[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"white-spot-lesions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:white-spot-lesions":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,69,101,128,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100652176","effect-of-bg-versus-ri-on-the-depth-of-wsl-100652176",false,"NCT07770724","Effect of BG Versus RI on the Depth of WSL","Effect of Bioactive Glass Versus Resin Infiltration (ICON) on the Depth of White Spot Lesions: An in Vitro Study","Inclusion Criteria:\n\n* Upper and lower premolars will be collected from patients undergoing extractions.\n\n  * The teeth should be healthy with no carious lesions.\n  * The crown and root morphology of teeth should be normal.\n  * The extracted premolar teeth of patients should have no history of previous dental treatment.\n\nExclusion Criteria:\n\n* • Fractured premolars due to any cause.\n\n  * Loss of enamel due to parafunctional habits.\n  * Presence of enamel anomalies (amelogenesis imperfecta, hypoplasia etc.).\n  * Presence of stains, demineralization, decay, fluorosis and restorations",true,"ALL","15 Years","35 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this in vitro study is to assess the mean lesion depth improvement and hardness of artificial white spot lesions by comparing the effects of bioactive glass toothpaste and resin infiltration (ICON).",[28],"White Spot Lesions",[30,31,32,33],"white spot lesions","orthodontic brackets","resin infiltration","Fluoride toothpaste","NOT_YET_RECRUITING","2026-08-13",{"date":37,"type":38},"2026-08-18","ACTUAL",{"date":40,"type":22},"2026-09-01",{"date":42,"type":22},"2027-03-30",{"name":44,"class":45},"Riphah International University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100646256","preventive-potential-of-fluoride-sealants-in-adolescent-orthodontic-patients-100646256","NCT07691879","Preventive Potential of Fluoride Sealants in Adolescent Orthodontic Patients","The Potential of Fluoride Sealants in Preventing White Spot Lesions During Orthodontic Treatment","Inclusion Criteria\n\n* Age between 10 and 17 years\n* Initiation of fixed orthodontic treatment in the upper jaw\n* Presence of all teeth 15-25\n* Written consent from patients and legal guardians\n\nExclusion Criteria\n\n* Pre-existing white spot lesions\n* Active carious lesions\n* Structural enamel defects\n* Systemic diseases affecting oral health\n* Vestibular restorations in the anterior region\n* Little Index \\> 9","10 Years","17 Years",{"count":57,"type":22},40,"OBSERVATIONAL","The aim of this trial is to investigate the potential of using an adhesive bonding agent that also acts as a fluoride sealant when placing fixed orthodontic appliances in adolescent patients, as an alternative to regular bonding agents.\n\nThe main question it aims to answer is:\n\n\\- Does an adhesive fluoride sealant reduce the prevalence of white spot lesions in orthodontic adolescent patients after an observation period of 3 months?\n\nParticipants who need orthodontic treatment and who agree to take part in this study will have their orthodontic appliance placed using regular adhesive on one side of their upper jaw and fluoride sealant on the other.\n\nWhite spot lesion prevalence will be assessed using the Enamel Decalcification Index (EDI) at baseline and after 3 months.",[28],"2026-07-02",{"date":63,"type":38},"2026-07-09",{"date":40,"type":22},{"date":66,"type":22},"2027-05-01",{"name":68,"class":45},"Sigmund Freud PrivatUniversitat",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":16,"sex":17,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":46},"100495628","comparison-of-mi-paste-plus-and-resin-infiltration-in-white-spot-lesions-following-orthodontic-treatment-100495628","NCT05733676","Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment","Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals in the age range of 12-21 years who had undergone fixed orthodontic appliance therapy for a duration of 12-36 months.\n* Should have at least one white spot lesion on the labial surface of either maxillary or mandibular anterior teeth after debonding. Lesion visible with or without drying the lesion surface.\n* Patients with mild to moderate plaque accumulation. Fair oral hygiene. With a simplified Oral Hygiene Index of no more than 1.3-3.0\n\nExclusion Criteria:\n\n* Poor oral hygiene Simplified Oral Hygiene Index of 3.1-6.0 or more\n* Patients with hypoplasia or any developmental defects on the buccal of upper or lower incisors\n* Patients with any restorations on the buccal of upper or lower incisors\n* Patients that have presented WSL on the buccal of upper or lower incisors before orthodontic treatment was initiated.\n* Patients that have received any re-mineralizing agent other than regular toothpaste during the last three months\n* Patient with allergy to milk or any of their products\n* Patient with any medical \u002F oral or mental condition\n* Patients or legal guardians that does not speak or read English","12 Years","21 Years",{"count":79,"type":22},62,[25],"Dental cavities are among the most frequent diseases that affect teeth, particularly in patients who are treated with braces due to the difficulty in maintaining good oral hygiene in the presence of the mouth appliances. The white spot lesion (WSL) is the first clinical sign of cavities that presents itself as a milky-white opacity when located on the front face of the tooth. The aim to manage these early lesions focuses on promoting natural remineralization and preventing further demineralization. Various materials have been introduced for management of WSLs including MI paste and MI paste combined with fluoride (MI paste plus). Recently, a new material called resin infiltration has been found to treat these lesions with high esthetic results and great performance. According to the few numbers of in-vivo studies investigating the effectiveness of remineralization products, the aim of the current study is to clinically compare the outcome of the resin-infiltration and etching + MI paste plus to stop and improve the appearance of the WSL on front teeth in patients after treatment with braces.",[28,83,84,85],"Orthodontic Appliance Complication","Caries Arrested","Smooth Surface Caries",[87,88,89,90],"White spot lesion","caries","arrested","orthodontic","RECRUITING","2026-06-25",{"date":94,"type":38},"2026-06-30",{"date":96,"type":38},"2023-05-30",{"date":98,"type":22},"2028-10-01",{"name":100,"class":45},"University of Alberta",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100639870","qlf-and-digital-imaging-for-caries-activity-assessment-after-orthodontic-treatment-100639870","NCT07608471","QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment","Diagnostic Performance of Smartphone, 3D Imaging, QLF-D, and ICDAS Clinical Criteria for Non-Cavitated Caries Activity Assessment in Post-Orthodontic Patients Under a Preventive Program","Inclusion Criteria:\n\n* Participants aged 11 to 46 years\n* Completed fixed orthodontic treatment\n* Presence of at least four active non-cavitated caries lesions (ICDAS 1-3)\n* Lesions located on vestibular surfaces of anterior teeth and\u002For premolars\n* Ability to attend follow-up visits during the three-month study period\n* Signed informed consent and\u002For assent form\n\nExclusion Criteria:\n\n* Systemic conditions affecting salivary flow or enamel structure\n* Extensive cavitated lesions requiring restorative treatment\n* Ongoing orthodontic treatment\n* Use of medications that significantly affect oral conditions\n* Inability to cooperate with imaging procedures or follow-up visits","11 Years","46 Years",{"count":111,"type":22},30,"This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS clinical criteria for assessing non-cavitated caries lesion activity in post-orthodontic patients under a preventive follow-up program. Thirty participants aged 11 to 46 years with active initial caries lesions will be followed for three months. Clinical examinations, QLF-D imaging, smartphone photographs, and intraoral 3D scans will be obtained at baseline and follow-up visits combined with professional prophylaxis and oral hygiene reinforcement. The study will analyze changes in lesion activity, fluorescence parameters, and surface characteristics over time, as well as the agreement and diagnostic performance among the evaluated methods.",[114,28,115,116],"Dental Caries","Caries Lesion Activity","Post-Orthodontic Enamel Demineralization",[114,118,115,116],"Dental Caries White Spot Lesions","2026-05-20",{"date":121,"type":38},"2026-05-27",{"date":123,"type":22},"2026-07-21",{"date":125,"type":22},"2027-04-22",{"name":127,"class":45},"Universidad El Bosque, Bogotá",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":16,"sex":17,"minAge":76,"maxAge":19,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":137,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":46},"100615378","a-novel-remineralizing-self-etch-primer-for-orthodontic-bracket-bonding-100615378","NCT07291830","A Novel Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding","Clinical Effectiveness of a Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Full permanent dentition including incisors, canines, premolars, and molars (excepting 3rd molars;\n* Teeth with sound, non-carious buccal enamel and no pretreatment with chemical agents such as hydrogen peroxide,\n* No previous orthodontic treatment with fixed appliances.\n\nExclusion Criteria:\n\n* Participants unable to give informed consent,\n* Had craniofacial anomalies,\n* Require orthognathic surgery as part of their treatment,\n* Had congenital enamel defects.",{"count":136,"type":22},45,[25],"This randomized clinical trial aims to evaluate the clinical effectiveness of a remineralizing self-etch primer used for orthodontic bracket bonding. The study compares bonding performance, enamel surface effects, and clinical outcomes between the experimental primer and the conventional bonding protocol,verify the potential remineralization effect, and examine the amount of adhesive remnants left on enamel over a period of 6 months.",[28,140],"Enamel Demineralization",[142,143],"Orthodontic Bracket Bonding","Self-Etch Primers","2026-05-01",{"date":146,"type":38},"2026-05-07",{"date":148,"type":22},"2026-05-15",{"date":150,"type":22},"2026-12-30",{"name":152,"class":45},"University of Baghdad",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":16,"sex":17,"minAge":160,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":165,"conditions":166,"keywords":169,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":4},"100585028","ai-generated-whatsapp-reminders-vs-no-reminders-impact-on-oral-health-in-young-adults-100585028","NCT06897033","AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young Adults","Effect of Artificial Intelligence-Generated WhatsApp Reminders Compared to No Reminders on Oral Health Among Young Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Received a non-surgical periodontal treatment and oral hygiene instructions.\n* Own a smartphone with WhatsApp installed.\n* Willing and able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Individuals with pre-existing oral health conditions requiring specialized care.\n* Patients who received surgical periodontal interventions.\n* Participation in another oral health or diet-related study.\n* Individuals who do not use WhatsApp or are unwilling to receive messages through the platform.","20 Years","40 Years",{"count":163,"type":22},60,[25],"This randomized controlled trial aims to evaluate the effectiveness of artificial intelligence-generated WhatsApp reminders on improving oral hygiene practices among individuals aged 20-40 years visiting the periodontal clinic at El-Qasr El-Ainy Dental Hospital. Participants will be randomly assigned to either receive health education followed by AI-generated WhatsApp reminders over a 3-month period or to a control group receiving health education only. The primary outcome is the presence of white spot lesions, assessed using the modified Gorelick White Spot Lesion (WSL) index. Secondary outcomes include the presence of dental plaque, measured by the Plaque Index (PI). This study seeks to determine whether AI-generated reminders can enhance oral hygiene adherence compared to standard health education alone.",[28,167,168],"Dental Plaque","Oral Hygiene, Oral Health",[170,171],"Oral hygiene","Reminders","2025-03-27",{"date":174,"type":38},"2025-04-02",{"date":176,"type":22},"2025-05",{"date":178,"type":22},"2025-09",{"name":180,"class":45},"Cairo University"]