[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urogynecologic-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urogynecologic-surgery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100651941","phase-2-postoperative-tizanidine-use-in-pelvic-reconstructive-surgery-a-pilot-study-100651941",false,"NCT07766837","Postoperative Tizanidine Use in Pelvic Reconstructive Surgery: A Pilot Study","TIPS","Inclusion Criteria:\n\n* female, age ≥18 and ≤89 years old\n\n  * any race\u002Fethnicity\n  * English and\u002For Spanish fluency\n  * undergoing apical suspension:\n\n    * sacrocolpopexy (laparoscopic or robotic)\n    * uterosacral ligament suspension (vaginal, laparoscopic, or robotic)\n    * sacrospinous ligament fixation\n    * iliococcygeus suspension\n  * surgery being performed at Hartford Hospital\n\nExclusion Criteria:\n\n* male\n\n  * age \\\u003C18 or ≥90 years old\n  * pregnant\n  * breastfeeding\n  * documented diagnosis of hypotension in EMR problem list, BP in office or at pre-op PAC (confirmed on repeat) to be systolic \\\u003C100 mm Hg and\u002For diastolic \\\u003C70 mm Hg\n  * known intolerance or sensitivity to tizanidine\n  * current use of:\n\n    * CYP1A2 inhibitor:\n    * clonidine (alpha-2 agonist) antihypertensive\n    * opioid\n    * muscle relaxant\n  * pre-existing\n\n    * hepatic impairment as defined as transaminitis with ALT or AST \\>2x upper limit of normal\n    * diagnoses of cirrhosis, alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD)\n    * renal impairment as defined by creatinine clearance \\\u003C25 mL\u002Fmin\n  * obstructive sleep apnea\n  * non-English or non-Spanish speaking\n  * past opioid dependence\n  * concurrent diagnosis of malignancy\n  * concurrent surgery apart from pelvic reconstructive surgery with another specialty\n  * unable\u002Funwilling to consent to participate","FEMALE","18 Years","89 Years",{"count":20,"type":21},186,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this clinical trial is to evaluate whether adding tizanidine to the standard postoperative pain regimen improves recovery after pelvic reconstructive surgery in adult women. The main questions it aims to answer are:\n\nDoes postoperative tizanidine improve patient-reported recovery 4-6 weeks after surgery? Does tizanidine reduce postoperative pain, opioid use, constipation, and healthcare utilization while improving functional recovery?\n\nResearchers will compare standard postoperative care plus tizanidine with standard postoperative care alone to determine whether tizanidine improves postoperative recovery.\n\nParticipants will:\n\n* Be randomly assigned to receive either standard postoperative pain management alone or standard postoperative pain management plus tizanidine for 2 weeks after surgery.\n* Complete electronic surveys before surgery, 1-2 days after surgery, 2 weeks after surgery, and 4-6 weeks after surgery to assess pain, recovery, activity, and bowel function.\n* Allow researchers to review information from their electronic medical record, including healthcare utilization and postoperative outcomes, during the 4-6 weeks following surgery.",[27,28,29],"Post Operative","Post Operative Analgesia","Urogynecologic Surgery",[31,32,33],"post operative","tizanidine","urogynecology","NOT_YET_RECRUITING","2026-08-11",{"date":37,"type":38},"2026-08-17","ACTUAL",{"date":40,"type":21},"2026-07-29",{"date":42,"type":21},"2028-07-29",{"name":44,"class":45},"Hartford Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100643655","does-trendelenburg-positioning-during-pulmonary-recruitment-breaths-affect-post-laparoscopy-shoulder-pain-100643655","NCT07631728","Does Trendelenburg Positioning During Pulmonary Recruitment Breaths Affect Post-laparoscopy Shoulder Pain","Trendelenburg Positioning During Pulmonary Recruitment Breaths: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Robot-assisted laparoscopic surgery for benign gynecologic indication\n* Surgery is booked for 60 minutes or longer\n* Reliable working phone number or email\n\nExclusion Criteria:\n\n* Patients with baseline opioid use\n* Patients with existing shoulder or neck pain\n* Active malignancy-related pain or surgery for malignant indication\n* Concomitant upper abdominal or thoracic surgery\n* Pre-existing emphysema, chronic obstructive pulmonary disease, or pneumothorax\n* Non-English speaking",true,{"count":55,"type":21},120,[57],"NA","The goal of this clinical trial is to evaluate whether different positioning in the operating room during removal of laparoscopic surgical gas differs in post-surgery shoulder pain. An additional goal of this study is to evaluate whether positions change other post-surgery metrics such as bloating, time to passing gas, nausea and vomiting, and time to oral intake.\n\nResearchers will compare Trendelenburg positioning where your head is tilted down to supine (level or flat) positioning during removal of surgical gas.\n\nParticipants will be asked to complete brief surveys at 24 and 72-hours post-surgery.",[60,61,29],"Pain, Post-operative","Pneumoperitoneum",[63,64,65,66,67],"Trendelenburg","pneumoperitoneum","post-laparoscopy shoulder pain","post-laparoscopy pain","gynecologic surgery","2026-06-01",{"date":70,"type":38},"2026-06-08",{"date":68,"type":21},{"date":73,"type":21},"2027-11",{"name":75,"class":45},"Ankita Gupta",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100637156","postoperative-vaginal-compression-after-prolapse-surgery---an-rct-100637156","NCT07612202","Postoperative Vaginal Compression After Prolapse Surgery - an RCT","A Randomized Controlled Trial on Postoperative Vaginal Compression After Prolapse Surgery","Inclusion criteria:\n\n* Planned anterior colporrhaphy, posterior colporrhaphy, or cervical amputation at the day surgery department, Nordsjællands Hospital, Capital Region, Denmark\n* Age 18 years and older\n\n  . Cognitively capable patient\n* Received information material as described in the protocol\n\nExclusion criteria:\n\n* Failure to pause blood-thinning medication on the day of surgery, if this was planned\n* Failure to discontinue regular intake of fish oil or ginger extract four weeks prior to the procedure\n* Immunosuppressed patients\n* Planned perineorrhaphy\n* Surgery involving more than two compartments\n* Non-Danish speaking patients",{"count":84,"type":21},360,[57],"The goal of this clinical trial is to learn if omitting postoperative vaginal compression (packing) can facilitate a more efficient recovery after elective surgery for uterovaginal prolapse. The main questions it aims to answer are: Will the omission of vaginal compression result in a non-inferior (unchanged) rate of prolapse recurrence within the first three months after surgery? Does the omission of vaginal compression lead to a shorter hospital stay and a faster return of normal bladder function? Researchers will compare a group that receives no postoperative vaginal compression to a control group that receives standard vaginal gauze packing for two hours to see if skipping the packing leads to shorter hospital stays and faster bladder emptying without increasing the risk of the prolapse returning.",[88,89,29],"Postoperative Care","Prolapse Genital",[91,92,93,94],"postoperative","randomised ccontrolled trial","vaginal compression","prolapse surgery","2026-05-21",{"date":97,"type":38},"2026-05-28",{"date":99,"type":21},"2026-06-03",{"date":101,"type":21},"2028-12",{"name":103,"class":45},"Christiane Marie Bourgin Folke Gam",1]