[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"uterine-atony-with-hemorrhage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:uterine-atony-with-hemorrhage":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100646809","phase-4-oxytocin-bolus-versus-infusion-in-high-risk-patients-undergoing-elective-cesarean-section-inbox-hr-100646809",false,"NCT07688512","Oxytocin Bolus Versus Infusion in High-Risk Patients Undergoing Elective Cesarean Section (INBOX-HR)","Randomized Double-Blinded Clinical Trial of Oxytocin Bolus Versus Infusion in High-Risk Patients Undergoing Elective Cesarean Section","INBOX-HR","Inclusion Criteria:\n\n* Undergoing elective cesarean section under spinal anesthesia or combined spinal anesthesia (CSE)\n* Patients must be able to provide written informed consent in either English or Spanish\n* Parturient classified as high risk for postpartum hemorrhage as defined by the adapted California Maternal Quality Care Obstetric Hemorrhage Risk Screen\n\nExclusion Criteria:\n\n* Parturient in labor or ruptured membranes\n* Patient does not possess the physical and mental capacity to provide informed consent\n* Urgent or emergent cesarean sections\n* Patients with a known major coagulopathy\n* Patients with significant thrombocytopenia limiting neuraxial anesthesia (\\\u003C70k)\n* Patients on therapeutic anticoagulation at time of procedure\n* Patients on the placenta accreta spectrum\n* Patients with severe cardiac disease contraindicating oxytocin\n* Patients with an allergy to oxytocin","FEMALE","18 Years","45 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The goal of this randomized, double-blind clinical trial is to learn if Oxytocin is most effective at achieving adequate uterine tone (important for preventing postpartum hemorrhage) when administered as a bolus or an infusion in patients at high-risk for postpartum hemorrhage in elective cesarean sections. The main questions that will be answered are:\n\n1. Is Oxytocin bolus more effective than Oxytocin infusion at achieving adequate uterine tone at 2 minutes after the baby is born and every minute thereafter?\n2. Does Oxytocin bolus cause less maternal side effects than Oxytocin infusion?\n3. Does Oxytocin bolus result in less blood loss than Oxytocin infusion in high risk for postpartum hemorrhage patients undergoing elective cesarean sections?\n\n3\\. Are patients more satisfied with their cesarean section when they receive Oxytocin bolus or Oxytocin infusion?\n\nResearchers will compare the 2 methods of Oxytocin administration, bolus versus infusion, to see which method is more effective or if they are equally effective.\n\nParticipants will:\n\n1. Be randomized to receive either Oxytocin bolus or Oxytocin infusion during their cesarean section but after the baby is born.\n2. Be asked a question about their experience 2 hours after the surgery.\n3. Allow the research team to collect information about how they are doing from their hospital medical records.",[28,29,30,31],"Postpartum Hemorrhage","Uterine Atony","Uterine Atony With Hemorrhage","Elective Cesarean Section",[33],"Oxytocin bolus vs infusion in elective cesarean section in patients at high risk for postpartum hemorrhage","NOT_YET_RECRUITING","2026-07-30",{"date":37,"type":38},"2026-08-03","ACTUAL",{"date":40,"type":22},"2026-08",{"date":42,"type":22},"2029-02",{"name":44,"class":45},"Stony Brook University","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100638930","exteriorization-versus-in-situ-hysterotomy-repair-during-cesarean-effects-on-uterine-tone-100638930","NCT07606846","Exteriorization Versus In Situ Hysterotomy Repair During Cesarean: Effects on Uterine Tone","Uterine Exteriorization Versus In Situ Hysterectomy Repair During Cesarean Delivery: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-55\n* Undergoing cesarean section\n\nExclusion Criteria:\n\n* Patient age \\\u003C18 or \\>55\n* Case urgency deemed too great for consent","55 Years",{"count":55,"type":22},60,[57],"NA","During standard cesarean deliveries, there are two ways that obstetricians repair the incision on the uterus (hysterotomy after delivery of the baby. One method involves lifting the uterus out of its regular place in the abdomen to repair the incision (uterine exteriorization for repair). The second method involves leaving the uterus inside the abdomen to repair the uterus (in situ repair). Both of these methods are regularly used by obstetricians during cesarean deliveries, and it is not currently known if one has benefits over the other. Currently, surgeons use both methods, but lifting the uterus out of its place is slightly more common. In this study, participants will be randomly assigned to have one of these techniques performed during their surgery. Researchers will be investigating whether one technique or the other leads to better contraction of the uterus after delivery, less bleeding, less intra-operative nausea\u002Fvomiting, or a better patient experience than another.",[28,29,30,60],"Cesarean Section",[28,29,62,60,63,64],"Uterine Atony with Hemorrhage","Cesarean Delivery","Uterine Tone","2026-05-22",{"date":67,"type":38},"2026-05-27",{"date":69,"type":22},"2026-06-01",{"date":71,"type":22},"2029-06-01",{"name":73,"class":45},"Stanford University"]