[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"symptomatic-bradycardia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:symptomatic-bradycardia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100652153","pace-cognition-proof-of-concept-study-100652153",false,"NCT07769424","PACE Cognition Proof-of-Concept Study","Impact of Physiologic Pacemaker Programming on Cognitive Function and Health Status in Patients With Symptomatic Bradycardia","Inclusion Criteria:\n\n\\- Patient requiring a pacemaker for bradycardia\n\nExclusion Criteria:\n\n* Vulnerable adult unable to give consent\n* Unable to answer questionnaire\n* Children\n* Pregnant women\u002Fpersons\n* Prisoners\n* Adults lacking capacity to consent or adults with diminished or fluctuating capacity to consent\n* Non-English speakers\n* Individuals unable to read\n* Employees or students of the researcher\n* Active members of the military or DoD personnel","ALL","18 Years",{"count":19,"type":20},110,"ESTIMATED","INTERVENTIONAL",[23],"NA","This proof-of-concept study will evaluate whether physiologic pacemaker programming improves cognitive function and health status in patients with symptomatic bradycardia who require permanent pacemaker implantation.\n\nParticipants will be randomized to either standard pacemaker programming at 60 beats per minute or individualized physiologic rate pacing between 60 and 90 beats per minute using the myPACE algorithm. Cognitive function and health status will be assessed before pacemaker implantation and again at the routine 3-month pacemaker clinic visit.\n\nThe primary outcome is change in Montreal Cognitive Assessment total score. The secondary outcome is change in SF-36 mental component summary score.",[26,27,28,29],"Symptomatic Bradycardia","Cognitive Function","Pacemaker","Health Status",[31,32,33,34,35],"PACE Cognition","Symptomatic bradycardia","Physiologic pacing","Pacemaker programming","myPACE algorithm","NOT_YET_RECRUITING","2026-08-17",{"date":39,"type":40},"2026-08-19","ACTUAL",{"date":42,"type":20},"2026-10-01",{"date":44,"type":20},"2028-10-01",{"name":46,"class":47},"University of Minnesota","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100628956","basic-and-clinical-study-of-cardiac-ganglion-catheter-ablation-for-the-treatment-of-significant-bradycardia-100628956","NCT07468383","Basic and Clinical Study of Cardiac Ganglion Catheter Ablation for the Treatment of Significant Bradycardia","Inclusion Criteria:\n\n1. Age range: 18 - 65 years old\n2. Have symptoms related to bradycardia (syncope, dizziness, blackout, palpitations, fatigue, listlessness, inability to concentrate and decreased activity endurance, etc.)\n3. Meet one of the following conditions: ①Dynamic electrocardiogram shows an average heart rate of less than 50 beats per minute or there is a heart arrest lasting more than 3 seconds during the day; ②Transient second or third degree atrioventricular conduction block without hemodynamic disorders during the day\n4. The atropine test showed that the sinus heart rate increased by ≥ 25%, or the heart rate was ≥ 90 beats per minute, or the atrioventricular conduction block was significantly improved to be no more than first-degree atrioventricular conduction block.\n\nExclusion Criteria:\n\n1. A history of severe trauma caused by bradycardia\n2. Regular use of antiarrhythmic drugs within the past 3 months\n3. Prior implantation of a cardiac pacemaker\n4. Existing implantation of, or indication for implantation of, electronic devices with pacing function, such as cardiac contractility modulators (CCMs), implantable cardioverter-defibrillators (ICDs), or cardiac resynchronization therapy (CRT) devices\n5. Bradycardia or atrioventricular block caused by medications or other reversible factors (e.g., hyperkalemia, hypothyroidism)\n6. Bradycardia or atrioventricular block associated with obstructive sleep apnea syndrome (OSAS)\n7. Coronary revascularization within the past 3 months, or unstable coronary heart disease despite standardized medical treatment or revascularization\n8. Stroke or transient ischemic attack (TIA) within the past 3 months\n9. A history of open-heart surgery\n10. Severe congenital heart disease\n11. Complicated with severe ventricular arrhythmia\n12. Severe cardiac insufficiency with left ventricular ejection fraction (LVEF) ≤ 35%\n13. Severe cardiomyopathy, such as hypertrophic obstructive cardiomyopathy (HOCM), dilated cardiomyopathy (DCM), or cardiac amyloidosis\n14. Severe aortic or mitral valve stenosis\n15. Pregnancy or lactation period\n16. Expected survival time of less than 1 year\n17. Refusal to sign the informed consent form\n18. Other conditions deemed ineligible by the researchers","65 Years",{"count":56,"type":20},188,[23],"This study adopts a strategy combining basic research with clinical investigation to systematically explore the therapeutic value of cardioneuroablation in the treatment of vagally-mediated bradycardia. The study design fully considers the complexity of the scientific question and the feasibility of clinical translation. Through rigorous experimental design and standardized operational procedures, the reliability and reproducibility of the study results are ensured.",[26,60],"Autonomic Nervous System Diseases",[62,26,63,64],"cardioneuroablation","Efficacy","Safety","RECRUITING","2026-03-11",{"date":68,"type":40},"2026-03-13",{"date":70,"type":40},"2025-08-01",{"date":72,"type":20},"2028-07-31",{"name":74,"class":47},"Beijing Anzhen Hospital",1]