[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tcmo-ngs-prescription\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tcmo-ngs-prescription":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100659602","effectiveness-of-selected-traditional-chinese-medicine-topical-agents-on-long-distance-runner-versus-exercise-therapy-as-control-for-patellofemoral-pain-syndrome-100659602",false,"NCT07865169","Effectiveness of Selected Traditional Chinese Medicine Topical Agents on Long Distance Runner Versus Exercise Therapy as Control for Patellofemoral Pain Syndrome","外敷中藥(吳氏處方)治療長跑手膝痛的臨床研究 Effectiveness of Selected Traditional Chinese Medicine Topical Agents on Long Distance Runner Versus Exercise Therapy as Control for Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* Mean running distance \\> 20 km\u002Fweek and 10 km\u002Fsession. If kilometer per week conflicted with kilometers per session, for example, 40 km\u002Fweek with a frequency of 5 times\u002Fweek, it is classified according to kilometers per week.\n* Clinical diagnosis of Alzheimer's Disease\n* Be between 18 and 60 years of age and able to provide written informed consent.\n* Have experienced knee pain for more than four weeks.\n* Have no history of external medical interventions, physical therapy, or lower limb surgery for PFPS within the past six weeks, and no acupuncture treatment on knee within the past month.\n\nExclusion Criteria:\n\n* Presence of absolute contraindications for Chinese herbal medicated plasters;\n* Pregnancy or lactation;\n* Oral or topical use of non-steroidal anti-inflammatory drugs within the past two weeks;\n* Steroid injections within the past two months;\n* Clinical, radiographic, or MRI evidence of meniscal or other intra-articular lesions, cruciate ligament or collateral ligament injury or laxity;\n* Concurrent conditions including diabetes, goiter, coagulation disorders, hepatic or renal failure, chronic obstructive pulmonary disease, cardiac disease, neurological disorders, psychiatric disorders, acute or chronic infections, or malignancies;\n* Presence of redness, swelling, burning sensation, pain, infection, or ulceration around the patellar;\n* History of knee surgery, patellar dislocation, fracture (local or at the hip joint), ankle or hip joint injury, meniscus or ligament injury;\n* Lower limb tendinitis, low back pain, sacroiliac joint pain, or any neurological or cardiovascular disease;\n* Presence of rheumatic disease, septic arthritis, osteoarthritis, Osgood-Schlatter disease, or Chondro-Larsen-Johansson syndrome; or clinical assessment indicating significant knee effusion, pronounced hip or lumbar pain (potentially causing referred knee pain), or impairment in performing prescribed exercises; or recurrent patellar subluxation or dislocation;\n* Presence of patella folding syndrome or deep vein thrombosis;\n* Presence of joint fibrosis;\n* Presence of tumors;","ALL","18 Years","60 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: With the rising popularity of long-distance running in Hong Kong, running-related injuries have become more common, particularly patellofemoral pain syndrome (PFPS), which is one of the most prevalent conditions among endurance runners. PFPS can negatively affect training consistency, race performance, and long-term participation. While exercise therapy is the primary intervention, patient adherence and long-term outcomes remain limited. Traditional Chinese Medicine ointment (TCMO, Ng's formula) has shown anti-inflammatory and tissue-repairing properties, making it a promising adjunct therapy for PFPS.\n\nObjective:\n\n1. To evaluate the efficacy and safety of selected topical agents used in Traditional Chinese Medicine on PFPS in long-distance runners.\n2. To assess the impact of these topical agents on running performance in PFPS patients.\n\nMethods: A randomized, controlled, parallel-group, single-blinded trial will be conducted with 50 participants. Group A will receive TCMO combined with exercise therapy, while Group B will receive exercise therapy alone. The intervention lasts four weeks, with weekly follow-ups to monitor adherence. Primary outcomes include Kujala Scale (AKPS), eccentric step-down test, and fastest finishing time of recorded race distances. Safety will be monitored through participant reports and exclusion of individuals with contraindications.",[27,28],"Patellar Femoral Syndrome","TCMO (Ng's Prescription)","NOT_YET_RECRUITING","2026-10-02",{"date":32,"type":33},"2026-10-08","ACTUAL",{"date":35,"type":21},"2026-09-15",{"date":37,"type":21},"2026-12-31",{"name":39,"class":40},"Hong Kong Baptist University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":61,"locationsCount":41},"100658851","effectiveness-of-topical-chinese-medicine-ointment-therapy-tcmo-ngs-prescription-eccentric-exercise-for-tennis-elbow-as-control-a-randomized-controlled-trial-100658851","NCT07858981","Effectiveness of Topical Chinese Medicine Ointment Therapy (TCMO) (Ng's Prescription) Eccentric Exercise for Tennis Elbow as Control: a Randomized Controlled Trial.","外敷中藥（吳氏處方）治療網球肘的臨床研究 Effectiveness of Topical Chinese Medicine Ointment Therapy (TCMO) (Ng's Prescription) Eccentric Exercise for Tennis Elbow as Control: a Randomized Controlled Trial.","Inclusion Criteria:\n\n* Men and women aged 18 to 65 who are able to give written informed consent\n* Meet the diagnostic criteria of the LE\n* Lateral elbow pain duration more than 3 weeks\n* No history of allergic reactions to Chinese medicine ointment\n* No history of medical treatment, physical therapy for pain in LE, or upper limb surgery within the past six months\n* No history of acupuncture treatment within the past month\n* No other serious medical conditions\n* No participation in other clinical trials during the same period\n\nExclusion Criteria:\n\n* Absolute contraindications exist for the use of traditional Chinese Medicine ointment\n* Participants are in pregnancy or lactation\n* Use of non-steroidal anti-inflammatory drugs during the previous weeks\n* Receipt of corticosteroid injection within the past two months\n* Brachioradial bursitis\n* Participants with severe comorbidities, such as poorly controlled diabetes mellitus, thyroid enlargement, coagulation disorder, hepatic or renal failure, chronic obstructive pulmonary disease (COPD), cardiovascular disease, neurological disorder, psychiatric illness, acute or chronic infections, or malignant tumors\n* Local skin changes around the lateral epicondyle of the humerus, including erythema, warmth, pain, infections, or ulceration\n* Receipt of acupuncture treatment for LE within the two weeks prior to intervention.","65 Years",{"count":51,"type":21},48,[24],"B. Introduction Tennis elbow, medically termed lateral epicondylitis (LE), is a prevalent musculoskeletal disorder characterized by pain and tenderness over the lateral epicondyle of the humerus. Excessive mechanical stress on the elbow tendons, often caused by repetitive movements or manual labor, contributes to microtrauma and cumulative strain of the forearm and elbow musculature. Clinically, the site of maximal tenderness is situated just anterior and distal to the lateral epicondyle itself. Moreover, studies have demonstrated that pain intensity and grip strength are closely associated with manual test outcomes in chronic tennis elbow, further supporting the functional relevance of these diagnostic measures. Although historically associated with racquet sports, contemporary evidence indicates that the condition is more frequently linked to occupational and daily activities such as typing, carpentry, and healthcare work.Epidemiological studies estimate an annual prevalence of approximately 1.3% and an incidence of 3.4 per 1,000 individuals, making it one of the most common causes of elbow pain in adults aged 30-60 years.\n\nThe disorder exerts a considerable impact on modern life. Participants often experience reduced grip strength and functional limitations that interfere with essential tasks such as lifting, writing, or using tools. This functional impairment contributes to work productivity loss and increased healthcare utilization, resulting in substantial economic burden. Moreover, lifestyle factors such as smoking and repetitive manual work has been shown to negatively influence prognosis, with a subset of participants requiring surgical intervention after six months of unsuccessful conservative treatment. Collectively, these findings underscore that tennis elbow is not merely a sports-related injury but a significant occupational health issue, affecting individual well-being and societal efficiency in today's workforce.\n\nA pilot randomize controlled cross-over trial of TCMO (Ng's prescription) in 2024 has significant efficacy on LE and can effectively improve the pain symptoms of participants (95%CI: -22.4 to -5.28, p: 0.0032). Modern drug treatments for tennis elbow mainly focus on reducing pain and inflammation. While this can provide short-term relief and help participants tolerate daily activities or rehabilitation, it often does not address the underlying tendon degeneration and impaired healing.\n\nC. Trial Objective\n\n1. Primary objective:\n\n   To evaluate the efficacy of TCMO (Ng's prescription) in reducing pain intensity of LE through randomized controlled trial (RCT).\n2. Secondary objective:\n\nTo evaluate safety of TCMO (Ng's prescription) of LE through randomized controlled trial (RCT). To assess functional improvement of TCMO (Ng's prescription) (PRTEE). Randomization and allocation concealment To minimize research bias, 48 participants will be assigned to two treatment groups and a control group in a 1:1 ratio. Block randomization via Sealed Envelope tool, with gender as the stratification criterion. Sealed opaque envelopes and password-protected file. RA generates sequence; Research Assistant II (RAII) blinded. To further minimize potential bias, evaluators and data analysts involved in the study will be blinded to treatment assignments. RAII will manage and analyze collected data. The PI will assess participant outcomes and oversee the entire study process. Group A: receive Topical Chinese Medicine Ointment (TCMO)（Ng's prescription）and eccentric exercise Group B: receive eccentric exercise only",[55,28],"Lateral Epicondylitis","2026-10-01",{"date":58,"type":33},"2026-10-05",{"date":35,"type":21},{"date":37,"type":21},{"name":39,"class":40}]