[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"terminal-illness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:terminal-illness":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,94,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100642173","empowering-monterey-bay-residents-for-activated-collaborative-and-equitable-care-100642173",false,"NCT07652359","Empowering Monterey Bay Residents for Activated, Collaborative, and Equitable Care","EMBRACE - Empowering Monterey Bay Residents for Activated, Collaborative, and Equitable Care","EMBRACE","Inclusion Criteria:\n\n* Participants must be receiving clinical care by a primary care physician in the Monterey area\n* Participants must be 18 years or older.\n* Participants must speak either English or Spanish.\n* Participants must be able to consent verbally in English or Spanish to all study procedures.\n* Participants must self-identify as a racial\u002Fethnic minorities OR identify as having low-income status\n\nExclusion Criteria:\n\n\\- Patients unable to respond to survey questions in either English or Spanish.","ALL","18 Years",{"count":20,"type":21},138,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of the EMBRACE Study is to evaluate whether a facilitated intervention improves shared decision-making (SDM) and patient activation among low-income and minority individuals more than usual care only. The ultimate goal is to enhance SDM and patient activation in care.",[27,28,29,30],"Shared Decision-Making","Quality of Life","Advanced Illness","Terminal Illness",[32,33],"Goals of care","Advanced care planning","RECRUITING","2026-07-14",{"date":37,"type":38},"2026-07-16","ACTUAL",{"date":35,"type":21},{"date":41,"type":21},"2030-01-14",{"name":43,"class":44},"Stanford University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":72,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100629619","non-invasive-detection-and-preservation-of-neurocognitive-signals-in-the-peri-death-period-using-brain-computer-interface-and-artificial-intelligence-100629619","NCT07477028","Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence","Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence: A Prospective Observational Study (NeuroCogPresv)","NeuroCogPresv","Inclusion Criteria:\n\n1. Adults ≥18 years with terminal illness or severe acute trauma\n2. Do-not-resuscitate (DNR\u002FDNI) order in place\n3. Surrogate decision-maker available and willing to provide informed consent\n4. Expected survival ≤7 days (physician estimate)\n\nExclusion Criteria:\n\n1. Brain death already declared \\> 24 hours prior to enrollment\n2. Contraindication to EEG\u002FBCI headset placement (e.g., severe scalp injury)\n3. Patient lacks a legally authorized representative",{"count":55,"type":21},20,"OBSERVATIONAL","Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power, cross-frequency coupling, and distinct spreading depolarization waves. This prospective, observational feasibility study utilizes rapid-deployment, high-density, noninvasive BCI hardware paired with proprietary AI analytics to detect, classify, and securely archive these terminal neurocognitive signals.\n\nObjectives: (1) Quantify transient gamma-band activity and cross-frequency connectivity post-clinical death; (2) Validate the efficacy of machine learning models for real-time signal classification in high-noise clinical environments; (3) Establish a highly secure, encrypted bio-informational archive of peri-life EEG data.\n\nDesign: Prospective, open-label, multicenter, observational cohort (n\\>20).",[30,59,60,61,62,63,64,65,66,67,68,69,70,71],"End-of-Life Care","Death","Brain Death","Death Anxiety","Consciousness","Electroencephalography","Gamma Oscillations","Near-Death Phenomena","Cognitive","Cognition","Memory","EEG","Severe Acute Trauma",[73,74,75,60,65,68,63,76,77,78,69,79,80,81,82],"AI","BCI","Brain Computer Interface","Pefi-death","Brain death","Reservation","Life","Life experience","Transfer","Convergence","NOT_YET_RECRUITING","2026-03-12",{"date":86,"type":38},"2026-03-17",{"date":88,"type":21},"2026-09-01",{"date":90,"type":21},"2035-09-30",{"name":92,"class":93},"Noah Tech, Corp.","INDUSTRY",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":45},"100563375","digipall-a-trial-of-digital-patient-reported-outcome-and-biomarker-monitoring-in-palliative-care-100563375","NCT06615349","DigiPall; a Trial of Digital Patient Reported Outcome and Biomarker Monitoring in Palliative Care","DigiPall; a Randomized Controlled Trial of Digital Patient Reported Outcome and Biomarker Monitoring in Palliative Care","Inclusion Criteria:\n\n* Patients with established diagnosis of a metastatic cancer\u002Fsevere illness with limited life expectancy receiving palliative care services\n* Estimated life expectancy \\\u003C24 months (physician's guess)\u002F \\>3 months\n* Karnofsky Index ≥ 50% \u002F ECOG≤ 2\n* Aged \\>18 years\n* Owns and uses a smartphone\n* Give written informed consent\n\nExclusion Criteria:\n\n* Patients under curative treatment\n* Relevant cognitive impairment",{"count":102,"type":21},382,[24],"The aim of this study is to test if a system consisting of a wearable device measuring heartbeats and steps, together with daily communication with a chatbot on the smartphone asking the patients about their symptoms and giving tips, can reduce unplanned hospital readmissions and improve well-being in advanced cancer and severely ill patients.",[30,106],"Terminal Cancer",[108,109,110,111,112,113],"Palliative Care","chatbot","wearable","PROMs","rehospitalisation","mobile health","2025-07-07",{"date":116,"type":38},"2025-07-10",{"date":118,"type":38},"2025-06-11",{"date":120,"type":21},"2027-09",{"name":122,"class":44},"David Blum",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":45},"100524411","differences-in-acceptability-of-music-therapy-sessions-played-live-compared-to-a-recording-thereof-100524411","NCT06108375","Differences in Acceptability of Music Therapy Sessions Played Live Compared to a Recording Thereof","Inclusion Criteria:\n\n* Age \\>18 years old\n* Capacity to provide informed consent\n* Patients with established diagnosis of a metastatic cancer\u002Fsevere illness with limited life expectancy on a palliative care ward at the University Hospital Zurich\n\nExclusion Criteria:\n\n• Inability to answer a questionnaire due to physical limitations as well as cognitive or linguistic reasons.",{"count":130,"type":21},25,[24],"The present study seeks to assess differences in feasibility and acceptability of music therapy played live and listening to a recording thereof at the palliative care ward of the University Hospital Zurich. As a secondary objective the investigators aim to extend the limited findings on the putative effect of music therapy in palliative care populations derived from objective measures of human autonomic response combined with subjective psychological outcomes to support evidence-based medicine. The investigators will implement a commercially available tracker, the wristband 287-2 by Corsano, to investigate multiple simultaneous biomarkers of autonomic response to music therapy and a recording thereof, such as heart rate, heart rate variability, electrodermal activity and distal body temperature.\n\nTo investigate subjective quality of life and psychological outcomes, the investigators will administer highly validated and widely used questionnaires, namely the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire 15 Palliative Care, the Edmonton Symptom Assessment System and the Hospital Anxiety and Depression Scale.",[30,106],{"date":135,"type":38},"2025-07-11",{"date":137,"type":38},"2023-10-24",{"date":139,"type":21},"2026-03",{"name":141,"class":44},"University of Zurich"]