[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-induced-diaphragmatic-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-induced-diaphragmatic-dysfunction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100653595","nutritional-risk-and-diaphragmatic-thickness-in-mechanically-ventilated-copd-patients-100653595",false,"NCT07788170","Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients","Nutritional Risk Assessment and Diaphragmatic Thickness for Predicting Outcome in Elderly Mechanically Ventilated COPD Patients","Inclusion Criteria:\n\n* Adult patients aged ≥ 60 years\n* Confirmed diagnosis of Chronic Obstructive Pulmonary Disease (COPD) according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria\n* Admission to the intensive care unit (ICU) or respiratory ICU for acute exacerbation of COPD\n* Requirement for invasive mechanical ventilation for ≥ 48 hours\n* Provision of informed consent by the patient or a first-degree relative\u002Flegal guardian\n\nExclusion Criteria:\n\n* Pre-existing neuromuscular disease affecting diaphragmatic or peripheral muscle function (e.g., myasthenia gravis, muscular dystrophy, poliomyelitis, motor neuron disease)\n* Known diaphragmatic paralysis or phrenic nerve injury predating admission\n* Severe limb edema, amputation, or lower-limb deformity precluding valid anthropometric measurement\n* Terminal illness or malignancy with an expected survival of \\\u003C 48 hours\n* Duration of mechanical ventilation \\\u003C 48 hours, or death\u002Fextubation occurring before baseline assessment completion\n* Subcutaneous emphysema or thoracic\u002Fabdominal wall pathology precluding adequate diaphragmatic ultrasound acoustic windows","ALL","60 Years",{"count":19,"type":20},120,"ESTIMATED","OBSERVATIONAL","Malnutrition and muscle wasting are frequent complications in patients with chronic obstructive pulmonary disease (COPD) experiencing acute exacerbations. In critically ill patients who require invasive mechanical ventilation, nutritional depletion and ventilator-induced diaphragmatic dysfunction can complicate recovery and prolong intensive care unit (ICU) stays.\n\nThe purpose of this prospective observational cohort study is to evaluate nutritional status and diaphragmatic structure in elderly patients (aged 60 years and older) with COPD who require invasive mechanical ventilation for at least 48 hours.\n\nParticipants will undergo bedside assessments, including:\n\n* Calculation of clinical risk scores within the first 24 hours of ICU admission: modified Nutrition Risk in the Critically Ill (mNUTRIC), Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II).\n* Anthropometric measurements: mid-upper arm circumference (MUAC) and calf circumference (CC) measured at baseline, day 7, and the day of weaning.\n* Diaphragmatic ultrasonography: point-of-care ultrasound to measure diaphragm thickness at end-expiration and end-inspiration at baseline, day 7, and during weaning trials.\n\nThe main goal is to evaluate the relationship between nutritional risk (assessed by the mNUTRIC score) and diaphragmatic thickness, and to determine how these parameters correlate with clinical outcomes such as weaning success, total duration of mechanical ventilation, ICU length of stay, and ICU mortality.",[24,25,26,27,28],"Chronic Obstructive Pulmonary Disease (COPD)","Acute Exacerbation of Chronic Obstructive Pulmonary Disease","Malnutrition","Respiratory Failure","Ventilator-Induced Diaphragmatic Dysfunction",[30,31,32,33,34,35,36,37,38,39],"modified NUTRIC score","Diaphragmatic ultrasound","Diaphragm thickness","Mechanical ventilation","Mid-upper arm circumference","Calf circumference","Sarcopenia","Weaning failure","APACHE II","SOFA score","NOT_YET_RECRUITING","2026-08-22",{"date":43,"type":44},"2026-08-26","ACTUAL",{"date":46,"type":20},"2026-10",{"date":48,"type":20},"2027-11",{"name":50,"class":51},"Assiut University","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100555708","therapeutically-alternatives-in-ventilator-induced-diaphragm-dysfunction-critically-ill-patients-100555708","NCT06515600","Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients","Does Flow Trigger Sensitivity Adjustment Is Translational Mechanisms For Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients?","Age (years)\n\nWeight (kg)\n\nHeight (cm)\n\nBMI (kg\u002Fm²)\n\nInclusion Criteria:\n\n* Patients who had undergone MV for 48 hours or more in a controlled mode.\n* Patients could not generate maximum inspiratory pressure of more than 15 mbar\n* Patients had diaphragmatic excursion less than 3 cm. (normal level from 3 to 5 cm.)(It can increase in a condition person to 7-8 cm).\n* Patients had a diaphragmatic thickness fraction of less than 30%\n\nExclusion Criteria:\n\n* Patients with comorbidities interfering and compromising weaning like cardiac arrhythmia, pericardial effusion, congestive heart failure, or unstable acute coronary syndrome.\n* Patients who had inadequate training performance of the inspiratory muscle such as those having myopathy or neuropathy.\n* Patients hemodynamically unstable.\n* Patients who had a major neurological deficit.\n* Sedated Patients.",true,"20 Years","90 Years",{"count":63,"type":20},30,"INTERVENTIONAL",[66],"NA","The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).",[28],[70,71,72,73,74],"Trigger Sensitivity","Diaphragmatic dysfunction","Mechanical Ventilator","Minute Ventilation","Tidal Volume","2024-07-18",{"date":77,"type":44},"2024-07-23",{"date":79,"type":20},"2024-08-01",{"date":81,"type":20},"2024-10-15",{"name":83,"class":51},"South Valley University"]