[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"walking-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:walking-impairment":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,94,122,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100596813","combining-rtms--aerobic-exercise-to-treat-depression-and-improve-post-stroke-walking-100596813",false,"NCT07050355","Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking","Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking (RESTORATION)","RESTORATION","Inclusion criteria:\n\n* age \\>21\n* stroke at least 12 months prior\n* screen positive for depressive symptoms (PHQ-9 \\> 5) and HAM-D17 ≥ 12\n* residual paresis in the lower extremity (Fugl-Meyer LE motor score \\\u003C34)\n* ability to walk without assistance and without an AFO at speeds ranging from 0.2-1.0 m\u002Fs\n* not currently on antidepressant medications or no changes in antidepressant dosage in the last 4 weeks and clinically stable\n* HAM-D17 question #9 regarding suicide \\\u003C2\n* provision of informed consent. I\n* All subjects who screen for major depressive disorder will be formally diagnosed by the project psychiatrist at each site using the Structured Clinical Interview for DSM5 (SCID-5).\n* All subjects who meet criteria for the training portion must complete an exercise tolerance test and be cleared for participation by the study physician.\n\nExclusion criteria:\n\n* unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking\n* history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's\n* history of COPD or oxygen dependence\n* history of traumatic brain injury\n* blindness or severe visual impairment\n* history of psychosis or other Axis I disorder that is primary\n* life expectancy \\\u003C1 yr.\n* severe arthritis or problems that limit participation in testing or training\n* history of DVT or pulmonary embolism within 6 months\n* uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions\n* severe hypertension with systolic \\>200 mmHg and diastolic \\>110 mmHg at rest\n* attempt of suicide in the last 2 years or suicidal risk assessed by SCID\n* history of seizures or currently prescribed anti-seizure medications\n* current enrollment in a trial to enhance motor recovery\n* currently participating in behavioral treatment for depression\n* currently exercising ≥ 2 times per week (≥20 minutes)\n* contraindications to TMS\n* pregnancy or other contraindications to MRI.","ALL","21 Years",{"count":20,"type":21},96,"ESTIMATED","INTERVENTIONAL",[24],"NA","Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD).\n\nInvestigators propose to determine the efficacy of combining two known anti-depressant treatments shown to be effective in non-stroke depression, aerobic exercise (AEx) and repetitive transcranial magnetic stimulation (rTMS), on post-stroke depressive symptoms. This project is based on the idea that depression negatively affects the potential for the brain to adapt in response to treatment such that rehabilitation may not produce the same changes that it does in non-depressed individuals. Investigators believe that effective treatment for PSD will result in a virtuous cycle whereby reducing depression enhances response to rehabilitation, thereby facilitating functional gains. That is, effectively treating depression will enable individuals to better recover from stroke.",[27,28,29],"Stroke","Depression - Major Depressive Disorder","Walking Impairment",[31,32,33,34,35,36],"stroke","rehabilitation","neuromodulation","TMS","walking","exercise","RECRUITING","2026-08-01",{"date":40,"type":41},"2026-08-04","ACTUAL",{"date":43,"type":41},"2024-11-01",{"date":45,"type":21},"2029-08-31",{"name":47,"class":48},"Medical University of South Carolina","OTHER",2,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":70,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":93},"100646434","closed-loop-vagus-nerve-stimulation-clv-for-recovery-of-gait-after-spinal-cord-injury-sci-100646434","NCT07689227","Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)","Early Feasibility Study of the ReWire System for Closed-Loop Vagus Nerve Stimulation (CLV) Paired With Rehabilitation After Spinal Cord Injury (SCI) - Lower Limb Study","Inclusion Criteria:\n\n1. Ability to provide signed and dated informed consent.\n2. Willingness and ability to comply with all study procedures and protocol requirements for the duration of the study.\n3. Age 18 to 64 years.\n4. Chronic, non-penetrating, motor incomplete spinal cord injury \\[Association Impairment Scale (AIS) grade C or D\\] occurring ≥12 months prior to enrollment, resulting in impairment in lower limb function.\n5. Ambulatory with residual gait impairment attributable to spinal cord injury.\n6. Self-selected gait speed of \\\u003C 0.8 m\u002Fs as measured by the 10 meter walk test.\n7. Score of 2 or less on at least 4 measures on the Ambulation subsection of the SCI-Functional Independence scale (SCI-FIS).\n8. In otherwise good general health as determined by medical history and physical examination.\n9. Meets all clinical criteria for VNS implantation as determined by the Site PI and clinical care team.\n\nExclusion Criteria:\n\n1. Any history of spinal cord injuries by penetrating traumatic, non-traumatic or congenital causes.\n2. Evidence of right-sided recurrent laryngeal nerve injury on pre-operative laryngoscopy, if required (Note: Participants with a history of right-sided anterior cervical surgery must undergo laryngoscopy prior to surgical scheduling. A finding of right-sided recurrent laryngeal nerve injury results in exclusion).\n3. Excessive scar tissue on intraoperative assessment that precludes safe implantation (Note: Participants with a history of left-sided anterior cervical surgery will undergo intraoperative assessment of scar tissue. If excessive scar tissue is deemed to preclude safe implantation, the procedure will be abandoned and the participant excluded for safety reasons. A history of left-sided anterior cervical surgery or prior recurrent laryngeal nerve injury alone does not result in exclusion).\n4. Concomitant clinically significant brain injuries.\n5. Deficits in language or attention that interfere with study participation.\n6. Presence of any other implanted electrical stimulation device.\n7. Prior injury to the vagus nerve.\n8. Presence of any other implanted investigational device.\n9. Neck circumference of \\> 18.5 inches or significant overlying tissue and\u002For scarring that may hinder device communication.\n10. Psychiatric, psychosocial, and\u002For cognitive disorder or impairment that could interfere with study participation as assessed by medical evaluation.\n11. Current or past: (a) medical (psychiatric, non-psychiatric) condition, disease, disorder, injury, or disability\\*; or (b) non-medical situation or circumstance that, in the opinion of the Site PI, study participation:\n\n    1. may pose a significant or undue risk to the person;\n    2. make it unlikely the person will complete all the study requirements per protocol; or\n    3. may adversely impact the integrity of the data or the validity of the study results.\n\n    \\[\\*Examples include, but are not limited to, the following types of conditions, diseases or disorders: renal insufficiency or failure, vascular disease, unstable or concerning cardiac disease, endocrinologic concerns (e.g., poorly controlled diabetes), immunosuppression, respiratory issues, psychiatric (e.g., schizophrenia), neurologic (e.g., cognitive, seizure), sickle cell disease, lupus, clotting disorders, active neoplastic disease (excluding basal or squamous cell carcinoma of the skin with intent for curative excision), recent documented history (within the last 3 months) of dysphagia or aspiration difficulty\\]\n12. Is female and lactating, pregnant, or plans to become pregnant during the study. Participants of child-bearing potential that are sexually active must use a reliable form of birth control. Acceptable birth control methods: (a) sterilization surgery for women, (b) surgical sterilization implant for women, (c) sterilization surgery for men (including all male partners), (d) Long-acting reversible contraceptives (LARC)-implantable rod and Intrauterine Device (IUD), (e) contraceptive shots\u002Finjection every 3 months, (f) oral contraceptives (pills), (g) contraceptive patch, (h) vaginal contraceptive ring, and (i) complete abstinence.\n13. Abusive use of alcohol or drugs that could interfere with participation, as determined by the Site PI.\n14. Concurrently participating in another interventional clinical study.\n15. Requires or plans the use of diathermy, transcranial magnetic stimulation, or electroconvulsive therapy (ECT) during the course of the study.\n16. Is known to be under incarceration or legal detention as determined by the Site PI.\n17. Non-English speaking, unless the enrolling site has an IRB-approved translated consent and qualified medical interpreter resources available in the participant's language to support all study visits and procedures.","18 Years","64 Years",{"count":60,"type":21},20,[24],"The purpose of this study is to evaluate the safety, feasibility, and preliminary effectiveness of the ReWire system, which delivers vagus nerve stimulation (VNS) paired with lower limb rehabilitation to improve gait in individuals with mobility impairments resulting from chronic, incomplete spinal cord injury (SCI).",[64,65,66,67,29,68,69],"Spinal Cord Injury (SCI)","Gait","Reduced Physical Activity","Lower Limb Functions","Mobility Impairment","Functional Mobility",[71,72,73,74,75,76,77,65,78,79,80,81,82],"Vagus nerve stimulation (VNS)","Spinal cord injury (SCI)","Closed-loop vagus nerve stimulation (CLV)","ReWire System","Physical and rehabilitation therapy","XNerve Medical","Texas Biomedical Device Center (TxBDC)","Reduced physical activity","Lower limb functions","Walking impairment","Mobility impairment","Functional mobility","NOT_YET_RECRUITING","2026-07-23",{"date":86,"type":41},"2026-07-27",{"date":88,"type":21},"2026-09-30",{"date":90,"type":21},"2028-12",{"name":92,"class":48},"The University of Texas at Dallas",4,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":121},"100635252","body-weight-supported-and-virtual-reality-gait-training-in-stroke-patients-100635252","NCT07550270","Body Weight-Supported and Virtual Reality Gait Training in Stroke Patients","A Comparative Evaluation of the Effectiveness of Body Weight-Supported Forward and Backward Gait Training Versus Virtual Reality-Assisted Gait Training in Patients With Stroke","Inclusion Criteria:\n\n* Patients experiencing their first-ever stroke\n* Patients with a post-stroke duration of more than 2 weeks\n* Patients with plantar flexor muscle spasticity of the lower extremity less than grade 3 according to the Modified Ashworth Scale (MAS)\n* Patients with a Brunnstrom stage of the lower extremity greater than 2\n* Patients who are able to stand independently or under supervision for at least 2 minutes for standing assessments\n* Patients who are able to walk at least 10 meters independently or under supervision, with or without an assistive device, for walking assessments\n* Patients with sufficient cognitive function to understand study instructions (Mini-Mental State Examination \\[MMSE\\] score \\> 23)\n* Patients with stable medical and psychological conditions\n* Patients who are willing to participate in the study\n\nExclusion Criteria:\n\n* Patients with bilateral hemispheric lesions\n* Patients with severe cardiovascular or musculoskeletal conditions that prevent walking (e.g., fixed ankle contracture)\n* Patients using a permanent urinary catheter, or those with pressure ulcers or urinary and\u002For fecal incontinence\n* Patients with unilateral neglect\n* Patients with neurological conditions other than stroke that may affect balance performance (e.g., Parkinson's disease, epilepsy, meningitis, cerebellar disorders, vertigo, dizziness, polyneuropathy) or musculoskeletal disorders (e.g., severe low back pain, knee disorders)\n* Patients with severe visual, hearing, or speech impairments","45 Years","75 Years",{"count":104,"type":21},30,[24],"The aim of this study is to compare the effects of body weight-supported gait training that includes virtual reality-assisted dual-task applications with body weight-supported forward and backward gait training on functional capacity, gait parameters (such as step length, gait speed, and balance), cognitive functions and psychological status in patients with stroke. The findings of this study are expected to contribute to the development of more effective rehabilitation strategies for improving mobility in patients with stroke",[27,29,108,109],"Balance","Gait Training",[31,111],"gait training","2026-04-19",{"date":114,"type":41},"2026-04-24",{"date":116,"type":41},"2026-03-26",{"date":118,"type":21},"2026-12",{"name":120,"class":48},"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital",1,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":143,"locationsCount":121},"100624116","clinical-impacts-of-structured-robotic-gait-training-programs-100624116","NCT07405450","Clinical Impacts of Structured Robotic Gait Training Programs","Inclusion Criteria:\n\n* able to fit into Trexo robotic gait trainer (both leg length and weight); height of \\\u003C\\~5'6\", weight \\\u003C150 lbs.)\n* able to fulfill training requirements throughout training period\n* able to comply with study procedures (assessments, training)\n* any age\n\nExclusion Criteria:\n\n* those with contraindications to training with a robotic gait trainer (ie. medical condition or recent surgery requiring lower extremity immobilization or weight-bearing restriction (ie. fracture, unstable hip subluxation), medical condition requiring a physical activity restriction (ie. unstable arrythmia), pain or symptomatic hypotension while standing, contracture such that the Trexo Robotic Gait Training does not result in forward movement)\n* those involved in a potentially confounding intervention (will be discussed case-by-case to determine risk of impacting the study results).",{"count":129,"type":21},120,[24],"Background and Rationale:\n\nWalking impairments impacts the 2-3\u002F1000 children who have cerebral palsy1,2, and others unable to walk due to other central nervous system disorders such as a traumatic brain injury. The impacts of this and related impairment impact all aspects of life. The lifelong costs of these is staggering in terms of dollars (over $1 million\u002Fchild) and health adjusted life years (\\~half compared to typically developing populations despite only slightly shorter lifespans). Yet there are currently no effective interventions to treat the fundamental balance impairment that underlie these problems4,5. Early use of robotic gait trainers have shown many benefits6,7, however access to these trainers is limited due to cost, availability, and ease of use within the home. Currently, there are a few options for an overground robotic gait trainer supported by the stability of a walker. The Trexo, is an option designed for use at home or in a community settings, but barriers to access mean that access to this therapy is out of reach for many people who may see benefits.\n\nResearch Questions and Objectives:\n\nThe aim of this study is to (a) evaluate the feasibility of a clinical robotic gait training program and (b) evaluate the effectiveness of these types of programs in achieving patient, family, and therapist goals. The study will examine adherence to a structured training program to determine if training with a robotic gait trainer in a hospital setting is feasible for the entire length of the designed training program. Goals will be set, a re-evaluation of these goals will be completed following the training program to determine whether or not the clinical program of robotic gait training was successful in helping patients reach the goals set out at the beginning of the program.",[133,29],"Neuromotor Impairments",[135,136],"Robotic Walking","Trexo","2026-02-10",{"date":139,"type":41},"2026-02-12",{"date":141,"type":41},"2022-11-01",{"date":118,"type":21},{"name":144,"class":48},"University of Calgary",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":151,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":22,"phases":154,"briefSummary":155,"conditions":156,"keywords":157,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":121},"100597377","investigating-the-mechanisms-of-welwalk-robot-in-restoring-motor-function-of-the-lower-extremities-in-stroke-patients-100597377","NCT07057700","Investigating the Mechanisms of Welwalk Robot in Restoring Motor Function of the Lower Extremities in Stroke Patients","Inclusion Criteria:\n\n* Patients or family gave written informed consents to participate in this study.\n* Patients with first hemiplegia caused by primary supratentorial intracerebral hemorrhage or cerebral infarction.\n* Within 1 year of stroke onset\n* Aged ≥ 20\n* Body weight is between 40 and 80 kg\n* No excessive spasticity in hip, knee, and ankle joints (Modified Ashworth Scale \\\u003C3)\n* sufficient cognition to follow simple instructions and to understand the content and purpose of the study (Chinese version-MOCA ≥ 20 points)\n* Patients who have risks of giving-way when they walk with Ankle-Foot orthosis (AFO)\n\nExclusion Criteria:\n\n* A history of myocardial infarction\n* Muscular or neurological disorder including diabetic neuropathy\n* Symptomatic angina or arrhythmia\n* Symptomatic respiratory disorder\n* Communicable infection\n* Joint contracture or limb deformity that affects walking (Range of motion of hip extension \\\u003C 5 degree, knee extension \\\u003C -5 degree (can be flexible), ankle dorsiflexion with knee extension position \\\u003C 5 degree)\n* Heterotropic ossification that restrict the range of motion of joints of lower extremities\n* Being vulnerable to fracture like severe osteoporosis of spine or lower extremities\n* Incontinence of urine or feces that may deface the robotic knee-ankle-foot device of Welwalk\n* Inadequate control of hypertension (resting systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 120 mmHg)\n* Inadequate control of tachycardia (heart rate at rest ≥ 120 bpm)\n* Training restriction due to reduced cardiac function or respiratory dysfunction\n* Visual or auditory impairment hindering training\n* Pregnant patients\n* Recent participation in other clinical trials\n* Patient whom examination doctor judge improper as a trial subject\n* Anyone not able to sustain the training protocol with Welwork or regular training","20 Years",{"count":153,"type":21},38,[24],"Current evidence and clinical applications of robotic gait training devices for motor function recovery post-stroke are increasingly available. Although existing research demonstrates that robotic gait training can improve patients' gait and balance, there remains a lack of in-depth investigation into its specific mechanisms of action concerning central nervous system (CNS) reorganization - notably, changes in activity within the motor cortex and associated neural networks. The intrinsic changes within the CNS have received insufficient attention, limiting a comprehensive and profound understanding of the rehabilitation outcomes. Therefore, this study aims to elucidate the potential mechanisms underlying robotic gait training-induced neuroplasticity by integrating functional near-infrared spectroscopy (fNIRS) technology with multi-dimensional lower limb motor function assessment tools (such as FAC, BBS, AMEDA, 10MWT, 6MWT, TUGT). It will systematically investigate the effects of robotic gait training on both the central nervous system and lower limb motor function in stroke patients. Furthermore, the study will compare the differences in functional recovery efficacy between robotic gait training and conventional rehabilitation therapies.",[27,29],[31,158,159,160],"Lower limb dysfunction","robotics","gait","2025-07-09",{"date":163,"type":41},"2025-07-10",{"date":165,"type":21},"2025-07-01",{"date":167,"type":21},"2027-06-01",{"name":169,"class":48},"Ruijin Hospital"]