[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgical-site-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgical-site-infection":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,38,0,25,[9,71,99,124,148,177,209,231,265,294,319,345,369,400,429,458,489,520,545,567,593,617,641,668,690],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":36,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":70},"100648262","hernia-sac-flap-coverage-of-mesh-in-bony-edged-ventral-hernia-repair-100648262",false,"NCT07720154","Hernia Sac Flap Coverage of Mesh in Bony-Edged Ventral Hernia Repair","Sac-Flap Peritonealization of Mesh in Bony-Edged Ventral Hernias: A Randomized Controlled Trial","PERI-SAC","Inclusion Criteria:\n\n* Age 18 years or older.\n* Elective open repair planned for a complex ventral hernia (primary or incisional) in which at least one margin of the fascial defect is formed by bone - that is, a subxiphoid or costal-margin, suprapubic, or iliac or lumbar location - confirmed on cross-sectional imaging (CT or MRI) and at operation.\n* A hernial sac of sufficient quality and surface area to raise a pedicled flap adequate to cover the planned mesh, as judged at operation.\n* Planned retromuscular (sublay) synthetic mesh repair, with or without posterior component separation (transversus abdominis release).\n* Able to give written informed consent and to attend scheduled follow-up for 12 months.\n\nExclusion Criteria:\n\n* Emergency or urgent operation (incarceration with strangulation, obstruction, or perforation).\n* Active intra-abdominal infection, or a contaminated or dirty operative field (CDC wound class III-IV) at the time of randomization.\n* Planned use of biologic or composite intraperitoneal mesh, or a bridged (non-fascial-closure) repair as the primary plan.\n* Hernial sac absent, destroyed, densely scarred, or too small to raise a viable covering flap.\n* Concurrent bowel resection or stoma creation expected to alter the wound-contamination class.\n* ASA physical status V.\n* Life expectancy less than 12 months, or active malignancy under treatment with anticipated short survival.\n* Pregnancy.\n* Inability or unwillingness to provide informed consent or to comply with follow-up","ALL","18 Years","75 Years",{"count":22,"type":23},180,"ESTIMATED","INTERVENTIONAL",[26],"NA","This trial asks whether covering the inner, bowel-facing surface of a hernia mesh with a flap of the patient's own hernia sac improves healing after repair of a complex ventral (abdominal wall) hernia in which one edge of the defect is bone - for example hernias next to the breastbone and ribs, above the pubic bone, or at the iliac crest.\n\nIn these \"bony-edged\" hernias the mesh is both hardest to fix and hardest to cover. There is no fascia on the bony side for the surgeon to stitch the mesh to, and the lining layer of the abdomen cannot be closed underneath the mesh because the plane that carries it stops at the bone. The mesh may therefore be left in contact with the bowel, which can lead to dense adhesions, mesh erosion, chronic pain and, rarely, a fistula.\n\nNormally the hernia sac - the thin membrane that lines the hernia - is cut away and discarded. In this trial the surgeon instead preserves it as a living, blood-supplied flap, rotates it underneath the mesh, and stitches it in place as a new lining layer that separates the mesh from the bowel and covers the bony edge. The technique uses only the patient's own tissue: no extra mesh, no donor site and no added cost.\n\nOne hundred and eighty adults undergoing planned (non-emergency) open repair of a bony-edged complex ventral hernia will be randomly assigned in equal numbers to one of two groups: standard retromuscular (sublay) mesh repair with the added sac flap (90 participants), or standard retromuscular mesh repair alone, with the sac handled in the conventional way (90 participants). Every other step of the operation is the same in both groups.\n\nThe main question is whether the sac flap reduces the number of participants who develop any wound or mesh problem in the first 30 days after surgery. This is measured as a composite called a surgical site occurrence, which includes wound infection, seroma, haematoma, skin or soft-tissue death, wound breakdown, mesh exposure and fistula. The trial also compares complications needing a drainage or operative procedure, hernia recurrence at 12 months, overall complication severity, operating time, blood loss, hospital stay, readmission, reoperation, pain, quality of life and death.\n\nParticipants, ward and clinic staff, the doctors who assess the wounds, the radiologist who reads the follow-up scans and the trial statistician will not know which operation was performed; only the operating surgeon will. The group assignment is revealed only during the operation, after the surgeon has confirmed that the defect truly has a bony edge and that the sac is suitable for a flap. Participants are followed for 12 months.",[29,30,31,32,33,34,35],"Incisional Hernia","Abdominal Hernia","Complex Ventral Hernia","Surgical Site Infection","Seroma","Postoperative Complications","Ventral Hernia",[37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57],"ventral hernia","incisional hernia","complex abdominal wall reconstruction","bony-edged hernia","subxiphoid hernia","suprapubic hernia","lumbar hernia","iliac crest hernia","hernial sac","sac flap","peritonealization","neo-peritoneum","autologous tissue coverage","retromuscular mesh","sublay mesh repair","transversus abdominis release","posterior component separation","surgical site occurrence","mesh-visceral interface","mesh erosion","hernia recurrence","RECRUITING","2026-08-16",{"date":61,"type":62},"2026-08-18","ACTUAL",{"date":64,"type":62},"2026-08-15",{"date":66,"type":23},"2028-08-15",{"name":68,"class":69},"Minia University","OTHER",1,{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":24,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":70},"100549891","irrisept-solution-for-instrumented-spine-surgery-100549891","NCT06439953","Irrisept Solution for Instrumented Spine Surgery","Impact of Prophylactic Use of Irrisept Irrigation System for Spinal Instrumentation","Inclusion Criteria:\n\n* Age: 18+ years old\n* Indications: deformity, oncologic, degenerative, trauma\n* Standard layer-by-layer closure\n* Locoregional flap-based closure\n\nExclusion Criteria:\n\n* Acute\u002Fchronic open wounds (spine or non-spine)\n* On-going non-spinal infection within 30 days of index operation\n* Concurrent antibiotic use (for spine or non-spine infections)\n* History of prior spinal infection\n* Allergy to vancomycin or chlorhexidine\n* Suspicion for osteomyelitis\n* Other surgery within 90 days post-operatively fromm index\n* Concurrent enrollment in other trial",{"count":79,"type":23},200,[26],"Various spine surgeons perform wound irrigation using saline mixed with vancomycin, relying on mechanical debridement of non-viable tissue, physical disruption of biofilm, and bacteriostatic effect against gram positive flora. When used as a powder, topical application of vancomycin has demonstrated increased risk of symptomatic seroma formation, which is an adverse outcome that often requires bedside or intra-operative aspiration. Broad-spectrum antiseptic agents, such as Irrisept, offer bacteriocidal properties to eliminate hardware inoculation, thereby minimizing the risk of deep space infection, while obviating the risk of seroma development.",[83,84,85,32,86,87,88,89],"Post-Op Complication","Spine Surgery","Site Infection","Spinal Instrumentation","Index Spinal Instrumentation","Layer-by-Layer Closure","Locoregional Flap-Based Closure","2026-08-12",{"date":92,"type":62},"2026-08-14",{"date":94,"type":62},"2024-10-01",{"date":96,"type":23},"2028-04",{"name":98,"class":69},"Rhode Island Hospital",{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":24,"phases":108,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":123},"100484341","phase-4-decolonization-to-reduce-after-surgery-events-of-surgical-site-infection-100484341","NCT05586776","Decolonization to Reduce After-Surgery Events of Surgical Site Infection","DECREASE SSI","Inclusion Criteria:\n\n* 18 years of age or older\n* Recent open (not solely laparoscopic) surgery involving an abdominal incision within the past 14 days. For cesarean section, recruitment restricted to BMI ≥ 40.\n* Able to communicate regularly by phone\n* Able to bathe, shower or have this task performed by a caregiver\n\nExclusion Criteria:\n\n* Transfer to an acute care hospital\n* Discharged to receive end-of-life hospice measures\n* Discharged more than 14 days after surgery\n* Allergic to mupirocin and\u002For chlorhexidine\n* Active infection at enrollment\\*\n\n  \\*Refers to\n  1. Infections requiring systemic antibacterial agents, so viral illness (e.g., COVID, flu) is not an exclusion.\n  2. Topical antibacterial agents do not count toward exclusion (e.g., topical products for acne)\n  3. Prophylactic antibacterial agents do not count toward exclusion\n* Surgical incision not closed at discharge",{"count":107,"type":23},2700,[109],"PHASE4","The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.",[32],[32,113],"SSI","2026-07-17",{"date":116,"type":62},"2026-07-21",{"date":118,"type":62},"2023-01-17",{"date":120,"type":23},"2027-12",{"name":122,"class":69},"University of California, Irvine",4,{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":130,"sex":131,"minAge":4,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":24,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":146,"locationsCount":70},"100647786","effect-of-betadine-vaginal-cleansing-before-cesarean-section-to-reduce-postoperative-infectious-morbidity-100647786","NCT07715409","Effect of Betadine Vaginal Cleansing Before Cesarean Section to Reduce Postoperative Infectious Morbidity","Inclusion Criteria:\n\n\\- Women undergoing elective or emergency cesarean section. Received prophylactic antibiotics before surgery\n\nExclusion Criteria:\n\n* Active infection No prophylactic antibiotics Chorioamnionitis Placenta previa with antepartum hemorrhage",true,"FEMALE",{"count":133,"type":23},600,[26],"This randomized controlled trial aims to evaluate the efficacy of preoperative vaginal cleansing with 5% povidone-iodine in reducing postoperative infectious morbidity among women undergoing cesarean section. The primary outcomes include wound-related complications, while secondary outcomes include postoperative fever, endometritis, wound infection, and white blood cell count.",[137,32,138],"Cesarean Section","Endometritis","NOT_YET_RECRUITING","2026-07-15",{"date":142,"type":62},"2026-07-20",{"date":144,"type":23},"2027-05-01",{"date":144,"type":23},{"name":147,"class":69},"Mohamed Mousa Mohamed Mousa",{"id":149,"slug":150,"hasResults":12,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":24,"phases":157,"briefSummary":158,"conditions":159,"keywords":163,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":176},"100593243","treating-emergency-laparotomy-incisions-with-negative-pressure-wound-therapy-100593243","NCT07003906","Treating Emergency Laparotomy Incisions With Negative Pressure Wound Therapy","TELIN","Inclusion Criteria:\n\n* ≥18 years old\n* Written informed consent\n* \\>10 cm midline incision with primary skin closure\n* Emergency laparotomy\n\nExclusion Criteria:\n\n* Not able to consent (e.g. dementia, impaired cognitive function, unconscious)\n* Subjects not possible to follow up as assessed by the Investigator\n* Allergy to dressing material\n* Pregnancy or breastfeeding (females of childbearing potential)\n* Previous enrolment in the current study\n* Expected reoperation with 28 days of index laparotomy\n* Emergency laparotomy within 3 months",{"count":156,"type":23},720,[26],"The goal of this clinical trial is to investigate Negative Pressure Wound Therapy (NPWT) in adults undergoing emergency laparotomy. The main question it aims to answer is:\n\nDoes NPWT decrease wound complications?\n\nResearchers will compare it against regular dressings to see if NPWT is superior.",[160,161,32,29,162],"Surgical Incision","Wound Dehiscence","Quality of Life",[164,165,166],"emergency surgery","negative pressure wound therapy","randomised controlled trial","2026-07-02",{"date":169,"type":62},"2026-07-07",{"date":171,"type":62},"2025-12-16",{"date":173,"type":23},"2035-12",{"name":175,"class":69},"Uppsala University",6,{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":131,"minAge":19,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":24,"phases":187,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":207,"locationsCount":70},"100646632","steri-strip-application-versus-standard-wound-closure-for-cesarean-section-incisions-100646632","NCT07686913","Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions","A Randomized Prospective Trial Comparing Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions","STRIP-CS","Inclusion Criteria:\n\n* Female patients age 18 years or older\n* Pregnant patients undergoing cesarean delivery at Riverside University Health System Medical Center (RUHS)\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to Steri-Strip™ materials or adhesives\n* Inability or unwillingness to provide informed consent\n* Anticipated inability to complete the 30-day postpartum follow-up evaluation",{"count":186,"type":23},610,[26],"This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery. Steri-Strips are adhesive strips that are commonly placed over a surgical incision to provide support while the wound heals. At our hospital, Steri-Strips are routinely used after C-sections in addition to standard wound closure techniques, although they are not considered part of the standard recommended closure method.\n\nResearchers want to determine whether adding Steri-Strips actually reduces wound complications such as infection, fluid collection under the skin, or reopening of the incision. Previous studies have shown mixed results, with some suggesting little difference in wound healing outcomes while others reported differences in scar appearance. Steri-Strips may also increase costs, add time to the surgery, and occasionally cause skin irritation or allergic reactions.\n\nParticipants in this study will be randomly assigned to one of two groups. One group will receive standard cesarean wound closure with Steri-Strips, while the other group will receive standard wound closure without Steri-Strips. Researchers will compare wound healing, complications, patient outcomes, and costs between the two groups.\n\nThe goal of this study is to determine whether Steri-Strips improve recovery after cesarean delivery and whether their routine use is beneficial and cost-effective. The findings may help guide future recommendations for cesarean wound care and improve outcomes for patients undergoing C-section delivery.",[137,32,161,33],[137,191,192,193,194,195,32,161,33,196,197,198,199,200,201],"Cesarean Delivery","C-Section","Steri-Strips","Skin Closure","Wound Closure","Postoperative Wound Complications","Obstetric Surgery","Incision Management","Surgical Wound Healing","Maternal Morbidity","Randomized Controlled Trial","2026-06-29",{"date":169,"type":62},{"date":205,"type":23},"2026-06",{"date":120,"type":23},{"name":208,"class":69},"Riverside University Health System Medical Center",{"id":210,"slug":211,"hasResults":12,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":130,"sex":131,"minAge":19,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":24,"phases":218,"briefSummary":219,"conditions":220,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":70},"100616883","local-subcutaneous-gentamicin-for-prevention-of-surgical-site-infection-after-elective-cesarean-section-100616883","NCT07311395","Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section","Local Subcutaneous Administration of Gentamicin for the Prevention of Surgical Site Infection Following Elective Cesarean Section: A Randomized Controlled Pilot Study.","Inclusion Criteria:\n\n* Women aged 18 years and older.\n* Undergoing elective cesarean section.\n* Gestational age \\>= 24 weeks.\n* Planned postoperative follow-up of 30 days.\n* Eligible for standard antibiotic prophylaxis according to institutional protocol.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Known allergy of hypersensitivity to aminoglycosides.\n* Known allergy of hypersensitivity to systemic antibiotic prophylaxis agents.\n* Current or planned use of immunomodulatory or immunosuppressive therapy.\n* Requirement for therapeutic ( non- prophylactic) antibiotic treatment at the time of surgery.\n* Active infection or clinical condition requiring antibiotic treatment.\n* Inability or unwillingness to comply with study procedures or follow-up.",{"count":217,"type":23},100,[26],"The goal of this clinical trial is to evaluate whether local subcutaneous administration of gentamicin reduces the incidence of surgical site infection (SSI) following elective cesarean section. The study will also assess the safety of local gentamicin administration. The main questions this study aims to answer are:\n\n* Does local subcutaneous administration of gentamicin reduce the rate of superficial and deep surgical site infections within 30 days after elective cesarean delivery?\n* Are there differences between groups in postoperative complications, including wound healing, fever, need for additional antibiotic treatment, or hospital readmission?\n\nResearchers will compare women who receive local subcutaneous gentamicin at the surgical site in addition to standard antibiotic prophylaxis to women who receive standard antibiotic prophylaxis alone.\n\nParticipants will:\n\n* Undergo an elective cesarean section according to standard clinical practice\n* Receive either local subcutaneous gentamicin administration or no local antibiotic administration, in addition to standard systemic antibiotic prophylaxis\n* Be followed clinically for signs of surgical site infection and other postoperative complications during hospitalization and at follow-up visits up to 30 days after surgery",[32],"2026-06-23",{"date":223,"type":62},"2026-06-26",{"date":225,"type":62},"2025-12-08",{"date":227,"type":23},"2027-01-07",{"name":229,"class":230},"Western Galilee Hospital-Nahariya","OTHER_GOV",{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":238,"enrollmentInfo":239,"targetDuration":241,"studyType":242,"phases":4,"briefSummary":243,"conditions":244,"keywords":249,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":261,"leadSponsor":263,"locationsCount":4},"100626681","post-amputation-stump-infection-as-a-predictor-of-persistent-residual-limb-pain-a-prospective-cohort-study-100626681","NCT07438795","Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study","INF-STUMP-PAIN","Inclusion Criteria:\n\n* Traumatic upper or lower limb amputation\n* Enrollment within 4 weeks after surgery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic pain in the affected limb\n* Severe cognitive impairment\n* Terminal illness limiting follow-up\n* Refusal or inability to complete follow-up assessments","60 Years",{"count":240,"type":23},150,"6 Months","OBSERVATIONAL","Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and long-term pain persistence. This prospective cohort study aims to determine whether early post-amputation stump infection independently predicts persistent clinically significant residual limb pain at 3 and 6 months after surgery.",[245,246,247,32,248],"Residual Limb Pain","Stump Pain","Post-Amputation Pain","Phantom Limb Pain (PLP)",[250,251,252,253,254,255,256],"Traumatic amputation","stump infection","residual limb pain","chronic pain","surgical site infection","blast injury","neuropathic pain","2026-06-01",{"date":259,"type":62},"2026-06-03",{"date":221,"type":23},{"date":262,"type":23},"2026-12-23",{"name":264,"class":69},"Ukrainian Society of Regional Anesthesia and Pain Therapy",{"id":266,"slug":267,"hasResults":12,"nctId":268,"briefTitle":269,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":24,"phases":273,"briefSummary":274,"conditions":275,"keywords":279,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":4},"100631955","phase-4-innovative-sternal-closure-techniques-evaluating-stratafix-and-dermabond-for-reduced-complications-in-cabg-patients-100631955","NCT07507409","Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients","Inclusion Criteria:\n\n\\- Patients aged 18 years and older undergoing CABG surgery.\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the trial.\n* Patients who do not read or speak English.\n* Patient with allergy to surgical adhesives or sutures",{"count":272,"type":23},401,[109],"The goal of this clinical trial is to learn if a new method of closing the breastbone after heart bypass surgery can improve healing and reduce complications in adults undergoing coronary artery bypass graft (CABG) surgery.\n\nThe main questions it aims to answer are:\n\nDoes this new closure method reduce infections and wound reopening? Does it improve healing, recovery, and overall patient outcomes?\n\nResearchers will compare patients who receive the new closure method to past patients who received the standard method to see if outcomes are better.\n\nParticipants will:\n\nReceive the new closure method during their surgery (as part of standard care) Be followed during their normal recovery up to their 6-week follow-up visit Complete a short quality-of-life questionnaire (about 10 minutes) Have their recovery assessed, including healing, complications, and hospital use\n\nResearchers will also look at quality of life, heart complications, hospital readmissions, antibiotic use, scar appearance, and overall costs to understand the full impact of the new method.",[276,32,277,278],"Cardiovascular Disease","Superficial Sternal Wound Infection","Mediastinitis",[280,281,282,283,284],"STRATAFIX","DERMABOND","Sternal Closure","Suture","CABG","2026-04-07",{"date":287,"type":62},"2026-04-13",{"date":289,"type":23},"2026-05-01",{"date":291,"type":23},"2028-05-01",{"name":293,"class":69},"Unity Health Toronto",{"id":295,"slug":296,"hasResults":12,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":301,"enrollmentInfo":302,"targetDuration":4,"studyType":24,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":70},"100582883","chlorhexidine-gluconate-versus-saline-for-flushing-the-surgical-area-during-colorectal-cancer-surgery-100582883","NCT06869096","Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery","A Comparative Study of Chlorhexidine Versus Saline Irrigation of the Surgical Area During Colorectal Cancer Surgery: a Multicenter, Stratified Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients aged 18-85 years,\n2. Patients with surgically resectable colorectal tumors confirmed by CT\u002FMRI before surgery\n3. All patients had a performance status score of 0 or 1 in the Eastern Tumor Cooperative group\n4. American Society of Anesthesiology grade I-III\n\nExclusion Criteria:\n\n1. The tumor may have distant metastasis\n2. History of previous abdominal surgery\n3. The patient has a history of other malignant tumors diagnosed in the past 5 years and has received radiotherapy and chemotherapy in the past\n4. There are obvious contraindications to surgery (obvious abnormal liver and kidney function, pregnancy)\n5. Participated in other clinical trials within the past 6 months","85 Years",{"count":303,"type":23},532,[26],"The aim of this study was to compare the effectiveness of chlorhexidine versus saline in flushing the surgical area during colorectal cancer surgery. The primary outcomes included surgical site infection, postoperative complication rates, et al.",[307,32,308,309],"Colorectal Cancer","Chlorhexidine","Complications","2026-03-29",{"date":312,"type":62},"2026-03-31",{"date":314,"type":62},"2024-07-02",{"date":316,"type":23},"2026-12-31",{"name":318,"class":230},"Nanchong Central Hospital",{"id":320,"slug":321,"hasResults":12,"nctId":322,"briefTitle":323,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":325,"targetDuration":4,"studyType":24,"phases":327,"briefSummary":328,"conditions":329,"keywords":334,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":343,"locationsCount":70},"100631531","investigating-the-impact-of-cold-atmospheric-plasma-treatment-on-wound-healing-at-cannulation-sites-in-patients-following-extracorporeal-life-support-100631531","NCT07501897","Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Receiving extracorporeal life support (ECLS)\n* Presence of cannulation site wound requiring wound care\n\nExclusion Criteria:\n\n* Pre-existing severe dermatological conditions at the cannulation site\n* Severe coagulopathy precluding local intervention\n* Concurrent receipt of other experimental wound treatments\n* Life expectancy \\\u003C 48 hours",{"count":326,"type":23},65,[26],"This study aims to evaluate a new wound treatment called cold atmospheric plasma (CAP) for patients receiving extracorporeal life support (ECLS). Patients on extracorporeal life support (ECLS) often develop wounds at the sites where tubes are inserted, and these wounds can be difficult to heal and prone to infection.\n\ncold atmospheric plasma (CAP) is a gentle, non-heat treatment that can kill bacteria, reduce inflammation, and promote wound healing. In this study, patients will be randomly assigned to receive either standard wound care alone or standard care plus cold atmospheric plasma (CAP) treatment.\n\nResearchers will compare both groups to see whether cold atmospheric plasma (CAP) can reduce infection, improve healing speed, and decrease the need for additional procedures. The study will also monitor safety to ensure the treatment is well tolerated.\n\nThe goal is to find a more effective and safe way to improve wound healing in critically ill patients.",[330,331,32,332,333],"ExtraCorporeal Life Support (ECLS)","Wound Infection","Delayed Wound Healing","Biofilm-Associated Infection",[335,336],"Extracorporeal Life Support","cold atmospheric plasma","2026-03-25",{"date":339,"type":62},"2026-03-30",{"date":341,"type":62},"2026-03-12",{"date":316,"type":23},{"name":344,"class":69},"National Taiwan University Hospital",{"id":346,"slug":347,"hasResults":12,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":351,"eligibilityCriteria":352,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":353,"targetDuration":4,"studyType":24,"phases":355,"briefSummary":356,"conditions":357,"keywords":358,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":368},"100473643","phase-4-duration-of-cardiac-antimicrobial-prophylaxis-outcomes-study-100473643","NCT05447559","Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study","Multicentre, Adaptive, Double-blind, Three-arm, Placebo-controlled, Noninferiority Trial Examining Antimicrobial Prophylaxis Duration in Cardiac Surgery","CALIPSO","Inclusion Criteria:\n\n\\- Adult patients undergoing cardiac surgery involving a median sternotomy\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* American Society of Anesthesiology (ASA) 5\n* Subjects with GFR \\\u003C40mL\u002Fmin\u002F1.73m2 or those requiring continuous renal replacement therapy, haemodialysis or peritoneal dialysis\n* Surgery for suspected or proven endocarditis or deep sternal wound infection\n* Documented cefazolin hypersensitivity\n* Documented methicillin resistant Staphylococcus aureus (MRSA) colonisation or infection in the 12-months prior to index surgery\n* Cardiac transplantation\n* Procedures involving insertion ventricular assist device or mechanical circulatory support device\n* Procedures not involving a median sternotomy\n* Patients previously enrolled and randomised to the CALIPSO trial",{"count":354,"type":23},9180,[109],"This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections, health economic and microbiological impact after intraoperative only (Arm A), to 24 hours (Arm B) and, to 48 hours (Arm C) of IV cefazolin and placebo postoperative surgical antimicrobial prophylaxis in patients undergoing cardiac surgery",[32],[359],"Cardiac surgery","2026-03-22",{"date":337,"type":62},{"date":363,"type":62},"2023-02-07",{"date":365,"type":23},"2028-06",{"name":367,"class":69},"Monash University",27,{"id":370,"slug":371,"hasResults":12,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":375,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":377,"targetDuration":379,"studyType":242,"phases":4,"briefSummary":380,"conditions":381,"keywords":382,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":123},"100513553","novosyn-chd-vs-polyglactin-910-suture-to-close-wounds-after-emergency-or-elective-laparotomy-or-laparoscopic-surgery-100513553","NCT05966961","Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery","'All Comer'\u002F'Real-world' Registry-based Randomized, Prospective, Multicenter Clinical Trial to Evaluate the Incidence of Complications Using Novosyn® CHD Suture Versus Polyglactin 910 Suture to Close the Wound After Emergency or Elective Laparotomy or Laparoscopic Surgery","POLYNOVO-CHD","Inclusion Criteria:\n\n* Patients undergoing an emergency or elective laparotomy or laparoscopic surgery.\n* Written informed consent\n* Age≥ 18 years\n* Not incapacitated patient\n\nExclusion Criteria:\n\n* No exclusion criteria except patients with allergy or hypersensitivity to chlorhexidine",{"count":378,"type":23},2998,"30 Days","The aim of the study is to elucidate, if the colonization of bacteria is lower on the Novosyn® CHD suture compared to uncoated Polyglactin 910 suture, which will be assessed by the incidence of surgical site infections (SSI: A1 and A2). The results of this registry will generate further clinical evidence for the use and the benefit of a Chlorhexidine coated suture used to close the wound after an emergency or elective laparoscopic or laparotomy surgery. The benefit for individual patients lies in the early diagnosis of complications and in the optimized postoperative controls of a clinical study.",[32],[383,384,385,386,387,388,389],"Chlorhexidine coated suture","emergency laparoscopic surgery","emergency laparotomy surgery","elective laparoscopic surgery","elective laparotomy surgery","Novosyn®","Polyglactin 910","2026-03-05",{"date":392,"type":62},"2026-03-06",{"date":394,"type":62},"2023-09-18",{"date":396,"type":23},"2028-12",{"name":398,"class":399},"Aesculap AG","INDUSTRY",{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":404,"acronym":405,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":407,"targetDuration":4,"studyType":24,"phases":408,"briefSummary":409,"conditions":410,"keywords":413,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":70},"100418223","studying-how-outpatient-water-affects-risks-with-drains-shower-study-100418223","NCT04725916","Studying How Outpatient Water affEcts Risks With Drains (SHOWER Study)","SHOWER","Inclusion Criteria:\n\n* Patients having one of the following procedures at Geisinger Medical Center in which drains are placed\n\n  * Breast reduction\n  * Lower panniculectomy\n  * Fleur-de-lis panniculectomy\n* ≥18 years of age\n* Able and willing to provide consent\n\nExclusion Criteria:\n\n* Patients on antibiotics at the time of surgery\n* Patients sent home on antibiotics after surgery\n* Patients who work in healthcare with direct patient contact\n* Patients having a panniculectomy to be eligible for a kidney transplant\n* Patients having a ventral hernia repair at the time of the panniculectomy\n* Patients admitted to the hospital for \\>1 night",{"count":217,"type":23},[26],"This is a prospective randomized, controlled, unblinded, interventional feasibility study to evaluate if showering with post operative drains in place leads to an increase in complications. The patients included in the study will be those undergoing breast reductions and panniculectomies at Geisinger Medical Center. The patients will be randomized post operatively into one of two groups: 1) patients instructed to shower with drains in place, and 2) patients instructed not to shower while they have drains in place.",[411,34,32,412],"Postoperative Wound Infection","Drain Site Complication",[414,415,416,417,418,419],"Panniculectomy","Breast reduction surgery","Postoperative showering","Surgical drain","Fleur-de-lis panniculectomy","Massive weight loss surgery","2026-02-18",{"date":422,"type":62},"2026-02-20",{"date":424,"type":62},"2022-02-23",{"date":426,"type":23},"2027-07-15",{"name":428,"class":69},"Sean Devitt",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":436,"enrollmentInfo":437,"targetDuration":4,"studyType":24,"phases":439,"briefSummary":440,"conditions":441,"keywords":444,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":70},"100619601","prevention-of-surgical-site-infection-in-open-paediatric-groin-surgeries-using-intravenous-prophylactic-antibiotics-and-antimicrobial-coated-sutures-100619601","NCT07346742","Prevention of Surgical Site Infection in Open Paediatric Groin Surgeries Using Intravenous Prophylactic Antibiotics and Antimicrobial-coated Sutures","Intravenous Prophylactic Antibiotics and Antimicrobial-Coated Sutures in Preventing Surgical Site Infection in Open Paediatric Groin Surgeries: A 3-arm Randomized Controlled Trial","Inclusion Criteria:\n\n* All patients with clinical conditions requiring daycase open groin surgery\n\nExclusion Criteria:\n\n1. Re-operations\n2. Immunocompromised patients\n3. Malnourished patients\n4. Complicated groin pathologies e,g obstructed inguinal hernia\n5. History of antibiotic usage in the last seven days","15 Years",{"count":438,"type":23},174,[26],"The goal of this clinical trial is to learn if the use of prophylactic antibiotics and antimicrobial-coated sutures can prevent surgical site infection in children undergoing open groin surgeries. The main question it aims to answer is:\n\n• Does the use of intravenous prophylactic antibiotics or antimicrobial-coated sutures significantly reduce the occurrence of surgical site infection in children undergoing open groin surgeries?\n\nResearchers will compare no antibiotic use to the use of intravenous prophylactic antibiotics, or antimicrobial-coated sutures to see if the use of intravenous prophylactic antibiotics and antimicrobial-coated sutures significantly reduces the occurrence of surgical site infection following open groin surgeries in children.\n\nParticipants will:\n\n* Undergo open groin surgery with either the use of intravenous prophylactic antibiotic or antimicrobial-coated sutures or without antibiotic use\n* Visit the clinic on postoperative days 5, 13 and 30 for review of the surgical wounds for any sign of infection.",[442,443,32],"Inguinal Hernia","Hydroceles",[445,446,447,448],"Paediatric groin surgeries","Intravenous prophylactic antibiotics","Antimicrobial-coated sutures","Double blinded randomized controlled trial","2026-01-08",{"date":451,"type":62},"2026-01-16",{"date":453,"type":62},"2025-03-09",{"date":455,"type":23},"2026-02-27",{"name":457,"class":69},"Olawumi Olajide",{"id":459,"slug":460,"hasResults":12,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":465,"enrollmentInfo":466,"targetDuration":4,"studyType":24,"phases":468,"briefSummary":470,"conditions":471,"keywords":472,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":70},"100544053","phase-3-diluted-aqueous-povidone-iodine-compared-to-saline-to-decrease-surgical-site-infections-100544053","NCT06363877","Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections","Wound Irrigation and Peritoneal Lavage With Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections","Inclusion Criteria:\n\n* 18 to 80 years of age\n* undergoing an exploratory laparotomy for Centers for Disease Control class II and III wounds\n\nExclusion Criteria:\n\n* Pregnancy\n* Preoperative abdominal wall skin\u002Fsoft tissue infection\n* Iodine allergy\n* Patients unlikely to survive beyond 30 days\n* Patients with mesh placement or placement of a foreign body except for drains","80 Years",{"count":467,"type":23},1100,[469],"PHASE3","This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.",[32],[473,474,475,476,477,478,479],"Intraoperative Wound Irrigation","Intraoperative Peritoneal Lavage","Povidone-Iodine","Normal Saline","Exploratory Laparotomy","Clean Contaminated Wounds","Contaminated Wounds","2025-11-17",{"date":482,"type":62},"2025-11-19",{"date":484,"type":62},"2024-06-03",{"date":486,"type":23},"2026-11",{"name":488,"class":69},"Loma Linda University",{"id":490,"slug":491,"hasResults":12,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":495,"eligibilityCriteria":496,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":497,"targetDuration":4,"studyType":24,"phases":499,"briefSummary":500,"conditions":501,"keywords":504,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":515,"completionDateStruct":516,"leadSponsor":518,"locationsCount":123},"100606827","phase-4-gut-decolonisation-with-neomycinmetronidazole-or-rifaximin-before-colon-surgery-100606827","NCT07180615","Gut Decolonisation With Neomycin\u002FMetronidazole or Rifaximin Before Colon Surgery","Neomycine\u002FMetronidazole- vs Rifaximin-based Gut Decolonisation Prior to Colon Surgery: a Randomized Multicenter Trial","NeoRiDe","Inclusion Criteria:\n\n* aged ≥ 18 years\n* undergoind planned colon surgery\n* colon surgery will be included in Swissnoso SSI surveillance\n* informed consent\n\nExclusion Criteria:\n\n* contraindications and\u002For intolerance to one of the study compounds\n* patients with underlying active infection (wound contamination class IV) at the timepoint of incision\n* pregnant women\n* unable to follow study protocol",{"count":498,"type":23},458,[109],"The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery. The study includes adult patients who will have colon surgery.\n\nThe main question it aims to answer are:\n\n-Does the Rifaximin treatment prevent surgical site infections as well as the Neomycin\u002FMetronidazole treatment?\n\nOther things the study will look at:\n\n* How often infections happen, stratified on how deep they are, the type of surgery the patients got, or if bowel cleaning was done before surgery.\n* How many people will die after surgery\n* How long people stay in hospital\n\nParticipants will:\n\n* Take either Rifaximin or Neomycin\u002FMetronidazole one day before surgery to clean their gut\n* Keep a diary until the surgery to record medication intake and any side effects\n* Be contacted by phone 30 days after surgery to ask about their condition and any side effects,",[32,502,503],"Colon Surgery","Surgical Site Infections",[113,254,505,506,507,508,509,510,511],"Metronidazol","flagyl","neomycine","rifaximin","colon surgery","antibiotics","preoperative decolonisation","2025-09-11",{"date":514,"type":62},"2025-09-18",{"date":257,"type":23},{"date":517,"type":23},"2029-06-30",{"name":519,"class":69},"Universität Luzern",{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":526,"eligibilityCriteria":527,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":528,"targetDuration":4,"studyType":242,"phases":4,"briefSummary":530,"conditions":531,"keywords":532,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":70},"100602987","ai-algorithm-for-surveillance-of-deep-surgical-site-infections-after-elective-colorectal-surgery-100602987","NCT07130656","AI Algorithm for Surveillance of Deep Surgical Site Infections After Elective Colorectal Surgery.","A Novel AI Algorithm With Enhanced Accuracy for Surveillance of Deep Surgical Site Infections After Elective Colorectal Surgery. A Diagnostic Accuracy Study.","Infect-IA-2","Inclusion Criteria:\n\n* Elective colorectal resection\n\nExclusion Criteria:\n\n* Emergency surgery\n* Infection present at operation\n* Previous intestinal stoma",{"count":529,"type":23},1200,"Epidemiological surveillance is one of the eight core components of the World Health Organization Infection Prevention and Control Programmes. These include surveillance programmes for surgical site infection (SSI).\n\nAt present, for SSI surveillance, infection control teams perform a manual time-consuming work, which could make a transition to automated surveillance leveraging the new information technology.\n\nThe aim of this study was to evaluate the performance of a novel algorithm to detect SSI in a cohort of elective colorectal surgery patients who have been previously screened within a nationwide healthcare-associated infection surveillance system.",[32],[32,533,534,535],"Surveillance","Articicial inteligence","Algorithms","2025-08-19",{"date":538,"type":62},"2025-08-24",{"date":540,"type":62},"2025-01-15",{"date":542,"type":23},"2025-10-30",{"name":544,"class":69},"Hospital de Granollers",{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":551,"eligibilityCriteria":527,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":552,"targetDuration":4,"studyType":242,"phases":4,"briefSummary":553,"conditions":554,"keywords":555,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":564,"leadSponsor":566,"locationsCount":70},"100564224","chatgpt-4-for-surgical-site-infection-detection-from-electronic-health-records-after-colorectal-surgery-100564224","NCT06626399","ChatGPT-4 for Surgical Site Infection Detection From Electronic Health Records After Colorectal Surgery.","Evaluation of ChatGPT-4 for the Detection of Surgical Site Infections From Electronic Health Records After Colorectal Surgery: A Diagnostic Accuracy Study.","Infect-IA-3",{"count":467,"type":23},"Epidemiological surveillance is one of the eight core components of the World Health Organization Infection Prevention and Control Programmes. These include surveillance programmes for surgical site infection (SSI).\n\nAt present, for SSI surveillance, infection control teams perform a manual time-consuming work, which could make a transition to automated surveillance leveraging the new information technology.\n\nThis study aimed to evaluate the ability of ChatGPT-4o to detect surgical site infection at the three anatomical levels.",[32],[556,533,557,558,559],"Surgical site infection","ChatGPT","Natural language processing","Artificial inteligence","2025-08-12",{"date":562,"type":62},"2025-08-15",{"date":540,"type":62},{"date":565,"type":23},"2025-11-30",{"name":544,"class":69},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":130,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":24,"phases":576,"briefSummary":578,"conditions":579,"keywords":584,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":70},"100328836","early-phase-1-zinc-oxide-versus-petrolatum-following-skin-surgery-100328836","NCT03561376","Zinc Oxide Versus Petrolatum Following Skin Surgery","Zinc Oxide Versus Petrolatum Following Skin Surgery: A Head-to-head, Prospective, Split-scar Study","Inclusion Criteria:\n\n1. ≥ 18 years of age\n2. Linear closure, non-scalp site\n3. ≥ 4.5 cm in length (final incision\u002Fclosure length)\n4. End to end symmetry (surgical site is not grossly asymmetric from end to end)\n5. Grossly uninfected site\n\nExclusion Criteria:\n\n1. ≤ 18 years\n2. Visibly asymmetric linear scar\n3. Grossly infected surgical site\n4. History of allergy to topical zinc oxide",{"count":575,"type":23},30,[577],"EARLY_PHASE1","Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale (POSAS), a quantitative objective assessment of scar appearance. Trained observers (board-certified dermatologists) will score the observer portion of the scale. POSAS outcomes, post-operative infections, linear density of epidermal seal will be assessed at the 1 week, 4 weeks, 8 weeks, and 6 months post-operative periods and compared between the two groups. Participants will have parking validated for all visits and upon completion of all portions of the study will receive a standardized skin care gift bag containing samples for hypoallergenic skin care products (washes, moisturizers, etc.).",[160,580,581,32,582,583],"Surgery--Complications","Surgical Wound","Scar","Hypertrophic Scar",[582],{"date":586,"type":62},"2025-08-14",{"date":588,"type":62},"2021-09-01",{"date":590,"type":23},"2026-10-30",{"name":592,"class":69},"Melissa Pugliano-Mauro",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":4,"eligibilityCriteria":599,"healthyVolunteers":130,"sex":131,"minAge":19,"maxAge":4,"enrollmentInfo":600,"targetDuration":4,"studyType":24,"phases":602,"briefSummary":603,"conditions":604,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":70},"100566031","a-novel-surgical-irrigation-solution-in-post-mastectomy-reconstruction-evaluating-xperience-100566031","NCT06649890","A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™","A Randomized Control Trial Evaluating the Efficacy of Xperience™ Surgical Irrigation Solution Versus Dilute Povidone-Iodine in Preventing Surgical Site Infections and Improving Postoperative Outcomes in Implant-Based Breast Reconstruction","Inclusion Criteria:\n\n* Older than 18 years old\n* Willing to comply with all study-related procedures\n* Available for the duration of the study\n* Participants undergoing double mastectomy surgery followed by one of the following: (1) Immediate reconstruction with tissue expander placement, (2) Delayed reconstruction with tissue expander or implant placement, (3) Immediate reconstruction with implant placement, (4) Second-stage reconstruction with tissue expander to implant exchange\n\nExclusion Criteria:\n\n* Participants unable to participate in follow-up visits\n* Participants undergoing unilateral mastectomy\n* Tissue expanders placed by a surgeon outside of the UNC Chapel Hill Hospital System\n* Undergoing autologous reconstruction\n* Participant is unable to provide signed and dated informed consent\n* Unwilling or unable to comply with all study-related procedures.\n* Known history of sensitivity or allergic reaction to any of the components of the Xperience™ irrigation solution or dilute povidone-iodine irrigation\n* Participant with any conditions that would be a contraindication to receiving surgery such as contraindications to general anesthesia\n* Pregnant, planning to become pregnant or breast feeding participants\n* Individuals providing informed consent with any mental impairment or condition that would make them unable to properly consent without use of legally authorized representative (LAR) or additional participant protections.\n* Incarcerated participants",{"count":601,"type":23},224,[26],"Goal of the Clinical Trial:\n\nThe purpose of this clinical trial is to learn whether Xperience™ surgical irrigation solution is more effective than a standard dilute povidone-iodine solution in reducing surgical site infections (SSIs) following implant-based breast reconstruction in female patients, aged 18 and older. It will also assess the safety and overall surgical outcomes when using Xperience™ compared to povidone-iodine.\n\nMain Questions the Study Aims to Answer:\n\n* Does the use of Xperience™ decrease the incidence of surgical site infections compared to povidone-iodine?\n* What are the differences in the rates of premature implant removal due to infection between patients treated with Xperience™ and those treated with povidone-iodine?\n* Are there fewer post-surgical complications with Xperience™ compared to povidone-iodine?\n\nStudy Design:\n\nParticipants in this study will be randomly assigned to receive either Xperience™ or a dilute povidone-iodine solution during their bilateral implant-based breast reconstruction. Only the research team will know which irrgiation is given- the participant will not know.\n\nParticipant Will:\n\n* Undergo the surgical procedure using one of the two irrigation solutions.\n* Receive regular post-operative check-ups to monitor for signs of infection and other complications.\n* Have data collected on any post-surgical complications, the necessity for early implant removal, and overall surgical outcomes.",[32,605,606,607],"Surgical Complication","Implant Infection","Implant Complication","2025-08-06",{"date":610,"type":62},"2025-08-07",{"date":612,"type":62},"2025-06-30",{"date":614,"type":23},"2028-06-30",{"name":616,"class":69},"University of North Carolina, Chapel Hill",{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":4,"eligibilityCriteria":623,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":238,"enrollmentInfo":624,"targetDuration":4,"studyType":24,"phases":625,"briefSummary":627,"conditions":628,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":70},"100515275","phase-2-outcomes-of-high-volume-saline-irrigation-vs-povidone-iodine-solution-cleaning-of-iowi-in-preventing-ssis-in-emergency-laparotomies-100515275","NCT05989386","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of Intraoperative Incision Wound in Preventing Surgical Site Infections in Emergency Laparotomies: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi\n\n  * The age of patients should be between 18-60 years old.\n\nExclusion Criteria:\n\n* Diabetic patients\n* Immune-suppressed patients\n* Patients taking steroids\n* Patients undergoing chemo-radiotherapy.\n* Pregnant females\n* Previous abdominal surgery within the last 30 days.\n* Presence of concurrent abdominal wall infections.\n* Trauma Laparotomies\n* Large Bowel perforations",{"count":79,"type":23},[626,469],"PHASE2","The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients undergoing emergency laparotomies. The main question it aims to answer are:\n\n* Incidence of SSI after intervention\n* Length of hospital stay\n\nParticipants will be randomly assigned to two groups receiving either of the two groups:\n\nGroup A: 1000ml of IOWI with saline solution prior to incision closure Group B: The incisional wound will be closed conventionally without irrigation.\n\nResearchers will compare groups A( experimental group) and B (control group) to compare the incidence of superficial surgical site infections after intervention.",[32,581,160,629,630,631,331,33],"Emergency Laparotomies","Laparotomies","Post Operative Wound Infection","2025-06-14",{"date":634,"type":62},"2025-06-18",{"date":636,"type":62},"2023-04-29",{"date":638,"type":23},"2025-12-29",{"name":640,"class":69},"Dow University of Health Sciences",{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":4,"eligibilityCriteria":647,"healthyVolunteers":130,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":648,"targetDuration":4,"studyType":24,"phases":650,"briefSummary":651,"conditions":652,"keywords":655,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":70},"100539863","phase-4-ostomy-primary-closure-with-01-betainepolyhexanide-wound-irrigation-compared-to-pursestring-closure-100539863","NCT06309368","Ostomy Primary Closure With 0.1% Betaine\u002FPolyhexanide Wound Irrigation Compared to Pursestring Closure","To Close or Not to Close: Surgical Site Infection Rates in Ostomy Primary Closure With 0.1% Betaine\u002FPolyhexanide Wound Irrigation Compared to Conventional Ostomy Closure by Secondary Intention","Inclusion Criteria:\n\n* All patients 18 years or older with an diverting loop ileostomy reversal indication will be enrolled\n* Signed consent\n\nExclusion Criteria:\n\n* Under 18 years old, unable to provide consent, has a parastomal hernia requiring mesh repair, or has an end ileostomy",{"count":649,"type":23},84,[109],"The goal of this clinical trial is to compare two types of closure in patients with ostomies that are ready for closure. The main questions it aims to answer are:\n\n1. Surgical site infection rates\n2. Patient quality of life\n3. Time to wound healing\n\nParticipants will undergo either complete ostomy wound closure after washing out the wound with Prontosan, or their ostomy wound will be closed using the Pursestring method, where the wound will be left partially open and allowed to heal from the inside out. Researchers will compare these two groups' outcomes (questions to be answered) as listed above.",[32,653,654],"Wound Surgical","Colorectal Disorders",[656,32,657,658],"Ostomy","Primary Closure","Secondary Closure","2025-05-27",{"date":661,"type":62},"2025-06-02",{"date":663,"type":62},"2024-03-14",{"date":665,"type":23},"2029-12",{"name":667,"class":69},"University of Nevada, Las Vegas",{"id":669,"slug":670,"hasResults":12,"nctId":671,"briefTitle":672,"officialTitle":673,"acronym":674,"eligibilityCriteria":675,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":676,"targetDuration":4,"studyType":24,"phases":678,"briefSummary":679,"conditions":680,"keywords":4,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":688,"locationsCount":70},"100586804","phase-4-prevention-of-trauma-related-infections-through-an-embedded-clinical-trials-network-100586804","NCT06920147","PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network","PRevention Of Trauma-related Infections Through an Embedded Clinical Trials (PROTECT) Network","PROTECT","Inclusion Criteria:\n\n* Trauma laparotomy within 90 minutes of arrival\n\nExclusion Criteria:\n\n* Patients with a known allergy to cephalosporins or β-lactamase inhibitors\n* Prisoners\n* Pregnant and lactating women",{"count":677,"type":23},300,[109],"The purpose of this study is to compare the effectiveness of 2 prophylactic antibiotic regimens, ertapenem and cefazolin with metronidazole, in preventing organ space surgical site infections (OS-SSI) after emergency trauma laparotomy embedded into routine clinical care and to validate a Bayesian OS-SSI risk calculator using Trauma Quality Improvement Program (TQIP) standardized variables",[32],"2025-04-08",{"date":683,"type":62},"2025-04-11",{"date":685,"type":23},"2025-05-01",{"date":687,"type":23},"2027-03-31",{"name":689,"class":69},"The University of Texas Health Science Center, Houston",{"id":691,"slug":692,"hasResults":12,"nctId":693,"briefTitle":694,"officialTitle":695,"acronym":4,"eligibilityCriteria":696,"healthyVolunteers":130,"sex":131,"minAge":4,"maxAge":4,"enrollmentInfo":697,"targetDuration":4,"studyType":24,"phases":698,"briefSummary":699,"conditions":700,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":701,"lastUpdatePostDateStruct":702,"startDateStruct":704,"completionDateStruct":706,"leadSponsor":708,"locationsCount":70},"100550987","subcutaneous-lavage-in-cesarean-section-100550987","NCT06454227","Subcutaneous Lavage in Cesarean Section","Antiseptic Washing Prior to Skin Closure During Cesarean Delivery- a Randomized Control Trial","Inclusion Criteria:\n\n* pregnant women undergoing cesarean delivery\n\nExclusion Criteria:\n\n* pregnant women undergoing vaginal delivery",{"count":133,"type":23},[26],"The goal of this clinical trial is to learn if antiseptic washing prior to skin closure during cesarean section reduces rates of surgical site infection.\n\nintraoperative washing is a common practice in other surgical fields and several studies have shown efficacy in reducing postoperative infection rates. no randomized control trial has tested this intervention during cesarean section.\n\nThe main questions we aim to answer are:\n\nDoes subcutaneous antiseptic washing reduce the rates of surgical site infection? Does antiseptic washing improve scar healing? Does antiseptic washing reduce hospital stay, postpartum fever rates and readmission cases?\n\nResearchers will compare subcutaneous antiseptic washing to no intervention to see if surgical site infection rates reduce\n\nParticipants will:\n\nconsent to participate in the trial Visit the postpartum clinic 30 days after surgery",[32],"2025-03-17",{"date":703,"type":62},"2025-03-19",{"date":705,"type":62},"2024-09-22",{"date":707,"type":23},"2028-12-01",{"name":709,"class":69},"Hadassah Medical Organization"]