[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tic-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tic-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100574056","pathogenesis-of-pediatric-obsessive-compulsive-disorder-based-on-the-microbiota-gut-brain-axis-100574056",false,"NCT06754319","Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis","We recruited outpatient children and adolescents with OCD confirmed by the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (4th edition). The following inclusion and exclusion criteria were also applied:\n\nInclusion Criteria:\n\n(1) 7-17 years old, (2) Y-BOCS score ≥16, (3) with or without a history of TD, (4) Drug-naïve or drug-free for 8 weeks, (5) Wechsler IQ score ≥ 80.\n\nExclusion Criteria:\n\n* History of serious medical, neurological illness or other psychotic disorders other than OCD (tic disorder excepted).\n* Previous exposure to cognitive behavioral therapy (CBT) for OCD or TD.\n* serious suicide risk.\n* Has taken antibiotics, probiotics, prebiotics, corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), or immunosuppressants within the past 8 weeks.\n* Has a history of gastrointestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, constipation, hemorrhoids, or a history of gastrointestinal surgery, or has a history of autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus.\n* Participants with claustrophobic, heart pacemaker, mechanical heart valve, mechanical implant such as an aneurysm clip, hip replacement, or any other pieces of metal that have accidentally entered their body.",true,"ALL","7 Years","17 Years",{"count":20,"type":21},125,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics, neuroimaging and electroencephalography (EEG), conducted before and after treatment with selective serotonin reuptake inhibitors (SSRIs). The results will be compared with those of pediatric OCD paitents comorbid with tic disorder (TD) and healthy controls. The findings are expected to further elucidate the potential pathogenesis of OCD, providing a theoretical basis for identifying novel clinical intervention targets and optimizing treatment strategies.",[25,26],"Obsessive-Compulsive Disorder","Tic Disorder",[28,29,30],"microbiota-gut-brain axis","pediatric OCD","microbiome","RECRUITING","2026-07-30",{"date":34,"type":35},"2026-08-03","ACTUAL",{"date":37,"type":35},"2024-08-24",{"date":39,"type":21},"2027-12-31",{"name":41,"class":42},"Shanghai Mental Health Center","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":15,"sex":16,"minAge":50,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100560406","sensorimotor-and-psychosocial-trajectories-in-adolescents-with-tic-disorder-100560406","NCT06576726","Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder","* Inclusion criteria for adolescents with tic disorder:\n\n  * adolescent age 11-17 years of age\n  * adolescent diagnosis of chronic tic disorder (Tourette syndrome, chronic motor tic disorder, chronic vocal tic disorder)\n  * English-speaking adolescent and caregiver\u002Fadult proxy (as validated questionnaires are in English)\n  * adolescent and caregiver\u002Fadult proxy willingness and ability to complete relevant questionnaires\n* Exclusion criteria for for adolescents with tic disorder:\n\n  * cognitive or attentional impairment precluding ability of adolescent or caregiver\u002Fadult proxy to complete questionnaires and other study measures\n  * adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder\n  * adolescent diagnosis of pervasive genetic disorder besides chronic tic disorders and their known comorbidities\n  * adolescent with severe medical conditions unrelated to chronic tic disorders (e.g. uncontrolled seizures, prominent heart conditions)\n  * other variables that might influence ratings outside of the typical presentation of chronic tic disorders\n* Additional exclusion criteria for EEG tasks for chronic tic disorder sample\\*\\*\n\n  * adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days\n  * use of marijuana or recreational substances within the past 30 days\n  * history of seizure\n  * history of hearing loss or abnormalities\n  * history of neuropathy or overt sensory deficit\n  * history of brain surgery or skull-penetrating\u002Fdeforming trauma\n  * history of stroke, brain cancer, or other significant neurologic illness\u002Fdisorder \\*\\* Individuals excluded based on these criteria are ineligible for the EEG portion of the study but can complete the remainder of the study measures.\n* Inclusion criteria for control (neurotypical adolescent) participants\n\n  * adolescent age 11-17 years of age\n  * English-speaking adolescent and caregiver\u002Fadult proxy (as validated questionnaires are in English)\n  * adolescent and caregiver\u002Fadult proxy willingness and ability to complete relevant questionnaires\n* Exclusion criteria for control sample\n\n  * history of tics, ADHD, OCD, or other significant neurodevelopmental or neuropsychiatric disorder.\n\n    \\*\\* Note: adolescents with history of mood or anxiety disorder are eligible.\n  * cognitive or attentional impairment precluding ability of adolescent or caregiver\u002Fadult proxy to complete questionnaires and other study measures\n  * adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder\n  * adolescent diagnosis of pervasive genetic disorder\n  * adolescent with severe medical conditions (e.g. uncontrolled seizures, prominent heart conditions)\n  * other variables that might influence ratings\n* Additional exclusion criteria for EEG tasks for control sample\\*\n\n  * adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days\n  * use of marijuana or recreational substances within the past 30 days\n  * history of seizure\n  * history of hearing loss or abnormalities\n  * history of neuropathy or overt sensory deficit\n  * history of brain surgery or skull-penetrating\u002Fdeforming trauma\n  * history of stroke, brain cancer, or other significant neurologic illness\u002Fdisorder","11 Years",{"count":52,"type":21},351,"Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population. Current clinical care for individuals with tic disorders is limited: no interventions are proven to prevent or stop the disorder exist, and most treatments focus solely on tics, though other symptoms often affect quality of life more than tics. To develop new treatments and improve care for people with tics, researchers need to better understand the different symptoms people experience and how the brain causes these symptoms.\n\nMany individuals with tic disorders have sensory and movement symptoms other than tics. A common sensory symptom is increased sensitivity to common sensations, such as glare from sunlight, tags in shirt collars, and noises from passing cars. A common movement symptom is poor handwriting and\u002For poor coordination. In one study of adolescents with tic disorder, difficulty with hand coordination predicted tic severity 7.5 years later, suggesting that sensory and\u002For motor difficulties may be a risk factor for more severe tics later in life. Despite how common they are, much is unknown about sensory and motor difficulties experienced by people with tic disorders.\n\nAdditionally, most studies of people with tics enroll younger children. As a result, little is known about sensory, motor, and psychosocial development in adolescents with tics. Knowledge of sensory and motor difficulties in adolescents with tics is important to understand because, in other adolescent populations, such difficulties are associated with worse mental and social health and worse quality of life. Deepening insight into the sensory, motor, and psychosocial development of adolescents with tic disorders is crucial to identify causes and risk factors for poor health in this population.\n\nThe goals of this study are to measure sensory and motor symptoms and function in adolescents with tics and to compare them to adolescents without tics. The research team will enroll adolescents with tics and adolescents without tics to participate in the study. Adolescent participants will complete questionnaires, electroencephalogram (EEG) tasks, and other sensory and motor tasks at baseline (with 2 study visits occurring within 30 days of each other) and 2 years later (again, with 2 study visits, occurring within 30 days of each other). A parent or other adult who knows the adolescent well will also complete questionnaires as part of the study.",[55,26],"Tourette Syndrome",[57,58,59,60,61,62,63,64,65,66],"Tourette syndrome","tic disorder","sensorimotor","sensory","motor","sensory over-responsivity","psychosocial","development","behavioral","neurophysiology","2025-11-18",{"date":69,"type":35},"2025-11-24",{"date":71,"type":35},"2024-10-24",{"date":73,"type":21},"2030-05",{"name":75,"class":42},"Vanderbilt University Medical Center",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":15,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":43},"100563204","effectiveness-of-symptom-management-application-on-parental-care-ability-of-children-with-tourette-syndrome-100563204","NCT06613126","Effectiveness of Symptom Management Application on Parental Care Ability of Children With Tourette Syndrome","Constructing and Evaluating the Effectiveness of an Intelligent Interaction System for Symptom Management on the Care Needs and Related Factors of Children With Tourette Syndrome and Their Parents","Inclusion Criteria:\n\n1. Parents of children between 6-12 years old who are diagnosed with Tourette Syndrome by pediatricians.\n2. Parents who are the primary caregivers\n3. Parents with normal cognitive functioning who can communicate in Mandarin.\n\nExclusion Criteria:\n\n1\\. Children with Tourette Syndrome who are suffering from intellectual disability or critical diseases.","20 Years","60 Years",{"count":86,"type":21},180,"INTERVENTIONAL",[89],"NA","This study developed a Tourette Syndrome (TS) symptom management application (APP) to improve the care needs, sleep quality, anxiety, quality of life, and parenting relationship of parents of children with Tourette Syndrome.",[55,26,92],"Neurodevelopmental Disorder",[94,95,96,97],"symptom management","Application","parent","children with Tourette Syndrome","2024-09-30",{"date":100,"type":35},"2024-10-03",{"date":102,"type":35},"2024-09-25",{"date":104,"type":21},"2026-07-31",{"name":106,"class":42},"National Taipei University of Nursing and Health Sciences"]