[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"total-thyroidectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:total-thyroidectomy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,73,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100649300","evaluation-of-levothyroxine-replacement-therapy-after-total-thyroidectomy-using-a-smart-wristband-100649300",false,"NCT07733375","Evaluation of Levothyroxine Replacement Therapy After Total Thyroidectomy Using a Smart Wristband","Comparative Evaluation of the Effectiveness of Levothyroxine Replacement Therapy After Total Thyroidectomy Using Smart Wristband-Measured Nocturnal Heart Rate and Heart Rhythm Parameters Versus Thyroid Function Tests","SMART-THY","Inclusion Criteria:\n\nAge 18 years or older. Undergoing total thyroidectomy at the Department of General Surgery, Yeditepe University Faculty of Medicine Hospital.\n\nInitiation of levothyroxine as part of routine postoperative clinical care. Willing and able to attend the routine 1-month postoperative thyroid function test follow-up visit.\n\nWilling and able to wear the Xiaomi Smart Band 10 throughout the study period. Able to provide written informed consent.\n\nExclusion Criteria:\n\nHistory of cardiac arrhythmia. Current use of beta-blockers or other antiarrhythmic medications that may affect heart rate.\n\nHistory of heart failure or advanced cardiovascular disease. Diagnosed sleep disorders that may interfere with nighttime heart rate measurements.\n\nPregnancy. Inability or unwillingness to wear the smart wristband as required. Missing clinical or laboratory data required for outcome assessment. Refusal to participate or withdrawal of informed consent.","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine whether nighttime heart rate and heart rhythm data collected by a smart wristband can identify under- or over-replacement with levothyroxine before the routine 1-month thyroid function tests in adults who have undergone total thyroidectomy.\n\nAfter total thyroidectomy, patients usually start levothyroxine replacement therapy, and the dose is adjusted about 1 month later based on thyroid function tests. This study aims to determine whether changes in nighttime heart rate and heart rhythm can provide an earlier indication that the levothyroxine dose is too low or too high.\n\nThe main questions it aims to answer are:\n\nCan nighttime heart rate and heart rhythm measured by a smart wristband identify under- or over-replacement with levothyroxine before routine thyroid function testing? How well do smart wristband measurements agree with thyroid function test results?\n\nParticipants will:\n\nWear a smart wristband after total thyroidectomy. Continue taking levothyroxine as prescribed by their physician. Undergo routine thyroid function testing approximately 1 month after surgery as part of standard clinical care.\n\nAllow researchers to compare smart wristband measurements with thyroid function test results to evaluate whether wearable data can provide an earlier indication of inadequate or excessive levothyroxine replacement.",[25,26,27],"Total Thyroidectomy","Hyperthyroidism","Hypothyroidism",[25,29,30,31,32,33],"Levothyroxine Replacement Therapy","Wearable Devices","Nighttime Heart Rate","Postoperative Hypothyroidism","Postoperative Hyperthyroidism","RECRUITING","2026-07-24",{"date":37,"type":38},"2026-07-29","ACTUAL",{"date":40,"type":38},"2026-07-22",{"date":42,"type":21},"2027-02-01",{"name":44,"class":45},"Yeditepe University Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100648424","phase-4-the-association-between-bilateral-intermediate-cervical-plexus-block-and-salivary-biomarkers-of-surgical-stress-response-following-total-thyroidectomy-100648424","NCT07721818","The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary Biomarkers of Surgical Stress Response Following Total Thyroidectomy","Inclusion Criteria:\n\n* ASA I or ASA II\n* euthyroid status\n* signed informed consent\n\nExclusion Criteria:\n\n* patients who refuse to sign the informed consent form\n* infection at the block injection site\n* hypersensitivity or contraindications to the medication used in the study\n* hypo\u002Fhyperthyroidism at the time of surgery\n* presence of substernal goiter\n* additional surgical interventions during the procedure\n* history of previous neck surgery or radiation\n* coagulopathy\n* uncontroled respiratory disease\n* diabetes mellitus\n* autoimune disease\n* chronic corticosteroid therapy\n* smokers\n* pregnant women",{"count":54,"type":21},48,"INTERVENTIONAL",[57],"PHASE4","The aim of this study is to evaluate how an ultrasound-guided bilateral intermediate cervical plexus block affects the surgical stress response in individuals undergoing total thyroidectomy. The primary objective is to quantify this physiological response through the analysis of specific stress and inflammatory biomarkers collected from the participants' saliva.\n\nThe clinical trial will encompass a total of 48 patients, randomized equally into two distinct cohorts of 24 participants each. The control group will undergo standard total intravenous anesthesia (TIVA), whereas the experimental group will receive the bilateral intermediate cervical plexus block in combination with the TIVA protocol.\n\nIt is hypothesized that integrating this regional nerve block with total intravenous anesthesia will significantly attenuate the surgical stress response, evidenced by a reduction in salivary biomarker concentration, compared to utilizing TIVA alone during thyroid surgery.\n\nValidating this hypothesis would offer robust scientific evidence to advocate for the routine integration of the bilateral intermediate cervical plexus block into standard anesthetic practices for total thyroidectomy. Ultimately, this approach aims to minimize perioperative stress and facilitate a more rapid postoperative recovery for patients.",[60,25,61,62],"Surgical Stress Response","Saliva Collection","Cervical Plexus Block","NOT_YET_RECRUITING","2026-07-20",{"date":66,"type":38},"2026-07-23",{"date":68,"type":21},"2026-08-01",{"date":70,"type":21},"2027-04",{"name":72,"class":45},"University Hospital Dubrava",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":55,"phases":82,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100545529","impact-of-manual-therapy-on-laryngeal-function-following-total-thyroidectomy-100545529","NCT06383091","Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy","Man Total Thy","Inclusion Criteria:\n\n* The study population consists of individuals with malignant or benign thyroid disease scheduled to undergo total thyroidectomy\n* native speakers of English\n* All patients will be greater than or equal to 18 years of age\n\nExclusion Criteria:\n\n* Participants will be excluded if they have completed voice therapy prior\n* are current smokers\n* have organic vocal fold pathology or clear mucosal changes to the vocal folds that can affect vibration (e.g., vocal fold scar, polyp, or nodules),\n* pre-existing unilateral or bilateral vocal fold paralysis\n* have had prior surgical neck or chest history including central or lateral neck dissection\n* pre- or post-operative abscess or inflammation\n* have a history of head, neck, or chest radiation, diagnosed baseline oral or pharyngeal dysphagia\n* have recently started taking in the last 3 months, plan to start taking or increase the level of testosterone during the treatment period\n* greater than 10% otherwise unexplained weight loss\n* had a recent aspiration pneumonia",{"count":81,"type":21},20,[83],"NA","In this clinical trial, the investigators are seeking to learn if a course of voice therapy, including neck massage, stretches and pain science education in addition to voice exercise and scar massage will effectively treatment patient complaints of swallowing or voice changes after total thyroidectomy as compared to voice exercise and scar massage alone.\n\nThe main questions it aims to answer are:\n\nWill neck massage, stretches and pain science education reduce patient complaints of swallowing changes after total thyroidectomy?\n\nWill neck massage, stretches and pain science education reduce patient complaints of voice changes after total thyroidectomy?\n\nWill neck massage, stretches and pain science education reduce patient complaints of scar tethering and quality changes after total thyroidectomy?\n\nWill neck massage, stretches and pain science education improve quality of life after total thyroidectomy?\n\nParticipants will:\n\nParticipate in 4 visits with the participant's endocrine\u002Flaryngology surgeon. One prior and 3 after surgery for endoscopic evaluation and tests.\n\nParticipate in 5 Speech-Language Pathology Sessions for intervention exercises and tests. One prior and 4 after surgery.\n\nComplete a journal of the participant's Home Exercise Practice",[25],[87,88,89,90],"manual","pain neuroscience education","total thyroidectomy","Speech Pathology","2026-06-17",{"date":93,"type":38},"2026-06-22",{"date":95,"type":38},"2024-06-03",{"date":97,"type":21},"2027-12",{"name":99,"class":45},"Johns Hopkins University",2,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":55,"phases":110,"briefSummary":111,"conditions":112,"keywords":116,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":46},"100624939","comparing-pteye-assisted-versus-conventional-total-thyroidectomy-100624939","NCT07416149","Comparing PTeye-assisted Versus Conventional Total Thyroidectomy","Reducing Post-operative Hypoparathyroidism With Probe-based Near Infrared Autofluorescence (NIRAF)- Assisted Total Thyroidectomy Versus Conventional Total Thyroidectomy, a Randomized-controlled Trial","Inclusion Criteria:\n\n* Adult patients ≥18 years of age\n* Undergoing total thyroidectomy, or completion total thyroidectomy\n* Pre-operative serum adjusted calcium levels within normal ranges\n\nExclusion Criteria:\n\n* Patients on pre-operative calcium or vitamin D supplements\n* Patients with pre-operative vitamin D deficiency, defined as serum vitamin D\\\u003C30nmol\u002FL\n* Patients with untreated primary or secondary hyperparathyroidism\n* Patient with known non-surgical hypoparathyroidism diseases\n* Patients with estimated glomerular filtration rate \\\u003C30ml\u002F1.73m2\u002Fmin, on dialysis, or having a history of kidney transplant",{"count":109,"type":21},210,[83],"This is a prospective, single-blinded, randomized controlled trial to evaluate whether PTeye™ can reduce post-operative hypoparathyroidism (PH). The study will enroll consecutive patients undergoing total thyroidectomy in a teritary endocrine surgery unit in Hong Kong, randomizing them into receiving conventional surgery versus PTeye™-assisted surgery. Subjects will be assigned to the two groups before surgery. Subjects will be under medical care as in usual practice.",[113,114,115,25],"Hypocalcemia","Parathyroid","Hypoparathyroidism Post-surgical",[117,118,119,120,121,122],"Thyroidectomy","calcium","hypocalcemia","post operation","hypoparathyroidism","PTeye™ parathyroid detection system","2026-02-12",{"date":125,"type":38},"2026-02-17",{"date":127,"type":38},"2025-09-16",{"date":129,"type":21},"2028-12-31",{"name":131,"class":45},"The University of Hong Kong"]