[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wounds-nonpenetrating\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wounds-nonpenetrating":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":31,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":55,"leadSponsor":57,"locationsCount":5},"100657788","predictors-of-in-hospital-mortality-in-severe-abdominal-trauma-100657788",false,"NCT07843628","Predictors of In-Hospital Mortality in Severe Abdominal Trauma","Predictors of Mortality in Severe Abdominal Trauma: A Prospective Cohort From a Tertiary Center","Inclusion Criteria:\n\n* Age 16 years or older.\n* Abdominal trauma, blunt or penetrating, meeting at least one criterion for severity: Abbreviated Injury Scale (AIS) for the abdominal region of 3 or more; and\u002For an abdominal injury requiring emergency laparotomy, laparoscopy or angioembolisation; and\u002For admission to the intensive care unit for management of an abdominal injury.\n* Presentation within 24 hours of injury.\n* Informed consent provided by the patient or, for incapacitated patients, by a legal representative, with deferred consent procedures as specified in the protocol.\n\nExclusion Criteria:\n\n* Death on arrival, or within the first 15 minutes of admission before meaningful resuscitation or data capture.\n* Isolated minor abdominal injury not meeting the severity definition (AIS-abdomen below 3 and not requiring operative or radiological intervention or critical-care admission).\n* Transfer out of the centre before the primary outcome can be ascertained.\n* Known pregnancy (managed on a separate obstetric-trauma pathway).\n* Declined consent.","ALL","16 Years",{"count":19,"type":20},430,"ESTIMATED","OBSERVATIONAL","Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and calibrated in high-income trauma systems and may perform differently in high-volume referral hospitals elsewhere, where patients frequently arrive after a prehospital delay and already in established shock.\n\nThis study will prospectively follow consecutive patients aged 16 years and older admitted to a single tertiary trauma centre with severe abdominal injury over a 12-month period. Severe abdominal trauma is defined as an Abbreviated Injury Scale score of 3 or more for the abdominal region, and\u002For an abdominal injury requiring emergency laparotomy, laparoscopy or angioembolisation, and\u002For admission to intensive care for management of an abdominal injury. A total of 430 evaluable patients is anticipated.\n\nInformation generated as part of routine trauma care will be recorded prospectively from arrival until hospital discharge: age, sex and comorbidity; injury mechanism, time from injury to arrival and mode of arrival; arrival physiology (systolic blood pressure, heart rate, shock index, Glasgow Coma Scale, respiratory rate, oxygen saturation, temperature); admission biochemistry (arterial lactate, base deficit, pH, haemoglobin, platelet count, INR); imaging and operative findings with American Association for the Surgery of Trauma organ injury grades; transfusion and operative management; and in-hospital complications.\n\nThe primary outcome is in-hospital all-cause mortality. Survivors and non-survivors will be compared, and a multivariable logistic regression model will be built to identify admission and early in-hospital variables that independently predict death. Model discrimination and calibration will be assessed and internally validated by bootstrap resampling, and performance will be compared with that of the Injury Severity Score, Revised Trauma Score, TRISS and the MGAP score. If the model is robust, a simplified integer bedside risk score will be derived and internally validated.\n\nThe study is purely observational: it mandates no additional investigations, interventions or visits, and all clinical decisions remain with the attending trauma team according to institutional ATLS-based protocols. The findings are intended to support locally valid triage, transfusion and damage-control decision-making and to enable fair outcome benchmarking between comparable centres.",[24,25,26,27,28,29,30],"Abdominal Injuries","Wounds and Injuries","Wounds, Nonpenetrating","Wounds, Penetrating","Multiple Trauma","Shock, Hemorrhagic","Hospital Mortality",[32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48],"Abdominal trauma","Blunt abdominal trauma","Penetrating abdominal trauma","In-hospital mortality","Prediction model","Risk stratification","Shock index","Arterial lactate","Base deficit","Trauma-induced coagulopathy","Massive transfusion","Damage-control surgery","Injury Severity Score","Revised Trauma Score","TRISS","MGAP score","AAST organ injury scale","RECRUITING","2026-10-01",{"date":52,"type":53},"2026-10-02","ACTUAL",{"date":50,"type":53},{"date":56,"type":20},"2027-10-30",{"name":58,"class":59},"Minia University","OTHER"]