fallopian tube, or uterine lesion on preoperative imaging\n* Previous bilateral salpingectomy or bilateral salpingo-oophorectomy\n* Presence of ESSURE, or other tubal-implanted birth control at the time of surgery\n* Current pregnancy\n* Emergent procedure or emergency procedure that has to be completed within 24 hours where clinical consent occurs in the inpatient setting or where the patient's immediate well-being is in danger or condition may be life threatening\n* Primary surgeon anticipates that OS will add significant time (\\>30-40min) to the planned procedure.\n* Inability to access the pelvis (ex., patient prone\u002Flateral position) during the planned procedure.\n* Known history of pelvic fibrosis or significant adhesions.\n* Procedures with palliative intent only","45 Years",{"count":619,"type":23},266,[95],"The purpose of this study is to find out how many participants are interested in a surgical preventive procedure after watching an educational video. Before and after watching the video, participants will complete questionnaires in the clinic.",[30],[624,625,626,627,628,629],"abdominal surgery","pelvic surgery","Opportunistic Salpingectomy","ovarian cancer prevention","24-006","Memorial Sloan Kettering Cancer Center",{"date":631,"type":43},"2026-06-24",{"date":633,"type":43},"2024-03-08",{"date":635,"type":23},"2028-03-08",{"name":629,"class":50},10,{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":642,"acronym":4,"eligibilityCriteria":643,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":644,"targetDuration":646,"studyType":145,"phases":4,"briefSummary":647,"conditions":648,"keywords":650,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":660,"locationsCount":51},"100577856","postoperative-pain-of-robotic-endoscopic-and-open-lateral-neck-dissection-100577856","NCT06803732","Postoperative Pain of Robotic, Endoscopic and Open Lateral Neck Dissection","Inclusion Criteria:\n\n* Patients underwent lateral neck dissection via robotic, endoscopic or open approach\n* Clinical diagnosis of differentiated thyroid cancer\n* Clinical diagnosis of metastatic lateral lymph nodes\n\nExclusion Criteria:\n\n* Participants with distant metastasis\n* Participants with history of neck surgery or radiation\n* Participants with vocal fold fixation by preoperative fibrolaryngoscope",{"count":645,"type":23},600,"6 Months","Postoperative pain is a good indicator to confirm the advantages of the surgical methods in the era of minimally invasive surgery. Lateral neck dissection requires extensive dissection which may leads to postoperative numbness and pain. Robotic thyroid surgery has the advantage of precise and careful dissection and avoid the L-shape incision in the open approach. The study aims to explore the pain intensity and severity of lateral neck dissection on operation day, postoperative month 1 and postoperative month 3 among the robotic, endoscopic and open approach.",[649,411,30],"Pain, Postoperative",[651,652,653],"Lateral neck dissection","Robotic thyroid surgery","Minimally invasive surgery","2026-06-20",{"date":631,"type":43},{"date":657,"type":43},"2024-11-01",{"date":659,"type":23},"2027-12-31",{"name":428,"class":50}]