[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tmj-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tmj-disorder":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100652140","machine-learning-for-evaluating-and-diagnosing-temporomandibular-disorders-100652140",false,"NCT07771296","Machine Learning for Evaluating and Diagnosing Temporomandibular Disorders","Development of an Integrated Evaluation-to-Treatment Framework to Enhance Clinical Efficiency and Effectiveness in Temporomandibular Disorders","Inclusion Criteria:\n\n* Patients diagnosed with temporomandibular disorders (TMDs) screened by the Department of Dentistry, Division of Oral and Maxillofacial Surgery at En Chu Kong Hospital, who have failed to respond to analgesic treatment for at least one week.\n* Patients clinically examined and identified as having pain predominantly originating from muscles associated with mandibular movement.\n* Patients aged between 18 and 70 years (inclusive) with full legal capacity.\n* Patients who are willing to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* Patients meeting any of the following clinical scale thresholds: Generalized Anxiety Disorder-7 (GAD-7)≥ 10, Patient Health Questionnaire-9 (PHQ-9) ≥ 15, Patient Health Questionnaire-15 (PHQ-15) ≥ 10, or Pittsburgh Sleep Quality Index (PSQI) \\> 5.\n* Patients with tumors of the temporomandibular joint (TMJ) or head and neck region.\n* Patients with acute or chronic infections.\n* Patients with a history of neuropathy or stroke.\n* Patients with a history of head and neck trauma.\n* Patients diagnosed with fibromyalgia.\n* Patients diagnosed with autoimmune or rheumatic diseases.\n* Patients diagnosed with irritable bowel syndrome (IBS).\n* Patients with claustrophobia (unable to undergo MRI examination).\n* Women who are pregnant or lactating, or parents currently in the infant care\u002Fnursing period.\n* Patients who have received invasive treatment for temporomandibular joint disorders within the past 3 months.","ALL","18 Years","70 Years",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to improve clinical efficiency and effectiveness in treating Temporomandibular Disorders (TMD). The researchers will integrate machine learning technology with clinical examination data, CBCT, and MRI to identify the core underlying issues of each patient. Based on this precise, AI-assisted diagnosis, the study will implement a tailored treatment framework. The final goal is to develop predictive algorithms that can determine MRI necessity while ensuring that clinical interventions are highly targeted, efficient, and successful.",[27,28,29],"Temporomandibular Disorders (TMD)","TMJ Disorder","TMJ Pain",[31,32,33,34,35,36,37,38],"Machine Learning","Cone-Beam Computed Tomography","CBCT","Magnetic Resonance Imaging","MRI","Proprioceptive Training","low level laser","Laser Acupuncture","NOT_YET_RECRUITING","2026-08-18",{"date":42,"type":43},"2026-08-20","ACTUAL",{"date":45,"type":21},"2026-10-05",{"date":47,"type":21},"2027-07-31",{"name":49,"class":50},"En Chu Kong Hospital","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100619870","clinical-microbial-and-tissue-based-characterization-of-patients-treated-for-severe-temporomandibular-joint-pathology-100619870","NCT07350239","Clinical, Microbial and Tissue-based Characterization of Patients Treated for Severe Temporomandibular Joint Pathology","Prospective Clinical, Microbial and Tissue-based Characterization Analyses of Severe Temporomandibular Joint Pathology","Inclusion Criteria:\n\n* Patients subjected to open TMJ surgery such as arthroplastic surgery with or without autogen or allogen reconstruction\n* Preserved biobank material (resected bone and soft tissue).\n\nExclusion Criteria:\n\n* Absence of biobank material.\n* Inability to give informed consent.",{"count":59,"type":21},20,"OBSERVATIONAL","The general objective of this observational study is to clarify the clinical, microbial, and tissue characteristics, aetiology, and risk factors behind severe TMJ pathology. The main questions it aims to answer are:\n\n* What are the clinical and histologic characteristics of patients with severe pathology of the TMJ?\n* Can microbial DNA be found in TMJ tissue from patients with severe pathology of the TMJ, and if so, does this correlate to the outcome of the surgery?",[28,63,64],"Ankylosis","Osteoarthritis",[66,67,68,69,70,71,72],"TMJ","Temporomandibular joint","TMJ disorder","oral and maxillafacial surgery","TMJ pain","TMJ ankylosis","Severe osteoarthritis","2026-01-13",{"date":75,"type":43},"2026-01-20",{"date":77,"type":21},"2026-03-01",{"date":79,"type":21},"2029-02-01",{"name":81,"class":50},"Örebro University, Sweden",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100612924","fmri-study-on-dctmd-patients-100612924","NCT07259902","FMRI Study on DC\u002FTMD Patients","Mapping the Neuroplasticity of Patients Affected by Chronic Temporomandibular Disorders on fMRI","Inclusion Criteria:\n\n* Afflicted with temporomandibular disorder (TMD) associated with chronic pain diagnosed by an experienced specialist among the authors; the disorder, to be considered chronic, must have been present for at least six months.\n* Patients with adequate sensorimotor abilities to participate in the study. This included sufficient vision to read from a computer or tablet screen at a normal distance, sufficient hearing ability to understand normal language, and sufficient motor ability to control a table mouse or computer.\n\nExclusion Criteria:\n\n* Control subjects, participating voluntarily in the study, must have met the following inclusion criteria:\n* Healthy subjects defined as free from temporomandibular disorders or diagnosed psychological and\u002For psychiatric disorders.",true,{"count":91,"type":21},60,[24],"Temporomandibular disorders (TMD) are among the most common causes of chronic pain worldwide. It is estimated that about 5-12% of the global population is affected, and some conditions, such as arthritis, may be causative factors. Depending on severity, the joints involved can affect multiple functions of the masticatory system, such as the ability to speak, chew, swallow, limit facial expressions, and even breathe. Moreover, most patients with TMD may report painful conditions in other parts of the body, with comorbidities including chronic fatigue syndrome, chronic headache, endometriosis, fibromyalgia, interstitial cystitis, irritable bowel syndrome, back pain, sleep disorders, and vulvodynia. Another significant condition that frequently occurs alongside TMD is psychological distress in the form of anxiety and\u002For depression.\n\nThe study proposed by this research protocol aims to investigate the presence of TMD and associated psychological\u002Fpsychiatric disorders such as anxiety and depression. The innovative value of the research lies in evaluating whether the association between these disorders may lead to neuroplastic changes at the brain level, which could guide targeted therapies. Only a few studies in the literature have explored this possible association, with inconclusive and conflicting results.\n\nThe study will be prospective in design, based on reference clinical\u002Fdiagnostic criteria and functional neuroimaging.",[28],"2025-11-27",{"date":97,"type":43},"2025-12-02",{"date":99,"type":21},"2026-01-01",{"date":101,"type":21},"2031-01-01",{"name":103,"class":50},"University of Milan",1]