[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tof\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tof":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100651312","residual-neuromuscular-blockade-and-pacu-admission-100651312",false,"NCT07758868","Residual Neuromuscular Blockade and PACU Admission","Incidence and Clinical Implications of Residual Neuromuscular Blockade in Patients Planned for Post-Anesthesia Care Unit Admission: A Prospective Observational Study","Inclusion Criteria: Patients aged 18-90 years with American Society of Anesthesiologists (ASA) physical status I-III who underwent elective surgery under general anesthesia and received a neuromuscular blocking agent were included in the study.\n\nExclusion Criteria: Patients younger than 18 years or older than 90 years, those requiring postoperative invasive mechanical ventilation and transfer to the intensive care unit while intubated, patients undergoing emergency surgery, and those with a pre-existing neuromuscular disorder were excluded from the study.","ALL","18 Years","90 Years",{"count":20,"type":21},160,"ESTIMATED","OBSERVATIONAL","Residual neuromuscular blockade (RNMB) remains an underrecognized postoperative safety concern associated with pulmonary complications, prolonged post-anesthesia care unit stay, and reduced patient satisfaction. Because conventional clinical tests are insufficiently sensitive and specific, current guidelines recommend quantitative neuromuscular monitoring to confirm adequate recovery, defined as a train-of-four ratio of ≥0.9.\n\nThis prospective observational study included adult patients aged 18-90 years with ASA physical status I-III who underwent elective surgery under general anesthesia with neuromuscular blocking agents. Demographic, clinical, anesthetic, surgical, and reversal-related variables were recorded. Postoperative neuromuscular recovery was quantitatively assessed at the adductor pollicis muscle using TOFscan® acceleromyography at the 10th postoperative minute. Patients were subsequently followed in either the PACU or surgical ward according to clinical indications, and postoperative adverse events were documented. The study aimed to evaluate the incidence and potential determinants of RNMB in accordance with contemporary neuromuscular monitoring guidelines.",[25],"TOF","NOT_YET_RECRUITING","2026-08-06",{"date":29,"type":30},"2026-08-11","ACTUAL",{"date":32,"type":21},"2026-08-10",{"date":34,"type":21},"2026-10-01",{"name":36,"class":37},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":48,"conditions":49,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":4},"100593751","quality-of-life-in-operated-adult-patients-with-tetralogy-of-fallot-and-correlation-with-myocardial-strain-analysis-by-cmr-100593751","NCT07010510","Quality of Life in Operated Adult Patients With Tetralogy of Fallot and Correlation With Myocardial Strain Analysis by CMR","Quality of Life in Operated Adult Patients With Tetralogy of Fallot and Correlation With Myocardial Strain Analysis by Cardiac Magnetic Resonance Imaging and Exercise Test","* Inclusion criteria:\n\n  * Adult TOF patients who were referred for surgical repair of TOF either valve sparing repair (VSR) or valved conduit (stented valve conduits, freestyle valved conduits, bio-prosthesis, or homograft).\n  * Adults (age ≥18 years) with repaired TOF.\n  * Undergoing routine CMR for clinical follow-up.\n  * Sinus rhythm or known history of ventricular arrhythmia.\n* Exclusion criteria:\n\n  * Confounding other congenital defects e.g. AV canal.\n  * Significant aortic regurgitation or stenosis.\n  * Significant mitral regurgitation.\n  * Residual significant major aorto-pulmonary collaterals (MAPCAs).\n  * Patients with contraindications to CMR (e.g., pacemakers, severe renal impairment, claustrophobic).\n  * Poor-quality CMR images precluding strain analysis.",{"count":47,"type":21},100,"Title:\n\nFunctional Assessment and Arrhythmia Prediction in Adult Patients with Repaired Tetralogy of Fallot Using a Multimodality Approach\n\nBackground:\n\nTetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect. Surgical repair has improved survival into adulthood, but long-term complications like arrhythmias and heart failure remain common. Assessing health-related quality of life (HRQOL) and cardiac function is essential.\n\nAim:\n\nAssess functional status of adult patients with repaired TOF using a multimodal approach, including myocardial strain analysis via CMR.\n\nIdentify predictors of arrhythmia using strain and clinical parameters.\n\nMethods:\n\nDesign: Prospective observational study over one year.\n\nPopulation: Adults (≥18 years) with repaired TOF undergoing follow-up CMR.\n\nAssessments:\n\nClinical evaluation (NYHA class)\n\nEchocardiography (RV size, function, valve status)\n\nLaboratory tests (BNP, NT-proBNP)\n\nExercise testing (METs, VO₂ max)\n\nECG \\& 24-hour Holter monitoring (QRS duration, arrhythmias)\n\nCMR (volumes, flow, fibrosis, strain analysis of RA, RV, LV)\n\nOutcomes:\n\nPrimary: Functional assessment of repaired TOF patients.\n\nSecondary: Detection of arrhythmia and need for further interventions (e.g., ICD or ablation).\n\nStatistical Analysis:\n\nComparison between arrhythmic and non-arrhythmic groups.\n\nLogistic regression for predictors of arrhythmia.\n\nROC analysis to determine optimal strain cut-off values.\n\nEthical Considerations:\n\nEthics committee approval and informed consent.\n\nData confidentiality maintained.",[25],"2025-05-30",{"date":52,"type":30},"2025-06-08",{"date":54,"type":21},"2025-06",{"date":56,"type":21},"2030-01",{"name":58,"class":59},"Assiut University","OTHER"]