[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"trauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:trauma":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,86,0,25,[9,50,80,101,116,152,179,202,225,254,290,321,344,361,389,410,441,468,495,519,543,568,593,618,641],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100486430","integrated-suicide--trauma-therapy-for-suicide-risk-100486430",false,"NCT05613972","Integrated Suicide & Trauma Therapy for Suicide Risk","Using Integrated Suicide and Trauma Therapy to Reduce Suicide Risk Among Adults With a History of Childhood Trauma","ISTT","Inclusion Criteria:\n\n* Beck Scale for Suicidal Ideation \\> 10\n* Presence of childhood trauma defined by a minimum moderate score on any of the Childhood Trauma Questionnaire subscales (emotional abuse, physical, abuse, sexual abuse, emotional neglect, and physical neglect\n* any psychiatric diagnosis as long as there are no impairments that limit consent or understanding of ISTT (e.g. active psychosis)\n* Ability to provide informed consent\n* Not receiving other psychotherapy concurrently\n* Ability to undergo psychotherapy in English\n\nExclusion Criteria:\n\n* The presence of cognitive impairment and\u002For active psychosis that would limit consent or understanding of ISTT\n* Unwilling or unable to provide informed consent","ALL","18 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The investigators have developed a novel suicide intervention, Integrated Suicide and Trauma Therapy (ISTT). ISTT combines Brief-Skills for Safer Living (Brief-SfSL)-a promising method to enhance coping skills and reduce suicidality-with a trauma therapy component to alleviate the specific impacts of childhood trauma on suicide risk. The aim of this pilot is to test 12-weeks of ISTT to alleviate suicide risk among individuals with a history of childhood trauma and current suicidality.",[28,29,30],"Suicide","Trauma","Major Depressive Disorder",[32,33,34,35,36],"Childhood trauma","Early life adversity","Adverse childhood experiences","Suicide intervention","Psychotherapy","RECRUITING","2026-08-13",{"date":40,"type":41},"2026-08-17","ACTUAL",{"date":43,"type":41},"2025-12-08",{"date":45,"type":22},"2027-07",{"name":47,"class":48},"Unity Health Toronto","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100512891","phase-2-calcium-and-vasopressin-following-injury-early-resuscitation-cavalier-trial-100512891","NCT05958342","CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial","CAVALIER","Inclusion Criteria:\n\nPrehospital Phase:\n\nInjured patients at risk of hemorrhagic shock being transported from scene or referral hospital to a participating CAVALIER trial site who meet the following criteria:\n\n1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site\n\nOR\n\n1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site\n\nEarly In-Hospital Phase:\n\nInjured patients at a participating CAVALIER trial site at risk of hemorrhagic shock who meet the following criteria:\n\n1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial site\n\nOR\n\n1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial site\n\nAND\n\n2.Blood\u002Fblood component transfusion initiated in prehospital setting or deemed clinically indicated within 60 minutes of arrival at the enrolling trauma center\n\nAND 3. Clinical team deems Operating Room for major hemorrhage control procedure (e.g., laparotomy, thoracotomy, vascular exploration or extremity amputation) indicated within 60 minutes of arrival at the enrolling trauma center\n\nAND\n\n4\\. Anticipated admission to intensive care unit (ICU)\n\nExclusion Criteria:\n\nPrehospital Phase\n\n1. Wearing NO CAVALIER opt-out bracelet\n2. Age \\> 90 or \\\u003C 18 years of age\n3. Isolated fall from standing injury mechanism\n4. Known prisoner\n5. Known pregnancy\n6. Traumatic arrest with \\> 5 minutes of CPR without return of vital signs\n7. Brain matter exposed or penetrating brain injury\n8. Isolated drowning or hanging victims\n9. Objection to study voiced by subject or family member at the scene or at the trauma center\n10. Inability to obtain IV\u002FIO access\n\nEarly In-Hospital Phase:\n\n1. Wearing NO CAVALIER opt-out bracelet\n2. Age \\> 90 or \\\u003C 18 years of age\n3. Isolated fall from standing injury mechanism\n4. Known prisoner\n5. Known pregnancy\n6. Traumatic arrest with \\> 5 minutes of CPR without return of vital signs\n7. Brain matter exposed or penetrating brain injury\n8. Isolated drowning or hanging victims\n9. Objection to study voiced by subject or family member at the scene or at the trauma center\n10. Inability to obtain IV access","90 Years",{"count":59,"type":22},1050,[61],"PHASE2","The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.",[29,64],"Hemorrhage",[66,67,68,69],"hemorrhagic shock","trauma","calcium gluconate","vasopressin","2026-08-03",{"date":72,"type":41},"2026-08-06",{"date":74,"type":41},"2024-06-30",{"date":76,"type":22},"2028-03",{"name":78,"class":48},"Jason Sperry",16,{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":49},"100630632","acute-subdural-hematoma-100630632","NCT07490197","Acute Subdural Hematoma","Acute Subdural Hematoma Registry","Inclusion Criteria:\n\n* ≥18 years old\n* Included in the Methodist Dallas Medical Center Trauma Registry\n* Acute subdural hematoma identified on computed tomography scan or magnetic resonance imaging of the brain in the trauma bay within 72 hours of a traumatic event\n\nExclusion Criteria:\n\n* \\\u003C18 years old\n* Prisoners, pregnant persons, or other protected population",{"count":88,"type":22},100,"OBSERVATIONAL","This retrospective data repository will serve as a means to aggregate and analyze standard surgical interventions and Middle Meningeal Arteryembolization as suitable treatment options for Acute Subdural Hematoma.",[29],"2026-07-31",{"date":94,"type":41},"2026-08-04",{"date":96,"type":41},"2024-01-30",{"date":98,"type":22},"2028-02",{"name":100,"class":48},"Methodist Health System",{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":108,"targetDuration":109,"studyType":89,"phases":4,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":114,"leadSponsor":115,"locationsCount":49},"100630630","traumatic-cardiac-arrest-100630630","NCT07490171","Traumatic Cardiac Arrest","Traumatic Cardiac Arrest Registry","Inclusion Criteria:\n\n≥18 years old Included in the MDMC Trauma Registry Cardiac arrest in pre-hospital setting or trauma bay\n\nExclusion Criteria:\n\n\\\u003C18 years old Prisoners, pregnant persons, or other protected population",{"count":88,"type":22},"5 Years","This retrospective data repository will serve as a means to aggregate and analyze order of pre-hospital care (intubation, medication, etc) as it relates to Traumatic cardiac arrest.",[29],{"date":94,"type":41},{"date":96,"type":41},{"date":98,"type":22},{"name":100,"class":48},{"id":117,"slug":118,"hasResults":12,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":12,"sex":18,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":23,"phases":127,"briefSummary":128,"conditions":129,"keywords":136,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":49},"100610407","animal-assisted-therapy-100610407","NCT07227181","Animal Assisted Therapy","Effects of Animal-Assisted Therapy on Trauma Patient's Willingness to Participate in Ambulation","Inclusion Criteria:\n\n* Adults (18 years of age and older)\n* trauma patients\n* emergency general surgery patients\n* pediatric patients (4 - 17 years old)\n\nExclusion Criteria:\n\n* weight bearing limitation\n* spine instability\n* oxygen requirement \\>2LPM, GCS \\\u003C15,\n* high fall risk (as evidenced by door label)\n* fear of dogs\n* allergies to dogs\n* prisoners","4 Years","99 Years",{"count":126,"type":22},128,[25],"This study looks at whether walking with a therapy dog helps adult and pediatric trauma patients move more during their hospital stay. Early movement after an injury or surgery can prevent problems such as blood clots, pressure sores, and muscle loss, but pain and anxiety often make it hard for patients to get out of bed.\n\nEach patient in this study takes part in two walking sessions-one with a certified therapy dog and one without a dog. The order is randomized, so some patients walk with the dog first and others walk without the dog first. Before and after each walk, patients fill out short surveys about their pain, anxiety, and motivation to move. The research team measures how far and how long each patient walks in both sessions.\n\nThe goal of this project is to see if therapy dog visits can safely and effectively improve mobility, reduce pain and anxiety, and make walking more enjoyable for trauma patients. Findings from this study may help hospitals design better rehabilitation programs that use animal-assisted therapy to support physical and emotional recovery.",[130,29,131,132,133,134,135],"Anxiety","Hospitalized Adult Patients","Rehabilitation","Physical Mobility Impairment","Therapy Dog","Pediatric Patient (1m-21y)",[137,134,138,139,140,141,142],"Animal-Assisted Therapy","Trauma Patients","Early Mobilization","Anxiety Reduction","Pain Reduction","Human-Animal Interaction","2026-07-23",{"date":145,"type":41},"2026-07-24",{"date":147,"type":41},"2025-07-23",{"date":149,"type":22},"2026-12",{"name":151,"class":48},"Andrew Bernard",{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":12,"sex":18,"minAge":159,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":23,"phases":162,"briefSummary":163,"conditions":164,"keywords":168,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":170,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":178},"100573170","onyx-liquid-embolic-ide-clinical-study-100573170","NCT06742801","Onyx™ Liquid Embolic IDE Clinical Study","PELE IDE Clinical Study, Peripheral Onyx™ Liquid Embolic Safety and Effectiveness of The Onyx™ LES for Embolization of Arterial Hemorrhage in the Peripheral Vasculature","Inclusion Criteria:\n\n1. Patient is ≥ 22 years old.\n2. Active arterial bleeding in the peripheral vasculature confirmed by radiologic and\u002For endoscopic imaging and deemed suitable for embolization treatment by the investigator.\n\n   In this study, peripheral vasculature is defined as outside the brain and heart.\n3. Patient or legally authorized representative (LAR) is able to provide written consent to participate in the study.\n4. Life expectancy of \\>30 days, in the opinion of the investigator at the time of enrollment.\n5. Target treatment area is free from prior embolization treatment.\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding.\n2. Symptoms of active infection.\n3. Patient is known to be participating in the study of an investigational drug, biologic, or device.\n4. Contrast allergy or other contraindication to angiography, CT, or catheterization, including contrast sensitivity that cannot be adequately treated prior to index procedure.\n5. Known allergy to components of Onyx™.\n6. Target vasculature unsuitable for the delivery of Onyx™ based upon physician assessment.\n7. More than 4 target lesions will require embolization, in the investigator's opinion after imaging-based assessment.","22 Years",{"count":161,"type":22},119,[25],"The purpose of this study is to evaluate the safety and effectiveness of Onyx™ LES in the treatment of subjects with active arterial bleeding in the peripheral vasculature outside of the heart and brain.",[165,29,166,167,64],"Peripheral Arterial Hemorrhage","GI Bleed","Ulcer",[165,169],"Embolization treatment",{"date":145,"type":41},{"date":172,"type":41},"2025-05-09",{"date":174,"type":22},"2027-05",{"name":176,"class":177},"Medtronic Endovascular","INDUSTRY",18,{"id":180,"slug":181,"hasResults":12,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":49},"100499586","oct-in-open-fracture-and-infected-fracture-100499586","NCT05785182","OCT in Open Fracture and Infected Fracture","Optical Coherence Tomography Imaging to Visualize Bacteria or Biofilm on Hardware, Bone and Soft Tissue in Open Fracture and Infected Fracture","Inclusion Criteria:\n\n* Age 18 years or older\n* Open fracture\n* Fracture Related Infection\n\nExclusion Criteria:\n\n* Metatarsal fractures",{"count":187,"type":22},40,"This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.",[190,29,191,192],"Trauma Injury","Open Fracture","Fracture Infection","2026-07-21",{"date":195,"type":41},"2026-07-22",{"date":197,"type":41},"2023-03-27",{"date":199,"type":22},"2027-06",{"name":201,"class":48},"Dartmouth-Hitchcock Medical Center",{"id":203,"slug":204,"hasResults":12,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":211,"conditions":212,"keywords":4,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":4},"100646286","tbe-zone-01-pms-in-japan-100646286","NCT07691931","TBE Zone 0\u002F1 PMS in Japan","GORE® TAG® Thoracic Branch Endoprosthesis Zone 0\u002F1 Post-Market Surveillance in Japan","Inclusion Criteria:\n\nThose who are suitable for use of TBE according to the Japan package insert. \\[Reference: Purpose of Use or Effects of TBE at the time of launch\\] The GORE® TAG® Thoracic Branch Endoprosthesis is intended for use in patients with the following diseases of the aortic arch and descending thoracic aortic lesions who fulfill anatomical requirements for treatment of such diseases while preserving blood flow to a single aortic arch target branch vessel.\n\n* Thoracic aortic aneurysm\n* Traumatic transection\n* Complicated Stanford type A (after surgical repair) and B aortic dissection (including dissecting aortic aneurysm) who have not responded to medical therapy\n\nThe GORE® TAG® Thoracic Branch Endoprosthesis may be used in combination with designated stent grafts with validated efficacy and safety.\n\nExclusion Criteria:\n\nN\u002FA",{"count":210,"type":22},75,"The goal of this surveillance is to confirm the safety and efficacy of TBE under actual use in the Zone 0\u002F1 lesion on post-marketing usage conditions.",[213,214,29],"Aneurysm of Aorta, Thoracic","Dissection of Aorta, Thoracic","NOT_YET_RECRUITING","2026-07-06",{"date":218,"type":41},"2026-07-09",{"date":220,"type":22},"2026-09",{"date":222,"type":22},"2035-09",{"name":224,"class":177},"W.L.Gore & Associates",{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":12,"sex":18,"minAge":232,"maxAge":19,"enrollmentInfo":233,"targetDuration":4,"studyType":23,"phases":235,"briefSummary":236,"conditions":237,"keywords":241,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":4},"100572913","hospital-based-continuous-patient-monitoring-system-100572913","NCT06739447","Hospital Based Continuous Patient Monitoring System","Implementing a Hospital-based Continuous Patient Monitoring System Using Consumer Wearable Devices in Ghana","Inclusion Criteria:\n\n* Pediatric patients presenting with traumatic injury\n* Pediatric patients postoperative status after an appendectomy\n\nExclusion Criteria:\n\n* Pediatric patients missing their upper limbs,\n* Pediatric patients who cannot wear a Fitbit on their wrist for known allergies to rubber or those with traumatic or medical conditions that prevent them from being able to comfortably wear a Fitbit on either hand","3 Years",{"count":234,"type":22},250,[25],"In Ghana, and many other low and middle income countries in Africa, manual vital signs monitoring is the prevalent mode of vital signs monitoring because continuous bedside monitors are non-functional. This lack of continuous vital signs monitoring may result in missed opportunities to catch physiologic deterioration.\n\nThe investigators propose to develop a dashboard that is based on the Garmin Venu 3, a consumer wearable device that reliably measures heart rate, SPO2, and respiratory rate, as an alternative to bedside monitors in hospitals in Ghana.",[29,238,239,240],"Appendectomy","Pediatric ALL","Vital Signs Monitoring",[242,243,67,244],"Garmin Venu 3","pediatric appendectomy","vital sign monitoring","2026-06-30",{"date":247,"type":41},"2026-07-02",{"date":249,"type":22},"2026-09-01",{"date":251,"type":22},"2030-01-30",{"name":253,"class":48},"University of Alabama at Birmingham",{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":23,"phases":263,"briefSummary":264,"conditions":265,"keywords":268,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":49},"100644863","preventing-harmful-alcohol-use-among-trauma-patients-in-cameroon-100644863","NCT07677449","Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon","Implementation of a Culturally Adapted Alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT) Program in Cameroon","Inclusion Criteria:\n\n* Adult trauma patients aged 18 years and older presenting to the Emergency Department of Limbe Regional Hospital.\n* Positive alcohol screening based on the Single Alcohol Screening Question (SASQ).\n* AUDIT-C score ≥4 for men or ≥3 for women.\n* Able to provide informed consent.\n* Resident within the study catchment area and available for follow-up.\n* Access to a telephone or another reliable means of contact for follow-up assessments.\n\nExclusion Criteria:\n\n* Severe cognitive impairment preventing participation in study procedures or - provision of informed consent.\n* Severe traumatic brain injury or other medical condition requiring immediate life-saving intervention that precludes participation.\n* Current psychosis or severe psychiatric illness preventing meaningful participation in the intervention.\n* In police custody or other circumstances limiting ability to participate in follow-up.\n* Planned relocation outside the study catchment area during the study follow-up period.\n* Previously enrolled in the study.",{"count":262,"type":22},690,[25],"\\*\\*Brief Summary\\*\\*\n\nAlcohol use is a major contributor to injury burden in Cameroon, particularly among trauma patients presenting to emergency departments. Despite the strong association between alcohol use and injury, structured alcohol screening and intervention programs are not routinely integrated into trauma care in Cameroon. This study aims to evaluate a Cameroon-adapted Screening, Brief Intervention, and Referral to Treatment (SBIRT) program for trauma patients at the Limbe Regional Hospital.\n\nThe study will be conducted in three phases: (1) training emergency department healthcare providers on a culturally adapted SBIRT program; (2) evaluating the feasibility, acceptability, and fidelity of SBIRT implementation in routine emergency care; and (3) assessing the effectiveness of SBIRT in reducing harmful alcohol use among trauma patients. Healthcare workers will be trained to deliver SBIRT, and eligible trauma patients screening positive for risky alcohol use will be enrolled in a randomized waitlist-controlled trial. Participants will undergo alcohol screening using validated tools and will be followed for six months. Outcomes will include alcohol use measured by the Alcohol Use Disorders Identification Test (AUDIT), phosphatidylethanol (PEth) biomarker levels, referral uptake, implementation outcomes, and patient well-being measures.\n\nThe study is expected to generate evidence on the feasibility and effectiveness of integrating alcohol interventions into trauma care in a low-resource setting and inform future scale-up of SBIRT programs in Cameroon and similar settings.",[266,267,29],"Alcohol Use Disorder","Alcohol-Related Injury",[269,270,267,271,272,273,274,275,276,277,278,279,280,281,138],"Alcohol Use Disorder (AUD)","Alcohol Screening","Screening, Brief Intervention, and Referral to Treatment (SBIRT)","Brief Intervention","Emergency Department","Trauma Care","AUDIT-C","Referral to Treatment","Substance Use Intervention","Emergency Medicine","Implementation Science","Injury Prevention","Road Traffic Injury","2026-06-27",{"date":245,"type":41},{"date":285,"type":22},"2027-03",{"date":287,"type":22},"2030-08",{"name":289,"class":48},"University of Buea",{"id":291,"slug":292,"hasResults":12,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":297,"sex":18,"minAge":298,"maxAge":57,"enrollmentInfo":299,"targetDuration":4,"studyType":23,"phases":301,"briefSummary":302,"conditions":303,"keywords":307,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":4},"100540003","exploring-ptsd-symptoms-barriers-and-facilitators-to-mindfulness-100540003","NCT06311188","Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness","Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness-based Stress Reduction for Justice-Involved Black\u002FAfrican American Female Adolescents and Parents\u002FCaregivers","Inclusion Criteria:\n\n* Black girls aged 14-18\n* Black girls with a misdemeanor and\u002For felony charge in their lifetime\n* Positive PTSD screen (PC-PTSD score of 2 or more; if more than one JI BAFA are from the same family, the investigators will recruit the girl with the highest PTSD score)\n* Black girls report juvenile justice involvement within 12 months prior\n* Black girls live with a P\u002FC (mothers, fathers, and other caregivers\u002Flegal guardians) who will also participate in the study\n* Parents\u002FCaregivers nominated by the girls to participate in the study who are between the ages of 18 and 90 years of age\n* Legal\u002F social services providers \u002F educators who work with the population.\n\nExclusion Criteria:\n\n* Prisoners per the IRB definition\n* Black girls who are younger than 14 and older than 18\n* Severe cognitive delay so the youth cannot complete the assessment instruments, as measured using the Montreal Cognitive Assessment (MoCA)\n* Active psychosis requiring a greater level of care \\[Structured Clinical Interview for DSM Disorders (SCID)\\]. Screening for the study will take place prior to consent\u002Fassent of the study participants\n* Parents\u002FCaregivers who are not nominated by the girls to participate in the study who are not between the ages of 18 and 90 years of age\n* Legal\u002F social services providers \u002F educators who have been working with the population for less than three years.",true,"14 Years",{"count":300,"type":22},90,[25],"The purpose of this study is to investigate justice-involved Black\u002FAfrican American female adolescents' (JI BAFAs; N=35) self-reported outcomes: stress, posttraumatic stress disorder (PTSD), recidivism, etc., as well as their parents\u002Fcaregivers' (P\u002FCs; N=35) stress and pre- and post- intervention results along with their views of an adapted intervention.",[304,29,305,306],"Stress","PTSD","HPA",[308,309,310,311],"Nonrandomized trial","Black girls","Legal system involvement","Cortisol Biomarker","2026-06-12",{"date":314,"type":41},"2026-06-16",{"date":316,"type":22},"2026-07-08",{"date":318,"type":22},"2027-01-31",{"name":320,"class":48},"University of Michigan",{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":297,"sex":18,"minAge":19,"maxAge":327,"enrollmentInfo":328,"targetDuration":4,"studyType":23,"phases":330,"briefSummary":331,"conditions":332,"keywords":333,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":49},"100642529","litter-packaging-in-the-lateral-position-effects-of-position-and-vacuum-mattress-packaging-on-pulmonary-function-100642529","NCT07644793","Litter Packaging in the Lateral Position: Effects of Position and Vacuum Mattress Packaging on Pulmonary Function","Inclusion Criteria:\n\n* Subjects must be 18 to 65 years old. Per the harness manufacturer's recommendation, participants must weigh between 130 and 300 pounds and have a waist between 32 and 42 inches.\n\nExclusion Criteria:\n\n* Weight greater than 300 pounds or less than 130 pounds, pregnancy, any known heart condition or murmur or lower extremity edema or wheezing detected on pre-participation exam, or a waist size \\\u003C32\" or \\>42\". Prior to suspension, female participants of childbearing potential will self-administer an FDA approved urine pregnancy test supplied by the investigator. Results will be verified by the investigator.","65 Years",{"count":329,"type":22},24,[25],"This is a study to look at the effect on breathing of various ways to package a person in a rescue litter. We will measure lung function in a litter, lying down, lying down in a vacuum mattress, one the side in a vaccum mattress, and vertical in a vacuum mattress.",[29],[334,335,67],"pulmonary function","search and rescue","2026-06-08",{"date":312,"type":41},{"date":339,"type":22},"2026-08-15",{"date":341,"type":22},"2026-12-31",{"name":343,"class":48},"University of California, San Francisco",{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":351,"targetDuration":109,"studyType":89,"phases":4,"briefSummary":352,"conditions":353,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":49},"100630629","enteric-anastomoses-100630629","NCT07490158","Enteric Anastomoses","Enteric Anastomoses in Trauma","Inclusion Criteria:\n\n18 years old Included in the MDMC(Methodist Dallas Medical Center) Trauma Registry Any diagnosis code indicative of injury to the large and\u002For small bowel (S36.5 and\u002For S36.4)\n\nExclusion Criteria:\n\n\\\u003C18 years old Prisoners, pregnant persons, or other protected population.",{"count":88,"type":22},"This retrospective data repository will serve as a means to aggregate and analyze best practices as relative to traumatic colon injury outcomes.",[29],{"date":355,"type":41},"2026-06-10",{"date":357,"type":41},"2024-02-16",{"date":359,"type":22},"2028-01",{"name":100,"class":48},{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":367,"eligibilityCriteria":368,"healthyVolunteers":12,"sex":18,"minAge":369,"maxAge":4,"enrollmentInfo":370,"targetDuration":4,"studyType":23,"phases":372,"briefSummary":374,"conditions":375,"keywords":378,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":4},"100643542","early-phase-1-clinical-evaluation-of-an-ai-risk-prediction-system-ai-trips-100643542","NCT07634185","Clinical Evaluation of an AI Risk Prediction System (AI-TRiPS)","Clinical Evaluation of an AI Risk Prediction and Decision Support System for Early Management of Injured Patients: a Stepped-wedge Cluster Randomised Trial","AI-TRiPS","Inclusion Criteria:\n\nClinician Participants\n\n* Senior clinical decision-maker involved in the initial trauma resuscitation (e.g. consultant or senior trainee in emergency medicine, anaesthesia, intensive care medicine, or surgery).\n* Based at one of the four participating Major Trauma Centres.\n* Able and willing to provide informed consent.\n* Completed the required study-specific training.\n\nTrauma Patients\n\n* Aged 16 years and above.\n* Treated and transported to a participating Major Trauma Centre by London's Air Ambulance.\n* Managed by one or more participating trauma clinicians during the resuscitation.\n\nExclusion Criteria:\n\nClinician Participants\n\n● Decline or withdraw informed consent at any stage.\n\nTrauma Patients\n\n* Aged under 16\n* Not treated by London's Air Ambulance.\n* Transported to a non-participating hospital.\n* Not managed by any participating clinicians.\n* Presenting with injuries resulting from burns, hangings, drownings, or isolated psychiatric emergencies.\n* Have registered a national NHS data opt-out or otherwise requested that their routine clinical data not be used for research.","16 Years",{"count":371,"type":22},1200,[373],"EARLY_PHASE1","The goal of this clinical study is to evaluate a software device and its impact on clinician behaviour during the initial management of trauma patients in a real-world clinical setting. Known as the AI-TRiPS Device this software uses real-time prehospital data and machine learning-based risk predictions which are displayed digitally for hospital trauma teams prior patient arrival.\n\nThe investigators will use a Stepped Wedge Cluster Randomised Controlled study design with an integrated process evaluation.\n\nThe Device will be deployed across the London Major Trauma System where the Major Trauma Centres will be the clusters. Each cluster will transition from control (standard care) to intervention at a pre-specified time (time of transition is randomised).\n\nPrimary Outcome: Clinician behaviour, assessed via the accuracy of risk prediction and clinician confidence.\n\nSecondary Outcome: Clinician acceptability, care process metrics, patient outcomes, and safety endpoints.\n\nPrimary study population: Hospital trauma clinicians, following initial resuscitation of each eligible trauma patient, who will complete electronic questionnaires.\n\nSecondary study population: Adult trauma patients, data will be collected for the duration of their index admission to hospital, to assess outcomes and enable comparison with clinician risk predictions.",[29,376,377],"Injury","Decision Support Systems, Clinical",[379,380],"Device trial, prediction tool, trauma","clinical decision support","2026-06-03",{"date":336,"type":41},{"date":384,"type":22},"2026-06-01",{"date":386,"type":22},"2027-12-01",{"name":388,"class":48},"Queen Mary University of London",{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":12,"sex":18,"minAge":396,"maxAge":4,"enrollmentInfo":397,"targetDuration":4,"studyType":23,"phases":399,"briefSummary":400,"conditions":401,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":403,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":49},"100556130","optimizing-recovery-in-trauma-patients-by-integrating-enhanced-nutrition-delivery-100556130","NCT06521086","Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery","Optimizing Recovery in Trauma Patients: Integrating Enhanced Nutrition Delivery With Muscle Assessments, Functional Outcomes and Quality of Life","Inclusion Criteria:\n\n* Patients who are at least 45 years old and presented to the Emergency Department as a leveled trauma\n* Patients who have the ability to tolerate oral nutrition\n* Patients who have had a standard of care CT scan this admission\n\nExclusion Criteria:\n\n* Expected withdrawal of life-sustaining treatment within 48 hours\n* Traumatic Brain Injury\n* Presence of lower extremity fracture(s)\n* Mechanical Ventilation\n* Subjects for who the Investigator would recommend a different supplement based on their medical condition.\n* Prisoner\n* Pregnancy for women of child-bearing potential","45 Years",{"count":398,"type":22},60,[25],"This is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients. Subjects will be randomized 1:1 to either enhanced nutrition or control arm. Subjects randomized to the enhanced nutrition arm will receive oral nutrition supplements (ONS) up to 3 times per day while in the hospital and for 4 weeks after discharge. Subjects in the standard of care arm will receive normal nutrition recommendations from their clinical providers. Participants in both groups will undergo non-invasive tests that measure how much energy (calories) they are using, body composition, and muscle mass.",[29,402],"Critical Illness",{"date":381,"type":41},{"date":405,"type":41},"2026-02-18",{"date":407,"type":22},"2028-05-30",{"name":409,"class":48},"Duke University",{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":297,"sex":417,"minAge":19,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":23,"phases":421,"briefSummary":422,"conditions":423,"keywords":427,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":437,"leadSponsor":439,"locationsCount":49},"100640077","trauma-informed-yoga-intervention-in-young-women-100640077","NCT07589777","Trauma-Informed Yoga Intervention in Young Women","Trauma-Informed Yoga Intervention: A Randomized Controlled Trial on Psychological Trauma, Emotion Regulation, and Interoceptive Awareness in Young Adult Women","Inclusion Criteria:\n\n* Being a woman aged 18-25 years\n* Providing voluntary written informed consent after being informed about the study\n* Scoring within the highest 25th percentile on the Transmitted Psychological Trauma Scale based on the pre-screening assessment, indicating high levels of trauma-related symptoms\n* Having no physical limitations that would prevent participation in weekly sessions and being medically eligible to engage in yoga practices\n* Agreeing to comply with the study protocol, including attendance at intervention sessions and completion of all assessments\n\nExclusion Criteria:\n\n* Inability to provide reliable responses due to the presence of active psychotic disorder, bipolar disorder, or severe cognitive impairment\n* Being in an acute psychological crisis\n* Initiation of intensive psychotherapy targeting trauma symptoms (e.g., trauma-focused therapy) within the past 3 months or participation in a similar structured psychosocial intervention during the study period\n* Presence of serious musculoskeletal, cardiovascular, or neurological conditions or injuries that would prevent participation in yoga, or medical restriction of physical activity by a physician\n* Having an established regular practice of yoga or meditation","FEMALE","25 Years",{"count":420,"type":22},46,[25],"The aim of this study is to evaluate the effects of a trauma-informed yoga intervention on psychological trauma symptoms, difficulties in emotion regulation, and interoceptive awareness in young adult women.",[29,424,425,426],"Young Adult Females","Awareness","Emotional Regulation",[428,429,430,431,432],"trauma-informed yoga","emotion regulation","interoceptive awareness","psychological trauma","randomized controlled trial","2026-05-09",{"date":435,"type":41},"2026-05-15",{"date":384,"type":22},{"date":438,"type":22},"2026-11-30",{"name":440,"class":48},"Saglik Bilimleri Universitesi",{"id":442,"slug":443,"hasResults":12,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":297,"sex":417,"minAge":19,"maxAge":4,"enrollmentInfo":448,"targetDuration":4,"studyType":23,"phases":449,"briefSummary":450,"conditions":451,"keywords":456,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":465,"leadSponsor":467,"locationsCount":49},"100637653","prenatal-yoga-intervention-in-pregnant-women-100637653","NCT07585916","Prenatal Yoga Intervention in Pregnant Women","Effects of a Prenatal Yoga Intervention on Traumatic Childbirth Perception, Self-Perception, and Delivery Preferences in Pregnant Women","Inclusion Criteria:\n\n* Being at or beyond the 16th week of gestation (second trimester or later)\n* Being aged 18 years or older\n* Having no diagnosis of high-risk pregnancy based on obstetric evaluation\n* Having no medical restriction on physical activity or yoga practice as determined by a physician\n* Providing written informed consent after being informed about the study\n\nExclusion Criteria:\n\n* Diagnosis of high-risk pregnancy (e.g., preeclampsia, placenta previa, premature rupture of membranes, risk of preterm birth, or other serious obstetric complications)\n* Physician-imposed restriction on physical activity\n* Presence of serious systemic conditions that would prevent participation in yoga practice\n* Inability to complete the questionnaires reliably due to psychiatric or cognitive conditions\n* Declining to participate or not providing informed consent",{"count":420,"type":22},[25],"The aim of this study is to determine the effects of a prenatal yoga intervention on traumatic childbirth perception, self-perception, and delivery preferences in pregnant women.",[452,453,29,454,455],"Pregnant Women","Prenatal Yoga","Body Image","Delivery",[457,458,459,460,461],"perception of traumatic childbirth","body image","preferred mode of delivery","pregnant women","prenatal yoga",{"date":463,"type":41},"2026-05-14",{"date":435,"type":22},{"date":466,"type":22},"2026-12-30",{"name":440,"class":48},{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":474,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":23,"phases":478,"briefSummary":479,"conditions":480,"keywords":481,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":491,"leadSponsor":493,"locationsCount":49},"100638171","data-driven-lay-first-responder-program-in-cameroon-100638171","NCT07581327","Data-Driven Lay First Responder Program in Cameroon","Implementation of a Data-Driven Pre-Hospital Lay First Responder Program in Cameroon","K-LFR Project","Inclusion Criteria:\n\n\\- Trauma patients presenting to Limbe Regional Hospital and enrolled in the Cameroon Trauma Registry\n\nExclusion Criteria\n\n\\- Trauma patients not included in the Cameroon trauma registry at Limbe regional hospital.",{"count":477,"type":22},1812,[25],"Cameroon experiences a high burden of injury-related morbidity and mortality and currently lacks a formal pre-hospital care system. Lay First Responder (LFR) programs have been implemented in several low-and middle-income countries to improve early injury care by training non-medical community members with high exposure to injury, such as commercial drivers, in basic first aid and safe transport of injured patients.\n\nThe study aims to implement and evaluate a data-driven, context-adapted LFR program in Cameroon using an implementation science approach. Quantitative trauma registry data and qualitative stakeholder interviews will be used to adapt the LFR curriculum to local injury patterns and care gaps. LFR program implementation will be associated with increased chances of survival on presentation and improved trauma outcomes.\n\nThe study is an interrupted time series evaluation of an LFR intervention where prehospital care rates and clinical patterns in the Cameroon Trauma Registry (CTR) patients at Limbe Regional hospital will be compared between historical pre-implementation controls and post-implementation of a data-driven lay first responder training program (the intervention).",[29,376],[482,29,483,281,484,485,486],"Lay First Resposnder","Pre-Hospital care","By-stander response","Trauma systems","Emergency Care","2026-05-05",{"date":489,"type":41},"2026-05-12",{"date":220,"type":22},{"date":492,"type":22},"2028-09",{"name":494,"class":48},"Sabrinah Christie",{"id":496,"slug":497,"hasResults":12,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":501,"eligibilityCriteria":502,"healthyVolunteers":12,"sex":18,"minAge":369,"maxAge":4,"enrollmentInfo":503,"targetDuration":4,"studyType":23,"phases":504,"briefSummary":505,"conditions":506,"keywords":507,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":515,"completionDateStruct":517,"leadSponsor":518,"locationsCount":49},"100554146","swift-canada-study-of-whole-blood-in-frontline-trauma-100554146","NCT06495294","SWiFT Canada (Study of Whole Blood in Frontline Trauma)","SWiFT Canada (Study of Whole Blood in Frontline Trauma): A Pilot Randomized Controlled Trial Assessing Prehospital Whole Blood Versus Component Therapy in Traumatic Hemorrhage","SWiFTCanada","Inclusion Criteria:\n\n* Patient who has suffered a traumatic injury\n* Attended by a participating Ornge AAS clinical team\n* Requires prehospital blood transfusion to treat major traumatic hemorrhage\n\nExclusion Criteria:\n\n* Pediatric (age \\\u003C16 or transported to pediatric trauma centre \\[if age unknown\\])\n* No intravenous or intraosseous access (should be assessed prior to opening box)\n* Knowledge that patient will object to being given blood transfusion for any reasons\n* Blood already administered on-scene, prior to arrival of the participating Ornge AAS",{"count":398,"type":22},[25],"Traumatic injuries affect people of all ages, races, and socioeconomic backgrounds. The Global Burden of Disease study showed that globally in 2019, there were more than 4.4 million deaths due to injury. Furthermore, unintentional injuries are the leading cause of death for people aged 5-29 years worldwide. Uncontrolled bleeding accounts for a significant proportion of these deaths, with approximately 20% occurring in the first 24 hours and 40% occurring within the first 30 days.\n\nBlood transfusion is a life-saving treatment in the management of bleeding patients until bleeding is controlled in hospital, typically delivered through different blood components (red blood cells, plasma and platelets). These components are derived from a whole blood donation and are stored in separate bags (units). There are challenges in carrying separate blood products, such as additional weight in kit bags, and transfusing multiple blood products at the scene can delay transport to hospital.\n\nIn Ontario, Ornge Air Ambulance carries red blood cells and plasma to transfuse prehospital. However, a prehospital transfusion strategy has not been established and practice varies across the Canadian setting, and more broadly across the world.\n\nThis trial aims to investigate if carrying and transfusing two units of whole blood instead of four units (two red blood cells and two plasma) is feasible and leads to better outcomes for patients.",[29],[508,509,510,511],"prehospital","major hemorrhage","transfusion","emergency medicine","2026-04-29",{"date":514,"type":41},"2026-05-06",{"date":516,"type":41},"2024-12-16",{"date":285,"type":22},{"name":47,"class":48},{"id":520,"slug":521,"hasResults":12,"nctId":522,"briefTitle":523,"officialTitle":523,"acronym":524,"eligibilityCriteria":525,"healthyVolunteers":297,"sex":417,"minAge":19,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":23,"phases":528,"briefSummary":529,"conditions":530,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":49},"100532729","women-focused-encounters-for-resilience-independence-strength-and-eudaimonia-100532729","NCT06216600","Women Focused Encounters for Resilience Independence Strength and Eudaimonia","WE RISE","Inclusion Criteria:\n\n1. Is a woman\n2. Able to read and understand English\n3. Able to participate in a low intensity exercise program\n4. HIV-seropositive\n5. At risk substance use (any illegal or unprescribed drug), tobacco, marijuana or alcohol use (four or more drinks in one day or 8 or more in one week).\n6. Reports missing more ART doses than previous months, or \\> 5 in a month, or has a detectable HIV viral load\n7. Experienced interpersonal violence\n8. Able and willing to provide informed consent\n\nExclusion Criteria:\n\n1. Unwilling to participate in video record sessions (used to evaluate the quality of the intervention)\n2. Enrolled in hospice\n3. Not willing or not able to comply with study advisory board group participation agreement.",{"count":527,"type":22},300,[25],"The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS\u002FHIV (SAVA) to improve medication adherence for women living with HIV (WLWH). This intervention will be implemented by community based organizations that focus on WLWH across four counties. The main question it aims to answer are:\n\n* Will peer provision of ACT, exercise, and social support improve medication adherence for WLWH?\n* Will community based organizations be able to sustain the intervention after research is completed, and what changes will need to be made to sustain the intervention.",[531,532,29,533],"HIV Infections","Substance Use","Medication Adherence","2026-04-27",{"date":536,"type":41},"2026-05-01",{"date":538,"type":41},"2024-09-19",{"date":540,"type":22},"2028-05-31",{"name":542,"class":48},"University of California, San Diego",{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":547,"acronym":548,"eligibilityCriteria":549,"healthyVolunteers":12,"sex":18,"minAge":369,"maxAge":4,"enrollmentInfo":550,"targetDuration":4,"studyType":23,"phases":551,"briefSummary":552,"conditions":553,"keywords":556,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":49},"100575764","boosting-refugee-integration-through-psychological-intervention-100575764","NCT06776523","Boosting Refugee Integration Through Psychological Intervention","BRIGHT","The inclusion criteria for participating in the study are:\n\n* refugees and asylum seekers (RAS) aged 16 or older;\n* residing in one of the participating local sites (Swiss municipalities, namely, Gemeinden, and transitional asylum centers, namely, Durchgangszentren) where PM+ is offered and which gave their consent for participation in the RCT;\n* speaking at least one of the following 12 languages: German, English, French, Arabic, Farsi, Kurdish, Tigrinya, Turkish, Ukrainian, Russian, Tamil, and Pashto;\n* obtaining a score of 20 or higher on the Kessler Psychological Distress Scale (K10; Kessler et al., 2002), a brief clinically validated screening questionnaire that assesses general psychological distress in the past 30 days. A score equal to or higher than 20 is used as an indication of moderate to high levels of psychological distress.\n\nThe exclusion criteria for participating in the study are:\n\n* significant cognitive or neurological impairment measured through specific tools developed by the WHO and integrated into the PM+ manual (impairment questionnaire);\n* acute medical conditions or severe mental disorders (e.g., psychotic or substance-abuse disorders) measured through specific tools developed by the WHO and integrated into the PM+ manual (impairment questionnaire);\n* acute risk of suicide as measured by the Suicidal Ideation Attribution Scale (SIDAS; van Spijker et al., 2014) and the Thoughts of Suicide Questionnaire (World Health Organization WHO, 2016).",{"count":371,"type":22},[25],"Refugees and asylum seekers (RAS) face numerous stressors and adversities which put them at risk for developing mental health problems. However, access to adequate mental health care in host countries is limited. To address this problem, the World Health Organization (WHO) introduced Problem Management Plus (PM+), a short, low-intensity psychological intervention administered by non-professionals, aiming to alleviate common mental disorders among crisis-affected communities.\n\nThe present study aims at expanding the existing PM+ intervention by providing additional booster sessions and homework reminders while evaluating its effectiveness and implementation in the public health system.",[554,305,29,555],"Psychological Distress","Common Mental Health Problems",[557,554,558,559],"Problem Management Plus","Mental Health Care","Refugees","2026-04-21",{"date":534,"type":41},{"date":563,"type":41},"2025-01-16",{"date":565,"type":22},"2027-09",{"name":567,"class":48},"University of Zurich",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":4,"eligibilityCriteria":574,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":575,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":577,"conditions":578,"keywords":581,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":49},"100571429","mg-osteocrete-post-treatment-outcomes-100571429","NCT06720142","Mg OSTEOCRETE Post-Treatment Outcomes","Clinical and Radiographic Outcomes of Patients Treated With Mg OSTEOCRETE","Inclusion Criteria:\n\n* 18 years of age and older on the day of surgery\n* has received or will receive Mg OSTEOCRETE as a component of their treatment at this institution in accordance with Instructions for Use for the implanted product\n* Mg OSTEOCRETE is indicated for one of the following reasons:\n\n  1. as a bone void filler following bone tumor resection, or;\n  2. as an augment for defects causing aseptic loosening of orthopaedic implants, or;\n  3. to help substitute bone for trauma-related conditions\n\nExclusion Criteria:\n\n* any contraindication as per Instructions for Use for Mg OSTEOCRETE",{"count":576,"type":22},10,"Mg OSTEOCRETE is a bone substitute used to fill a defect in bone caused by excision of a tumor, orthopaedic hardware that has become loosened, or a trauma-related condition. The aim of this study is to determine the amount of time it takes for bone to heal after treatment with Mg OSTEOCRETE, and to better understand the efficacy of this treatment through clinical and patient-reported outcomes.",[579,29,580],"Cancer of Bone","Aseptic Loosening of Orthopaedic Hardware",[582,583,584],"bone defect","bone substitute","osteocrete",{"date":586,"type":41},"2026-04-22",{"date":588,"type":41},"2025-03-17",{"date":590,"type":22},"2028-03-17",{"name":592,"class":48},"Santiago Lozano-Calderon",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":18,"minAge":369,"maxAge":124,"enrollmentInfo":601,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":603,"conditions":604,"keywords":606,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":49},"100533025","blunt-adrenal-gland-injury-bad-guy-project-100533025","NCT06220448","Blunt ADrenal Gland injUrY (BAD GUY) Project","Exploring the Epidemiology and Burden of Blunt Adrenal Gland Injury in the Context of Major Trauma","BADGUY","Inclusion criteria:\n\n* Age \\> 16 years old\n* All patients with blunt thoraco-abdominal trauma\n\nExclusion criteria:\n\n* TBI with AIS \\> 3\n* Isolated TBI and Spinal cord injury\n* Patients died in emergency department",{"count":602,"type":22},5000,"Type: retrospective observational multicenter trial. Population of interest: adult patients suffering from thoraco-abdominal trauma undergoing both non-operative and operative management.\n\nHypothesis: Adrenal gland injury is a rare finding after blunt thoracoabdominal trauma. Short-term outcomes of blunt adrenal gland injury (BAGI) described in literature are contradictory. Reports on the outcomes related to this injury are variable and consider heterogeneous populations of trauma patients Aim: This study aims to explore the burden related to BAGI in an homogeneous population of patients sustaining blunt thoraco-abdominal trauma treated in different institution",[29,605],"Adrenal Gland Injury",[29,607,608],"blunt adrenal gland trauma","major trauma","2026-04-13",{"date":611,"type":41},"2026-04-16",{"date":613,"type":41},"2024-01-01",{"date":615,"type":22},"2027-09-30",{"name":617,"class":48},"Niguarda Hospital",{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":4,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":625,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":627,"conditions":628,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":637,"locationsCount":640},"100615286","comparative-outcomes-of-pcc-and-recombinant-activated-factor-viia-in-trauma-associated-massive-transfusion-100615286","NCT07290634","Comparative Outcomes of PCC and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion","Comparative Outcomes of Prothrombin Complex Concentrate and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion: A Retrospective Cohort Study","Inclusion Criteria:\n\n* Adults ≥18 years\n* Trauma patients directly admitted from the scene with highest-level trauma activation: Injury -Severity Score (ISS) \\>15.\n* Requirement for massive transfusion, defined as ≥3 units packed red blood cells (PRBC) within the first hour or ≥10 PRBC within the first 24 hours\n\nExclusion Criteria:\n\n* Traumatic cardiac injury\n* Death anticipated within the first hour of admission: ISS score \\>49\n* Pre-injury anticoagulant therapy\n* Known pregnancy\n* Pre-injury terminal illness",{"count":626,"type":22},4,"This study aims to compare the incidence of thromboembolic complications among trauma patients receiving PCC, rFVIIa, both agents, or neither during massive transfusion. Secondary objectives include comparing mortality, transfusion requirements, intensive care unit (ICU) and hospital length of stay, ventilator-free days, and the incidence of transfusion-associated adverse events such as transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO). Subgroup analyses will evaluate outcomes in patients with and without laboratory-confirmed TIC (INR \\>1.2).",[629,630,29],"Thromboembolus","Massive Blood Transfusion; Thrombocytopenia","2026-04-11",{"date":633,"type":41},"2026-04-14",{"date":635,"type":22},"2026-04-30",{"date":245,"type":22},{"name":638,"class":639},"Zeliha Alicikus","OTHER_GOV",2,{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":647,"eligibilityCriteria":648,"healthyVolunteers":12,"sex":18,"minAge":649,"maxAge":650,"enrollmentInfo":651,"targetDuration":4,"studyType":23,"phases":653,"briefSummary":654,"conditions":655,"keywords":656,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":49},"100589620","multiphase-optimization-strategy-most-for-treating-pediatric-post-traumatic-stress-disorder-ptsd-100589620","NCT06956781","Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)","Optimizing Behavioral Health Services Following Pediatric Trauma Exposure","MOST for PTSD","Inclusion Criteria:\n\nA child between the ages of 8-17 exposed to at least one DSM-defined trauma\n\nChild assent for participation\n\nThe participation of a caregiver with custodial rights to provide parental permission\n\nWilling to participate in treatment delivery and respond to surveys\n\nMeet PTSD diagnostic criteria that is the result of exposure to at least one of the identified traumas\n\nAbility to read and understand English\n\nWillingness to be randomized to an experimental condition\n\nPlacement in a stable caregiving environment for two months without an impending transition\n\nChildren currently taking psychotropic medications must have taken the medicine without dose adjustment for two months prior to study entry.\n\nCaregiver or child with a smartphone capable of downloading a freely available software application.\n\nExclusion Criteria:\n\nPsychiatric concerns requiring a higher level of care (e.g. suicidal ideation with intent; current psychotic disorder)\n\nAn intelligence quotient (IQ) \\\u003C 70\n\nCurrently receiving a behavioral health intervention for concerns related to PTSD or pediatric trauma\n\nA participating caregiver who is a perpetrator of any identified trauma (e.g. sexual abuse)\n\nMRI contraindicators (e.g. presence of metal in the body)","8 Years","17 Years",{"count":652,"type":22},200,[25],"The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are:\n\nWhat are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD?\n\nResearchers will:\n\nCompare components to a psychological placebo to estimate their effects and measure how they work\n\nExamine how components work alone and in conjunction with other components\n\nParticipants will:\n\nReceive different combinations of components and placebo\n\nAttend weekly treatment sessions\n\nProvide information to evaluate changes in PTSD",[305,29,239],[305,29,657,658],"Pediatric","Multiphase Optimization Strategy","2026-04-07",{"date":661,"type":41},"2026-04-08",{"date":663,"type":41},"2026-03-15",{"date":665,"type":22},"2028-08",{"name":667,"class":48},"University of Rochester"]