[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vitamin-a-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vitamin-a-deficiency":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,54,79,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100649515","vitamin-a-supplementation-and-breast-milk-vitamin-a-levels-in-mothers-of-preterm-infants-100649515",false,"NCT07736768","Vitamin A Supplementation and Breast Milk Vitamin A Levels in Mothers of Preterm Infants","The Impact of Maternal Daily Oral High-Dose Vitamin A Supplementation on Vitamin A Concentration in Breast Milk of Mothers of Preterm Infants","VITAL","Inclusion Criteria:\n\n* Mothers aged 18 to 45 years Delivered an infant born at less than 29 weeks' gestation Intending to provide breast milk for at least 4 months postpartum Willing and able to swallow oral tablets Willing to comply with study procedures, including blood draws and breast milk collection at scheduled time points Able to provide written informed consent\n\nExclusion Criteria:\n\n* Age less than 18 or greater than 45 years Contraindications to breastfeeding or inability to provide breast milk Known liver disease or conditions affecting vitamin A metabolism (e.g., chronic liver disease, known hypervitaminosis A) Baseline elevated vitamin A levels above the normal reference range Multiple gestation pregnancy (if you intend to exclude this-remove if not required) Known substance use disorder that may interfere with adherence or safety Infants with major congenital anomalies or known syndromic conditions Maternal refusal or inability to provide informed consent Planned discontinuation of breastfeeding within 4 months postpartum","ALL","18 Years","45 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","Preterm infants are at increased risk of vitamin A deficiency because they are born with low vitamin A stores and depend largely on breast milk to meet their nutritional needs. This study will evaluate whether daily maternal vitamin A supplementation increases vitamin A concentrations in the breast milk of mothers who deliver infants before 29 weeks of gestation.\n\nParticipants will receive a commercially available oral multivitamin supplement containing 1,300 mcg retinol activity equivalents (RAE) of vitamin A daily for four months after delivery. Breast milk samples will be collected at 2 weeks, 2 months, and 4 months postpartum to measure vitamin A concentrations. The study will assess whether maternal supplementation is a feasible approach for increasing breast milk vitamin A concentrations in mothers of preterm infants.",[28,29,30,31,32],"Premature","Preterm Infant Health","Vitamin A Deficiency","Human Milk","Breastfeeding",[34,35,36,37,38,39,40],"vitamin a supplementation","human milk retinol","breast milk vitamin A","infant nutrition","milk micronutrients","lactation","feasibility study","NOT_YET_RECRUITING","2026-07-26",{"date":44,"type":45},"2026-07-30","ACTUAL",{"date":47,"type":22},"2026-08-01",{"date":49,"type":22},"2027-11-01",{"name":51,"class":52},"University of Mississippi Medical Center","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":53},"100618774","effect-of-vitamin-a-supplementation-on-idiopathic-scoliosis-100618774","NCT07335991","Effect of Vitamin A Supplementation on Idiopathic Scoliosis","Effect of Vitamin A Supplementation on the Onset and Progression of Idiopathic Scoliosis: A Prospective, Single-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 6 and 15 years.\n2. Biochemically confirmed vitamin A deficiency (serum retinol \\\u003C 0.20 mg\u002FL) or insufficiency (serum retinol 0.20-0.29 mg\u002FL).\n3. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.\n4. Skeletally immature (Risser sign 0-3) with a major Cobb angle \\\u003C 40 degrees at baseline.\n5. Written informed consent\u002Fassent provided by the participant and legal guardian.\n\nExclusion Criteria:\n\n1. Unwillingness or inability to comply with all study procedures and follow-up visits.\n2. Plans to relocate outside the study area within the next 24 months.\n3. Previous high-dose vitamin A supplementation therapy within the past 12 months.\n4. Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots).\n5. Serum vitamin A level \\> 0.70 mg\u002FL (to avoid risk of hypervitaminosis A).\n6. Severe chronic health conditions that could confound study outcomes, including but not limited to:\n\n   * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.\n   * History of spine surgery or significant spinal trauma.\n   * Spinal tumor.\n   * Leg length discrepancy \\> 20 mm.\n   * Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes).\n   * Severe obesity (body mass index z-score ≥ 3).","6 Years","15 Years",{"count":64,"type":22},140,[25],"This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.",[30,68],"Idiopathic Scoliosis","RECRUITING","2026-05-14",{"date":72,"type":45},"2026-05-15",{"date":74,"type":45},"2025-05-13",{"date":76,"type":22},"2028-06-01",{"name":78,"class":52},"Second Affiliated Hospital of Wenzhou Medical University",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100550734","phase-2-vitamin-a-supplementation-in-allogeneic-stem-cell-transplantation-100550734","NCT06450925","Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.","A Randomized Double Blinded Trial of Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.","Inclusion Criteria:\n\n* Be 18 years of age or older\n* Be scheduled for allogeneic stem cell transplant.\n* Have a vitamin A level \\\u003C upper limit of normal for age.\n* Be able to tolerate enteral vitamin dose administration.\n* Have a total bilirubin level \\\u003C 1.5x ULN and an AST and\u002For ALT\\\u003C 3xULN for age\n* Receiving PBSCs as stem cell graft\n\nExclusion Criteria:\n\n* Ongoing raised intracranial pressure\n* Liver cirrhosis\n* Patients will be excluded if they are currently pregnant.",{"count":87,"type":22},190,[89],"PHASE2","The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.",[92,30,93],"Graft Vs Host Disease","Vitamin D Deficiency","2025-08-11",{"date":96,"type":45},"2025-08-12",{"date":98,"type":45},"2025-03-25",{"date":100,"type":22},"2029-08",{"name":102,"class":52},"Children's Hospital Medical Center, Cincinnati",3,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":53},"100574454","validation-and-simplification-of-the-retinol-isotope-dilution-technique-in-burkinabe-schoolchildren-100574454","NCT06759493","Validation and Simplification of the Retinol Isotope Dilution Technique in Burkinabe Schoolchildren","RID_VAB","Inclusion Criteria:\n\n* School children aged 7-12 years\n\n  * Child's guardian or parent is willing to provide informed consent\n  * Child's family plans to remain resident in the study areas during the study period\n\nExclusion Criteria:\n\n* Clinical evidence of vitamin A deficiency a mis en forme : Anglais (Royaume-Uni)a mis en forme : Anglais (États-Unis)a mis en forme : Anglais (États-Unis)a mis en forme : Anglais (États-Unis)\n\n  * Severe malnutrition (weight-for age Z score (WAZ) or height-for-age Z score (HAZ) \\\u003C-3 SD)\n  * Serious illnesses including tuberculosis, symptomatic HIV infection\n  * Child aged \\\u003C6 years or \\>12 years",true,"7 Years","12 Years",{"count":115,"type":22},158,"OBSERVATIONAL","Two cross-sectional, repeated-pass, community-based studies will be carried out during the school year. The first study will be conducted from November to December. This period corresponds to the end of the rainy season and the end of the mango season, which is one of the main sources of vitamin A in the Orodara region.\n\nThe second survey will be carried out 5 to 6 months (April-May of the following year) after data collection for the first study, corresponding to the mango season. The same schoolchildren recruited during the first phase of data collection (5 to 6 months earlier) will be the participants in the second study. The interest of this study is to use nuclear techniques to implement a strategy for the precise and accurate determination of Vitamin A status in order to reinforce existing Vitamin A interventions and policies.",[30,119],"Inflammation",[121,122,123,124,125],"Vitamin A","School","children","Isotope","Burkina Faso","2025-03-16",{"date":128,"type":45},"2025-03-18",{"date":130,"type":45},"2024-11-21",{"date":132,"type":22},"2025-06-30",{"name":134,"class":135},"Institut de Recherche en Sciences de la Sante, Burkina Faso","OTHER_GOV"]