[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"virtual-reality-exposure-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:virtual-reality-exposure-therapy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100649888","immersive-virtual-reality-and-exercise-programs-in-multiple-sclerosis-exerviem-iii-100649888",false,"NCT07738120","Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis: ExeRVIEM III","Effects of a Physiotherapy Program With High-Intensity Exercise and Immersive Virtual Reality in Multiple Sclerosis: Randomized Controlled Trial","ExeRVIEM III","Inclusion Criteria:\n\n* ≥18 years of age.\n* Confirmed diagnosis of MS.\n* Stable disease with no relapse in the previous 6 weeks.\n* Patients who will be take follow up by a neurologist at the referral hospital and will be members of the patient association.\n* Ability to perform moderate exercise.\n* Capacity to provide informed consent.\n\nExclusion Criteria:\n\n* Comorbidities that hinder the development of the VR program\n* Visual or vestibular impairment that would contraindicate VR use.\n* Recent changes in disease modifying therapy.","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","TITLE: Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis: ExeRVIEM III. INTRODUCTION: Multiple sclerosis (MS) is a chronic neuroimmunological and degenerative disease characterized by demyelination within the central nervous system. Its clinical course involves motor impairment, sensory disturbances, cognitive dysfunction, and a progressive decline in functional independence. MS is one of the leading causes of non-traumatic disability in young adults. This highlights the considerable impact of the disease, both in terms of healthcare burden and healthcare expenditure. Within this context, therapeutic exercise has evolved from being considered potentially harmful to being recognized as a safe and effective intervention capable of improving gait, balance, cardiorespiratory fitness, fatigue, and quality of life in people with MS. A model has been proposed for prescribing and progressing exercise at different stages of MS: passive range-of-motion exercises designed for patients with the most severe symptoms, a second stage incorporating active muscle-strengthening exercises, and finally, integrated exercise programs that incorporate strength, endurance, balance, and coordination training. Evidence from systematic reviews and meta-analyses shows that structured exercise (including high-intensity protocols when performed under supervision) is safe and can improve functional outcomes. Our ExeRVIEM III project (Physiotherapy program with High-Intensity Exercise Program and Immersive Virtual Reality in Multiple Sclerosis) represents a novel strategy to facilitate rehabilitation exercise programs using head-mounted virtual reality displays. HYPOTHESIS: The ExeRVIEM III project, based on training physical function in people with MS, is feasible and safe, and could have a potential clinical impact in the motor and cognitive domains, as well as applicability in community settings, such as patient associations. GENERAL OBJECTIVES: 1.1 To design and implement an ExeRVIEM III exercise program\u002Fprotocol for people with MS. 1.2 To evaluate the safety of the high-intensity virtual reality exercise program. SPECIFIC OBJECTIVES: 2.1 To analyze the possible changes in disability, functional variables, cognitive domains and biomarkers in the short and medium term in people who attend a patient association and carry out the ExeRVIEM III exercise program for people with MS. METHODOLOGY: A randomized controlled trial, double-arm (experimental and control group) study will be conducted at a patient association (Santiago de Compostela, Spain). The intervention will consist of an 6-month supervised virtual rehabilitation program, with two weekly sessions on alternate days, in addition to the standard rehabilitation prescribed by the patient association clinical team (physiotherapy, occupational therapy, and cognitive training sessions). An inmersive virtual reality (IVR) body combat exercise videogame will be used, administered via a virtual reality headset. In accordance with clinical guidelines for IVR, sessions will be intentionally brief (10 minutes) to minimize cybersickness and excessive fatigue. Assessments will be conducted at baseline (week 0) and immediately after the intervention (week 24). Demographic and clinical data will also be collected, including sex, age, comorbidities, disease duration, MS subtype, and pharmacological treatment. Assessments will be conducted at the patient association and in the Neurology Department of the referral hospital. Feasibility, safety, strength parameters, dual-task performance and fatigue levels assessments will be performed at the patient association by physiotherapists, while the remaining assessments will be completed at the hospital by a neurologist specializing in MS. The content of the assessments will be: Patient characteristics that will include data on age, sex, years since diagnosis, MS subtype, and pharmacological treatment. Feasibility: Number of virtual sessions attended by each participant (adherence rate via registration sheet). Rate Perceived Effort using the modified Borg scale, which measures the level of perceived exertion on a scale of 0 to 10 from no effort to maximum effort. Safety: adverse events using the Simulator Sickness Questionnaire (SSQ).Strength parameters using Five times sit to stand test (FTSST) and handgrip test. Functional mobility will be assessed using Timed and Go test (TUG) and with dual task performance using TUG-cog. Level of fatigue using the Fatigue Severity Scale (FSS). Level of disability: using the Expanded Disability Status Scale (EDSS).Gait will be evaluated using the 25Foot Walk Test (25FWT). Manual dexterity will be assessed using 9-Hole Peg Test (9HPT). Cognitive domains evaluated by the Symbol Digit Modalities Test (SDMT)Axonal injury biomarker evaluated by Neurofilament light chain (sNfL) concentrations.",[27,28,29,30,31],"Multiple Sclerosis","Exercise","Physical Therapy","Virtual Reality Exposure Therapy","Rehabilitation Exercise","RECRUITING","2026-07-28",{"date":35,"type":36},"2026-07-31","ACTUAL",{"date":38,"type":36},"2025-10-06",{"date":40,"type":21},"2026-08-07",{"name":42,"class":43},"University of Vigo","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":77,"locationsCount":4},"100580641","a-virtual-reality-couples-intervention-for-sexual-victimization-prevention-a-gender-swapping-transformative-approach-100580641","NCT06839937","A Virtual Reality Couples' Intervention for Sexual Victimization Prevention: a Gender-swapping Transformative Approach","A Virtual Reality Couples' Intervention for Sexual Victimization Prevention: a Gender-swapping Transformative Approach (REVISE)","REVISE","Inclusion Criteria:\n\n* Participants must be between 18 and 39 years old.\n* Couples must have been in a romantic relationship for at least six months.\n* Both partners must provide explicit informed consent to participate.\n* Participants must be able to read and write in Spanish to ensure comprehension of the study materials.\n\nExclusion Criteria:\n\n* Individuals with any physical condition that may hinder the use of VR equipment (e.g., epilepsy or severe motion sickness).\n* Individuals with a history of sexual harassment or problematic substance use, including drug or alcohol abuse.\n* Individuals experiencing significant mental health difficulties that require intensive treatment.\n* Participants with prior exposure to similar VR-based gender perspective-taking interventions.",true,"39 Years",{"count":56,"type":21},180,[24],"The goal of this clinical trial is to evaluate the effectiveness of REVISE (REalidad Virtual Inmersiva y SExualidad), an immersive virtual reality (IVR) intervention designed to promote empathy and reduce sexual harassment behaviors in heterosexual cisgender men.\n\nThe main questions that this study aims to answer are as follows.\n\nDoes experiencing gender swapping in IVR increase empathy towards survivors of sexual harassment?\n\nDoes the intervention modify attitudes toward gender roles and sexual harassment?\n\nResearchers will compare the three experimental groups to evaluate the effects of IVR:\n\n1. Identity Exchange Group with Exposure to Sexual Harassment: Participants embodied their partner's identity in a VR harassment scenario.\n2. Identity Exchange Group without Harassment Exposure: Participants embodied their partner's identity in a neutral VR scenario.\n3. Third-person Observer Group: Participants observe a harassment scenario in VR from their own perspective.\n\nParticipants will:\n\n1. Attend one virtual reality session in a laboratory setting.\n2. Undergo pre- and post-intervention assessments and a three-month follow-up.\n3. Complete self-report questionnaires and physiological measures (eye tracking and pupillometry).\n4. Participate in semi-structured interviews about their experiences. This study aims to explore how immersive VR embodiment can be used as a tool for gender violence prevention by fostering perspective-taking and behavioral change.",[60,61,62,30],"Sexual Harassment","Gender Based Violence","Empathy",[60,64,65,66,67,68,69],"Gender-Based Violence","Immersive Virtual Reality","Violence Prevention","Sexism","VR Intervention","Violence Against Woman","NOT_YET_RECRUITING","2026-03-18",{"date":73,"type":36},"2026-03-23",{"date":75,"type":21},"2027-03-30",{"date":75,"type":21},{"name":78,"class":43},"Universitat Oberta de Catalunya",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":44},"100611788","virtual-reality-exposure-therapy-for-obsessive-compulsive-disorder-a-randomized-controlled-trial-in-inpatients-100611788","NCT07245134","Virtual Reality Exposure Therapy for Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients","Virtual Reality Exposure Therapy in Patients With Obsessive-Compulsive Disorder: A Randomized Controlled Trial in Inpatients","OCD-VRET1","Inclusion Criteria:\n\n* Diagnosis of OCD (F42) using currently valid DSM-V and ICD-11\n* Fluent in Czech\n\nExclusion Criteria:\n\n* Any other psychiatric, neurological and serious somatic illness\n* Substance abuse\n* Psychotropic medication (e.g. benzodiazepines) except antidepressants, antipsychotic medication and hypnotics.\n* Contradictions to using a virtual reality (e.g., epilepsy, balance problems)\n* Pregnancy\n* Cardiostimulator and mental implants","17 Years","55 Years",{"count":90,"type":21},62,[24],"The aim of this study is to evaluate the efficacy of virtual reality exposure therapy (VRET) as a treatment for obsessive-compulsive disorder (OCD). Participants are randomly assigned to one of the following interventions: a) exposure condition - the group with a standard CBT program enriched with exposure therapy in VR (VRET), b) control condition 1 - the group with a standard CBT program enriched with VR cognitive training aimed at cognitive flexibility or c) control condition 2 - standard CBT program without any additional VR intervention. The treatment effect will be evaluated using pre\u002Fpost assessments, as well as monitoring adherence to exposure and response prevention assignments.",[94,30,95,96],"Obsessive-Compulsive Disorder","Virtual Reality Cognitive Training","Cognitive Behavior Therapy",[98,99,100,101],"obsessive-compulsive disorder","VR exposure therapy","cognitive flexibility","Inpatient clinic","2025-11-20",{"date":104,"type":36},"2025-11-24",{"date":106,"type":36},"2022-11-15",{"date":108,"type":21},"2026-12-30",{"name":110,"class":43},"National Institute of Mental Health, Czech Republic"]