[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-window-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-window-patients":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100647492","airway-occlusion-pressure-p01-guided-pressure-support-ventilation-versus-conventional-management-in-weaning-window-patients-100647492",false,"NCT07709182","Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients","Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Mechanically ventilated adult patients ≥ 21 years.\n* Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status.\n* Hemodynamically stable \\[mean arterial pressure (MAP) ≥60 mmHg\\].\n* All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive.\n\nExclusion Criteria:\n\n* Patients with neuromuscular disorders affecting respiratory drive\n* Glasgow Coma Scale (GCS) score below 8\n* Cervical spinal cord injury\n* Receipt of neuromuscular blockers within the previous 24 hours\n* Morbid obesity resulting in unreliable respiratory mechanics\n* Pregnancy\n* Deep sedation defined as RASS ≤ -2\n* Hemodynamic instability requiring escalating vasopressor support.","ALL","21 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to determine whether Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation is superior to conventional management for patients in weaning windows.",[26,27,28,29],"Airway Occlusion Pressure","Pressure Support Ventilation","Conventional Management","Weaning Window Patients","RECRUITING","2026-07-11",{"date":33,"type":34},"2026-07-16","ACTUAL",{"date":36,"type":34},"2026-02-01",{"date":38,"type":20},"2028-01-01",{"name":40,"class":41},"Tanta University","OTHER"]