[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tuberculosis-active\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tuberculosis-active":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100647882","scaf-tb---saving-children-and-their-families-from-tuberculosis-implementation-research-to-improve-tb-preventive-treatment-initiation-and-completion-rates-among-contact-persons-in-tajikistan-and-tanzania-100647882",false,"NCT07714707","SCAF-TB - Saving Children and Their Families From Tuberculosis: Implementation Research to Improve TB Preventive Treatment Initiation and Completion Rates Among Contact Persons in Tajikistan and Tanzania","SCAF-TB","Inclusion Criteria:\n\n* Contact persons (household and close contacts as defined by country guidelines) of people newly diagnosed with bacteriologically confirmed pulmonary TB disease (or as defined per national guidelines). National guidelines will determine whether we could include both contacts of index patients with drug-susceptible TB and drug-resistant TB.\n* Age ≥5 years\n* Able to provide written informed consent or assent.\n\nExclusion Criteria:\n\n* • Confirmed TB disease (evidenced by symptoms and\u002For clinical exam findings and\u002For chest radiographic findings suggestive of TB, positive mycobacterial culture or molecular TB testing or currently on TB treatment for TB disease)\n\n  * Likely to move outside the study area during the study period\n  * People already on TPT at time of recruitment\n  * Contra-indication for TPT:\n\n    * Known sensitivity or intolerance to isoniazid or rifamycins\n    * Suspected acute hepatitis or known chronic or unstable liver disease\n    * Alanine aminotransferase (ALT) \\> 3 times the upper limit of normal (ULN)\n    * Total bilirubin \\> 2.5 times the ULN\n    * On contra-indicated medications (as per national guidelines)\n  * Contra-indication for SIILTIBCY:\n\n    * Hypersensitivity to the active substances or to any of the excipients listed in section 6.1 of SIILTIBCY Product Information.\n    * Hypersensitivity to Lactococcus lactis.\n    * Severe local or systemic reaction to other Mycobacterium tuberculosis derived products\n    * Any vaccination within the last 4 weeks\n  * Contra-indication for AudibleHealth:\n\n    * Having any condition making someone cannot cough voluntarily:\n\nHaving aphasia Having a medical history of cribriform plate injury or cribriform plate surgery, diaphragmatic hernia, external beam neck\u002Fthroat \u002F maxillofacial radiation, phrenic nerve injury\u002Fpalsy, radical neck\u002Fthroat \u002F maxillofacial surgery, vocal cord trauma or nodules Having patent tracheostomy stoma\n\nWithin the past year, had:\n\nacute traumatic injury to the head, neck, throat, chest, abdomen, or trunk Chest\u002Fabdomen \u002F trunk trauma or surgery, Intracranial surgery Neurovascular injury Neurovascular surgery",true,"ALL","5 Years",{"count":20,"type":21},880,"ESTIMATED","INTERVENTIONAL",[24],"NA","The SCAF-TB study aims to evaluate how the WHO-endorsed SIILTIBCY skin test can be best implemented to test close contacts for tuberculosis infection (TBI) in Tajikistan and Tanzania, either facility-based or home-based delivered by community health workers (CHWs) with or without AI-facilitated diagnostic tools.\n\nThe overall goal of this study is to improve access to innovative tuberculosis (TB) preventive services among children and their families in Tanzania and Tajikistan, both settings with a high burden of TB. Persons in close contact with people diagnosed with bacteriologically confirmed TB disease will be identified through the index patient and home visits. They will decide the preferred location for TBI testing, either at home or at the facility. Community health workers will be trained to implement home-based TB prevention services, including TBI testing and AI-assisted reading, and ruling out TB disease using a cough app (along traditional screening practices).\n\nThe main objectives of the study are:\n\n1. To assess whether CHWs can reliably measure SIILTIBCY results in TB contact persons at their homes, with or without the support of AI-assisted reading tools.\n2. To determine how feasible and acceptable it is for CHWs to perform home-based SIILTIBCY testing, both with and without AI assistance.\n3. To assess the added value, feasibility, and acceptability of using a mobile cough screening application, administered by CHWs, to help rule out TB disease.\n4. To evaluate the impact of these home-based TBI testing strategies on improving uptake and completion of TB preventive treatment (TPT), as well as their budget implications for both the health care system and affected households.\n\nThe study will be conducted in primary health care facilities in Tajikistan and Tanzania, which have access to short-course TPT regimens. The study population is composed of persons in close contact with people diagnosed with bacteriologically confirmed TB disease, and eligible for TPT as per national guidelines.\n\nThe main outcomes of interest are:\n\n1. SIILTIBCY inter-reader agreement CHW (home-based) and HCW (facility-based)\n2. SIILTIBCY inter-reader agreement CHW with AI reading and without AI reading\n3. Proportion tested for TBI out of those eligible for TBI testing\n4. Proportion tested positive for TBI, stratified by demographic characteristics and mode of delivery\n5. Diagnostic agreement between a cough application and symptom screening\n6. Proportion initiated on TPT out of those eligible for TPT, stratified by regimen and mode of testing\n7. Proportion completing TPT out of those initiated on TPT, stratified by regimen and mode of testing.\n8. Interest-holders' perspectives on home-based TBI testing and cough app screening.\n9. Budgetary impact scaling-up home-based TBI testing and cough app screening",[27,28,29],"Tuberculosis Infection, Latent","Tuberculosis Active","TPT",[31,32,33,34,35,36,37,38,39],"AI tools","Contact investigation","Tuberculosis Preventive Treatment","Tanzania","kyrgyzstan","community health care","AI (Artificial Intelligence)","Cough screening App","SIILTIBCY","NOT_YET_RECRUITING","2026-07-14",{"date":43,"type":44},"2026-07-20","ACTUAL",{"date":46,"type":21},"2026-06",{"date":48,"type":21},"2028-03",{"name":50,"class":51},"KNCV Tuberculosis Foundation","OTHER",2,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":16,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100646750","shaping-a-community-based-pathway-to-improve-tb-surveillance-among-african-and-hindustan-immigrants-experiencing-vulnerabilities-100646750","NCT07687121","Shaping a Community-based Pathway to Improve TB Surveillance Among African and Hindustan Immigrants Experiencing Vulnerabilities","AFROHINDU-MIGT","Inclusion Criteria:\n\n\\- adult immigrants, aged 18 years or older, from Angola, Cape Verde, Guinea-Bissau, Mozambique, India, Bangladesh, or Nepal, who began their migration journey less than five years ago, who attend or are identified through community services or associated community networks, and who agree to participate by signing an informed consent form.\n\nExclusion Criteria:\n\n* Participants with a legally appointed representative\n* Participants incapable of understanding essential study information, even with linguistic or cultural mediation support and with any clinical condition that prevents the interview, informed consent, or screening process","18 Years",{"count":62,"type":21},200,"OBSERVATIONAL","This two-phase, mixed-methods approach project aims to develop a community-based, participatory, and co-created TB\u002FTB infection (TBI) screening care pathway for African and Hindustan immigrants, who often face socioeconomic vulnerabilities and barriers to healthcare access, including TB\u002FTBI screening. The first phase involves the co-design of a TB\u002FTBI screening care pathway through four thematic workshops using the Double-Diamond theoretical framework. These workshops will engage key stakeholders, including immigrants, community leaders, healthcare professionals, and academics, to identify barriers, define needs, and develop actionable measures to improve TB\u002FTBI screening care. The second phase involves a community-based study to implement the care pathway and estimate the incidence of TB and TBI among 200 immigrants from Angola, Cabo Verde, Guinea-Bissau, Mozambique, India, Bangladesh, and Nepal. Participants will be recruited through Grupcommunity services, and data will be collected on demographic, socioeconomic, health, and migration-related factors. The screening pathway will be implemented and evaluated, with patient-related outcomes measured to assess its effectiveness. The primary outcomes include the development of a culturally sensitive TB\u002FTBI screening care pathway and the estimation of TB and TBI incidence among high-risk immigrant populations. Secondary outcomes include the profiling of immigrant populations, the identification of social vulnerabilities, and the establishment of eligibility criteria for TB\u002FTBI screening in similar populations. We expected to advance knowledge on the specific needs of vulnerable immigrants regarding TB\u002FTBI screening and care and to empower communities, improve access to healthcare, and inform policymakers on tailored prevention and control strategies. The findings will contribute to the global effort to eliminate TB by addressing the unique challenges faced by immigrant populations in low-incidence countries like Portugal.",[66,67,28,27],"Tuberculosis","Tuberculosis (TB)",[69,70,66,71,72,73],"Immigrants","Migrants","Surveillance","Screening","Care pathway","2026-06-29",{"date":76,"type":44},"2026-07-07",{"date":78,"type":21},"2026-12-01",{"date":80,"type":21},"2027-05-01",{"name":82,"class":51},"Universidade Nova de Lisboa",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":52},"100640904","artificial-intelligence-driven-tuberculosis-landscape-analysis--stratification-research-100640904","NCT07611695","Artificial Intelligence-driven Tuberculosis Landscape Analysis & Stratification Research","TB-ATLAS","Inclusion Criteria for Model Development Cohort:\n\n* Patient with clinically diagnosed or bacteriologically confirmed pulmonary tuberculosis (TB) who received TB treatment;\n* Initiation of TB treatment on or after January 1, 2021;\n* Complete key diagnosis and treatment data available in the electronic medical record system.\n\nInclusion Criteria for External Validation Cohort:\n\n* Patient with clinically diagnosed or bacteriologically confirmed pulmonary tuberculosis (TB) who is planning to start TB treatment;\n* Voluntary participation with signed informed consent form (for adults ≥18 years); parental \u002F guardian consent and co-signed informed consent form are required for minors aged ≤ 18 years.\n\nExclusion Criteria:\n\n* Co-morbidity confounding: the presence of other active, life-threatening disease (e.g. late-stage malignancy, non-HIV severe immunodeficiency) for which the expected survival or priority of treatment may substantially interfere with the attribution of TB treatment outcomes;\n* Extremely poor treatment adherence: documented evidence indicating that the patient either never initiated treatment or was permanently lost to follow-up within the early treatment period (\\\u003C2 weeks), precluding the collection of any valid outcome data.",{"count":91,"type":21},31600,"The goal of this observational study is to establish and validate a comprehensive AI-driven clinical decision support system (AI-CDSS) in whole-chain management for pulmonary tuberculosis (TB) patients. The main question it aims to answer is:\n\nHow is the predictive performance of this system in terms of multiple key links during TB diagnosis and treatment? Can real-world benefits be derived from this system? This AI framework supports clinicians in making smarter decisions, ultimately improving cure rates and ensuring that every patient receives the most effective, personalized care possible.",[94,67,28],"Pulmonary Tuberculosis",[96,97,98,99],"tuberculosis","artificial intelligence","predictive model","clinical decision support system","2026-05-20",{"date":102,"type":44},"2026-05-28",{"date":104,"type":21},"2026-06-01",{"date":106,"type":21},"2028-06-30",{"name":108,"class":51},"Huashan Hospital"]