[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tbi-traumatic-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tbi-traumatic-brain-injury":51},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,40,58,84,110,139,166,192,214,243,267,292,316,349,382,411,435,456,475,500,518,546,565,588,630],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100641090","phase-1-feasibility-of-support-tbi-100641090",false,"NCT07625098","Feasibility of SUPPORT-TBI","From Isolation to Connection: A Dyadic Approach to Enhancing Health After TBI","Inclusion Criteria:\n\n* Age 18 or older\n* Live in a community setting (not an institutional setting)\n* Sustained a traumatic brain injury more than 6 months prior to enrollment\n* Report mild-moderate TBI-related disability (score of 5 or greater) on the Glasgow Outcome Scale - Extended\n* Report low social support (score of less than 50 on the MOS Social Support Survey)\n\nExclusion Criteria:\n\n* Insufficient English language fluency\n* Active substance use disorder (meets diagnostic criteria on the PRIME-MD MINI alcohol or non-alcoholic substances modules)\n* Active, untreated psychotic disorder (meets diagnostic criteria on the PRIME-MD MINI psychotic disorders module)\n* Severe memory impairment (score of less than 21 on the Montreal Cognitive Assessment)","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","Many people who have had a traumatic brain injury (TBI) struggle to stay connected with others. They often lose friendships, become isolated, and have strained family relationships. This lack of social support is linked to worse physical and mental health, lower quality of life, and even a shorter lifespan. The investigators developed a program where a person with TBI and one close supporter work together with a therapist over 12 weekly sessions. They learn skills in communication, setting shared goals, supporting each other emotionally, and problem-solving, with occasional guidance from a peer mentor who has been through a similar experience. This study will determine whether the program is practical to deliver. We are conducting a pilot study with 30 pairs of participants to test whether sessions run smoothly, whether people show up and stay engaged, and whether participants find the program worthwhile. Based on what they learn, the investigators will refine this program before testing it on a larger scale. If successful, this could lead to a practical, low-risk intervention that improves the lives of people with TBI and the family members and friends who support them.",[27],"TBI Traumatic Brain Injury","RECRUITING","2026-08-17",{"date":31,"type":32},"2026-08-19","ACTUAL",{"date":29,"type":32},{"date":35,"type":21},"2028-03-31",{"name":37,"class":38},"Washington University School of Medicine","OTHER",1,{"id":41,"slug":42,"hasResults":12,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":22,"phases":48,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":52,"startDateStruct":54,"completionDateStruct":55,"leadSponsor":57,"locationsCount":39},"100635231","phase-1-engage-tbi-feasibility-study-100635231","NCT07549997","ENGAGE-TBI Feasibility Study","Inclusion Criteria:\n\n* at least 18 years old\n* experienced a TBI \\> 6 months prior to enrollment, confirmed by a physician as documented in their medical record\n* live in the St. Louis area\n* report problems with social participation (retention of \\\u003C 80% of pre-TBI social activities as measured by Activity Card Sort)\n\nExclusion Criteria:\n\n* insufficient English language fluency to participate in the group intervention\n* have active substance use disorder (PRIME-MD MINI)\n* have an untreated psychotic disorder (PRIME-MD MINI)\n* have severe memory impairment that would limit their ability to recall strategies with support (Montreal Cognitive Assessment, \\\u003C 21)",{"count":47,"type":21},30,[24],"This study will first evaluate the feasibility of delivering the ENGAGE-TBI intervention in a community setting with adults with TBI.",[51],"TBI (Traumatic Brain Injury)",{"date":53,"type":32},"2026-08-18",{"date":29,"type":32},{"date":56,"type":21},"2028-04",{"name":37,"class":38},{"id":59,"slug":60,"hasResults":12,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":12,"sex":17,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":22,"phases":69,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100648363","paired-vns-for-tbi-rehabilitation-100648363","NCT07719829","Paired VNS For TBI Rehabilitation","VNS for TBI","Inclusion Criteria:\n\n* Age 22-80 years\n* History of severe TBI (initial GCS ≤ 8)\n* Regained consciousness with capacity to consent to the study\n* At least six months since injury\n* Full recovery of consciousness with command following (mGCS = 6)\n* Ongoing motor impairment with dependence in activities of daily living (modified Rankin Scale, mRS = 3-4)\n* Clinically stable for VNS implantation\n\nExclusion Criteria:\n\n* No capacity to consent to the study\n* History of stroke\n* History of cognitive disorder or other neurodegenerative disorder\n* History of epilepsy treated by VNS\n* History of brain tumors (primary or metastatic)\n* Requires diathermy\n* Pregnant\n* Previously implanted vagus nerve stimulator\n* Extensive prior neck surgery preventing dissection of the vagus nerve\n* History of severe spasticity, vagus nerve damage, or hearing loss","22 Years","80 Years",{"count":68,"type":21},20,[70],"NA","This study is evaluating whether pairing vagus nerve stimulation (VNS) with structured upper limb rehabilitation therapy can improve arm and hand function in individuals with chronic moderate to severe traumatic brain injury (TBI) and subsequent motor deficits.\n\nMany people who survive a TBI experience long-term weakness, poor coordination, and difficulty using one arm or hand. These motor impairments can significantly affect independence and quality of life. Traditional rehabilitation can help, but recovery is often incomplete.\n\nVagus nerve stimulation (VNS) is an FDA-approved therapy for certain neurological conditions and involves a small device implanted under the skin in the chest with a lead connected to the vagus nerve in the neck. The device delivers mild electrical pulses to the nerve. In this study, VNS will be paired with goal-directed upper limb rehabilitation exercises. The stimulation is delivered during specific movements in therapy sessions. This \"paired stimulation\" approach is designed to enhance neuroplasticity - the brain's ability to reorganize and form new connections - which may improve motor recovery.\n\nThe VNS device used in this study is FDA-approved for other conditions. However, its use paired with rehabilitation for upper limb recovery after traumatic brain injury is investigational.\n\nParticipants in this study will:\n\nUndergo surgical implantation of the VNS device.\n\nParticipate in structured upper limb rehabilitation therapy sessions where stimulation is paired with specific movements.\n\nComplete follow-up visits and assessments to measure changes in arm and hand function, strength, dexterity, and overall recovery.\n\nThe main goal of the study is to determine whether paired VNS and rehabilitation improves upper limb motor function compared to rehabilitation alone. Safety will also be closely monitored, including surgical outcomes and any device-related effects.\n\nThis study may help determine whether VNS paired with rehabilitation is a safe and effective way to enhance motor recovery after traumatic brain injury. Findings from this research could contribute to improved treatment strategies for individuals living with long-term motor impairments following TBI. If the results are promising, future studies plan to also include patients with acute TBI.\n\nParticipation is voluntary. All participants will be carefully evaluated to determine eligibility, and informed consent will be obtained before enrollment.",[73,51],"Traumatic Brain Injury","NOT_YET_RECRUITING","2026-08-11",{"date":77,"type":32},"2026-08-13",{"date":79,"type":21},"2027-01",{"date":81,"type":21},"2031-12",{"name":83,"class":38},"Stony Brook University",{"id":85,"slug":86,"hasResults":12,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":22,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":39},"100600877","evaluation-of-decision-making-fatigue-after-traumatic-brain-injury-100600877","NCT07103200","Evaluation of Decision-Making Fatigue After Traumatic Brain Injury","Evaluation of Decision-Making Fatigue After Traumatic Brain Injury (EDIFY)","EDIFY","Inclusion Criteria for TBI Participants:\n\n* Adults 18 years and older\n* Diagnosis of a mild to moderate TBI (GCS \\> 8 on admission)\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process\n\nInclusion Criteria for Healthy Participants:\n\n* Adults 18 years and older\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process",true,{"count":94,"type":21},40,[70],"This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.",[51],[99,100],"Mild TBI","Decision-Making Fatigue","2026-08-03",{"date":103,"type":32},"2026-08-05",{"date":105,"type":32},"2025-09-24",{"date":107,"type":21},"2029-07-15",{"name":109,"class":38},"University of Minnesota",{"id":111,"slug":112,"hasResults":12,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":123,"conditions":124,"keywords":125,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":138},"100617483","phase-3-efficacy-of-early-continuous-infusion-of-hss-on-the-neurological-outcome-at-6-months-in-tbi-patients-100617483","NCT07319208","Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.","Efficacy of Early Continuous Infusion of Hypertonic Saline Solution on the Neurological Outcome at 6 Months in Traumatic Brain Injured Patients. A Single-blinded, Multicenter, Randomized, Controlled Clinical Trial With Blinded Evaluation of the Primary Outcome.","COSMOS-TBI","Inclusion Criteria:\n\n* Patient admitted to intensive care unit\n* Traumatic brain injury with Glasgow Coma Scale ≤ 12\n* Intracranial pressure (ICP) monitoring based on the attending physician's clinical judgment, in accordance with guidelines or clinical\u002Fradiological signs considered at risk of intracranial hypertension\n* Inclusion during the first 12 hours after Intracranial pressure monitoring placement\n* Informed and signed consent\n* National health insurance\n\nExclusion Criteria:\n\n* Glasgow Coma Scale (score = 3) and persistent abnormal pupillaryreactivity despite urgent therapy\n* Associated cervical spinal cord injury\n* Imminent death and do-not-resuscitate orders\n* Coma secondary to cardiac arrest\n* Pregnancy (serum or urine test performed in routine care)\n* Severe Cardiac insufficiency\n* Severe chronic renal insufficiency\n* Severe hepatic insufficiency: patient presenting with oedemato-ascitic decompensation of liver cirrhosis or patient with Child-Pugh class C cirrhosis\n* High risk of follow-up difficulties after ICU discharge\n* Patients under court protection\n* Patient who does not speak French","75 Years",{"count":120,"type":21},760,[122],"PHASE3","The purpose of this study is to demonstrate the efficacy of early continuous intravenous infusion of hypertonic saline solution (HSS) to improve survival and independence in daily life activities (at 6 months) of patients with traumatic brain injury at high risk of intracranial hypertension.",[27],[126,127,128],"Traumatic brain injury","Saline Solution","Hypertonic","2026-07-27",{"date":131,"type":32},"2026-07-29",{"date":133,"type":32},"2026-04-21",{"date":135,"type":21},"2029-06-01",{"name":137,"class":38},"Nantes University Hospital",23,{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":148,"conditions":149,"keywords":151,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100649220","cognitive-network-restoration-therapy-for-moderate-to-severe-traumatic-brain-injury-a-feasibility-study-100649220","NCT07730099","Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study","Inclusion Criteria:\n\n1. History of moderate to severe TBI based on estimated worst Glasgow Coma Scale (GCS) score within first 48 hours of injury (acceptable GCS range = 3-12)\n2. Age ≥18 and \\\u003C75 years at the time of informed consent.\n3. At least 24 months from date of TBI injury\n4. Fluent in local language and able to independently provide consent\n5. Rating of upper moderate disability to lower good recovery on the Glasgow Outcome Scale-Extended (GOSE) at time of enrollment (acceptable GOSE range 5-7)\n6. Failure to return to pre-injury level of vocational or educational function\n7. Either receiving no CNS stimulants or other medications known to affect cognitive function, or on stable doses of these medications for at least last three months prior to signing consent.\n\nExclusion Criteria:\n\n1. History of major developmental, neurologic, psychiatric or substance use disorder with evidence of disability prior to onset of TBI\n2. Any DSM-5 personality disorder diagnosis, as determined by SCID-5-PD, will exclude the participant.\n3. Major medical co-morbidities: end stage renal failure, heart failure, severe congestive heart disease, coagulopathy, severe respiratory problems, liver failure, uncontrolled hypertension or other significant medical co-morbidities.\n4. Receiving anti-epileptic medications to control active seizures\n5. Have had a documented seizure within 3 months prior to signing consent\n6. Malignancy with \\\u003C 5 years life expectancy.\n7. Untreated \u002F uncontrolled (severe at the time of enrollment) depression or other psychiatric disorder.\n8. Women of childbearing age who do not regularly use an accepted contraceptive method. Participants who become pregnant after enrollment may be excluded from the study. Those who become pregnant prior to the surgical implantation of the DBS system will be excluded from the study.\n9. Inability to stop Coumadin or platelet anti-aggregation therapy before, during and after surgery.\n10. Previous DBS or other brain implants\n11. Previous ablative intracranial surgery\n12. Implantable hardware not compatible with MRI or unwilling to undergo MRI (e.g. claustrophobia)\n13. Condition requiring diathermy after DBS implantation\n14. Hardware, lesions or other factors limiting placement of electrodes in optimal target location in the judgment of the implanting surgeon\n15. Concurrent enrollment in any other clinical trial\n16. Any condition that, in the judgment of the PI, significantly increases risk or significantly reduces the likelihood of benefit from DBS","74 Years",{"count":94,"type":21},[70],"The purpose of this feasibility clinical investigation is to evaluate the safety and usability of central thalamic deep brain stimulation (CT-DBS) for use in patients with chronic moderate to severe traumatic brain injury (TBI) and to explore its potential effects on cognitive and functional outcomes.",[150,51],"Chronic Traumatic Brain Injury",[152,153,154,155],"Deep Brain Stimulation","DBS","TBI","Central thalamus","2026-07-25",{"date":158,"type":32},"2026-07-28",{"date":160,"type":21},"2027-02",{"date":162,"type":21},"2029-01",{"name":164,"class":165},"ReEmerge, Inc.","INDUSTRY",{"id":167,"slug":168,"hasResults":12,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":176,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":39},"100645635","a-pilot-study-of-home-based-rhythmic-auditory-stimulation-to-evaluate-mobility-balance-and-patient-reported-outcomes-after-traumatic-brain-injury-100645635","NCT07702513","A Pilot Study of Home-Based Rhythmic Auditory Stimulation to Evaluate Mobility, Balance, and Patient-Reported Outcomes After Traumatic Brain Injury","A Pilot Randomized Waitlist-Controlled Study of Home-Based Rhythmic Auditory Stimulation to Evaluate Mobility, Balance, and Patient-Reported Outcomes After Traumatic Brain Injury","BEAT TBI","Inclusion Criteria:\n\n1. have a moderate to severe TBI that required inpatient rehabilitation;\n2. able to ambulate independently, with or without an assistive device.;\n3. ambulating \\\u003C 1.4 m\u002Fs (comfortable walking speed)\n4. demonstrate a reciprocal gait pattern;\n5. ability to follow directions\u002Fstandardized instructions;\n\nExclusion Criteria:\n\n1. Uncontrolled cardiopulmonary, metabolic, or infectious disorder;\n2. history of orthopedic or additional neurological disorder that limited motor function before TBI;\n3. any reason that, in the opinion of the study investigators or medical team, would interfere with completing the study protocol such as behavioral concerns;\n4. uncontrolled seizure disorder;\n5. participation in any gait interventional trials in last eight weeks;\n6. hearing impairment limiting perception of rhythmic cues.",{"count":175,"type":21},33,[70],"The goal of this study is to learn whether a home-based rhythmic auditory stimulation (RAS) program using the MR-001 device can help improve walking, balance, and other health outcomes in adults with moderate to severe traumatic brain injury (TBI). The study will also look at how safe and feasible it is for people with TBI to use this device at home. The purpose is to determine the safety, feasibility, and adherence of a home-based, music-guided RAS intervention and to explore preliminary effects on mobility, cognition, mood, enjoyment, perceived change, and cortical excitation.\n\nThe main questions this study aims to answer are:\n\n1. Does training with the MR-001 device improve walking endurance, gait speed, and balance?\n2. Does the intervention improve cognition, mood, fatigue, and participants' impression of change?\n3. How enjoyable is the training experience for participants?\n4. How does the brain respond to walking with versus without rhythmic auditory stimulation?\n\nResearchers will compare the MR-001 intervention to a waitlist control group to see whether the device leads to improvements beyond usual activity.\n\nParticipants will:\n\n1. Use the MR-001 device at home for 30 minutes, three times per week for eight weeks\n2. Complete walking, balance, cognitive, and questionnaire assessments\n3. Participate in two lab sessions using functional near-infrared spectroscopy (fNIRS) to measure brain activity during walking\n4. Provide two fasting blood samples to measure BDNF, a biomarker related to neuroplasticity\n5. Complete study visits at baseline, after eight weeks, and (for the waitlist group) after their treatment period\n\nThis study will help determine whether a home-based, music-guided walking program can support long-term mobility and recovery after TBI.",[73,179,154,180,51],"Traumatic Brain Injury | Patient","TBI-Traumatic Brain Injury",[154,73,182,172],"Rhythmic Auditory Stimulation","2026-07-10",{"date":185,"type":32},"2026-07-14",{"date":187,"type":21},"2026-07-15",{"date":189,"type":21},"2028-01-15",{"name":191,"class":38},"Craig Hospital",{"id":193,"slug":194,"hasResults":12,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":203,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":39},"100632953","phase-1-nanopulse-laser-therapy-100632953","NCT07520383","Nanopulse Laser Therapy","Biomarker Responsiveness of Nanopulse Laser Therapy in Treatment of Traumatic Brain Injury","Inclusion Criteria:\n\n* Adults aged 18 years or older at the time of enrollment\n* Confirmed diagnosis of moderate to severe TBI (clinical assessment and radiographic evidence)\n* Admission to the neurosurgical or neurocritical care service with anticipated need for intracranial monitoring (e.g., microdialysis, ICP probe)\n* Able to initiate treatment within 48 hours of admission\n* Informed consent obtained from patient or legally authorized representative\n\nExclusion Criteria:\n\n* Patients younger than 18 years of age\n* Known or suspected pregnancy (verified via urine pregnancy test for females of childbearing age)\n* Incarcerated individuals or prisoners\n* Patients with pre-existing implanted cranial devices (e.g., deep brain stimulators) that may interfere with NPLT\n* Patients with severe scalp injury or open wounds at intended treatment site\n* Known allergy or hypersensitivity to adhesives or device components",{"count":47,"type":21},[24],"The purpose of this study is to evaluate the safety and effectiveness of a novel noninvasive therapy, Nanopulse Laser Therapy (NPLT), to improve recovery following traumatic brain injury (TBI).",[51],[51,204,205],"Near-Infrared Laser Therapy","Neurometabolic Biomarkers",{"date":207,"type":32},"2026-07-13",{"date":209,"type":21},"2026-08",{"date":211,"type":21},"2027-05",{"name":213,"class":38},"The University of Texas Medical Branch, Galveston",{"id":215,"slug":216,"hasResults":12,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":22,"phases":224,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":39},"100580575","cognitive-rehabilitation-for-victims-of-war-and-related-traumas-with-traumatic-brain-injury-and-cognitive-impairment-100580575","NCT06839079","Cognitive Rehabilitation for Victims of War and Related Traumas With Traumatic Brain Injury and Cognitive Impairment","Feasibility RCT of an Adapted Cognitive Rehabilitation Program for Victims of War and Related Traumas With TBI and Cognitive Impairment","Inclusion Criteria:\n\n1\\. Identify as asylum-seekers or refugees, survivors of intimate partner violence (IPV), OR report personal history of other trauma 3. Mild or moderate TBI sustained after the age of 18 4. Age 18-65 5. Subjective cognitive impairment 6. English or Spanish language proficiency 7. Ability to provide verbal informed consent 8. Ability and willingness to answer questionnaires and participation in the Intervention\n\nExclusion Criteria:\n\n1. Participation in cognitive rehabilitation treatment current or in past 3 months\n2. Severe TBI or TBI only sustained under the age of 18\n3. Diagnosis of bipolar, psychosis, active substance use, self-reported current active suicidal ideation (Potential participants can be screened again after 30 days in the case of suicidal ideation)","65 Years",{"count":223,"type":21},50,[70],"Researchers at Massachusetts General Hospital are looking to see if a program created to help improve thinking and memory can work for people affected by trauma, including asylum seekers and refugees, survivors of intimate partner violence (IPV) and others with traumatic brain injury (TBI). They're checking if this program is practical and if people find it helpful.\n\nThe study will have two groups. Participants will complete a first questionnaire and then be assigned to a group by chance. One group will participate in the program immediately and then answer the second questionnaire (approximately 3 months after the first questionnaire they did). Then they will wait and then answer the third and final questionnaire approximately 6 months after the first one.\n\nThe second group will wait and answer the second questionnaire approximately 3 months after the first one. Then they will receive the program and answer the third and final questionnaire (approximately 6 months after the first one they did.)",[51,227],"Cognitive Symptoms",[73,229,230,231,232,233],"Cognition","Refugees","Asylum Seekers","IPV","trauma-exposed populations","2026-07-07",{"date":236,"type":32},"2026-07-09",{"date":238,"type":32},"2025-10-15",{"date":240,"type":21},"2027-12",{"name":242,"class":38},"Massachusetts General Hospital",{"id":244,"slug":245,"hasResults":12,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":263,"leadSponsor":265,"locationsCount":39},"100644267","fibrinogen-to-albumin-ratio-as-a-predictor-of-acute-respiratory-distress-syndrome-in-traumatic-brain-injury-100644267","NCT07664358","Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Traumatic Brain Injury","Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Patients With Traumatic Brain Injury: The Prospective, Observational, Multi-center FARDS Study","FARDS","Inclusion Criteria:\n\n* Patients ≥ 18 years admitted to the ICU with traumatic Brain Injury\n* Admission to the ICU within 24 hours of injury.\n* Patients will be expected to remain under hospital care for follow-up\n* Availability of fibrinogen and albumin measurements within the first 24 hours of ICU admission.\n* Informed consent will be obtained from a legally authorized representative.\n\nExclusion Criteria:\n\n* Preexisting advanced chronic liver disease, nephrotic syndrome, or protein-losing enteropathy.\n* Pre-existing ARDS on admission.\n* Recipient of albumin, fibrinogen concentrate, or cryoprecipitate before admission sampling.\n* Use of anticoagulant or fibrinolytic therapy before admission.\n* Active malignancy or severe systemic infection at admission.\n* Direct sever lung injury\n* Pregnancy\n* Refusal of consent",{"count":252,"type":21},350,"OBSERVATIONAL","this study aims to assess the ability of fibrinogen-to-albumin ratio to predict the development of Acute respiratory distress syndrome in traumatic brain injury patients.",[256,257,258,51],"Fibrinogen","Albumin","ARDS","2026-07-01",{"date":261,"type":32},"2026-07-06",{"date":259,"type":32},{"date":264,"type":21},"2027-01-01",{"name":266,"class":38},"Tanta University",{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":285,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":39},"100621660","emergency-department-implementation-of-the-i-stat-alinity-traumatic-brain-injury-whole-blood-test-100621660","NCT07373509","Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test","Effectiveness of the Traumatic Brain Injury Whole Blood Test on Improving Assessment and Triage for Patients With GCS 13-15 Presenting to Emergency Departments","EDI","Inclusion Criteria:\n\n1. Aged 18 or older\n2. Presenting to an enrolling ED with ED Arrival GCS of 13-15 following reported head blunt impact within 24 hours of injury\n3. Meets Department of Defense (DoD) definition of mTBI:\n\nA traumatically induced physiological disruption of brain function as a result of an external force that is indicated by new onset or worsening of at least one of the following clinical signs immediately following the event:\n\n1. Any alteration of mental status (e.g., feeling dazed, disoriented, or confused)\n2. Any period of loss of or a decreased level of consciousness, observed or self-report (loss of consciousness 30 minutes or less, an alteration of consciousness up to 24 hours)\n3. Any loss of memory for events immediately before or after the injury (post-traumatic amnesia up to 1-day post-injury)\n\nExclusion Criteria:\n\n1. Treating emergency department provider does not think a head CT scan is needed\n2. Inability to obtain results for iSTAT Alinity TBI test within 24 hours of injury\n3. Treating emergency department attending physician is not willing to participate\n4. Pre-existing neurologic condition\n5. Contraindication or inability to complete blood draw\n6. Significant polytrauma that, in the opinion of the principal investigators, could impact peripheral GFAP levels or require a full body scan\n7. History of penetrating TBI\n8. History of neurosurgical intervention for previous TBI\n9. Penetrating TBI for current injury\n10. Any history of brain surgery\n11. Any history of brain tumor\n12. Patients on psychiatric hold",{"count":276,"type":21},340,"The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential outcomes with clinical implications. The main questions it aims to answer are:\n\n1. Determine the number of patients with non-elevated (i.e., below clinical cutoff) whole blood iSTAT Alinity tests who also receive CT scans.\n2. What are the obstacles for using the i-STAT Alinity for its FDA-indicated use",[51,279],"Implementation Research",[281,73,282,283,284],"Concussion","CT scan","Blood Biomarker","i-STAT Alinity TBI Test",{"date":261,"type":32},{"date":287,"type":32},"2026-01-13",{"date":289,"type":21},"2030-04",{"name":291,"class":38},"Shawn Eagle",{"id":293,"slug":294,"hasResults":12,"nctId":295,"briefTitle":296,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":66,"enrollmentInfo":299,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":301,"conditions":302,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":315},"100553034","cerebral-autoregulation-brain-perfusion-and-neurocognitive-outcomes-after-traumatic-brain-injury-100553034","NCT06480838","Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury","CAPCOG-TBI","Inclusion Criteria:\n\n* Documented\u002FVerified TBI (ACRM Criteria) (eg, motor vehicle (MV) occupant, MV pedestrian\u002Fcyclist, fall, other non-intentional, violence\u002Fassault)\n* A documented moderate to severe TBI defined as: Glasgow Coma Scale (GCS) \\\u003C 13, or loss of consciousness (LOC) \\> 30 minutes, or posttraumatic amnesia (PTA) \\> 24 hours or intracranial neuroimaging abnormalities\n* Between the age 18 - 80 year-old\n* ≤ 1 week postinjury\n* Acute brain CT for clinical care\n* Admitted to the hospital for TBI\n* Visual acuity\u002Fhearing adequate for testing\n* Fluent in English or Spanish\n* Patient or LAR ability to provide informed consent\n\nExclusion Criteria:\n\n* Age greater or less than the range 18-80 years\n* Significant polytrauma that would interfere with follow-up and outcome assessment\n* Major debilitating baseline mental health disorders (e.g., schizophrenia, bipolar disorder, severe depression with active suicidal thoughts at the time of evaluation) that would interfere with follow-up and the validity of outcome assessment.\n* Major debilitating neurological disease (e.g., stroke, CVA, dementia, tumor) impairing baseline awareness, cognition, or validity of follow-up and outcome assessment.\n* Significant history of pre-existing conditions that would interfere with follow-up and outcome assessment (e.g., active substance abuse, alcoholism, HIV\u002FAIDs, end-stage cancers, learning disabilities, developmental disorders)\n* Patients on psychiatric hold\n* Prisoners or patients in custody\n* Pregnancy in female subjects\n* Low likelihood of follow-up (e.g., participants or family indicating low interest, residence in another state or country, homeless or lack of reliable contacts)\n* Current participant in an interventional trial (e.g., drug, device, behavioral)\n* Penetrating TBI\n* Spinal cord injury with ASIA score of C or worse\n* Contraindications to MRI",{"count":300,"type":21},130,"Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\\\u003C 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.",[303,304,305,51,154],"Traumatic Brain Injury With Loss of Consciousness","Brain Injury Traumatic Severe","Brain Injury Traumatic Moderate","2026-06-30",{"date":308,"type":32},"2026-07-02",{"date":310,"type":32},"2023-09-01",{"date":312,"type":21},"2029-05-31",{"name":314,"class":38},"University of Texas Southwestern Medical Center",3,{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":323,"targetDuration":4,"studyType":22,"phases":325,"briefSummary":327,"conditions":328,"keywords":331,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":39},"100646627","phase-4-suvorexant-3---pe-pc-100646627","NCT07686731","Suvorexant 3 - PE-PC","Suvorexant: Targeting Orexin to Augment Exposure Therapy in Veterans With PTSD and Insomnia","Inclusion Criteria:\n\n1. Adults 18-75 years who are U.S. military Veterans; able to read\u002Funderstand English and provide written informed consent;\n2. Exposure to a DSM-5 Criterion A traumatic event;\n3. Current PTSD, duration \\> 3 months, CAPS-5 total score ≥ 12\n4. Insomnia diagnosis indicated by ISI score \\>14\n5. If taking non-exclusionary psychotropics (e.g., SSRI\u002FSNRI, tetracyclic antidepressants, tricyclics, antipsychotics, and mood stabilizers, insomnia medication, neuroleptics, anti-psychotics) must be on a dose stable ≥ 4 weeks before randomization.\n6. If in supportive psychotherapy, stable ≥ 6 weeks before randomization (no concurrent exposure-based PTSD or CBT-I).\n7. Women of childbearing potential: negative urine pregnancy test at screening; agree to use a medically acceptable contraception method during treatment.\n\nExclusion Criteria:\n\n1. DSM-5 alcohol, marijuana, and\u002For other substance use disorder in the last 3 months. Mild alcohol and marijuana use not meeting criteria for disorder permissible;\n2. Lifetime bipolar disorder I or II, schizophrenia, schizoaffective disorder, obsessive-compulsive disorder, or major depressive disorder with psychotic features;\n3. Exposure to trauma in the last 3 months;\n4. Prominent suicidal or homicidal ideation, any suicidal behavior in the past 3 months on the Columbia Suicide Severity Rating Scale (C-SSRS)83, or increased risk of suicide that necessitates additional therapy or inpatient treatment;\n5. Pre-existing sleep apnea by type III device with AHI \\>15 in the absence of adherence to effective treatment (such as CPAP or oral device);\n6. Night shift work or extreme morning or evening tendencies;\n7. Neurologic disorder or systemic illness affecting CNS function;\n8. Chronic or unstable medical illness (i.e., angina, myocardial infarction within the past 6 months, congestive heart failure, preexisting hypotension or orthostatic hypotension, heart block or arrhythmia, chronic renal or hepatic failure, pancreatitis, and severe chronic obstructive pulmonary disease);\n9. Severe cognitive impairment as assessed by the MoCA (or alternative validated threshold per site SOP)\n10. Pregnancy or breastfeeding, or unwillingness to use effective contraception (women of childbearing potential).\n11. Previous adverse reaction to a hypnotic;\n12. Current use of sedative-hypnotics, benzodiazepines, moderate or strong CYP3A inhibitors, or strong CYP3A inducers or Digoxin;\n13. Current participation in exposure-based PTSD or behavioral insomnia treatments.",{"count":324,"type":21},142,[326],"PHASE4","The goal of this clinical trial is to learn if combining suvorexant (a sleep medication) with a shorter form of prolonged exposure therapy called PE-PC works to treat PTSD symptoms and improve sleep in Veterans and military personnel with PTSD and insomnia, with and without mild-to-moderate traumatic brain injury (TBI). The main questions it aims to answer are:\n\nDoes suvorexant, when combined with PE-PC therapy, reduce PTSD symptoms more than PE-PC with a placebo (a look-alike substance that contains no drug)? Does suvorexant, when combined with PE-PC therapy, improve psychosocial and physical functioning more than PE-PC with a placebo?\n\nResearchers will compare PE-PC combined with suvorexant to PE-PC combined with a placebo to see if adding suvorexant improves PTSD symptoms, sleep, and overall functioning in Veterans.\n\nParticipants will:\n\nReceive weekly PE-PC therapy sessions for 8 weeks Take suvorexant (10-20 mg) or a placebo each night during the 8-week treatment period.\n\nComplete repeated assessments of PTSD symptoms, sleep, and psychosocial and physical functioning throughout the study.",[329,330,51],"PTSD - Post Traumatic Stress Disorder","Insomnia",[332,330,333,334,154,335,336,337,338,339,340],"PTSD","Sleep","Veterans","Prolonged Exposure Therapy for Primary Care (PE-PC)","Stress Disorders, Post-Traumatic","suvorexant","Sleep Initiation and Maintenance Disorders","Orexin Receptor Antagonists","Dual Orexin Receptor Antagonists (DORA)","2026-06-29",{"date":234,"type":32},{"date":344,"type":21},"2026-09-01",{"date":346,"type":21},"2029-08-30",{"name":348,"class":38},"Northern California Institute of Research and Education",{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":92,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":356,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":358,"conditions":359,"keywords":366,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":39},"100630260","fnirs-for-disorders-of-consciousness-100630260","NCT07485361","fNIRS for Disorders of Consciousness","Functional Near-infrared Spectroscopy in Disorders of Consciousness: Protocol Testing and Pilot in Neuro-ICU Setting","Inclusion Criteria:\n\nHealthy Control Participants:\n\n* Age 18 years or older\n* Proficient in English language\n* Intact cognition\n* Montreal Cognitive Assessment (MoCA) score \\> 26\n\nDoC Patients:\n\n* Age 18 years or older\n* Proficient in English language\n* Surrogate decision maker available\n* Admission to the intensive care unit within 28 days\n* Documented Glasgow Coma Scale (GCS) score\n* Auditory Function subscale score ≥1 on the Coma Recovery Scale-Revised (CRS-R)\n\nExclusion Criteria:\n\nHealthy Control Participants:\n\n* Known baseline hearing impairment without available hearing aids\n* Neurological or psychiatric history\n\nDoC Patients:\n\n* Known baseline hearing impairment without available hearing aids\n* Inability to obtain informed consent\n* Extensive bilateral frontal injury on available imaging (CT\u002FMRI)\n* Patients who have undergone craniectomy surgery\n* IV sedation in the past 24 hours\n* Absent auditory startle response (\\\u003C1 from Auditory Function subscale score of CRS-R)",{"count":357,"type":21},55,"The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care unit (Neuro-ICU). DoC include conditions such as coma and minimally conscious state that occur after severe brain injury. These conditions make it difficult to assess a person's level of awareness because many clinical tests rely on observable behaviors such as speaking or moving, which are commonly impaired after brain injury.\n\nThe main questions the study aims to answer are:\n\n* Can fNIRS detect changes in brain activity in healthy adults when they receive sensory stimulation or perform mental tasks?\n* Can the same fNIRS protocol be used in patients with disorders of consciousness in the Neuro-ICU to measure brain responses and determine whether the method is feasible in this clinical setting?\n\nThe investigators will first study healthy adult volunteers to establish baseline brain responses and determine which tasks produce the most reliable signals. The protocol will then be applied to patients with disorders of consciousness admitted to the Neuro-ICU.\n\nParticipants will take part in a single research session lasting about 30 to 45 minutes while wearing the lightweight fNIRS headband that measures brain oxygen levels using near-infrared light. During the session, participants will:\n\n* Wear a non-invasive fNIRS headband placed on the forehead\n* Receive gentle sensory stimulation (for example, compression devices on the legs or hands)\n* Listen to sounds or spoken sentences\n* Perform guided mental tasks such as imagining walking through their home or imagining moving a limb\n\nThe study does not test a treatment and will not change medical care. The goal is to determine whether fNIRS can safely and reliably measure brain activity at the bedside and provide preliminary information that may help guide future research on improving the assessment of consciousness after brain injury.",[360,361,362,363,364,365,27],"Disorders of Consciousness Due to Severe Brain Injury","Disorders of Consciousness","Coma","Minimally Conscious State","Unresponsive Wakefulness Syndrome","Brain Injury",[367,368,369,370,371,372],"Functional Near-Infrared Spectroscopy","Neurocritical Care","Functional Neuroimaging","Neuro Intensive Care Unit","Neurovascular Coupling","Consciousness Assessment","2026-06-04",{"date":375,"type":32},"2026-06-08",{"date":377,"type":32},"2026-05-01",{"date":379,"type":21},"2026-12",{"name":381,"class":38},"University of California, Los Angeles",{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":391,"conditions":392,"keywords":397,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":4},"100612884","neuro-inflammation-in-extremity-trauma-risk-verification-in-elbow-trauma-the-nerve-study-100612884","NCT07259382","Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Study","Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Pilot Cohort Study","NERVE","Inclusion Criteria:\n\n* Adults 18 years or older with an acute elbow fracture and\u002For dislocation less than a week old\n* Open surgery as the chosen treatment\n\nExclusion Criteria:\n\n* Patient with a history of ipsilateral upper limb trauma or pathology, neurological disorder.\n* Patient unable to answer questionnaires.\n* Patient unavailable for a one-year follow-up, for example from another country.\n* Patient with vascular injury or open fracture\n* Patient with an active inflammatory disease (ex: rheumatoid arthritis)\n* Patient using anti-inflammatory drugs or immunosuppressants at the time of the injury.\n* Patient with another acute ipsilateral injury to the upper limb\n* Polytrauma patients with other injuries than the elbow fracture and concomitant central or peripheral neurological injury.",{"count":20,"type":21},"The primary goal of this proposal is to improve the understanding of the mechanisms causing persistent pain and disability in elbow fracture patients and their associated functional limitations. The specific objectives are as follows for elbow fractures:\n\n1\\) To describe NI mechanisms using biomarkers; 2) To identify factors related to increased NI biomarkers level; 3) To describe the associations between NI and outcomes; 4) To use these findings to refine a larger fully powered prognostic cohort study Hypotheses\n\n1. Level of neuro-inflammation (NI) biomarkers\\* will be significantly higher in patients presenting with both elbow fracture and CNS injury or PNI.\n2. Consumption of opioid in mg of morphine equivalent will be higher in patients with a higher level of NI biomarkers.\n3. Function, assessed by validated joint and limb specific functional questionnaires and QoL will be worse in patients with a higher level of NI biomarkers.\n4. Chronic pain at 3 months will be higher (McGill Pain questionnaire V2, Neuropathic pain questionnaire, NPRS) in patients with a higher level of NI biomarkers.\n5. Duration of tourniquet use and nerve dissection will be correlated to elbow fracture outcome with a higher level of NI biomarkers.\n\n   * Target biomarkers based on preliminary study will include, but not be limited to: TNFa, IL6, Substance P, IL-1B, TREM-2, IL-16, CCL22, VEGF-a, BMPs (table 1).",[393,394,395,27,396],"Elbow Dislocation","Elbow Fractures","Inflammation Biomarkers","Nerve Injury",[398,399,400,401,154],"Biomarkers","Elbow fracture","elbow dislocation","Nerve injury","2026-04-27",{"date":404,"type":32},"2026-04-28",{"date":406,"type":21},"2026-06-01",{"date":408,"type":21},"2030-12-31",{"name":410,"class":38},"Université de Montréal",{"id":412,"slug":413,"hasResults":12,"nctId":414,"briefTitle":415,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":92,"sex":17,"minAge":418,"maxAge":18,"enrollmentInfo":419,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":421,"conditions":422,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":39},"100531096","individual-cerebral-hemodynamic-oxygenation-relationships-ichor-1-100531096","NCT06195345","Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)","ICHOR 1","Inclusion Criteria:\n\n* Individuals who are able to tolerate an MRI.\n* Are patients scheduled for a clinically indicated MRI.\n* Between birth and up to 18 years.\n\nExclusion Criteria:\n\n* Presence of an MRI-incompatible device or implant (e.g. pacemakers, stents)\n* Unable to tolerate the enclosed spaces and loud noises for the duration of time in scanner required to obtain an MRI.\n* Preterm infants less than 25 weeks\n* Any patient who is clinically too unstable to extend their MRI by up-to 7.5 minutes.","1 Minute",{"count":420,"type":21},1000,"This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study.",[423,51,154,424,425],"HIE","Hemodynamic Instability","Hypoxic-Ischemic Encephalopathy","2026-04-24",{"date":428,"type":32},"2026-04-29",{"date":430,"type":32},"2018-11-01",{"date":432,"type":21},"2035-11-01",{"name":434,"class":38},"Children's Hospital Los Angeles",{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":439,"acronym":4,"eligibilityCriteria":440,"healthyVolunteers":92,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":443,"conditions":444,"keywords":445,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":39},"100626016","long-lasting-effect-of-hyperbaric-oxygen-therapy-on-cognitive-function-in-traumatic-brain-injury-patients-100626016","NCT07430150","Long Lasting Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Traumatic Brain Injury Patients","Inclusion Criteria:\n\n1. Diagnosed with traumatic brain injury\n2. Age 18 years or older at treatment\n3. Completed a 60 session hyperbaric treatment course at the Sagol Center for Hyperbaric Medicine and Research, Shamir Medical Center (Assaf Harofeh), and performed a neurocognitive evaluation by the computerized test Neurotrax.\n4. Willing and able to sign an informed consent. -\n\nExclusion Criteria:\n\n1. An inability to perform a neurocognitive computerized test.\n2. Any head trauma, neurodegenerative diseases or CVA after hyperbaric treatment completion.\n3. Diagnosis of a psychiatric disorder including: major depression, schizophrenia, bipolar disorder\n4. Active malignancy\n5. Chronic use of medications that may compromise cognitive function",{"count":442,"type":21},100,"To evaluate the cognitive functions of patients who suffered brain injury due to traumatic head injury and were previously treated in a hyperbaric chamber between one and four years after the end of treatment.",[51],[446],"Hyperbaric Therapy","2026-04-16",{"date":133,"type":32},{"date":450,"type":32},"2021-12-28",{"date":452,"type":21},"2030-01",{"name":454,"class":455},"Assaf-Harofeh Medical Center","OTHER_GOV",{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":460,"acronym":461,"eligibilityCriteria":462,"healthyVolunteers":92,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":463,"targetDuration":4,"studyType":22,"phases":464,"briefSummary":466,"conditions":467,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":474,"locationsCount":39},"100464448","early-phase-1-stimulating-after-recovery-from-traumatic-brain-injury-100464448","NCT05327829","Stimulating After Recovery From Traumatic Brain Injury","SMART","Inclusion Criteria:\n\n* Adults 18 years and older\n* Diagnosis of a mild to moderate TBI (GCS \\> 8 on admission)\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process\n\nHealthy participants:\n\n* Adults 18 years and older\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process\n\nExclusion Criteria:\n\n* Open wound on scalp\n* Severe TBI diagnosis or GCS of less than 8 on admission\n* Non-English speaking\n* Incarcerated\n* Implanted defibrillator or pacemaker\n* Visual impairment that hinders ability to complete computerized assessments\n\nHealthy subject exclusion criteria:\n\n* Less than 18 years of age\n* Open wound on scalp\n* TBI diagnosis\n* Non-English speaking\n* Incarcerated\n* Implanted defibrillator or pacemaker\n* Visual impairment that hinders ability to complete computerized assessments",{"count":47,"type":21},[465],"EARLY_PHASE1","This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and decision-making.",[51],"2026-04-01",{"date":470,"type":32},"2026-04-07",{"date":472,"type":32},"2025-03-31",{"date":189,"type":21},{"name":109,"class":38},{"id":476,"slug":477,"hasResults":12,"nctId":478,"briefTitle":479,"officialTitle":480,"acronym":4,"eligibilityCriteria":481,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":482,"targetDuration":4,"studyType":22,"phases":484,"briefSummary":485,"conditions":486,"keywords":487,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":494,"completionDateStruct":496,"leadSponsor":498,"locationsCount":39},"100609251","adaptation-of-the-stair-nt-for-first-responders-100609251","NCT07212140","Adaptation of the STAIR-NT for First Responders","Adaptation of the STAIR-NT Intervention to Respond to Psychological Health Conditions for First Responders With a History of Traumatic Brain Injury","Inclusion Criteria:\n\n* 18 years or older\n* be a first responder within the state of Minnesota\n* have a history of a TBI\n* screen for PTSD.\n\nExclusion Criteria:\n\n* Does not meet inclusion criteria.",{"count":483,"type":21},80,[70],"This study is a randomized controlled pilot examining the implementation of an adapted intervention, Skills Training in Affective and Interpersonal Regulation-Narrative Therapy (STAIR-NT), among a first responder population with a history of TBI and PTSD.",[329,180],[332,154,488,489,490],"First responders","STAIR-NT","GMT","2026-03-03",{"date":493,"type":32},"2026-03-05",{"date":495,"type":21},"2026-06",{"date":497,"type":21},"2027-06",{"name":499,"class":38},"Florida State University",{"id":501,"slug":502,"hasResults":12,"nctId":503,"briefTitle":504,"officialTitle":504,"acronym":505,"eligibilityCriteria":506,"healthyVolunteers":12,"sex":17,"minAge":507,"maxAge":508,"enrollmentInfo":509,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":510,"conditions":511,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":512,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":516,"locationsCount":39},"100517944","brain-development-in-young-children-following-mild-traumatic-brain-injury---pilot-study-100517944","NCT06024122","Brain Development in Young Children Following Mild Traumatic Brain Injury - Pilot Study","KAOUENN","Inclusion Criteria:\n\n* Patient group with mild traumatic brain injury (mTBI) :\n\n  1. Children aged between 36 months (3 years) and 71 months and 31 days (5 years; before their 6th birthday)\n  2. Presentation to the emergency department within 48 hours post-injury\n  3. Documented, unintentional traumatic event (e.g. blow, fall, etc.) resulting in non-penetrating head injury\n  4. Diagnosis of mTBI (World Health Organization (WHO) paediatric diagnostic criteria)\n* Control group with orthopaedic injury:\n\n  1. Children aged between 36 months (3 years) and 71 months and 31 days (5 years; before their 6th birthday)\n  2. Presentation to the emergency department within 48 hours post-injury\n  3. Documented, unintentional traumatic event (e.g. blow, fall, etc.) resulting in trauma to an upper or lower limb\n  4. Diagnosis of simple fracture, sprain, contusion or unspecified trauma to a limb (mild).\n\nExclusion Criteria:\n\n* Diagnosis of previous TBI (any severity, any age)\n* Intentional injury,\n* Administration of sedative drugs that can alter brain function\n* Complications following injury\n* MRI contraindication,\n* Parent non-fluent in French,\n* Prematurity,\n* Diagnosis of a severe neurological, developmental, or psychiatric disorder\n* Children in foster care at the time of recruitment","36 Months","71 Months",{"count":20,"type":21},"Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties. However, our knowledge of the exact consequences of injuries on young children's brains and behavior is limited. These consequences may be different in children under 6, as their brains are fragile and undergoing significant developmental changes.\n\nThe aim of this study is to determine the extent to which a concussion sustained before the age of 6 years is associated with changes in young children's brain structure, function and behaviours, using a brain imaging.\n\nIn this study, the results of a group of 30 children with a concussion will be compared to those of 30 children of the same age with an orthopaedic injury to the upper or lower limbs.",[51],{"date":493,"type":32},{"date":514,"type":32},"2024-07-03",{"date":379,"type":21},{"name":517,"class":455},"Institut National de la Santé Et de la Recherche Médicale, France",{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":522,"acronym":4,"eligibilityCriteria":523,"healthyVolunteers":12,"sex":17,"minAge":524,"maxAge":4,"enrollmentInfo":525,"targetDuration":4,"studyType":22,"phases":526,"briefSummary":527,"conditions":528,"keywords":530,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":540,"completionDateStruct":542,"leadSponsor":544,"locationsCount":39},"100626912","efficacy-and-safety-of-6degrees-mymove-interactive-virtual-reality-compared-to-passive-virtual-reality-in-subacute-stroke-and-traumatic-brain-injury-rehabilitation-a-randomized-controlled-trial-100626912","NCT07441798","Efficacy and Safety of 6Degrees MyMove Interactive Virtual Reality Compared to Passive Virtual Reality in Subacute Stroke and Traumatic Brain Injury Rehabilitation: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Time since neurological event: At least 2 weeks post-stroke or post-head injury.\n2. Motor impairment: Upper extremities: Presence of hemiparesis without complete paralysis. Participants receiving rehabilitation focused on functional transfer to the contralateral hand using compensatory or adaptive motor learning strategies will also be eligible. Lower extremities: Presence of partial voluntary movement sufficient to allow participation in rehabilitation training.\n3. Cognitive ability: Sufficient cognitive capacity to understand instructions and engage with VR-based training, as determined by the principal investigator and\u002For treating physician.\n4. Medical stability: Medically stable condition allowing participation in the training.\n5. Informed consent: Ability to provide written informed consent personally or via a legal guardian.\n6. Final eligibility will be determined by the principal investigator\u002F treating physician.\n\nExclusion Criteria:\n\n1. Severe cognitive or language impairment: Cognitive deficits or language comprehension impairments that prevent safe and meaningful participation.\n2. Neurological deficits interfering with VR: Severe hemispatial neglect or visual field deficits that interfere with VR use. Moderate neglect may be permitted at the investigator's discretion.\n3. Medical contraindications:\n\n   * Uncontrolled epilepsy\n   * Severe vestibular or vertigo disorders","40 Years",{"count":20,"type":21},[70],"Stroke and traumatic brain injury frequently result in persistent upper and lower limb motor impairment. While conventional rehabilitation improves outcomes, patient adherence and training intensity remain limiting factors. Immersive virtual reality (VR)-based therapy may enhance neuroplasticity by delivering high-intensity, task-oriented motor practice with enriched sensory feedback.\n\nThis randomized controlled trial evaluates the efficacy and safety of the 6Degrees MyMove interactive VR system compared to passive VR exposure in individuals undergoing subacute inpatient rehabilitation after stroke or traumatic brain injury. Sixty participants will be randomized 1:1 to receive either interactive VR-based motor training or passive VR viewing, in addition to standard rehabilitation care, three times weekly for eight weeks.\n\nThe primary objective is to determine whether interactive VR leads to greater improvement in motor function compared to passive VR. Secondary outcomes include dexterity, gait speed, functional independence, psychological status, adherence, usability, and safety.",[27,529],"CVA (Cerebrovascular Accident)",[531,532,533,534,535,536],"Virtual Reality Therapy","Upper Limb Rehabilitation","Stroke Rehabilitation","Fugl-Meyer Assessment","Neurorehabilitation","Wearable Motion Sensors","2026-02-24",{"date":539,"type":32},"2026-03-02",{"date":541,"type":21},"2026-03-18",{"date":543,"type":21},"2028-12-31",{"name":545,"class":38},"Reuth Rehabilitation Hospital",{"id":547,"slug":548,"hasResults":12,"nctId":549,"briefTitle":550,"officialTitle":550,"acronym":4,"eligibilityCriteria":551,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":552,"targetDuration":4,"studyType":22,"phases":554,"briefSummary":555,"conditions":556,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":39},"100455025","depth-electrode-detection-of-cortical-spreading-depolarization-after-traumatic-brain-injury-100455025","NCT05205174","Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury","Inclusion Criteria:\n\n* Patient recommended to undergo EVD placement for the monitoring and possible treatment of Intracranial pressure (ICP) after TBI\n\nExclusion Criteria:\n\n* Contaminated scalp lacerations\n* Known systemic infection\n* Non-English speaking\n* Fixed, uncorrectable coagulopathy",{"count":553,"type":21},15,[70],"Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.",[51],"2026-02-19",{"date":559,"type":32},"2026-02-23",{"date":561,"type":32},"2025-04-03",{"date":563,"type":21},"2030-12-03",{"name":109,"class":38},{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":571,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":573,"targetDuration":4,"studyType":22,"phases":575,"briefSummary":576,"conditions":577,"keywords":578,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":583,"completionDateStruct":585,"leadSponsor":587,"locationsCount":39},"100552024","transcutaneous-auricular-neurostimulation-for-icu-patients-with-traumatic-brain-injury-100552024","NCT06467708","Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury","Delivering Transcutaneous Auricular Neurostimulation (tAN) to ICU Patients With Traumatic Brain Injury (tAN-TBI)","tAN-TBI","Inclusion Criteria:\n\n1. Post-resuscitation GCS score 12 or below and acute trauma-related intradural blood on head CT scan after TB\n2. Age 18 years or older (pediatric trauma patients are not routinely transported to Parkland)\n3. Consent from legally authorized representative\n\nExclusion Criteria:\n\n1. Hemodynamic instability\n2. Expected imminent mortality because of overwhelming neurological and\u002For systemic injury\n3. Unclear neurological status because of paralytic medications or intoxication with ethanol or other drugs\n4. Presence of other electrical stimulation devices (pacemaker, cochlear prosthesis, neurostimulator, etc.)\n5. Abnormal ear anatomy or ear infection\n6. Participant is pregnant or lactating\n7. Any other significant medical or psychosocial problems that, in the opinion of the investigator, would potentially cause harm to the participant, impact their ability to participate, or influence the results of the trial",{"count":574,"type":21},42,[70],"The overarching goal of this pilot study is to assess the feasibility and safety of transcutaneous auricular neurostimulation (tan) in ICU patients with TBi and to determine the effect of tan on serum markers of inflammation. exploratory analyses will examine effects on such physiological parameters as blood pressure, heart rate, and intracranial pressure (iCP), as well as measures of neurological function.",[51],[579],"Transcutaneous auricular neurostimulation (tAN)","2026-02-16",{"date":582,"type":32},"2026-02-18",{"date":584,"type":32},"2025-02-11",{"date":586,"type":21},"2027-02-11",{"name":314,"class":38},{"id":589,"slug":590,"hasResults":12,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":594,"eligibilityCriteria":595,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":596,"enrollmentInfo":597,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":599,"conditions":600,"keywords":607,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":315},"100624514","augmented-renal-clearance-in-neurocritical-care-100624514","NCT07410624","Augmented Renal Clearance in Neurocritical Care","Augmented Renal Clearance in Neurocritical Care Population: A Prospective Multicenter Study","Neuro-ARC","Inclusion Criteria:\n\n1. Age 18-85 years\n2. Admitted to ICU at one of the participating sites\n3. Diagnosis: SAH, TBI, ICH, meningitis, SE or ischemic stroke\n4. Provision of informed consent\n5. Foley catheter in place at time of consent (to facilitate urine collection)\n\nExclusion Criteria:\n\n1. Incarceration\n2. Anticipated ICU length of stay is \\\u003C 72 hours (insufficient time for monitoring)","85 Years",{"count":598,"type":21},512,"Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion dollars. Seizures and infections are common complications following acute neurological illnesses and contribute significantly to poor outcomes if not promptly treated with appropriately dosed anti-seizure medications and antibiotics, respectively. Limited research suggested that many of those patients present with a phenomenon called augmented renal clearance (ARC) or, in other words, enhanced kidney function. ARC may have a significant influence on how medications are removed from the body potentially resulting in insufficient doses and treatment failure. Therefore, patients with ARC require higher medication doses; however, ARC is largely undetected using kidney assessment methods currently used in practice. In addition, it is not clear how medications should be dosed in those with ARC. The majority of ARC research has not focused on patients with life-threatening neurological illnesses. Thus, clinicians are likely under-dosing vital medications in those patients, and completely unaware. There is an immediate need to address the gap in knowledge. Therefore, this research aims to characterize the phenomenon of ARC in patients with life-threatening neurological illnesses through identifying the frequency, duration, contributing factors and clinical impact of ARC. Adult patients admitted to the neurosciences intensive care unit for life-threatening neurological illnesses will be enrolled in the study. Urine and blood samples wil be collected from participants to determine the presence of ARC and identify its contributing factors. In addition, blood samples will be collected from participants treated with select antibiotics and anti-seizure medications to determine their concentration and propose dose adjustment in those with ARC. This research is expected to improve the care of patients with life-threatening neurological illnesses through efficient identification and monitoring of patients exhibiting ARC facilitating timely medication dosage optimization. Furthermore, recommendations of optimal doses of commonly used medications in patients with ARC would improve the likelihood of treatment success with potential to improve patients' health and wellbeing.",[51,601,602,603,604,605,606],"Status Epilepticus","Bacterial Meningitis","Augmented Renal Clearance (ARC)","Subarachnoid Hemorrhage, Aneurysmal","Ischemic Stroke","Intracerebral Hemorrhage",[608,609,610,611,612,613,614,615,616,617,154,618,619,620,621],"traumatic brain injury","seizures","status epilepticus","bacterial meningitis","brain infections","neuro-ICU","augmented renal clearance (ARC)","augmented kidney function","creatinine clearance","neurological injury","ARC","subarachnoid hemorrhage","ischemic stroke","antimicrobials","2026-02-15",{"date":582,"type":32},{"date":625,"type":32},"2021-10-01",{"date":627,"type":21},"2026-09-30",{"name":629,"class":38},"University of Alberta",{"id":631,"slug":632,"hasResults":12,"nctId":633,"briefTitle":634,"officialTitle":634,"acronym":635,"eligibilityCriteria":636,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":637,"enrollmentInfo":638,"targetDuration":4,"studyType":22,"phases":639,"briefSummary":640,"conditions":641,"keywords":653,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":673,"locationsCount":39},"100409377","cognitive-remediation-in-forensic-mental-health-care-100409377","NCT04610697","Cognitive Remediation in Forensic Mental Health Care","CRFMHC","Inclusion Criteria:\n\ni1. Age 18 - 55; i2. Ability to read and speak in fluent English; i3. Current status as inpatient on the Forensic Treatment Unit.\n\nExclusion Criteria:\n\ne1. Intellectual disability; e2. TBI with loss of consciousness followed by known severe neurological sequelae requiring hospitalisation and rehabilitation.","55 Years",{"count":47,"type":21},[70],"Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.\n\nOne empirically-validated method to train executive functions is cognitive remediation, which consists of cognitive exercises combined with coaching.\n\nThis trial investigates whether cognitive remediation can improve cognitive, functional, and clinical outcomes in forensic inpatients.",[642,643,51,644,645,646,647,648,649,650,651,652],"Psychotic Disorders","ADHD","Aggression","Substance Use Disorders","Violence","Cognitive Dysfunction","Anxiety","Depression","Schizophrenia","Offenders","Antisocial",[654,655,656,657,658,659,660,661,662,663,664,229,665],"Cognitive Remediation","Cognitive Training","Cognitive Enhancement","Cognitive Rehabilitation","Neuropsychological Rehabilitation","Executive Function","Forensic Mental Health","Forensic Psychology","Forensic Neuropsychology","Forensic Neuroscience","Forensic Rehabilitation","Executive Functioning","2025-12-04",{"date":668,"type":32},"2025-12-12",{"date":670,"type":32},"2020-02-10",{"date":672,"type":21},"2026-02-10",{"name":674,"class":38},"The Royal Ottawa Mental Health Centre"]