[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vancomycin-resistant-enterococci\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vancomycin-resistant-enterococci":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100653961","phase-2-a-clinical-trial-of-resistant-potato-starch-for-gut-mdro-decolonization-100653961",false,"NCT07792915","A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization","MDRO-Fiber","Inclusion Criteria:\n\n* Presence of C. difficile, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococcus (VRE), and\u002For Multi-drug resistant Enterobacteriaceae (MDRE) in the gut as determined by a stool test\n* Ambulatory\u002Fnot hospitalized at time of enrollment\n\nExclusion Criteria:\n\n* Allergy to any ingredient or source material in intervention or placebo product\n* Severe gastrointestinal condition that may be exacerbated by high dietary fiber intake (history of bowel obstruction, intestinal strictures, diverticulitis, active inflammatory bowel disease with structuring, gastroparesis, and\u002For severe gastrointestinal motility disorders)\n* Uncontrolled diabetes (hospitalized in previous 5 years due to diabetes)\n* Dysphagia\n* Fecal microbiome transplant in the last 30 days\n* Intestinal surgery in the last 30 days\n* Pregnancy or breastfeeding\n* Immunosuppression, defined as history of solid organ transplant or as receipt of ablative chemotherapy, steroids at the equivalent of ≥5 mg\u002Fday prednisone, antimetabolites, anti-TNF agents, calcineurin inhibitors, or mycophenolate at time of enrollment\n* Use of probiotics or fiber supplements in previous 30 days\n* Already on a decolonization protocol\n* Active infection requiring acute antibiotic treatment","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays, and increased healthcare costs. Many risk factors for MDRO infections are present in the Veteran population (such as older age, underlying medical conditions like diabetes, and stays in long-term healthcare settings). Some people can carry these organisms in their gut. Even without current symptoms, carrying these MDROs also increases risk of future infection. Effective, easy to use, and inexpensive interventions to reduce gut carriage of MDROs are needed to reduce risk of infection. Dietary fiber prebiotics have shown promise in improving the healthy gut microbiome, and the investigators have found that individuals with high fiber in their diets have reduced carriage of MDROs in the gut. The investigators propose a randomized controlled trial to test the effectiveness of a dietary fiber prebiotic intervention (resistant potato starch) in reducing gut MDRO carriage in Veterans with a history of MDRO carriage and\u002For infection. The investigators will also evaluate the effect on the gut microbiome as well as Veterans' experience with the fiber intervention.",[26,27,28,29,30],"Clostridium Infections","Methicillin-resistant Staphylococcus Aureus (MRSA)","Vancomycin-Resistant Enterococci","Carbapenem-Resistant Enterobacteriaceae","Asymptomatic Infections",[32,33,34,35,36,37,38],"Clostridioides","methicillin-resistant Staphylococcus aureus","Drug resistance, multiple","Gastrointestinal microbiome","Veterans","Dietary fiber","Prebiotics","NOT_YET_RECRUITING","2026-08-25",{"date":42,"type":43},"2026-08-28","ACTUAL",{"date":45,"type":20},"2027-01-01",{"date":47,"type":20},"2030-09-30",{"name":49,"class":50},"VA Office of Research and Development","FED"]