[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thoracic-organ-transplantation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thoracic-organ-transplantation":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100241579","genome-transplant-dynamics-100241579",false,"NCT02423070","Genome Transplant Dynamics","* INCLUSION CRITERIA:\n* Lung and heart transplant candidates. Dual organ transplants such as those that include lung or heart PLUS any other organ are also considered for enrollment.\n* Subjects who have undergone lung or heart transplants and are within 3 months of transplantation.\n* 14 years and older\n* Able to understand and be willing to sign the informed consent form. Subjects undergoing a double transplant will sign a single consent.\n* Retransplant candidates will be considered as a new transplants. These subjects will be approached for enrollment and if they consent to participate, they will be assigned a different SSPIN.\n\nEXCLUSION CRITERIA:\n\n-Pregnancy","ALL","14 Years","80 Years",{"count":19,"type":20},991,"ESTIMATED","OBSERVATIONAL","Study Description:\n\nHeart and lung transplants can save lives, but long-term success is often limited by organ rejection that is hard to detect early. This study is testing a new, non-invasive blood test that looks for small pieces of DNA from the donor organ in the patient s blood. We believe higher levels of this donor DNA may signal early rejection before damage becomes permanent.\n\nHypothesis:\n\nWe believe that measuring donor-derived DNA in the blood can help detect early signs of rejection and improve outcomes for transplant patients.\n\nThe study also collects genetic and biological samples to explore why some people are more at risk of complications after transplant. This may help guide future research and treatments.\n\nWho Can Join the Study:\n\nPeople receiving a heart or lung transplant (or both), age 14 and older\n\nPeople who are within three months of their transplant\n\nPeople who can understand and agree to take part in the study\n\nParticipants will be asked to provide blood and other samples, and some of these will be used in lab research to explore new ideas about how and why transplant rejection happens.\n\nThis research could lead to better ways to monitor and treat patients after a heart or lung transplant - and help improve long-term survival and quality of life....",[24],"Thoracic Organ Transplantation",[26,27,24,28,29,30],"Cell-free DNA","Acute Rejection","Non-Invasive Testing","Chronic Rejection","Natural History","RECRUITING","2026-08-18",{"date":34,"type":35},"2026-08-19","ACTUAL",{"date":37,"type":35},"2015-06-25",{"date":39,"type":20},"2034-11-30",{"name":41,"class":42},"National Heart, Lung, and Blood Institute (NHLBI)","NIH",6]