[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-limb-amputees\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-limb-amputees":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100435227","proprioceptive-sensorimotor-integration-with-neural-interfaces-for-hand-prostheses-100435227",false,"NCT04947462","Proprioceptive Sensorimotor Integration With Neural Interfaces for Hand Prostheses","PSI","Inclusion Criteria:\n\n* Veteran\n* Unilateral upper limb amputation above or below the elbow with fully healed and healthy surgical sites\n* Viable peripheral nerve function in the residual nerves serving the limb\n* Volitional activity of the residual muscles in the amputated limb or actuating movement of the limb\n* Medically fit to undergo general anesthesia\n* Fitted with a prosthesis by a certified prosthetic and orthotic specialist (CPO) and at least one month of experience using a prosthesis\n* Willingness and availability to follow the study protocol\n* Willingness to undergo psychological evaluation, if recommended by study surgeons or investigators, to determine that the participant is mentally competent and capable of completing the study-related activities\n\nExclusion Criteria:\n\n* Bilateral upper limb amputation, unless the amputation on the contralateral side only involves missing digits but does not qualify as a partial hand amputation\n* Inability to speak English\n* Medically unfit to undergo surgery\n* Pregnancy, or those who are of childbearing potential, unwilling to prevent pregnancy during the trial\n* Uncontrolled diabetes (Hemoglobin A1c (HgbA1c)\\>8.0%)\n* History of neuropathy and\u002For radiculopathy in the target limb\n* Active infection or open sores on the residual limb\n* History of frequent infection or sores with unknown cause\n* Inability to provide informed consent or follow experimental protocols\n* Severe pain that would prevent the participant from completing study-related activities\n* Poor surgical candidate","ALL","18 Years",{"count":19,"type":20},8,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to characterize proprioceptive sensations in the missing limb of upper limb amputees using nerve stimulation, and to develop advanced controllers for moving a prosthesis. Proprioceptive sensations are the sensations that tell individuals where their hand is in space, and if it is moving. The research team uses Functional Electrical Stimulation (FES), which involves applying small electric currents to the nerves. These signals are then transferred to the brain just like the information about the individual's intact hand used to be transferred to their brain. This study will test different placements for stimulation and determine which one(s) provide the individual with proprioceptive sensations. The investigators want to know what the participants feel and if the investigators can use proprioceptive sensation to give the participants information about limb movement and position.",[26],"Upper Limb Amputees",[28,29,30,31,32,33,34],"Proprioception","Prosthesis","Upper Extremity Limb Loss","Peripheral Nerve Stimulation","Embodiment","Sensorimotor","Neuroprostheses","RECRUITING","2026-08-19",{"date":38,"type":39},"2026-08-21","ACTUAL",{"date":41,"type":39},"2021-12-01",{"date":43,"type":20},"2030-05-31",{"name":45,"class":46},"VA Office of Research and Development","FED",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100553475","strategies-to-control-robotic-hand-prosthesis-via-hd-semg-and-to-restore-sensory-feedback-via-tens-100553475","NCT06486571","Strategies to Control Robotic Hand Prosthesis Via HD-sEMG and to Restore Sensory Feedback Via TENS","Development of Innovative Strategies for the Control of Robotic Hand Prostheses Based on High-density Electromyography and Restitution of Sensory Feedback Via Trans-cutaneous Electrical Stimulation","Inclusion Criteria:\n\n* Upper limb amputation;\n* Stable clinical condition;\n* Skin integrity of the stump;\n* Age between 18 and 65 years;\n* High level of motivation to participate in the study and acceptance of the purpose of the study;\n* Signed informed consent document.\n\nExclusion Criteria:\n\n* Clinical instability;\n* Dehiscence of the amputation wound;\n* Failure to complete the informed consent;\n* State of pregnancy;\n* Implanted devices that can interfere with TENS stimulation (e.g. pacemakers);","65 Years",{"count":57,"type":20},30,[23],"Upper limb amputation still causes severe disability today; prostheses currently on the market are able to restore partially to the amputee the lost functionality. In addition to the motor capacity of the limb, prosthetic systems should also aim to restore to the sensory information from the surrounding environment during contact with objects. Therefore, it is important to develop bidirectional prostheses. It is thus apparent that the development of new techniques for decoding the efferent channel, such as high-density surface electromyography, and for encoding of the afferent channel afferent, to return multimodal somatosensory sensations of mechanoception, nociception, and thermoception using TENS, isimportant to improve the patient's use of the prosthesis.",[26],[62,63,64,65,66],"Upper limb amputation","HD-sEMG","Pattern recognition","Sensory feedback","TENS","2024-06-27",{"date":69,"type":39},"2024-07-03",{"date":71,"type":39},"2024-04-23",{"date":73,"type":20},"2026-04-22",{"name":75,"class":76},"Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro","OTHER"]