[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"varicocelectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:varicocelectomy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100646920","effect-of-varicocelectomy-on-spermatogenic-cell-count-and-semen-parameters-100646920",false,"NCT07684963","Effect of Varicocelectomy on Spermatogenic Cell Count and Semen Parameters","Seminal Spermatogenic Cell Count Pre and Post Varicocelectomy: Relation to Seminal Parameters","Inclusion Criteria:\n\n* Infertile married males diagnosed with clinical varicocele.\n* Age between 20-45 years.\n* Patients indicated for varicocelectomy according to standard clinical guidelines.\n* Abnormal or suboptimal semen parameters on at least two semen analyses.\n\nExclusion Criteria:\n\n* Azoospermic patients (complete absence of sperm in semen).\n* History of previous varicocelectomy or scrotal surgery.\n* Presence of other known causes of infertility (e.g., genetic abnormalities, obstructive azoospermia).\n* Active genital infection or systemic infection affecting semen analysis.\n* Use of medications affecting spermatogenesis within the last 3 months (e.g., testosterone, chemotherapy).\n* Chronic systemic diseases known to affect fertility (e.g., uncontrolled diabetes, liver failure).\n* Severe leukocytospermia as confirmed by peroxidase (Endtz) test exceeding WHO reference limits.\n* Pus cell \\> 1 million\u002Fml by peroxidase.","MALE","20 Years","45 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate how varicocele surgery (varicocelectomy) affects the number of immature sperm cells (spermatogenic cells) found in the semen of infertile men. Varicocele, an abnormal dilation of veins in the scrotum, is a common cause of male infertility that can negatively impact semen quality and overall testicular function. While surgery is widely performed to improve standard semen parameters, this study specifically investigates its impact on the shedding of immature germ cells into the seminal fluid, which can be an indicator of impaired sperm production.\n\nResearchers will enroll 40 infertile married men, aged 20 to 45, who have been diagnosed with a clinical varicocele and exhibit abnormal semen parameters. All participants will undergo a single surgical intervention known as a subinguinal microsurgical varicocelectomy. To measure the effects of the surgery, participants will undergo careful semen analysis before the procedure, and again at 3 and 6 months postoperatively. The primary goal is to track changes in the spermatogenic cell count and abnormal sperm morphology, and to explore how these changes correlate with conventional semen parameters like sperm concentration, motility, and vitality.",[27,28,29,30],"Varicocele","Male Infertility","Infertility","Varicocelectomy",[32,33,34,35,36,37],"Spermatogenic Cells","Semen Parameters","Immature Germ Cells","Semen Analysis","Sperm Morphology","Round Cells","NOT_YET_RECRUITING","2026-06-28",{"date":41,"type":42},"2026-07-06","ACTUAL",{"date":44,"type":21},"2026-08",{"date":46,"type":21},"2027-09",{"name":48,"class":49},"Assiut University","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100609447","phase-4-sedative-and-analgesic-effects-of-dexmedetomidine-versus-ketamine-in-patients-undergoing-varicocelectomy-under-spinal-anaesthesia-a-prospective-randomized-comparative-trial-100609447","NCT07214701","Sedative and Analgesic Effects of Dexmedetomidine Versus Ketamine in Patients Undergoing Varicocelectomy Under Spinal Anaesthesia: A Prospective Randomized Comparative Trial","Inclusion Criteria:\n\n* Age: from 18 to 40 years\n* Sex: Male patients\n* Operation: varicocelectomy under spinal anesthesia\n* ASA physical states I-II\n\nExclusion Criteria:\n\n* Psychiatric or neurological disorders\n* Respiratory disorders\n* Cardiovascular disorders\n* Coagulation disorders\n* Contraindications to neuraxial block (allergy to L.A, peripheral issues)\n* spine deformity","ALL","18 Years","40 Years",{"count":60,"type":21},58,[62],"PHASE4","The demand for safe and effective sedation during spinal anesthesia has increased in recent years, particularly in ambulatory and minor surgical procedures. The ideal sedative agent should provide adequate anxiolysis and comfort, maintain cardiorespiratory stability, and allow rapid recovery without significant adverse effects .\n\nKetamine, a phencyclidine derivative, produces sedation, analgesia, and amnesia while maintaining airway reflexes and spontaneous respiration. However, it is often associated with undesirable psychomimetic reactions and sympathetic stimulation, including tachycardia and hypertension .\n\nIn contrast, dexmedetomidine, a highly selective α2-adrenergic agonist, provides cooperative sedation, analgesia, and reduced anesthetic requirements, but it may cause bradycardia and hypotension, particularly at higher doses .\n\nThe combination of ketamine and dexmedetomidine (often referred to as \"Ketadex\") has recently gained attention due to its synergistic effects. Evidence suggests that this combination improves hemodynamic stability, decreases emergence agitation, and provides superior analgesia compared to either agent alone \\[4,5\\]. Moreover, ketamine counteracts the bradycardia and hypotension induced by dexmedetomidine, while dexmedetomidine mitigates ketamine-induced psychomimetic side effects .\n\nDespite these advantages, the optimal dosing regimen and comparative efficacy of the two drugs when used individually remain subjects of clinical debate. Recent randomized controlled trials comparing intravenous dexmedetomidine and ketamine during spinal anesthesia reported differences in sedation quality, hemodynamic stability, and recovery profile . Therefore, this study aims to compare the sedative and hemodynamic effects of intravenous dexmedetomidine versus ketamine infusion in patients undergoing varicocelectomy under spinal anesthesia.\n\nthe study aim to Compare sedative, analgesic efficacy, and safety profile of intravenous dexmedetomidine versus ketamine in patients undergoing varicocelectomy under spinal anaesthesia",[30],"2025-10-05",{"date":67,"type":42},"2025-10-09",{"date":69,"type":21},"2025-11-01",{"date":71,"type":21},"2026-12-01",{"name":48,"class":49}]