[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"whipple-procedures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:whipple-procedures":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100645565","energy-expenditure-and-nutrition-after-pancreatic-surgery-100645565",false,"NCT07703813","Energy Expenditure and Nutrition After Pancreatic Surgery","Resting Energy Expenditure, Nutritional Intake, and Postoperative Outcomes in Patients Undergoing Total or Partial Pancreatectomy for Pancreatic Tumors: A Prospective Observational Cohort Study","NUTRI-PD","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo total or partial pancreatectomy (including pancreaticoduodenectomy\u002FWhipple procedure or distal pancreatectomy) for a pancreatic tumor\n* Able to complete indirect calorimetry measurement by canopy or face mask for the required duration\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years, greater than 75 years\n* Pregnancy\n* Inability to tolerate the calorimetry canopy or mask for the duration required for a valid measurement\n* Unable or unwilling to provide informed consent\n* patients already on preoperative enteral nutrition or unable to feed orally preoperatively","ALL","18 Years","75 Years",{"count":21,"type":22},150,"ESTIMATED","12 Months","OBSERVATIONAL","This prospective observational cohort study examines the energy requirements and nutritional care of patients undergoing total or partial pancreatectomy for pancreatic tumors. Patients undergoing pancreatectomy face major metabolic stress, a high burden of preoperative malnutrition, and frequent exocrine or endocrine insufficiency, yet procedure-specific nutritional guidance is limited. The study measures resting energy expenditure (REE) directly by indirect calorimetry during the early postoperative period and compares it with widely used predictive equations (Harris-Benedict, Schofield) and simplified weight-based targets (25 and 30 kcal\u002Fkg) to determine how accurately clinicians can estimate energy needs when calorimetry is unavailable. In the same patients, the study records the route of postoperative nutrition (enteral, parenteral, or combined), energy and protein intake relative to requirements, and diet-related symptoms, and follows postoperative complications, hospital readmission, mortality, and changes in body weight and body mass index through 3-6 months after surgery. By capturing measured energy expenditure and nutritional delivery in one cohort, the study aims to clarify whether adequacy of energy and protein intake, feeding route, or both influence recovery, and to provide primary data for developing individualized nutritional support protocols in this high-risk surgical population.",[27,28,29,30],"Whipple Procedures","Pancreatic Cancer","Pancreaticoduodenectomy","Pancreatic Neoplasms",[32,33,34,29,35,36],"Nutrition","Nutrition support","Indirect calorimetry","Surgical oncology nutrition","Postoperative nutrition","RECRUITING","2026-07-09",{"date":40,"type":41},"2026-07-14","ACTUAL",{"date":43,"type":41},"2017-01-10",{"date":45,"type":22},"2028-11-10",{"name":47,"class":48},"Evangelismos Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100616533","veno-arterial-co2-pressure-difference-to-arterio-venous-o2-difference-ratio--blood-lactate-levels-are-predictors-of-postoperative-outcome-in-whipple-procedures-100616533","NCT07306845","Veno-arterial CO2 Pressure Difference to Arterio-venous O2 Difference Ratio & Blood Lactate Levels Are Predictors of Postoperative Outcome in Whipple Procedures","Inclusion Criteria:\n\n* Adults (\\>18 years) undergoing open Whipple procedure under general anesthesia\n* Invasive monitoring (arterial line and central venous catheter)\n* Informed written consent\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Preoperative septic shock or hemodynamic instability.\n* severe pre-existing \\*\\*cardiopulmonary disease (e.g., severe COPD, heart failure).",{"count":57,"type":22},120,"INTERVENTIONAL",[60],"NA","Whipple surgery is a complex abdominal procedure associated with a high risk of hemodynamic instability and splanchnic hypoperfusion leading to anastomotic leaks, delayed gastric emptying, and organ dysfunction Traditional markers (e.g., MAP, mixed venous oxygen saturation \\[SvO₂\\], lactate) are indirect, invasive and often delayed.\n\nCO₂-derived variables (e.g., venous-to-arterial CO₂ gap \\[ΔCO₂\\], tissue CO₂ \\[PtCO₂\\], end-tidal CO₂ \\[EtCO₂\\] changes) provide earlier and more sensitive signs of microcirculatory dysfunction.",[63,27],"Postoperative Outcome",[65,66,67],"CO2 Pressure Difference","O2 Difference","Blood Lactate","NOT_YET_RECRUITING","2025-12-13",{"date":71,"type":41},"2025-12-29",{"date":73,"type":22},"2025-12-25",{"date":75,"type":22},"2026-06-25",{"name":77,"class":48},"Alexandria University"]