[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wound-surgical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wound-surgical":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,80,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100652155","negative-pressure-wound-therapy-devices-in-total-knee-arthroplasty-100652155",false,"NCT07770633","Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty","Randomized Controlled Clinical Trial for Closed Incision Negative Pressure Wound Therapy (NPWT) Devices in Total Knee Arthroplasty (TKA)","Inclusion Criteria:\n\n* Age 18 years or older\n* Undergoing primary total knee arthroplasty\n* Able to understand the study, provide informed consent, and participate in study procedures\n\nMeet at least one of the following co-morbidities:\n\n* BMI ≥35\n* Diabetes\n* Prior surgical incision(s) in the operative area\n* Chronic kidney disease\n\nExclusion Criteria:\n\n* Prisoners\n* Pregnant women\n* Patients who indicate they may not comply with post-operative instructions\n* Patients with active bleeding",true,"ALL","18 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult patients undergoing primary total knee arthroplasty (TKA) who meet predefined high-risk criteria for wound complications.\n\nA total of approximately 300 participants will be enrolled and randomized in a 1:1:1 fashion to receive one of the three study dressings applied over the closed surgical incision at the end of the procedure. All participants will otherwise receive standard perioperative and postoperative care. The primary follow-up period will extend through 90 days after surgery.\n\nThe primary objective is to compare the incidence of 90-day surgical site complications, including superficial infection, wound dehiscence, seroma, and hematoma, across the three dressing groups. Secondary objectives include evaluation of device usability, patient experience, and device-related issues (such as loss of seal, alarms, tubing or pump problems, fluid saturation, and premature dressing changes), as well as assessment of the interaction between skin closure method and device performance.\n\nResearch-specific activities are limited to eligibility confirmation, informed consent, randomization, administration of a brief postoperative patient survey at approximately postoperative day 7 and\u002For dressing removal, provider assessment of the dressing at removal, and collection of clinical outcomes from the medical record. No additional blood draws, imaging, or invasive procedures are required for participation.\n\nThis study is designed to address a gap in the literature by providing head-to-head comparative data on commonly used ciNPWT systems in a high-risk primary TKA population, with the goal of informing postoperative wound management strategies in clinical practice.",[27,28,29,30,31],"Wound Surgical","Diabetes","Obesity","Chronic Kidney Diseases","Smoking",[33,34],"Total Knee Arthroplasty","Total Knee Replacement","NOT_YET_RECRUITING","2026-08-17",{"date":38,"type":39},"2026-08-18","ACTUAL",{"date":41,"type":21},"2026-09-01",{"date":43,"type":21},"2030-12",{"name":45,"class":46},"The Cleveland Clinic","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100518031","pinta---prophylactic-incisional-negative-pressure-therapy-for-major-amputations-100518031","NCT06025253","PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations","Prophylactic Single-Use Negative Pressure Wound Therapy Devices for Closed Incision Major Amputations","PINTA","Inclusion Criteria:\n\n* Patients aged 18 years or older;\n* Patients undergoing major lower extremity amputation, including below-knee amputation, through-knee amputation and above-knee amputation, for any indication;\n* Patients with primary closure of the surgical incision using either interrupted or continuous sutures\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years;\n* Women who are pregnant and\u002For breast-feeding;\n* Patients with amputations performed without primary skin closure, including guillotine amputations, amputations deliberately left open for drainage purposes and amputations with soft tissues defects at the stump;\n* Patients with amputations where skin glue is the only means of skin closure\n* Patients with a clinically absent femoral pulse",{"count":56,"type":21},728,[24],"Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. This study is taking place to investigate if Negative Pressure Wound Therapy (NPWT) dressings reduces Surgical Site Infections, post surgical complications and improves scar appearance compared to standard dressings.",[27,60,61],"Wound Infection","Cosmesis",[63,64,65,66,67,68],"Negative Pressure Wound Therapy","Surgical Site Infection","Post-operative Complications","Health Economics","CoPaQ","WoundQol","RECRUITING","2026-07-20",{"date":72,"type":39},"2026-07-21",{"date":74,"type":39},"2024-03-01",{"date":76,"type":21},"2028-12",{"name":78,"class":46},"Royal College of Surgeons, Ireland",7,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100628301","this-is-a-study-to-find-out-whether-music-therapy-can-reduce-stress-during-wound-care-100628301","NCT07459855","This is a Study to Find Out Whether Music Therapy Can Reduce Stress During Wound Care","Music Therapy to Reduce Stress and Increase Satisfaction in Patients Undergoing Surgical Wound Dressings in the In-hospital Setting: a Randomized Study","Inclusion Criteria:\n\n* Hospitalized patients undergoing wound dressing procedures\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* Cognitive impairment or language barriers\n* Severe hearing impairment\n* Clinical instability requiring urgent medical intervention at the time of wound dressing",{"count":88,"type":21},50,[24],"This study involves hospitalized patients who need wound dressing procedures. Patients will be assigned by chance to one of two groups. One group will listen to music of their choice during wound care, while the other group will receive standard wound care without music. The investigators will then compare the two groups to see whether listening to music helps reduce stress and improve the experience during the procedure.",[27],"2026-03-03",{"date":94,"type":39},"2026-03-10",{"date":96,"type":21},"2026-02-11",{"date":98,"type":21},"2026-05-31",{"name":100,"class":46},"Ente Ospedaliero Cantonale, Bellinzona",1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":101},"100539863","phase-4-ostomy-primary-closure-with-01-betainepolyhexanide-wound-irrigation-compared-to-pursestring-closure-100539863","NCT06309368","Ostomy Primary Closure With 0.1% Betaine\u002FPolyhexanide Wound Irrigation Compared to Pursestring Closure","To Close or Not to Close: Surgical Site Infection Rates in Ostomy Primary Closure With 0.1% Betaine\u002FPolyhexanide Wound Irrigation Compared to Conventional Ostomy Closure by Secondary Intention","Inclusion Criteria:\n\n* All patients 18 years or older with an diverting loop ileostomy reversal indication will be enrolled\n* Signed consent\n\nExclusion Criteria:\n\n* Under 18 years old, unable to provide consent, has a parastomal hernia requiring mesh repair, or has an end ileostomy",{"count":110,"type":21},84,[112],"PHASE4","The goal of this clinical trial is to compare two types of closure in patients with ostomies that are ready for closure. The main questions it aims to answer are:\n\n1. Surgical site infection rates\n2. Patient quality of life\n3. Time to wound healing\n\nParticipants will undergo either complete ostomy wound closure after washing out the wound with Prontosan, or their ostomy wound will be closed using the Pursestring method, where the wound will be left partially open and allowed to heal from the inside out. Researchers will compare these two groups' outcomes (questions to be answered) as listed above.",[64,27,115],"Colorectal Disorders",[117,64,118,119],"Ostomy","Primary Closure","Secondary Closure","2025-05-27",{"date":122,"type":39},"2025-06-02",{"date":124,"type":39},"2024-03-14",{"date":126,"type":21},"2029-12",{"name":128,"class":46},"University of Nevada, Las Vegas"]