[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma-sequelae\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma-sequelae":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100652507","immunomonitoring-of-circulating-immune-cells-in-maxillofacial-surgery-100652507",false,"NCT07772063","Immunomonitoring of Circulating Immune Cells in Maxillofacial Surgery","MMUNOFACE: Immunomonitoring of Circulating Immune Cells in Maxillofacial Surgery","IMMUNOFACE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* managed in the department of maxillofacial surgery (Pitié-Salpêtrière Hospital)\n* Scheduled for surgery as part of treatment involving free flap reconstruction\n* Informed about the study, with no objections, and having provided written consent for genetic testing\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Individuals under legal protective measures","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","2 Months","OBSERVATIONAL","The immune response following facial reconstruction may help predict healing time and the date of discharge after maxillofacial surgery. Regulatory T cells (Tregs) are emerging as powerful modulators of the immune response in various contexts during reconstruction. Indeed, Tregs are involved in tissue regeneration, control the local inflammatory response, and promote effective tissue repair while limiting fibrosis. An early increase in circulating Tregs could serve as an indicator of a favorable reparative\u002Fregenerative response.\n\nPrimary objective: To identify changes in the proportion of regulatory T cells (Tregs) among circulating immune cells between the preoperative and postoperative periods, and to assess its association with length of hospital stay.\n\nPrimary outcome measure: proportion of regulatory T cells (Tregs) among CD4 lymphocytes, measured by flow cytometry at different time points (preoperative, perioperative, and postoperative), and its association with length of hospital stay (days).\n\nStudy Design: monocentric, including a maximum of 60 patients;\n\nInclusion criteria: Age ≥ 18 years; managed in the department of maxillofacial surgery (Pitié-Salpêtrière Hospital); Scheduled for surgery as part of treatment involving free flap reconstruction; Informed about the study, with no objections, and having provided written consent for genetic testing\n\nExclusion criteria: Pregnant or breastfeeding women; Individuals under legal protective measures\n\nResearch Process:\n\nAfter verifying eligibility criteria, patients will be informed about the study during a clinical visit. Following a reflection period that the patient deems necessary to make a decision, their lack of objection and consent to genetic testing will be obtained. As part of the research, a 7 mL tube of ACD blood will be collected in addition to the routine blood samples during routine blood draws at the following visits: preoperative, perioperative (during surgery), and postoperative follow-ups (Day 2, Day 5, and Day 15). These tubes will then be analyzed in the Immunology Research Laboratory of Prof. Miyara and Dr. Bouaoud (CIMI, Pitié Salpêtrière) using flow cytometry (counting\u002Fassay of Tregs and subpopulations). During the operation, surgical waste (bone, muscle, drainage fluids) will also be collected for research purposes; it will be analyzed in the immunology research laboratory of Prof. Miyara and Dr. Bouaoud (CIMI, Pitié Salpêtrière) using flow cytometry and, in some cases, single-cell transcriptomics when the sample meets the necessary quality criteria (sufficient cell count, viability, etc.).",[26,27,28],"Head and Neck Cancer (H&N)","Trauma Sequelae","Osteoradionecrosis of Jaws",[30,31],"Immunomonitoring of Circulating Immune","Cells Following Free Flap Reconstruction in Maxillofacial Surgery","NOT_YET_RECRUITING","2026-08-17",{"date":35,"type":36},"2026-08-19","ACTUAL",{"date":38,"type":21},"2026-09",{"date":40,"type":21},"2027-05",{"name":42,"class":43},"Assistance Publique - Hôpitaux de Paris","OTHER"]