[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tobacco-use-cessation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tobacco-use-cessation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,46,67,100,136,159,183,215,243,269,297,318,339],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100649272","adaptation-and-testing-of-a-novel-text-based-tobacco-cessation-and-education-intervention-in-kenyan-emergency-department-patients-100649272",false,"NCT07734727","Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department Patients","Text2Quit","Inclusion Criteria:\n\n* Current tobacco users (self-identified smokers).\n* Presenting to the Emergency Department (ED) at Kenyatta National Hospital (KNH).\n* Own a mobile phone capable of receiving text messages.\n* Willing to quit tobacco use.\n* Able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* Individuals unwilling or unable to provide consent.\n* Non-tobacco users.\n* Those without access to a mobile phone.\n* Patients who are critically ill or otherwise unable to participate (practically excluded at triage).","ALL","18 Years",{"count":19,"type":20},285,"ESTIMATED","INTERVENTIONAL",[23],"NA","In this study, investigators will adapt and implement Text2Quit in a Kenyan ED population will increase knowledge and cessation. Investigators will use a mixed-methods, hybrid implementation-effectiveness approach to assess these outcomes. Results will inform a randomized, controlled trial in a nationally representative sample of EDs in future. This study will be the first to target tobacco use in this population, the first to use mobile cessation, and will contribute to advancing implementation science on tobacco cessation globally. It will also provide a novel approach to implementation for mHealth interventions, with findings that can be generalized to other Non-Communicable Diseases and risk factors, such as alcohol use, hypertension and diabetes.",[26,27],"Tobacco Use","Tobacco Use Cessation",[29,30,31,32],"Kenya","Africa","Noncommunicable disease","global health","NOT_YET_RECRUITING","2026-08-04",{"date":36,"type":37},"2026-08-06","ACTUAL",{"date":39,"type":20},"2026-08",{"date":41,"type":20},"2028-06",{"name":43,"class":44},"Yale University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100649376","automating-tobacco-cessation-in-primary-care-100649376","NCT07735286","Automating Tobacco Cessation in Primary Care","Automating Tobacco Cessation in Primary Care Via EHR Integration: A Non-Randomized Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Patient at Penn Family Care or Edward Cooper Internal Medicine\n* Had an eligible scheduled or completed practice visit categorized as a new annual visit, return patient visit, return annual visit, or return patient sick visit\n* For the tobacco cessation intervention: Penn Family Care patient who had not previously completed the tobacco questionnaire\n* For the 30-day follow-up survey: Active smoker in the EHR as of the completed visit date or prescribed nicotine replacement therapy (NRT) between 3 days before and 30 days after the completed visit date\n* For the primary analysis: Active smoker in the EHR as of the completed visit date\n* For the primary analysis: Did not have an NRT prescription between 34 and 4 days before the completed visit date\n\nExclusion Criteria:\n\n* None except as specified in inclusion criteria.",{"count":54,"type":20},4800,[23],"This study focuses on improving how primary care teams identify patients who smoke and offer access to nicotine replacement therapy, or NRT. NRT includes medications such as nicotine patches, gum, or lozenges that can reduce cravings and support people who are interested in cutting back or quitting smoking. Although NRT is an evidence-based treatment option, it is not always discussed or prescribed during routine primary care visits. To better understand how NRT can be offered in primary care, the project will test a workflow at Penn Family Care that identifies patients who currently smoke and provides information about available tobacco treatment options. Edward Cooper Internal Medicine will serve as a comparison site. Patients who smoke and\u002For are prescribed NRT will also receive a 30-day follow-up survey to learn whether they received, picked up, or used NRT; whether it was useful; and what barriers they experienced.",[26,27],"2026-07-28",{"date":60,"type":37},"2026-07-29",{"date":62,"type":20},"2026-09-01",{"date":64,"type":20},"2027-08-01",{"name":66,"class":44},"University of Pennsylvania",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":80,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":45},"100646351","vergerx-for-smokers-not-ready-to-quit-100646351","NCT07693660","VergeRx for Smokers Not Ready to Quit","Optimizing Pharmacist-Led Tobacco Treatment for Individuals Who Smoke and Are Not Ready to Make a Quit Attempt in Federally-Qualified Health Centers","Inclusion Criteria:\n\n* Not ready to quit smoking in the next 30 days\n* Age ≥ 18 years\n* Able to read, speak, and understand English\n* Report smoking ≥ 5 cigarettes per day for the past 6 months\n* Own a cell phone\n* Willing and able to use nicotine replacement therapy (NRT) in the form of patch and lozenge\n\nExclusion Criteria:\n\n* Currently pregnant, or planning to become pregnant in the next 6 months",true,{"count":76,"type":20},592,[23],"This study uses a factorial optimization experiment to identify which treatment components help adults who smoke and are not ready to quit in the next 30 days (smokers not ready to quit, or SNRTQ) achieve smoking cessation. Participants are recruited through Federally Qualified Health Centers (FQHCs) in Virginia and West Virginia. All participants receive at least 8 weeks of nicotine replacement therapy (NRT) patch. Using a 2×2×2×2 factorial design, the study independently tests four components: a pharmacist-delivered behavioral program (VergeRx), a text-message support program (SmokefreeTXT), the addition of an NRT lozenge to the patch, and an extended 16-week course of the NRT patch versus the standard 8 weeks. The goal is to estimate the effect of each component on biochemically confirmed smoking abstinence so that an optimized treatment package can be assembled. The primary outcome is abstinence at 26 weeks; a secondary outcome is abstinence at 52 weeks.",[27],[81,82,83,84,85,86,87,88,89,90],"federally qualified health center","rural","urban","appalachia","smoking cessation","readiness to quit","smokers not ready to quit","pharmacists","low income","medicaid","2026-07-02",{"date":93,"type":37},"2026-07-09",{"date":95,"type":20},"2027-12-01",{"date":97,"type":20},"2032-11-01",{"name":99,"class":44},"University of Virginia",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":109,"briefSummary":110,"conditions":111,"keywords":115,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":133,"leadSponsor":135,"locationsCount":45},"100646196","feasibility-of-a-medical-legal-partnership-model-to-connect-coal-miners-quitaid-100646196","NCT07694492","Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid","Determining the Feasibility of Utilizing a Medical-Legal Partnership Model to Reach Coal Miners Who Use Tobacco and Nicotine Products and Connect Them to a Pharmacy-based Cessation Program","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Able to read, speak, and understand English\n* A coal miner who uses tobacco and nicotine products, lives in the U.S., and has a current black-lung workers' compensation case with a participating law office\n* Reports using tobacco and nicotine products daily for the past 6 months\n* Willing and able to use NRT in the form of patch or gum\n* Not pregnant or planning to become pregnant in the next 6 months\n\nExclusion Criteria:\n\n* Medical contraindication to NRT (e.g., within the past 30 days: heart attack or stroke; within the past 6 months: serious or worsening angina, or very rapid or irregular heartbeat requiring medication)\n* Pregnant or breastfeeding, or planning to become pregnant during the next 6 months",{"count":108,"type":20},120,[23],"Coal miners in Central Appalachia have among the highest rates of tobacco and nicotine product (TNP) use of any occupational group and face elevated rates of lung cancer and coal workers' pneumoconiosis (\"black lung\"). This study tests a novel medical-legal partnership (MLP) that \"flips\" the traditional referral direction: lawyers representing coal miners in black-lung workers' compensation cases identify clients who use TNPs and, through an ask-advise-connect process, connect them to community pharmacists who deliver QuitAid, a pharmacist-delivered medication therapy management (MTM) program, together with nicotine replacement therapy (NRT). The study has two aims: (1) an implementation-science evaluation of the ask-advise-connect process in black-lung law offices, and (2) a randomized feasibility pilot in which coal miners who use TNPs are randomized to receive QuitAid or not, with all participants receiving 24 weeks of NRT. As a feasibility pilot, the study is designed to estimate recruitment, randomization, retention, fidelity, and dose parameters to inform a future NCI R01, and is not powered to detect differences between conditions.",[27,112,113,114],"Tobacco Use Disorder","Nicotine Dependence","Smokeless Tobacco Use",[116,117,118,119,120,121,122,123,124,125,126,127,128,129],"Smoking Cessation","Lawyers","medical-legal partnership;","ask-advise-connect","pharmacist-delivered intervention","coal miners","medication therapy management (MTM)","nicotine replacement therapy","QuitAid","tobacco and nicotine products","Central Appalachia","black lung","workers' compensation","feasibility pilot",{"date":131,"type":37},"2026-07-10",{"date":62,"type":20},{"date":134,"type":20},"2027-12-31",{"name":99,"class":44},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":45},"100501166","comprehensive-tobacco-cessation-for-cancer-patients-and-survivors-100501166","NCT05805722","Comprehensive Tobacco Cessation for Cancer Patients and Survivors","Building a Comprehensive Tobacco Cessation Program for Cancer Patients and Survivors: \"A Breath of Fresh Air\"","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with study procedures and availability for the duration of the study\n* Have a documented history of cancer of any type, whether active or in remission\n* Identify as a current or recently-quit tobacco user\n\nExclusion Criteria:\n\n* Not a VCUHealth patient\n* Non English-speaking",{"count":144,"type":20},75,[23],"The purpose of this research study is to learn how best to incorporate tobacco cessation treatment into clinical care for cancer patients, survivors, and caregivers.",[27,148],"Cancer","RECRUITING","2026-06-29",{"date":152,"type":37},"2026-06-30",{"date":154,"type":37},"2023-04-12",{"date":156,"type":20},"2029-09-30",{"name":158,"class":44},"Virginia Commonwealth University",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":74,"sex":16,"minAge":166,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":172,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":181,"locationsCount":45},"100471199","comparative-effectiveness-of-mobile-health-smoking-cessation-approaches-among-underserved-patients-in-primary-care-100471199","NCT05415761","Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care","PROMOTE-UP","Inclusion Criteria:\n\n* ≥21 years old\n* Referred by the provider via Ask-Advise-Connect\n* Receiving care at one of the participating clinics\n* Daily access to their own smart phone (the study team will provide assistance to patients without a phone to obtain one through aid programs for low-income patients)\n* No household members already enrolled\n\nExclusion Criteria:\n\n* Unstable medical or psychiatric illness","21 Years",{"count":168,"type":20},1332,[23],"This study will evaluate the comparative effectiveness of three smoking cessation therapies: mobile health (mHealth) application iCanQuit, mHealth application iCanQuit + Motiv8, and the Florida quit line.",[27],[173,174],"tobacco use intervention","mobile health aids","2026-06-11",{"date":177,"type":37},"2026-06-12",{"date":179,"type":37},"2023-05-15",{"date":134,"type":20},{"name":182,"class":44},"University of Florida",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":191,"minAge":17,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":194,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":214},"100549784","integrating-chws-into-prenatal-care-for-maternal-smoking-cessation-100549784","NCT06438549","Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation","Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation: A Pilot Feasibility Study","SFHOPE","Inclusion Criteria:\n\n* \\\u003C 24 weeks pregnant\n* age \\> 18 years,\n* current smokers (100 cigarettes in their lifetime and \\>3 cigarettes per day in the last 7 days; including poly-tobacco use, combining cigarettes with non-combustible products) confirmed by expired carbon monoxide (CO)\n* willing to quit smoking and set a quit date in the next 2 weeks upon enrolling\n* enrolled in prenatal care at Loma Linda University Health (LLUH) or Riverside University Health System (RUHS)\n\nExclusion Criteria:\n\n* severe mental health problems that prevent informed consent and\u002For CHW intervention\n* women who were on Nicotine Replacement Therapy (NRT) or enrolled in a cessation program within 30 days\n* unwillingness to participate in audio-recorded key informant interviews or focus groups","FEMALE",{"count":193,"type":20},105,[23],"This develops a novel behavioral tobacco cessation program for pregnant smokers in San Bernardino County.",[26,27,197],"Tobacco Use in Childbirth",[199,200,201,202,203,204],"prevention","treatment","disparities and social inequality","tobacco use cessation","community health worker","pregnant smokers","2026-06-05",{"date":207,"type":37},"2026-06-08",{"date":209,"type":37},"2024-05-24",{"date":211,"type":20},"2027-08",{"name":213,"class":44},"Loma Linda University",2,{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":74,"sex":191,"minAge":17,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":21,"phases":224,"briefSummary":225,"conditions":226,"keywords":232,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":45},"100602905","trauma-informed-care-for-smoking-cessation-for-pregnancy-100602905","NCT07129590","Trauma-Informed Care for Smoking Cessation for Pregnancy","TRauma-Informed Care in Smoking cEssation for Pregnancy (RISE Pregnancy)","Inclusion Criteria:\n\nClinician Eligibility Criteria (Aims 1 - 3):\n\nIn Aims 1-3, will be recruiting clinicians working in our clinic sites.\n\n1. Nurse practitioner, physician assistant, nurse-midwife, medical doctor, registered nurse, clinical pharmacist, behavioral health professional, social worker, or any other healthcare professional caring for pregnant patient-participants.\n2. Age ≥ 18 years old.\n\nPatient-participant Eligibility Criteria (Aim 1):\n\nIn Aim 1, will be recruiting pregnant women (ages 18+) who:\n\n1. Currently smoking or report having smoked during a previous pregnancy\n2. Age ≥18 years old.\n3. Currently Pregnant.\n4. Identifies as a cisgender woman, or female at birth.\n5. Reports having experienced trauma aligned with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) definition for traumatic exposure.\n6. Proficient in English or Spanish languages.\n\nPatient-Participant Eligibility Criteria (Aim 2):\n\nPatient-participants will be recruited to give feedback on our intervention using Evidence-Based Quality Improvement (EBQI) meetings.\n\nInclusion criteria:\n\n1. Current or former patient in the participating clinical sites.\n2. Age ≥18 years old.\n3. Proficient in English or Spanish languages.\n\nPatient-Participant Eligibility Criteria (Aim 3): In Aim 3, will be recruiting pregnant women who are actively smoking and have histories of trauma (ages 18+).\n\nInclusion criteria:\n\n1. Currently smoking (ever smoked 100 cigarettes in their lifetime, smoked in the past 7 days and at least 1 cigarette per day, verified by CO≥6ppm)\n2. ≥18 years old\n3. Currently Pregnant\n4. Identifies as a cisgender women, or female at birth\n5. Meets DSM-5 Criterion A for trauma exposure on the Brief Trauma Questionnaire (BTQ)\n6. English or Spanish Proficient\n\nExclusion Criteria:\n\nClinician- and Patient-participant Exclusion criteria (Aims 1 - 3):\n\n1\\. Any condition, including active mental health crises or cognitive impairment, that would interfere with the ability to provide informed consent or safely complete the study.",{"count":223,"type":20},20,[23],"Trauma-informed approaches have been shown to support recovery from other substance use disorders and involve four key elements: (1) Realizing the prevalence of trauma and pathways to recovery, (2) Recognizing symptoms of trauma, (3) Responding by embedding knowledge of trauma into practices and policies and (4) Resisting re-traumatization (the 4Rs). In close partnership with Breathe California and a public safety-net clinic in San Francisco that serves primarily racial and ethnic minoritized (REM) pregnant women, the 4Rs along with the Ask, Advise, Assess, Assist and Arrange (the 5As) evidence-based intervention for tobacco cessation that is delivered by health care professionals and is a US Public Health Services clinical practice guideline for treating tobacco will be used to create and implement a smoking cessation intervention for pregnant women with experiences of trauma.",[116,227,27,228,229,230,231],"Tobacco Smoking","Smoking Reduction","Smoking, Cigarette","Trauma, Psychological","Trauma and Stressor Related Disorders",[233],"Pregnancy","2026-04-20",{"date":236,"type":37},"2026-04-23",{"date":238,"type":37},"2025-11-19",{"date":240,"type":20},"2026-07-31",{"name":242,"class":44},"University of California, San Francisco",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":21,"phases":253,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":45},"100583963","phase-3-cannabis-tobacco-co-use-treatment-study-100583963","NCT06883162","Cannabis-Tobacco Co-Use Treatment Study","Randomized Controlled Trial of Varenicline to Treat Tobacco and Cannabis Co-Use (RECLAIM)","RECLAIM","Inclusion criteria:\n\n1. Ages 18 and over (no upper age limit)\n2. Must smoke at least 5 tobacco cigarettes per day on at least 20 out of the past 30 days for the past 3 months\n3. Must express interest in quitting tobacco\n4. Must express interest in cannabis reduction and\u002For cessation\n5. Must submit a positive instant-read test for cotinine and cannabis prior to enrollment\n6. Must self-report cannabis use (THC-dominant products) on at 3 days per week out of the past 30 days\n7. Must be willing to take varenicline or placebo for 12 weeks\n8. Must reside in South Carolina\n\nExclusion criteria:\n\n1. Any significant or acutely unstable medical, psychiatric, or substance use problem (including clinically significant disorders) that would contraindicate research, interfere with safety, compromise data integrity, or preclude consistent study participation\n2. Pregnant or trying to become pregnant\n3. Use of medications with smoking cessation efficacy\n4. Regular use of e-cigarettes or other tobacco products (\\\u003C10 days in the past month)",{"count":252,"type":20},200,[254],"PHASE3","The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana). Varenicline is not FDA approved for the combination treatment of cigarette abstinence and cannabis reduction or abstinence. All participants will also receive counseling and access to online treatment modules during a quit attempt for cigarettes and a reduction attempt for cannabis. This study is being conducted by the Medical University of South Carolina. All procedures are conducted remotely and there is no in-person visits are needed.\n\nTo qualify, participants must be 18 or older, live in South Carolina, use cigarettes and cannabis, and are interested in quitting cigarettes and reducing cannabis.",[112,27,257,258,259],"Cannabis Use","Cannabis Use Disorder","Marijuana Use","2026-04-02",{"date":262,"type":37},"2026-04-03",{"date":264,"type":37},"2025-05-06",{"date":266,"type":20},"2029-01-01",{"name":268,"class":44},"Medical University of South Carolina",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":21,"phases":278,"briefSummary":280,"conditions":281,"keywords":283,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":45},"100473508","phase-1-oral-cannabidiol-for-tobacco-cessation-100473508","NCT05445804","Oral Cannabidiol for Tobacco Cessation","Inclusion Criteria:\n\n1. Have provided written informed consent\n2. Be between the ages of 18 and 65\n3. Report use of \\> 10 cigarettes per day for \\> 1 year with smoking status verified by either a positive breath carbon monoxide test (\\>8ppm) or urine cotinine test (\\>200ng\u002FmL) at screening\n4. Report interest in quitting tobacco in the next two months\n5. Are willing to engage in a series of practice quit attempts as part of the study.\n6. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests as determined by a licensed medical professional.\n7. For women of children bearing potential and men with female partners of child-bearing potential, must be willing to use an effective form of contraception during the study and for at least 30 days after the last study drug administration. Acceptable forms of contraception include: double barrier contraception or a combination of a barrier contraception and a hormonal implant, injectable, combined oral contraceptive, or a male partner who has had a vasectomy; intrauterine device or tubal ligation.\n\nExclusion Criteria:\n\n1. Meet Diagnostic and Statistical Manual-V criteria for substance use disorders except for nicotine or tobacco use disorders\n2. Are currently receiving or interested in immediately receiving behavioral treatment or medication for smoking cessation\n3. Test positive for drugs of abuse (except nicotine) and\u002For breath alcohol test at study admission\n4. Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity.\n5. Have a lifetime history of suicidal behavior (i.e. past suicide attempt), or current suicidal behavior or ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)\n6. Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding.\n7. Use of an over the counter, systemic or topical drug(s), herbal supplement(s), or vitamin(s) within 14 days (or 5 half-lives for that specific drug) of experimental sessions; which, in the opinion of the investigator or sponsor, will interfere with the study results or the safety of the participant\n8. Use of a prescription medication (with the exception of birth control prescriptions) within 14 days (or 5 half-lives for that specific drug) of experimental sessions; which, in the opinion of the investigator or sponsor, will interfere with the study result or the safety of the participant. This includes any medication metabolized via CYP2D6, CYP2C9, CYP2B10, or which induce\u002Finhibit CYP3A4 enzymes.\n9. Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g. Prinzmetal's angina).\n10. Have elevated serum liver transaminase (AST or ALT) above 2 x upper limit of normal, or elevated bilirubin above 1.5 x upper limit of normal.\n11. Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.\n\n    \\-","65 Years",{"count":277,"type":20},50,[279],"PHASE1","Cannabidiol is a compound found in cannabis plants that is well tolerated, has low abuse liability, and might be an effective medication to promote tobacco cessation. This clinical study will use a validated approach for screening tobacco cessation medications to determine if oral cannabidiol increases short-term tobacco abstinence, and evaluate mechanisms that might explain how cannabidiol alters smoking behavior. Results from this study will provide data on the therapeutic potential of cannabidiol for tobacco cessation.",[26,227,282,112,27],"Tobacco Dependence",[284,285,286,287],"Tobacco","Smoking","Cannabidiol","CBD","2026-01-05",{"date":290,"type":37},"2026-01-07",{"date":292,"type":37},"2022-11-01",{"date":294,"type":20},"2027-02-01",{"name":296,"class":44},"Johns Hopkins University",{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":21,"phases":305,"briefSummary":307,"conditions":308,"keywords":4,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":45},"100604339","phase-4-extended-intervention-for-tobacco-use-exit-for-people-experiencing-homelessness-100604339","NCT07148232","Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness","Inclusion Criteria:\n\n1. Age 18 years or older\n2. Able to understand study procedures and to comply with them for the entire length of the study.\n3. Ability of individual to understand a written informed consent document, and the willingness to sign it.\n4. Staying at the recruitment site and meeting criteria for homelessness as defined by the Homeless Emergency and Rapid Transition to Housing Act.\n5. Current smoking (smoking at least 5 cigarettes per day (cpd), verified via expired carbon monoxide (CO) \\>= 8 ppm using Micro+pro Smokerlyzer).\n6. Having an intention to quit smoking within the next six months.\n7. English speaking.\n\nExclusion Criteria:\n\n1. Contraindication to any study-related procedure or assessment.\n2. Reasons that preclude the use of nicotine replacement therapy (NRT) (e.g., pregnancy or myocardial infarction in the past two weeks).",{"count":304,"type":20},150,[306],"PHASE4","This study is investigating tobacco use and providing tobacco treatment among people experiencing homelessness in California, in San Francisco and Los Angeles.",[309,310,26,27,282],"Tobacco Cessation","Tobacco Abstinence",{"date":312,"type":37},"2025-11-21",{"date":314,"type":37},"2025-11-14",{"date":316,"type":20},"2027-06-30",{"name":242,"class":44},{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":325,"targetDuration":4,"studyType":327,"phases":4,"briefSummary":328,"conditions":329,"keywords":4,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":45},"100595328","tabacco-cessation-in-hospital-services-100595328","NCT07031024","Tabacco Cessation in Hospital Services","Tabacco Cessation: Evaluation of Patient Perceptions and Professional Practices in the Odontology Department of the Nice Institute of Oral Medicine","Inclusion Criteria:\n\n* Patients: Female male non gendered.\n* Over 18 years old\n* Whatever their state of healthRegular smoker: According to the Institut national de prévention et d'éducation pour la santé (INPES), a regular smoker is someone who reports smoking at least one cigarette (or equivalent) a day.\n* Whether or not they use any other form of 'drug'.\n* Whatever the reason for their consultation.\n* Signature of no objection form\n* Praticiens:- Male , Female non gendered\n* Age 18 years\n* General practitioner at CHU ( Professor - MCU - Assistant - Associate)\n* Specialist at the University Hospital (Professor - MCU - Assistant - Associate)\n* Intern (oral medicine - oral surgery - orthodontics)\n* student (4th, 5th and 6th year)\"\n\nExclusion Criteria:\n\n* Patients: Ex-smoker patients\n* Non-smokers\n* Patients under guardianship\n* Patients with language difficulties\n* Praticiens: - Non-dentistry students\n* Student in dentistry without clinical practice (2nd, 3rd year)\n* Practitioner with exclusive private practice\"",{"count":326,"type":20},300,"OBSERVATIONAL","Tobacco poses a health risk, whatever the method of consumption. According to the baro cancer 2021 : Only 23% of smokers say they have discussed smoking with a healthcare professional in the last 12 months. Studies in France on the practitioner's point of view have mainly been carried out in private practice, and at least 2 years ago. Few studies have looked at the patient's point of view. To date, no studies have been carried out in France on the patient's point of view. This is why the aim of our study is to: current state of smoking cessation in a hospital services: knowledge, attitudes and practices, from the point of view of the practitioner and the patient. Evaluation via a questionnaire.",[27],"2025-06-12",{"date":332,"type":37},"2025-06-22",{"date":334,"type":37},"2024-07-01",{"date":336,"type":20},"2025-08-30",{"name":338,"class":44},"Centre Hospitalier Universitaire de Nice",{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":21,"phases":349,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":45},"100583802","reach-through-equitable-implementation-in-utah-100583802","NCT06881069","Reach Through Equitable Implementation in Utah","Reach Through Equitable Implementation in Utah (REI-UT)","REI-UT","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Speak English or Spanish\n* Currently use tobacco\n* Live in a persistent poverty census tract\n* Present at participating clinics\n* Valid cell phone number in the electronic health record (EHR)\n* Electronic health records indicate they have not opted out of receiving text contact from the clinic\n\nExclusion Criteria:\n\n* Opt-out of study",{"count":348,"type":20},1560,[23],"The goal of this pragmatic, multilevel Type III Hybrid Effectiveness-Implementation trial is to increase the reach of existing evidence-based interventions (EBIs) for tobacco cessation and to mitigate the impact of adverse Social Drivers of Health (SDOH) among safety-net healthcare system patients who live in persistent poverty (PP) census tracts.\n\nAim 1: Test the ability of patient-level Conversational Agents (CA) \\& Patient Navigation (PN) dissemination strategies to increase the Reach (primary outcome) of evidence-based tobacco cessation treatment delivered via the Utah Tobacco and Nicotine Quit Services (Quit Services) among Community Health Center (CHC) patients who use tobacco and live in persistent poverty census tracts. Secondary analyses will examine the outcome of Reach of services for SDOH among these patients and will evaluate both 1) patient-level CA and PN dissemination strategies and 2) a clinic-level implementation strategy using a pre-post design.\n\nAim 2: Explore contextual factors (e.g., clinic size, patient composition, rurality, patient demographics) related to the Reach, Adoption, Implementation, and potential Maintenance of strategies.\n\nAim 3: Determine the cost-effectiveness of clinic and patient-level strategies based on Quit Services enrollment and service receipt for SDOH.\n\nThis trial implements a clinic-level implementation strategy, Ask-Advise-Connect (AAC), to address tobacco cessation and needs around social drivers of health for patients in all participating clinics. Eligible patients who are not enrolled in Quit Services four weeks after the clinical encounter, will receive text messages from a chatbot offering information and connections to the Quit Services and patient navigation support from a Community Health Worker.",[27,26,227,352,282],"Tobacco Chewing","2025-03-11",{"date":355,"type":37},"2025-03-18",{"date":357,"type":37},"2025-02-13",{"date":359,"type":20},"2028-01-30",{"name":361,"class":44},"University of Utah"]