[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urogynecology\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urogynecology":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100658653","phase-4-suzetrigine-following-urogynecologic-surgery-investigation-of-postoperative-pain-management-100658653",false,"NCT07856654","Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management","SUSI","Inclusion Criteria:\n\n* Women ≥ 40 years and ≤ 80\n* BMI \\>=18.0 and \\\u003C= 40.0\n* Can read and speak English or Spanish\n* Undergoing major urogynecologic surgery, defined as having at least one of the following:\n\n  * Robotic-assisted laparoscopic sacrocolpopexy\n  * Uterosacral ligament suspension (laparoscopic or vaginal approach)\n  * Uterosacral hysteropexy\n  * Sacrospinous hysteropexy\n  * Sacrospinous ligament fixation\n  * Conversion to laparotomy during primary surgery for prolapse repair\n\nExclusion Criteria:\n\n* • Current narcotic use defined as daily use for more than 7 consecutive days in the 3 months prior to surgery, or current treatment for opioid use disorder.\n\n  * Any opioid use within 30 days prior to the scheduled procedure date.\n  * Significant hepatic disease, defined as AST or ALT \\>3 times the upper limit of normal or Child-Pugh class B or C.\n  * Diagnosis of chronic pain syndrome or fibromyalgia\n  * Inability to provide written informed consent\n  * History of significant respiratory, cardiovascular, metabolic, neurologic, or psychiatric disease as deemed clinically significant by study team\n  * History of cardiac dysrhythmias requiring anti-arrhythmia treatment(s) within the last 2 years or QT prolongation (QTcF \\>450 ms) or pacemaker\u002FICD\n  * Severe kidney disease define as Estimated glomerular filtration rate (eGFR) of ≤ 30ml\u002Fmin\n  * Inability to receive or respond to text messages via mobile phone\n  * Receives transversus abdominis plane (TAP) block\n  * Allergy to any of the study medications\n  * Use of moderate or strong CYP3A inducers or inhibitors, including prescription medications, over-the-counter medications, and herbal supplements known to significantly affect CYP3A metabolism (e.g., ketoconazole, clarithromycin, rifampin, carbamazepine, phenytoin, ritonavir, and St. John's Wort).\n  * Pregnant or breastfeeding or planning to become pregnant within 30 days following last dose of study drug",true,"FEMALE","40 Years","80 Years",{"count":21,"type":22},48,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The goal of this clinical trial is to determine whether suzetrigine, when added to standardized multimodal postoperative analgesia improves pain control and reduces opioid consumption after apical suspension surgery for pelvic organ prolapse.\n\nResearchers will compare suzetrigine to a placebo (a look-alike substance that contains no drug) to evaluate this outcome.\n\nThe main questions it aims to answer are:\n\n* Does suzetrigine reduce postoperative pain scores compared to placebo?\n* Does suzetrigine reduce the need for opioid rescue medication after surgery?\n\nResearchers will compare participants receiving suzetrigine to participants receiving placebo, both on top of standard postoperative pain management, to see if suzetrigine lowers pain scores and opioid consumption after apical suspension surgery.",[28,29,30],"Pelvic Organ Prolapse (POP)","Postoperative Pain","Urogynecology",[32,33,34,35],"postoperative pain","suzetrigine","pelvic organ prolapse","urogynecology","NOT_YET_RECRUITING","2026-09-28",{"date":39,"type":40},"2026-10-02","ACTUAL",{"date":42,"type":22},"2026-11",{"date":44,"type":22},"2028-05",{"name":46,"class":47},"Aditi Talkad","OTHER"]