[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"umbilical-cord-clamping\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:umbilical-cord-clamping":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100657074","30-second-versus-pulsation-based-delayed-cord-clamping-in-term-newborns-100657074",false,"NCT07833059","30-Second Versus Pulsation-Based Delayed Cord Clamping in Term Newborns","Effects of 30-Second and Pulsation-Based Delayed Cord Clamping on Neonatal Metabolic Adaptation: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Pregnant women admitted to the Delivery Unit of Seyhan State Hospital MARSA Additional Service Building for vaginal delivery\n* Aged 18 years or older\n* Term pregnancy\n* Singleton, live pregnancy\n* Fetus in cephalic (vertex) presentation\n* Established vaginal labor and in the active phase of labor\n* Voluntary agreement to participate in the study and provision of written informed consent\n\nExclusion Criteria:\n\n* Planned elective or emergency cesarean delivery at admission or at the beginning of labor\n* Preterm or post-term pregnancy\n* Multiple pregnancy\n* Diagnosis of fetal growth restriction (IUGR) or fetal macrosomia\n* Intrauterine fetal death or major fetal congenital anomaly\n* High-risk maternal or obstetric conditions, including severe preeclampsia, eclampsia, placental abruption, or placenta previa\n* Meconium-stained amniotic fluid or a depressed newborn requiring advanced neonatal resuscitation, such as endotracheal intubation or chest compressions",true,"FEMALE","18 Years",{"count":20,"type":21},122,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to compare the effects of 30-second cord clamping and pulsation-based delayed cord clamping on neonatal metabolic adaptation in term newborns delivered vaginally. Eligible mother-newborn pairs will be randomly assigned in a 1:1 ratio to either 30-second cord clamping or pulsation-based delayed cord clamping. In the intervention group, the umbilical cord will be clamped after spontaneous cessation of cord pulsation, whereas in the control group, the cord will be clamped 30 seconds after birth. The primary outcome is umbilical arterial lactate level. Secondary outcomes include umbilical arterial pH, pCO2, pO2, HCO3-, base deficit, 1- and 5-minute Apgar scores, and maternal postpartum blood loss.",[27],"Umbilical Cord Clamping",[29,30,31,32,33,34,35],"Delayed Cord Clamping","Pulsation-Based Cord Clamping","Umbilical Cord Blood","Umbilical Arterial Lactate","Neonatal Metabolic Adaptation","Term Newborn","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-09-21",{"date":39,"type":40},"2026-09-22","ACTUAL",{"date":42,"type":21},"2026-10",{"date":44,"type":21},"2027-03",{"name":46,"class":47},"Tarsus University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100547469","physiological-umbilical-cord-clamping-in-patients-with-congenital-diaphragmatic-hernia-clinical-trial-100547469","NCT06408376","Physiological Umbilical Cord Clamping in Patients With Congenital Diaphragmatic Hernia. Clinical Trial","Inclusion Criteria:\n\n* Prenatal diagnosis of congenital diaphragmatic hernia\n* gestational age \\>34 weeks\n* Informed consent signed by the patient's parents\n\nExclusion Criteria:\n\n* Multiple gestation\n* Major malformation or fetal genetic anomaly diagnosed in the prenatal stage\n* Emergency cesarean section or maternal condition that prevents the approach\n* Lack of informed consent","ALL",{"count":57,"type":21},80,[24],"Congenital diaphragmatic hernia (CDH) is a malformation that affects 1 in every 3000 newborns. The diaphragm does not complete its closure during embryogenesis, which allows the abdominal organs to herniate into the thoracic cavity altering lung development. The lungs of patients with CDH are small, with a decreased surface area for gas exchange and developmental impair of the pulmonary vasculature, resulting in respiratory failure and pulmonary hypertension shortly after birth. When clamping the umbilical cord, a large part of the preload is abruptly excluded, generating an increase in vascular resistance, which in turn increase the afterload, resulting in a decrease in cardiac output. The output is restored by decreasing vascular resistance in pulmonary circuit after lung aeration upon receiving the preload of the right atrium, increasing pulmonary flow and thus sustaining the preload of the left ventricle. If pulmonary aeration occurs before clamping the umbilical cord, the pulmonary blood flow increases before placenta flow is lost, thus avoiding a decrease in cardiac output. This modality has been called physiological base cord clamping (PFC). The hypothesis is that PFC once ventilation has been established could prevent hypoxia and improve cardiac output in newborns with CDH and secondarily improve their hemodynamic parameters, stabilizing gas exchange and pulmonary hypertension during the first 24 hours of birth.",[27,61,62],"Congenital Diaphragmatic Hernia","Delayed Umbilical Cord Separation","RECRUITING","2024-05-06",{"date":66,"type":40},"2024-05-10",{"date":68,"type":40},"2022-06-14",{"date":70,"type":21},"2026-12-31",{"name":72,"class":73},"Hospital JP Garrahan","OTHER_GOV"]