[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wound-infection-post-traumatic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wound-infection-post-traumatic":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":50,"locationsCount":53},"100647332","drone-wound-study-severe-infection-after-drone-related-combat-trauma-100647332",false,"NCT07706608","DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma","DRONE-WOUND Study: Tissue Devitalization and Severe Infection Following Drone-Related Combat Trauma: A Prospective Multicenter Observational Cohort Study","DRONE-WOUND","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Combat-related injury caused by a confirmed drone-related mechanism, including first-person view (FPV) drones, drone-delivered explosive munitions, or other unmanned aerial vehicle (UAV)-associated injuries.\n* Open extremity injury requiring operative surgical debridement.\n* Hospital admission within 24 hours after injury.\n* Written informed consent provided by the participant or legally authorized representative, in accordance with local regulations.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Isolated superficial soft tissue injuries not requiring operative treatment. Injuries requiring immediate primary amputation before initial surgical assessment.\n* Patients transferred more than 24 hours after injury.\n* Pre-existing active infection involving the injured limb before the combat injury.\n* Patients who die before completion of the initial surgical debridement.\n* Prisoners or other individuals unable to provide informed consent when no legally authorized representative is available.","ALL","18 Years","60 Years",{"count":21,"type":22},500,"ESTIMATED","OBSERVATIONAL","Drone-related combat injuries have become one of the most devastating mechanisms of injury in modern warfare. These injuries often cause extensive tissue devitalization, contamination, open fractures, vascular injuries, and complex soft tissue damage, which may substantially increase the risk of severe wound infection, multidrug-resistant bacterial infection, repeated surgical procedures, limb loss, and sepsis. However, the relationship between the extent of tissue devitalization and the development of severe infection has not been systematically investigated.\n\nThe DRONE-WOUND Study is a prospective observational cohort study designed to evaluate the association between tissue devitalization and severe wound infection in patients with drone-related combat trauma. The study will collect detailed clinical, surgical, microbiological, and radiological data from injured patients treated at participating trauma centers. Measures of tissue injury, contamination, surgical management, microbiological findings, and infection outcomes will be analyzed to identify factors associated with severe infection and poor clinical outcomes.\n\nThe findings of this study are expected to improve understanding of the mechanisms leading to infection after drone-related injuries, support early identification of high-risk patients, and inform future strategies for surgical management, antimicrobial therapy, and infection prevention in combat trauma. Ultimately, the study aims to improve limb salvage, reduce infectious complications, and enhance outcomes for patients with severe drone-related injuries.",[26,27,28,29,30,31,32],"Combat Related Symptoms","Combat Trauma","Infection","Infection Complication","Wound - in Medical Care","Wound Infection Post-Traumatic","Surgical Site Infection (SSI)",[34,27,35,36,37,38,39,40,41],"Drone-Related Injury","Tissue Devitalization","Wound Infection","Severe Wound Infection","Surgical Site Infection","Multidrug-Resistant Organisms","Antimicrobial Resistance","Soft Tissue Injury","NOT_YET_RECRUITING","2026-07-11",{"date":45,"type":46},"2026-07-16","ACTUAL",{"date":48,"type":22},"2026-10-23",{"date":48,"type":22},{"name":51,"class":52},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":59,"conditions":67,"keywords":76,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100593309","phase-1-enhancing-wound-perfusion-in-high-risk-lower-extremity-orthopaedic-surgery-a-study-on-nitropaste-using-intraoperative-spy-imaging-100593309","NCT07004764","Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.","Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Feasibility Study on Nitropaste Using Intraoperative SPY Imaging.","SPY NITROPASTE","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Undergoing surgery for one of the following procedures:\n\n  * Current Procedural Terminology (CPT) 28415 - Open reduction calcaneal fracture ± internal\u002Fexternal fixation\n  * CPT-27814 - Open reduction of bimalleolar fracture ± internal\u002Fexternal fixation\n  * CPT-27822 - Open reduction trimalleolar ankle fracture, medial and lateral malleoli only, ± internal\u002Fexternal fix\n  * CPT-27823 - Open reduction trimalleolar ankle fracture, including posterior malleolus, ± internal\u002Fexternal fix\n  * CPT-27826 - Open reduction pilon fracture, internal\u002Fexternal fixation of fibula ONLY\n  * CPT-27827 - Open reduction pilon fracture, internal\u002Fexternal fixation of tibia ONLY\n  * CPT-27828 - Open reduction pilon fracture, internal\u002Fexternal fixation of tibia AND fibula\n  * CPT-27535 - Open reduction unicondylar tibial plateau fracture, ± internal\u002Fexternal fixation\n  * CPT-27536 - Open reduction bicondylar tibial plateau fracture, ± internal\u002Fexternal fixation\n  * CPT-28445 - Open reduction of talus fracture, ± internal\u002Fexternal fixation\n  * CPT-27650 - Primary Achilles tendon repair\n* English-speaking\n* Able to provide informed consent during preoperative clinic visit, in the preoperative nursing area, or on inpatient units.\n\nExclusion Criteria:\n\n* Contraindications to nitroglycerin, including known allergy.\n* Allergy to indocyanine green or components of ICG dye, including allergies to iodine or shell-fish.\n* Severe kidney injury, as determined by attending surgeon and\u002For anesthesiologist, that would impair clearance of ICG dye.\n* Pregnant patients",{"count":63,"type":22},15,"INTERVENTIONAL",[66],"PHASE1",[68,69,70,71,72,73,74,31,75],"Achilles Tendon Repairs\u002FReconstructions","Pilon Fracture of Tibia","Tibial Plateau Fracture","Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar)","Calcaneus Fractures","Talus Fracture","Wound Infection Deep","Wound Dehiscence, Surgical",[77,78,79,80,81,69,70,82,72,83,84,85,86,87],"Laser-assisted indocyanine green angiography","nitropaste","nitroglycerin","topical nitroglycerin","Achilles tendon repairs\u002Freconstructions","Ankle Fracture (bimalleolar equivalent, bimalleolar, or trimalleolar)","Talus fracture","Wound Dehiscence","Wound infection","tissue perfusion","Orthopaedic surgery","2026-03-30",{"date":90,"type":46},"2026-03-31",{"date":92,"type":22},"2026-11",{"date":94,"type":22},"2027-12",{"name":96,"class":52},"Johns Hopkins University",2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":64,"phases":107,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":4},"100628010","effectiveness-of-chlorhexidine-impregnated-gauze-versus-povidone-iodine-dressing-in-post-trauma-wound-care-100628010","NCT07456072","Effectiveness of Chlorhexidine Impregnated Gauze Versus Povidone Iodine Dressing in Post Trauma Wound Care","Inclusion Criteria:\n\n* Patients 18-65 years of age with acute post-trauma wounds.\n* Wounds that are clean contaminated at presentation.\n\nExclusion Criteria:\n\n* Patients with the known allergies to Chlorhexidine or Povidone-Iodine.\n* Chronic wounds or those with underlying chronic conditions, such as diabetes.\n* Patients with compromised immune systems.\n* Pregnant females","65 Years",{"count":106,"type":22},176,[108],"NA","To compare rate of infection and wound healing between chlorhexidine impregnated paraffin gauze and dry povidone-iodine dressings in post-traumatic wounds.",[31,111],"Wound Healing","2026-03-03",{"date":114,"type":46},"2026-03-06",{"date":116,"type":22},"2026-03-01",{"date":118,"type":22},"2026-05-31",{"name":120,"class":121},"Pakistan Institute of Medical Sciences","OTHER_GOV"]