[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"unresectable-stage-iii-nsclc\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:unresectable-stage-iii-nsclc":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100643519","phase-1-induction-chemoimmunotherapy-in-combination-with-chemoradiotherapy-and-consolidation-immunotherapy-in-unresectable-locally-advanced-non-small-cell-lung-cancer-100643519",false,"NCT07632365","Induction Chemoimmunotherapy in Combination With Chemoradiotherapy and Consolidation Immunotherapy in Unresectable Locally Advanced Non-Small Cell Lung Cancer","A Phase I\u002FII Multicenter Study Evaluating the Safety and Efficacy of Induction Chemoimmunotherapy Followed by Concurrent Chemoradiotherapy and Consolidation Immunotherapy in Unresectable Locally Advanced Non-Small Cell Lung Cancer","Inclusion Criteria:\n\n1. Age \\>18 years, male or female, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.\n2. Histologically or cytologically confirmed non-small cell lung cancer (NSCLC).\n3. Unresectable stage III NSCLC (according to the 8th edition of the AJCC staging system).\n4. No prior exposure to any other anti-tumor therapy.\n5. Absence of severe medical comorbidities or major organ dysfunction, as assessed by hematology, hepatic, renal, cardiac, and pulmonary function tests, meeting the following criteria: Hematology: Hemoglobin (HB) ≥ 90 g\u002FL (without blood transfusion within 14 days prior to enrollment); absolute neutrophil count (ANC) ≥ 1.5 × 10⁹\u002FL; platelet count (PLT) ≥ 100 × 10⁹\u002FL. Biochemistry: Total bilirubin (TBIL) ≤ 1.5 × the upper limit of normal (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN; serum creatinine (Cr) ≤ 1 × ULN, with an endogenous creatinine clearance rate \\> 60 mL\u002Fmin (calculated using the Cockcroft-Gault formula). Coagulation: Prothrombin time (PT)\u002Finternational normalized ratio (INR) and activated partial thromboplastin time (aPTT) ≤ 1.5 × ULN (unless the patient is receiving anticoagulant therapy, in which case PT or aPTT must be within the expected therapeutic range for the anticoagulant used).\n6. Life expectancy ≥ 3 months.\n7. Adequate understanding of the study, ability to complete treatment, suitability for follow-up, and voluntary provision of written informed consent.\n\nExclusion Criteria:\n\n1. Presence of small cell carcinoma components in the histological examination results.\n2. Co-occurrence of EGFR mutation, ALK rearrangement, or ROS-1 rearrangement positivity.\n3. History of other primary malignancies, with the following exceptions: Malignancies treated with curative intent with no known active disease and low potential for recurrence for ≥5 years prior to the first dose of investigational product (IP); adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease; or adequately treated carcinoma in situ without evidence of disease.\n4. Active or documented history of autoimmune or inflammatory diseases (including inflammatory bowel disease \\[e.g., colitis or Crohn's disease\\], diverticulitis \\[excluding diverticulosis\\], systemic lupus erythematosus, sarcoidosis syndrome, granulomatosis with polyangiitis \\[Wegener's syndrome\\], Graves' disease, rheumatoid arthritis, hypophysitis, uveitis, etc.).\n5. History of allogeneic organ transplantation.\n6. History of active primary immunodeficiency.\n7. Presence of uncontrolled concurrent illness, including but not limited to persistent or active infection (including tuberculosis, hepatitis B, hepatitis C, human immunodeficiency virus \\[HIV\\], etc.), symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, uncontrolled cardiac arrhythmia, active interstitial lung disease (ILD), severe chronic gastrointestinal disease associated with diarrhea, or psychiatric disorders\u002Fsocial situations that would limit compliance with study requirements, substantially increase the risk of adverse events (AEs), or compromise the patient's ability to provide written informed consent.\n8. Female patients who are pregnant or breastfeeding.\n9. Concurrent or prior use of immunosuppressive medication within 14 days prior to the first dose of induction immunotherapy. Exceptions include: intranasal, inhaled, or topical corticosteroids, or local corticosteroid injections (e.g., intra-articular injection); systemic corticosteroids at physiological doses not exceeding 10 mg\u002Fday of prednisone or its equivalent; corticosteroids as prophylactic premedication for hypersensitivity reactions (e.g., premedication for computed tomography \\[CT\\] scan); or systemic corticosteroid administration administered as part of chemoradiotherapy for locally advanced non-small cell lung cancer (NSCLC), or administered prophylactically or for the management of toxicity induced by chemotherapy and\u002For radiotherapy.\n10. Known allergy or hypersensitivity to any study drug or any excipient of a study drug.\n11. Patients judged by the investigator to be unable to comply with study procedures, restrictions, and requirements.","ALL","18 Years",{"count":19,"type":20},108,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","PIVOT study is a multicenter, phase I\u002FII clinical study designed to evaluate induction chemoimmunotherapy followed by concurrent chemoradiotherapy and consolidation immunotherapy in patients with unresectable locally advanced non-small cell lung cancer (NSCLC). Phase I consists of a single-arm safety lead-in study evaluating the safety and preliminary efficacy of the investigational regimen. If predefined safety criteria are met, the study proceeds to a phase II randomized controlled trial comparing induction chemoimmunotherapy followed by concurrent chemoradiotherapy and consolidation immunotherapy with the standard PACIFIC regimen. The objective of the phase II study is to determine whether the investigational treatment strategy improves progression-free survival while maintaining an acceptable safety profile compared with the standard PACIFIC regimen.",[27,28,29],"Non-Small Cell Lung Cancer","Locally Advanced Non-Small Cell Lung Cancer","Unresectable Stage III NSCLC",[31,32,33,34,35,36,37,38],"NSCLC","Stage III NSCLC","Unresectable NSCLC","Concurrent Chemoradiotherapy","Consolidation Immunotherapy","Chemoimmunotherapy","PD-1 Inhibitor","PACIFIC Regimen","RECRUITING","2026-07-22",{"date":42,"type":43},"2026-07-23","ACTUAL",{"date":45,"type":43},"2022-10-09",{"date":47,"type":20},"2028-12-31",{"name":49,"class":50},"Shanghai Chest Hospital","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100641953","phase-2-in-vivo-fluorescence-molecular-bronchoscopy-of-durvalumab-680lt-in-patients-with-unresectable-stage-iii-non-small-cell-lung-cancer-nsclc-after-chemoradiotherapy-100641953","NCT07653438","In Vivo Fluorescence Molecular Bronchoscopy of Durvalumab-680LT in Patients With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) After Chemoradiotherapy","In Vivo Fluorescence Molecular Bronchoscopy of Durvalumab-680LT in Patients With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) After Chemoradiotherapy - PulmoPrint","PulmoPrint","Inclusion Criteria:\n\n* Signed informed consent prior to participation in the study.\n* Age ≥ 18 years.\n* Histologically or cytologically confirmed unresectable stage III non-small cell lung cancer.\n* Completion of concurrent platinum-based chemoradiotherapy\n* Eligibility for adjuvant durvalumab per standard of care.\n* At least one tumor lesion or involved lymph node accessible by bronchoscopy or endoscopic\u002Fendobronchial ultrasound, suitable for biopsy\u002Ffine-needle aspiration (FNA) and fluorescence measurement.\n* Eastern Cooperative Oncology Group (ECOG) performance status 0-2.\n* Patient is considered fit to undergo a research bronchoscopy (with or without addition of endobronchial ultrasound; including propofol sedation or general anesthesia if either is indicated).\n\nExclusion Criteria:\n\n* Known history of infusion reactions to durvalumab, other anti-PD-L1 antibodies, or other monoclonal antibodies, according to the patient's medical history.\n* Contraindication for bronchoscopy or endoscopic\u002Fendobronchial ultrasound (if applicable), including severe uncorrectable coagulopathy, pre-existing severe respiratory insufficiency, or any other clinical reason as judged by the investigator.\n* Medical or psychiatric conditions compromising the patient's ability to provide informed consent, according to the treating physician.\n* Pregnancy or breastfeeding. A negative pregnancy test must be available for women of childbearing potential on the day of tracer administration.\n* Use of an investigational medicinal product within 30 days prior to tracer administration.",{"count":61,"type":20},20,[24],"PulmoPrint is a clinical study at the University Medical Center Groningen (UMCG) that investigates why some patients with unresectable stage III lung cancer don't respond to immunotherapy after chemoradiotherapy. To do this, a small dose of a fluorescently labeled version of the immunotherapy drug durvalumab is given via an intravenous (IV) drip, after which a bronchoscopy is performed to visualize where and how much of the drug reaches the tumor and lymph nodes - before the actual durvalumab treatment starts.",[65,29],"Stage III Non-small Cell Lung Cancer",[67,68,69],"Fluorescence molecular bronchoscopy","Durvalumab-680LT","Near-infrared fluorescence imaging","NOT_YET_RECRUITING","2026-07-13",{"date":73,"type":43},"2026-07-15",{"date":75,"type":20},"2026-09-01",{"date":77,"type":20},"2031-03-01",{"name":79,"class":50},"University Medical Center Groningen"]